Amino acid dipepetide frequency for Gloeothece citriformis (strain PCC 7424) (Cyanothece sp. (strain PCC 7424))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.845AlaAla: 4.845 ± 0.069	0.741AlaCys: 0.741 ± 0.021	3.253AlaAsp: 3.253 ± 0.054	4.089AlaGlu: 4.089 ± 0.059	2.572AlaPhe: 2.572 ± 0.036	4.299AlaGly: 4.299 ± 0.058	1.157AlaHis: 1.157 ± 0.03	5.959AlaIle: 5.959 ± 0.071	3.833AlaLys: 3.833 ± 0.057	7.721AlaLeu: 7.721 ± 0.089	1.334AlaMet: 1.334 ± 0.029	2.923AlaAsn: 2.923 ± 0.05	2.364AlaPro: 2.364 ± 0.043	4.055AlaGln: 4.055 ± 0.058	2.912AlaArg: 2.912 ± 0.048	4.053AlaSer: 4.053 ± 0.06	3.866AlaThr: 3.866 ± 0.051	4.353AlaVal: 4.353 ± 0.048	0.917AlaTrp: 0.917 ± 0.025	2.233AlaTyr: 2.233 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.554CysAla: 0.554 ± 0.019	0.18CysCys: 0.18 ± 0.01	0.52CysAsp: 0.52 ± 0.019	0.572CysGlu: 0.572 ± 0.019	0.446CysPhe: 0.446 ± 0.015	0.744CysGly: 0.744 ± 0.024	0.311CysHis: 0.311 ± 0.014	0.568CysIle: 0.568 ± 0.019	0.353CysLys: 0.353 ± 0.014	1.176CysLeu: 1.176 ± 0.024	0.134CysMet: 0.134 ± 0.01	0.37CysAsn: 0.37 ± 0.017	0.611CysPro: 0.611 ± 0.02	0.736CysGln: 0.736 ± 0.021	0.557CysArg: 0.557 ± 0.018	0.66CysSer: 0.66 ± 0.02	0.441CysThr: 0.441 ± 0.014	0.541CysVal: 0.541 ± 0.017	0.174CysTrp: 0.174 ± 0.009	0.409CysTyr: 0.409 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.781AspAla: 2.781 ± 0.042	0.499AspCys: 0.499 ± 0.018	2.145AspAsp: 2.145 ± 0.046	3.289AspGlu: 3.289 ± 0.055	2.378AspPhe: 2.378 ± 0.04	3.08AspGly: 3.08 ± 0.052	0.965AspHis: 0.965 ± 0.03	3.495AspIle: 3.495 ± 0.05	2.544AspLys: 2.544 ± 0.043	5.964AspLeu: 5.964 ± 0.063	0.687AspMet: 0.687 ± 0.022	2.331AspAsn: 2.331 ± 0.042	2.645AspPro: 2.645 ± 0.046	2.123AspGln: 2.123 ± 0.035	2.716AspArg: 2.716 ± 0.046	2.883AspSer: 2.883 ± 0.046	2.268AspThr: 2.268 ± 0.058	2.691AspVal: 2.691 ± 0.045	0.905AspTrp: 0.905 ± 0.027	2.174AspTyr: 2.174 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.047GluAla: 5.047 ± 0.072	0.477GluCys: 0.477 ± 0.016	3.261GluAsp: 3.261 ± 0.052	4.995GluGlu: 4.995 ± 0.071	2.448GluPhe: 2.448 ± 0.039	3.753GluGly: 3.753 ± 0.057	0.949GluHis: 0.949 ± 0.025	5.552GluIle: 5.552 ± 0.062	4.588GluLys: 4.588 ± 0.066	6.87GluLeu: 6.87 ± 0.066	1.39GluMet: 1.39 ± 0.03	3.176GluAsn: 3.176 ± 0.044	2.448GluPro: 2.448 ± 0.046	4.076GluGln: 4.076 ± 0.055	3.378GluArg: 3.378 ± 0.057	3.559GluSer: 3.559 ± 0.046	4.01GluThr: 4.01 ± 0.053	4.165GluVal: 4.165 ± 0.06	0.839GluTrp: 0.839 ± 0.024	1.874GluTyr: 1.874 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	2.646PheAla: 2.646 ± 0.036	0.544PheCys: 0.544 ± 0.018	2.188PheAsp: 2.188 ± 0.038	2.476PheGlu: 2.476 ± 0.045	1.968PhePhe: 1.968 ± 0.04	2.688PheGly: 2.688 ± 0.049	0.678PheHis: 0.678 ± 0.02	2.814PheIle: 2.814 ± 0.047	2.081PheLys: 2.081 ± 0.036	4.487PheLeu: 4.487 ± 0.061	0.718PheMet: 0.718 ± 0.02	2.145PheAsn: 2.145 ± 0.038	2.025PhePro: 2.025 ± 0.034	1.742PheGln: 1.742 ± 0.036	1.834PheArg: 1.834 ± 0.035	3.088PheSer: 3.088 ± 0.049	2.175PheThr: 2.175 ± 0.036	2.224PheVal: 2.224 ± 0.041	0.748PheTrp: 0.748 ± 0.024	1.568PheTyr: 1.568 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.157GlyAla: 4.157 ± 0.069	0.777GlyCys: 0.777 ± 0.023	3.092GlyAsp: 3.092 ± 0.052	4.165GlyGlu: 4.165 ± 0.052	2.963GlyPhe: 2.963 ± 0.041	4.717GlyGly: 4.717 ± 0.101	1.196GlyHis: 1.196 ± 0.033	5.383GlyIle: 5.383 ± 0.064	4.152GlyLys: 4.152 ± 0.067	6.862GlyLeu: 6.862 ± 0.076	1.445GlyMet: 1.445 ± 0.032	2.988GlyAsn: 2.988 ± 0.076	1.089GlyPro: 1.089 ± 0.027	3.012GlyGln: 3.012 ± 0.042	2.98GlyArg: 2.98 ± 0.045	3.641GlySer: 3.641 ± 0.059	3.586GlyThr: 3.586 ± 0.048	4.492GlyVal: 4.492 ± 0.063	1.131GlyTrp: 1.131 ± 0.028	2.396GlyTyr: 2.396 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	0.841HisAla: 0.841 ± 0.025	0.282HisCys: 0.282 ± 0.012	0.781HisAsp: 0.781 ± 0.026	0.846HisGlu: 0.846 ± 0.022	0.862HisPhe: 0.862 ± 0.021	1.014HisGly: 1.014 ± 0.026	0.719HisHis: 0.719 ± 0.026	1.063HisIle: 1.063 ± 0.025	0.834HisLys: 0.834 ± 0.02	2.535HisLeu: 2.535 ± 0.04	0.203HisMet: 0.203 ± 0.012	0.765HisAsn: 0.765 ± 0.02	1.394HisPro: 1.394 ± 0.031	1.393HisGln: 1.393 ± 0.034	1.058HisArg: 1.058 ± 0.029	1.24HisSer: 1.24 ± 0.025	0.791HisThr: 0.791 ± 0.026	0.678HisVal: 0.678 ± 0.022	0.384HisTrp: 0.384 ± 0.016	0.762HisTyr: 0.762 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.196IleAla: 6.196 ± 0.064	0.805IleCys: 0.805 ± 0.019	3.986IleAsp: 3.986 ± 0.055	5.279IleGlu: 5.279 ± 0.062	2.941IlePhe: 2.941 ± 0.048	4.734IleGly: 4.734 ± 0.056	1.262IleHis: 1.262 ± 0.029	5.339IleIle: 5.339 ± 0.066	3.965IleLys: 3.965 ± 0.057	7.813IleLeu: 7.813 ± 0.074	1.043IleMet: 1.043 ± 0.023	3.763IleAsn: 3.763 ± 0.057	3.933IlePro: 3.933 ± 0.046	3.072IleGln: 3.072 ± 0.046	3.315IleArg: 3.315 ± 0.048	4.771IleSer: 4.771 ± 0.064	4.178IleThr: 4.178 ± 0.049	4.22IleVal: 4.22 ± 0.055	0.973IleTrp: 0.973 ± 0.028	