Amino acid dipepetide frequency for Chroococcidiopsis thermalis (strain PCC 7203)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.044AlaAla: 9.044 ± 0.084	0.909AlaCys: 0.909 ± 0.021	4.048AlaAsp: 4.048 ± 0.057	5.555AlaGlu: 5.555 ± 0.061	3.129AlaPhe: 3.129 ± 0.047	5.993AlaGly: 5.993 ± 0.072	1.359AlaHis: 1.359 ± 0.027	8.313AlaIle: 8.313 ± 0.079	4.05AlaLys: 4.05 ± 0.046	8.867AlaLeu: 8.867 ± 0.086	1.787AlaMet: 1.787 ± 0.033	3.378AlaAsn: 3.378 ± 0.047	3.322AlaPro: 3.322 ± 0.046	4.688AlaGln: 4.688 ± 0.061	4.318AlaArg: 4.318 ± 0.058	5.052AlaSer: 5.052 ± 0.059	5.34AlaThr: 5.34 ± 0.061	6.076AlaVal: 6.076 ± 0.066	1.155AlaTrp: 1.155 ± 0.025	2.502AlaTyr: 2.502 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.681CysAla: 0.681 ± 0.019	0.186CysCys: 0.186 ± 0.011	0.618CysAsp: 0.618 ± 0.02	0.486CysGlu: 0.486 ± 0.018	0.431CysPhe: 0.431 ± 0.015	0.774CysGly: 0.774 ± 0.021	0.299CysHis: 0.299 ± 0.013	0.603CysIle: 0.603 ± 0.016	0.313CysLys: 0.313 ± 0.011	1.165CysLeu: 1.165 ± 0.029	0.177CysMet: 0.177 ± 0.01	0.354CysAsn: 0.354 ± 0.014	0.551CysPro: 0.551 ± 0.015	0.645CysGln: 0.645 ± 0.019	0.589CysArg: 0.589 ± 0.017	0.608CysSer: 0.608 ± 0.019	0.516CysThr: 0.516 ± 0.018	0.605CysVal: 0.605 ± 0.021	0.151CysTrp: 0.151 ± 0.01	0.352CysTyr: 0.352 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.792AspAla: 3.792 ± 0.048	0.538AspCys: 0.538 ± 0.018	2.052AspAsp: 2.052 ± 0.05	2.816AspGlu: 2.816 ± 0.048	2.149AspPhe: 2.149 ± 0.032	3.189AspGly: 3.189 ± 0.049	0.452AspHis: 0.452 ± 0.017	3.0AspIle: 3.0 ± 0.043	2.142AspLys: 2.142 ± 0.049	5.683AspLeu: 5.683 ± 0.059	0.745AspMet: 0.745 ± 0.021	1.745AspAsn: 1.745 ± 0.035	2.477AspPro: 2.477 ± 0.035	0.952AspGln: 0.952 ± 0.025	5.466AspArg: 5.466 ± 0.066	2.813AspSer: 2.813 ± 0.049	2.424AspThr: 2.424 ± 0.042	3.012AspVal: 3.012 ± 0.046	0.847AspTrp: 0.847 ± 0.022	1.709AspTyr: 1.709 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.536GluAla: 5.536 ± 0.062	0.486GluCys: 0.486 ± 0.017	2.617GluAsp: 2.617 ± 0.038	3.582GluGlu: 3.582 ± 0.052	2.426GluPhe: 2.426 ± 0.041	3.154GluGly: 3.154 ± 0.045	0.926GluHis: 0.926 ± 0.022	4.674GluIle: 4.674 ± 0.051	2.999GluLys: 2.999 ± 0.044	6.689GluLeu: 6.689 ± 0.07	1.3GluMet: 1.3 ± 0.027	2.28GluAsn: 2.28 ± 0.037	2.471GluPro: 2.471 ± 0.04	3.686GluGln: 3.686 ± 0.05	3.792GluArg: 3.792 ± 0.052	3.248GluSer: 3.248 ± 0.044	3.51GluThr: 3.51 ± 0.043	4.134GluVal: 4.134 ± 0.048	0.799GluTrp: 0.799 ± 0.021	1.785GluTyr: 1.785 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.33PheAla: 3.33 ± 0.045	0.518PheCys: 0.518 ± 0.018	2.212PheAsp: 2.212 ± 0.037	2.116PheGlu: 2.116 ± 0.036	1.69PhePhe: 1.69 ± 0.032	3.021PheGly: 3.021 ± 0.046	0.862PheHis: 0.862 ± 0.022	2.246PheIle: 2.246 ± 0.037	1.389PheLys: 1.389 ± 0.032	4.183PheLeu: 4.183 ± 0.059	0.646PheMet: 0.646 ± 0.019	1.641PheAsn: 1.641 ± 0.035	1.806PhePro: 1.806 ± 0.032	1.851PheGln: 1.851 ± 0.032	1.894PheArg: 1.894 ± 0.029	2.867PheSer: 2.867 ± 0.05	2.301PheThr: 2.301 ± 0.039	2.546PheVal: 2.546 ± 0.043	0.752PheTrp: 0.752 ± 0.021	1.398PheTyr: 1.398 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.399GlyAla: 5.399 ± 0.071	0.784GlyCys: 0.784 ± 0.022	3.574GlyAsp: 3.574 ± 0.052	3.975GlyGlu: 3.975 ± 0.047	3.004GlyPhe: 3.004 ± 0.045	5.017GlyGly: 5.017 ± 0.084	1.181GlyHis: 1.181 ± 0.034	5.089GlyIle: 5.089 ± 0.058	3.776GlyLys: 3.776 ± 0.052	6.91GlyLeu: 6.91 ± 0.073	1.631GlyMet: 1.631 ± 0.032	2.734GlyAsn: 2.734 ± 0.048	1.145GlyPro: 1.145 ± 0.028	3.092GlyGln: 3.092 ± 0.059	3.574GlyArg: 3.574 ± 0.054	4.247GlySer: 4.247 ± 0.064	3.929GlyThr: 3.929 ± 0.055	4.955GlyVal: 4.955 ± 0.06	1.16GlyTrp: 1.16 ± 0.025	2.409GlyTyr: 2.409 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.298HisAla: 1.298 ± 0.03	0.268HisCys: 0.268 ± 0.013	0.811HisAsp: 0.811 ± 0.024	0.873HisGlu: 0.873 ± 0.021	0.799HisPhe: 0.799 ± 0.021	1.145HisGly: 1.145 ± 0.029	0.643HisHis: 0.643 ± 0.023	0.983HisIle: 0.983 ± 0.024	0.688HisLys: 0.688 ± 0.02	2.242HisLeu: 2.242 ± 0.047	0.288HisMet: 0.288 ± 0.012	0.698HisAsn: 0.698 ± 0.019	1.367HisPro: 1.367 ± 0.028	1.15HisGln: 1.15 ± 0.026	1.11HisArg: 1.11 ± 0.023	1.205HisSer: 1.205 ± 0.026	0.92HisThr: 0.92 ± 0.027	0.996HisVal: 0.996 ± 0.027	0.347HisTrp: 0.347 ± 0.014	0.664HisTyr: 0.664 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.246IleAla: 8.246 ± 0.074	0.785IleCys: 0.785 ± 0.023	3.606IleAsp: 3.606 ± 0.043	4.253IleGlu: 4.253 ± 0.045	2.57IlePhe: 2.57 ± 0.038	4.73IleGly: 4.73 ± 0.066	1.249IleHis: 1.249 ± 0.026	3.142IleIle: 3.142 ± 0.05	2.234IleLys: 2.234 ± 0.036	6.66IleLeu: 6.66 ± 0.075	0.783IleMet: 0.783 ± 0.022	2.291IleAsn: 2.291 ± 0.037	3.574IlePro: 3.574 ± 0.046	3.09IleGln: 3.09 ± 0.04	3.054IleArg: 3.054 ± 0.043	4.081IleSer: 4.081 ± 0.049	3.144IleThr: 3.144 ± 0.041	4.821IleVal: 4.821 ± 0.06	0.904IleTrp: 0.904 ± 0.023	1.931IleTyr: 1.931 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.667LysAla: 3.667 ± 0.05	0.294LysCys: 0.294 ± 0.012	1.821LysAsp: 1.821 ± 0.036	2.399LysGlu: 2.399 ± 0.04	1.624LysPhe: 1.624 ± 0.029	2.504LysGly: 2.504 ± 0.047	0.798LysHis: 0.798 ± 0.023	3.063LysIle: 3.063 ± 0.048	1.86LysLys: 1.86 ± 0.033	4.866LysLeu: 4.866 ± 0.061	0.861LysMet: 0.861 ± 0.023	1.681LysAsn: 1.681 ± 0.032	2.327LysPro: 2.327 ± 0.037	2.67LysGln: 2.67 ± 0.043	2.255LysArg: 2.255 ± 0.033	2.712LysSer: 2.712 ± 0.044	2.672LysThr: 2.672 ± 0.045	2.924LysVal: 2.924 ± 0.044	0.442LysTrp: 0.442 ± 0.013	1.345LysTyr: 1.345 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.275LeuAla: 10.275 ± 0.095	1.067LeuCys: 1.067 ± 0.024	5.237LeuAsp: 5.237 ± 0.057	6.997LeuGlu: 6.997 ± 0.078	3.969LeuPhe: 3.969 ± 0.061	7.644LeuGly: 7.644 ± 0.088	1.994LeuHis: 1.994 ± 0.036	6.286LeuIle: 6.286 ± 0.07	4.977LeuLys: 4.977 ± 0.055	11.733LeuLeu: 11.733 ± 0.118	2.057LeuMet: 2.057 ± 0.037	4.152LeuAsn: 4.152 ± 0.048	5.983LeuPro: 5.983 ± 0.057	5.981LeuGln: 5.981 ± 0.068	5.821LeuArg: 5.821 ± 0.064	7.726LeuSer: 7.726 ± 0.077	6.174LeuThr: 6.174 ± 0.055	7.506LeuVal: 7.506 ± 0.073	1.47LeuTrp: 1.47 ± 0.039	2.675LeuTyr: 2.675 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	1.711MetAla: 1.711 ± 0.032	0.123MetCys: 0.123 ± 0.009	0.75MetAsp: 0.75 ± 0.02	0.977MetGlu: 0.977 ± 0.023	0.56MetPhe: 0.56 ± 0.018	1.371MetGly: 1.371 ± 0.029	0.367MetHis: 0.367 ± 0.015	0.795MetIle: 0.795 ± 0.022	0.982MetLys: 0.982 ± 0.024	2.043MetLeu: 2.043 ± 0.036	0.492MetMet: 0.492 ± 0.017	0.835MetAsn: 0.835 ± 0.023	0.946MetPro: 0.946 ± 0.022	1.087MetGln: 1.087 ± 0.023	1.093MetArg: 1.093 ± 0.026	1.335MetSer: 1.335 ± 0.026	1.407MetThr: 1.407 ± 0.032	1.263MetVal: 1.263 ± 0.027	0.168MetTrp: 0.168 ± 0.01	0.411MetTyr: 0.411 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.958AsnAla: 2.958 ± 0.045	0.438AsnCys: 0.438 ± 0.015	1.528AsnAsp: 1.528 ± 0.033	1.607AsnGlu: 1.607 ± 0.028	1.84AsnPhe: 1.84 ± 0.028	2.426AsnGly: 2.426 ± 0.045	0.716AsnHis: 0.716 ± 0.019	2.351AsnIle: 2.351 ± 0.042	1.335AsnLys: 1.335 ± 0.027	4.948AsnLeu: 4.948 ± 0.061	0.6AsnMet: 0.6 ± 0.019	1.633AsnAsn: 1.633 ± 0.039	2.613AsnPro: 2.613 ± 0.037	1.983AsnGln: 1.983 ± 0.038	2.408AsnArg: 2.408 ± 0.037	2.915AsnSer: 2.915 ± 0.043	2.147AsnThr: 2.147 ± 0.038	2.15AsnVal: 2.15 ± 0.036	0.732AsnTrp: 0.732 ± 0.02	1.423AsnTyr: 1.423 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.816ProAla: 3.816 ± 0.051	