2.376IleTyr: 2.376 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.021LysAla: 4.021 ± 0.059	0.384LysCys: 0.384 ± 0.016	2.56LysAsp: 2.56 ± 0.041	3.658LysGlu: 3.658 ± 0.06	1.855LysPhe: 1.855 ± 0.038	3.115LysGly: 3.115 ± 0.052	0.87LysHis: 0.87 ± 0.022	4.55LysIle: 4.55 ± 0.059	3.3LysLys: 3.3 ± 0.056	5.821LysLeu: 5.821 ± 0.064	1.052LysMet: 1.052 ± 0.024	2.802LysAsn: 2.802 ± 0.04	2.625LysPro: 2.625 ± 0.047	3.055LysGln: 3.055 ± 0.045	2.671LysArg: 2.671 ± 0.039	3.25LysSer: 3.25 ± 0.044	3.75LysThr: 3.75 ± 0.053	3.238LysVal: 3.238 ± 0.043	0.565LysTrp: 0.565 ± 0.018	1.564LysTyr: 1.564 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	8.339LeuAla: 8.339 ± 0.088	1.081LeuCys: 1.081 ± 0.026	5.55LeuAsp: 5.55 ± 0.057	8.079LeuGlu: 8.079 ± 0.074	4.09LeuPhe: 4.09 ± 0.059	7.48LeuGly: 7.48 ± 0.072	1.736LeuHis: 1.736 ± 0.031	8.289LeuIle: 8.289 ± 0.077	7.046LeuLys: 7.046 ± 0.072	11.204LeuLeu: 11.204 ± 0.112	2.174LeuMet: 2.174 ± 0.038	5.384LeuAsn: 5.384 ± 0.061	5.379LeuPro: 5.379 ± 0.059	5.057LeuGln: 5.057 ± 0.075	5.015LeuArg: 5.015 ± 0.069	8.282LeuSer: 8.282 ± 0.084	6.901LeuThr: 6.901 ± 0.083	6.624LeuVal: 6.624 ± 0.07	1.532LeuTrp: 1.532 ± 0.037	2.951LeuTyr: 2.951 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	1.565MetAla: 1.565 ± 0.029	0.123MetCys: 0.123 ± 0.009	0.727MetAsp: 0.727 ± 0.022	0.999MetGlu: 0.999 ± 0.024	0.556MetPhe: 0.556 ± 0.016	1.423MetGly: 1.423 ± 0.031	0.21MetHis: 0.21 ± 0.012	1.47MetIle: 1.47 ± 0.025	1.083MetLys: 1.083 ± 0.024	1.75MetLeu: 1.75 ± 0.037	0.47MetMet: 0.47 ± 0.017	0.919MetAsn: 0.919 ± 0.024	0.815MetPro: 0.815 ± 0.022	0.639MetGln: 0.639 ± 0.019	0.833MetArg: 0.833 ± 0.022	1.358MetSer: 1.358 ± 0.03	1.421MetThr: 1.421 ± 0.031	1.17MetVal: 1.17 ± 0.029	0.146MetTrp: 0.146 ± 0.009	0.366MetTyr: 0.366 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.494AsnAla: 2.494 ± 0.044	0.556AsnCys: 0.556 ± 0.018	1.928AsnAsp: 1.928 ± 0.053	2.152AsnGlu: 2.152 ± 0.042	2.169AsnPhe: 2.169 ± 0.037	2.647AsnGly: 2.647 ± 0.045	1.036AsnHis: 1.036 ± 0.026	3.021AsnIle: 3.021 ± 0.051	2.07AsnLys: 2.07 ± 0.037	6.274AsnLeu: 6.274 ± 0.078	0.702AsnMet: 0.702 ± 0.02	2.486AsnAsn: 2.486 ± 0.046	3.385AsnPro: 3.385 ± 0.059	3.072AsnGln: 3.072 ± 0.048	2.487AsnArg: 2.487 ± 0.039	3.272AsnSer: 3.272 ± 0.054	2.342AsnThr: 2.342 ± 0.038	2.066AsnVal: 2.066 ± 0.037	0.811AsnTrp: 0.811 ± 0.021	1.899AsnTyr: 1.899 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.435ProAla: 2.435 ± 0.04	0.376ProCys: 0.376 ± 0.017	2.913ProAsp: 2.913 ± 0.045	3.92ProGlu: 3.92 ± 0.056	1.886ProPhe: 1.886 ± 0.032	2.607ProGly: 2.607 ± 0.042	0.981ProHis: 0.981 ± 0.025	3.396ProIle: 3.396 ± 0.046	2.465ProLys: 2.465 ± 0.043	4.996ProLeu: 4.996 ± 0.063	0.754ProMet: 0.754 ± 0.02	2.417ProAsn: 2.417 ± 0.038	2.426ProPro: 2.426 ± 0.047	2.864ProGln: 2.864 ± 0.055	1.668ProArg: 1.668 ± 0.029	3.31ProSer: 3.31 ± 0.057	2.703ProThr: 2.703 ± 0.046	3.164ProVal: 3.164 ± 0.048	0.626ProTrp: 0.626 ± 0.02	1.504ProTyr: 1.504 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.009GlnAla: 4.009 ± 0.065	0.387GlnCys: 0.387 ± 0.016	2.308GlnAsp: 2.308 ± 0.036	4.226GlnGlu: 4.226 ± 0.062	1.992GlnPhe: 1.992 ± 0.036	3.422GlnGly: 3.422 ± 0.041	0.775GlnHis: 0.775 ± 0.023	4.055GlnIle: 4.055 ± 0.055	3.261GlnLys: 3.261 ± 0.053	6.33GlnLeu: 6.33 ± 0.081	1.105GlnMet: 1.105 ± 0.023	2.237GlnAsn: 2.237 ± 0.044	2.484GlnPro: 2.484 ± 0.048	3.752GlnGln: 3.752 ± 0.073	2.521GlnArg: 2.521 ± 0.043	3.04GlnSer: 3.04 ± 0.038	3.099GlnThr: 3.099 ± 0.047	3.444GlnVal: 3.444 ± 0.041	0.871GlnTrp: 0.871 ± 0.027	1.441GlnTyr: 1.441 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.692ArgAla: 2.692 ± 0.046	0.488ArgCys: 0.488 ± 0.02	2.28ArgAsp: 2.28 ± 0.038	3.419ArgGlu: 3.419 ± 0.053	2.134ArgPhe: 2.134 ± 0.041	2.815ArgGly: 2.815 ± 0.043	1.001ArgHis: 1.001 ± 0.027	3.2ArgIle: 3.2 ± 0.044	2.348ArgLys: 2.348 ± 0.042	5.636ArgLeu: 5.636 ± 0.055	0.884ArgMet: 0.884 ± 0.024	2.017ArgAsn: 2.017 ± 0.032	1.931ArgPro: 1.931 ± 0.038	3.062ArgGln: 3.062 ± 0.051	2.682ArgArg: 2.682 ± 0.051	2.838ArgSer: 2.838 ± 0.041	2.23ArgThr: 2.23 ± 0.038	3.078ArgVal: 3.078 ± 0.046	0.811ArgTrp: 0.811 ± 0.023	1.87ArgTyr: 1.87 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.695SerAla: 3.695 ± 0.048	0.652SerCys: 0.652 ± 0.021	3.124SerAsp: 3.124 ± 0.047	3.932SerGlu: 3.932 ± 0.053	2.794SerPhe: 2.794 ± 0.049	4.205SerGly: 4.205 ± 0.064	1.374SerHis: 1.374 ± 0.032	4.132SerIle: 4.132 ± 0.054	2.891SerLys: 2.891 ± 0.046	7.904SerLeu: 7.904 ± 0.076	1.172SerMet: 1.172 ± 0.023	2.872SerAsn: 2.872 ± 0.041	3.718SerPro: 3.718 ± 0.062	4.091SerGln: 4.091 ± 0.054	2.987SerArg: 2.987 ± 0.044	4.805SerSer: 4.805 ± 0.067	3.138SerThr: 3.138 ± 0.04	3.842SerVal: 3.842 ± 0.05	0.955SerTrp: 0.955 ± 0.026	2.063SerTyr: 2.063 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	3.888ThrAla: 3.888 ± 0.05	0.488ThrCys: 