0.359ProCys: 0.359 ± 0.015	2.858ProAsp: 2.858 ± 0.047	3.706ProGlu: 3.706 ± 0.053	1.751ProPhe: 1.751 ± 0.034	2.961ProGly: 2.961 ± 0.049	0.961ProHis: 0.961 ± 0.025	3.158ProIle: 3.158 ± 0.043	1.938ProLys: 1.938 ± 0.034	4.817ProLeu: 4.817 ± 0.051	0.765ProMet: 0.765 ± 0.02	2.026ProAsn: 2.026 ± 0.036	2.379ProPro: 2.379 ± 0.045	2.818ProGln: 2.818 ± 0.04	1.858ProArg: 1.858 ± 0.033	2.943ProSer: 2.943 ± 0.045	3.133ProThr: 3.133 ± 0.047	3.329ProVal: 3.329 ± 0.046	0.609ProTrp: 0.609 ± 0.019	1.377ProTyr: 1.377 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.132GlnAla: 5.132 ± 0.057	0.343GlnCys: 0.343 ± 0.015	1.997GlnAsp: 1.997 ± 0.035	3.208GlnGlu: 3.208 ± 0.046	1.833GlnPhe: 1.833 ± 0.03	3.383GlnGly: 3.383 ± 0.057	1.012GlnHis: 1.012 ± 0.022	3.836GlnIle: 3.836 ± 0.045	2.529GlnLys: 2.529 ± 0.041	6.478GlnLeu: 6.478 ± 0.072	1.228GlnMet: 1.228 ± 0.028	1.96GlnAsn: 1.96 ± 0.039	2.895GlnPro: 2.895 ± 0.045	4.348GlnGln: 4.348 ± 0.071	3.152GlnArg: 3.152 ± 0.04	2.868GlnSer: 2.868 ± 0.041	2.949GlnThr: 2.949 ± 0.041	3.858GlnVal: 3.858 ± 0.054	0.718GlnTrp: 0.718 ± 0.022	1.296GlnTyr: 1.296 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	4.065ArgAla: 4.065 ± 0.043	0.552ArgCys: 0.552 ± 0.018	2.955ArgAsp: 2.955 ± 0.047	3.684ArgGlu: 3.684 ± 0.043	2.286ArgPhe: 2.286 ± 0.035	3.305ArgGly: 3.305 ± 0.048	1.19ArgHis: 1.19 ± 0.026	3.581ArgIle: 3.581 ± 0.046	2.167ArgLys: 2.167 ± 0.04	6.498ArgLeu: 6.498 ± 0.059	1.091ArgMet: 1.091 ± 0.025	2.115ArgAsn: 2.115 ± 0.04	2.217ArgPro: 2.217 ± 0.034	4.002ArgGln: 4.002 ± 0.046	3.434ArgArg: 3.434 ± 0.049	3.937ArgSer: 3.937 ± 0.048	2.853ArgThr: 2.853 ± 0.042	3.807ArgVal: 3.807 ± 0.047	0.902ArgTrp: 0.902 ± 0.022	2.007ArgTyr: 2.007 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.771SerAla: 4.771 ± 0.051	0.679SerCys: 0.679 ± 0.019	3.207SerAsp: 3.207 ± 0.047	3.507SerGlu: 3.507 ± 0.041	2.522SerPhe: 2.522 ± 0.033	4.54SerGly: 4.54 ± 0.064	1.44SerHis: 1.44 ± 0.026	3.859SerIle: 3.859 ± 0.044	2.379SerLys: 2.379 ± 0.038	7.237SerLeu: 7.237 ± 0.072	1.218SerMet: 1.218 ± 0.026	2.552SerAsn: 2.552 ± 0.044	3.415SerPro: 3.415 ± 0.052	3.727SerGln: 3.727 ± 0.05	3.57SerArg: 3.57 ± 0.043	4.43SerSer: 4.43 ± 0.061	3.567SerThr: 3.567 ± 0.046	4.073SerVal: 4.073 ± 0.043	0.91SerTrp: 0.91 ± 0.02	1.912SerTyr: 1.912 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.333ThrAla: 5.333 ± 0.062	0.539ThrCys: 0.539 ± 0.016	2.623ThrAsp: 2.623 ± 0.037	3.115ThrGlu: 3.115 ± 0.038	2.051ThrPhe: 2.051 ± 0.035	4.361ThrGly: 4.361 ± 0.052	1.017ThrHis: 1.017 ± 0.023	3.838ThrIle: 3.838 ± 0.051	2.154ThrLys: 2.154 ± 0.037	6.127ThrLeu: 6.127 ± 0.054	0.761ThrMet: 0.761 ± 0.019	2.24ThrAsn: 2.24 ± 0.042	3.414ThrPro: 3.414 ± 0.05	2.98ThrGln: 2.98 ± 0.044	2.61ThrArg: 2.61 ± 0.044	3.516ThrSer: 3.516 ± 0.048	3.574ThrThr: 3.574 ± 0.052	4.181ThrVal: 4.181 ± 0.051	0.708ThrTrp: 0.708 ± 0.021	1.727ThrTyr: 1.727 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	6.605ValAla: 6.605 ± 0.072	0.698ValCys: 0.698 ± 0.018	3.392ValAsp: 3.392 ± 0.047	4.741ValGlu: 4.741 ± 0.053	2.63ValPhe: 2.63 ± 0.043	5.006ValGly: 5.006 ± 0.061	0.993ValHis: 0.993 ± 0.026	3.743ValIle: 3.743 ± 0.048	3.154ValLys: 3.154 ± 0.041	6.984ValLeu: 6.984 ± 0.064	1.459ValMet: 1.459 ± 0.031	2.664ValAsn: 2.664 ± 0.043	3.007ValPro: 3.007 ± 0.045	2.962ValGln: 2.962 ± 0.049	3.665ValArg: 3.665 ± 0.047	4.254ValSer: 4.254 ± 0.052	4.09ValThr: 4.09 ± 0.051	5.184ValVal: 5.184 ± 0.058	0.897ValTrp: 0.897 ± 0.025	1.879ValTyr: 1.879 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.947TrpAla: 0.947 ± 0.026	0.133TrpCys: 0.133 ± 0.009	0.623TrpAsp: 0.623 ± 0.022	0.843TrpGlu: 0.843 ± 0.024	0.612TrpPhe: 0.612 ± 0.019	0.976TrpGly: 0.976 ± 0.023	0.368TrpHis: 0.368 ± 0.014	0.87TrpIle: 0.87 ± 0.024	0.552TrpLys: 0.552 ± 0.018	2.015TrpLeu: 2.015 ± 0.041	0.37TrpMet: 0.37 ± 0.017	0.64TrpAsn: 0.64 ± 0.019	0.117TrpPro: 0.117 ± 0.008	1.39TrpGln: 1.39 ± 0.03	0.911TrpArg: 0.911 ± 0.025	0.882TrpSer: 0.882 ± 0.023	0.664TrpThr: 0.664 ± 0.019	0.891TrpVal: 0.891 ± 0.026	0.287TrpTrp: 0.287 ± 0.013	0.442TrpTyr: 0.442 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.282TyrAla: 2.282 ± 0.037	0.403TyrCys: 0.403 ± 0.017	1.474TyrAsp: 1.474 ± 0.03	1.653TyrGlu: 1.653 ± 0.031	1.391TyrPhe: 1.391 ± 0.026	2.084TyrGly: 2.084 ± 0.043	0.667TyrHis: 0.667 ± 0.02	1.717TyrIle: 1.717 ± 0.03	1.169TyrLys: 1.169 ± 0.027	3.579TyrLeu: 3.579 ± 0.042	0.458TyrMet: 0.458 ± 0.017	1.13TyrAsn: 1.13 ± 0.026	1.54TyrPro: 1.54 ± 0.027	1.919TyrGln: 1.919 ± 0.035	2.073TyrArg: 2.073 ± 0.04	1.877TyrSer: 1.877 ± 0.029	1.554TyrThr: 1.554 ± 0.03	1.696TyrVal: 1.696 ± 0.031	0.576TyrTrp: 0.576 ± 0.018	1.041TyrTyr: 1.041 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5740 proteins (1835617 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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