0.488 ± 0.017	2.687ThrAsp: 2.687 ± 0.042	3.617ThrGlu: 3.617 ± 0.059	2.143ThrPhe: 2.143 ± 0.039	4.048ThrGly: 4.048 ± 0.058	1.126ThrHis: 1.126 ± 0.026	4.015ThrIle: 4.015 ± 0.058	2.225ThrLys: 2.225 ± 0.03	6.891ThrLeu: 6.891 ± 0.074	0.784ThrMet: 0.784 ± 0.025	2.181ThrAsn: 2.181 ± 0.034	3.484ThrPro: 3.484 ± 0.053	3.109ThrGln: 3.109 ± 0.056	2.255ThrArg: 2.255 ± 0.043	3.337ThrSer: 3.337 ± 0.045	3.174ThrThr: 3.174 ± 0.049	3.94ThrVal: 3.94 ± 0.057	0.699ThrTrp: 0.699 ± 0.02	1.774ThrTyr: 1.774 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	4.705ValAla: 4.705 ± 0.072	0.647ValCys: 0.647 ± 0.021	2.975ValAsp: 2.975 ± 0.052	4.264ValGlu: 4.264 ± 0.053	2.471ValPhe: 2.471 ± 0.036	4.184ValGly: 4.184 ± 0.063	0.951ValHis: 0.951 ± 0.025	4.745ValIle: 4.745 ± 0.054	3.478ValLys: 3.478 ± 0.056	5.952ValLeu: 5.952 ± 0.063	1.258ValMet: 1.258 ± 0.024	2.979ValAsn: 2.979 ± 0.048	2.507ValPro: 2.507 ± 0.036	2.341ValGln: 2.341 ± 0.04	2.744ValArg: 2.744 ± 0.039	3.984ValSer: 3.984 ± 0.043	3.529ValThr: 3.529 ± 0.046	3.948ValVal: 3.948 ± 0.05	0.818ValTrp: 0.818 ± 0.032	1.866ValTyr: 1.866 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.776TrpAla: 0.776 ± 0.025	0.142TrpCys: 0.142 ± 0.008	0.705TrpAsp: 0.705 ± 0.027	1.038TrpGlu: 1.038 ± 0.027	0.663TrpPhe: 0.663 ± 0.022	1.124TrpGly: 1.124 ± 0.035	0.328TrpHis: 0.328 ± 0.013	0.995TrpIle: 0.995 ± 0.026	0.732TrpLys: 0.732 ± 0.023	1.954TrpLeu: 1.954 ± 0.037	0.324TrpMet: 0.324 ± 0.015	0.646TrpAsn: 0.646 ± 0.021	0.321TrpPro: 0.321 ± 0.014	1.124TrpGln: 1.124 ± 0.031	0.761TrpArg: 0.761 ± 0.023	0.871TrpSer: 0.871 ± 0.026	0.691TrpThr: 0.691 ± 0.02	0.877TrpVal: 0.877 ± 0.026	0.227TrpTrp: 0.227 ± 0.011	0.462TrpTyr: 0.462 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.793TyrAla: 1.793 ± 0.037	0.43TyrCys: 0.43 ± 0.018	1.579TyrAsp: 1.579 ± 0.032	1.841TyrGlu: 1.841 ± 0.04	1.506TyrPhe: 1.506 ± 0.028	2.124TyrGly: 2.124 ± 0.034	0.821TyrHis: 0.821 ± 0.021	1.921TyrIle: 1.921 ± 0.037	1.456TyrLys: 1.456 ± 0.029	4.052TyrLeu: 4.052 ± 0.056	0.408TyrMet: 0.408 ± 0.016	1.472TyrAsn: 1.472 ± 0.036	1.826TyrPro: 1.826 ± 0.038	2.384TyrGln: 2.384 ± 0.047	2.042TyrArg: 2.042 ± 0.036	2.104TyrSer: 2.104 ± 0.035	1.572TyrThr: 1.572 ± 0.037	1.59TyrVal: 1.59 ± 0.028	0.627TyrTrp: 0.627 ± 0.02	1.317TyrTyr: 1.317 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5656 proteins (1754939 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---