Amino acid dipepetide frequency for Kuraishia capsulata CBS 1993

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.446AlaAla: 5.446 ± 0.073
0.804AlaCys: 0.804 ± 0.02
3.525AlaAsp: 3.525 ± 0.04
4.427AlaGlu: 4.427 ± 0.051
2.823AlaPhe: 2.823 ± 0.037
3.921AlaGly: 3.921 ± 0.053
1.264AlaHis: 1.264 ± 0.023
4.054AlaIle: 4.054 ± 0.041
4.589AlaLys: 4.589 ± 0.043
6.57AlaLeu: 6.57 ± 0.053
1.482AlaMet: 1.482 ± 0.021
2.93AlaAsn: 2.93 ± 0.037
3.017AlaPro: 3.017 ± 0.049
2.481AlaGln: 2.481 ± 0.038
3.165AlaArg: 3.165 ± 0.037
5.977AlaSer: 5.977 ± 0.06
3.886AlaThr: 3.886 ± 0.04
4.427AlaVal: 4.427 ± 0.049
0.631AlaTrp: 0.631 ± 0.016
2.049AlaTyr: 2.049 ± 0.028
0.0AlaXaa: 0.0 ± 0.0
Cys
0.723CysAla: 0.723 ± 0.017
0.25CysCys: 0.25 ± 0.009
0.643CysAsp: 0.643 ± 0.018
0.617CysGlu: 0.617 ± 0.015
0.704CysPhe: 0.704 ± 0.014
0.887CysGly: 0.887 ± 0.024
0.31CysHis: 0.31 ± 0.013
0.796CysIle: 0.796 ± 0.018
0.583CysLys: 0.583 ± 0.017
1.314CysLeu: 1.314 ± 0.02
0.246CysMet: 0.246 ± 0.012
0.451CysAsn: 0.451 ± 0.013
0.486CysPro: 0.486 ± 0.014
0.375CysGln: 0.375 ± 0.011
0.517CysArg: 0.517 ± 0.014
1.008CysSer: 1.008 ± 0.023
0.588CysThr: 0.588 ± 0.015
0.835CysVal: 0.835 ± 0.017
0.157CysTrp: 0.157 ± 0.009
0.452CysTyr: 0.452 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.672AspAla: 3.672 ± 0.042
0.607AspCys: 0.607 ± 0.015
4.616AspAsp: 4.616 ± 0.069
5.076AspGlu: 5.076 ± 0.056
2.762AspPhe: 2.762 ± 0.028
3.215AspGly: 3.215 ± 0.04
1.149AspHis: 1.149 ± 0.022
3.502AspIle: 3.502 ± 0.036
2.995AspLys: 2.995 ± 0.035
5.931AspLeu: 5.931 ± 0.051
1.203AspMet: 1.203 ± 0.018
2.201AspAsn: 2.201 ± 0.028
2.83AspPro: 2.83 ± 0.038
2.014AspGln: 2.014 ± 0.028
2.365AspArg: 2.365 ± 0.029
5.149AspSer: 5.149 ± 0.054
2.788AspThr: 2.788 ± 0.033
3.899AspVal: 3.899 ± 0.041
0.719AspTrp: 0.719 ± 0.017
2.085AspTyr: 2.085 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
4.434GluAla: 4.434 ± 0.044
0.633GluCys: 0.633 ± 0.016
4.675GluAsp: 4.675 ± 0.055
6.127GluGlu: 6.127 ± 0.085
2.817GluPhe: 2.817 ± 0.035
3.131GluGly: 3.131 ± 0.035
1.202GluHis: 1.202 ± 0.02
4.209GluIle: 4.209 ± 0.041
4.837GluLys: 4.837 ± 0.054
6.563GluLeu: 6.563 ± 0.058
1.505GluMet: 1.505 ± 0.024
3.234GluAsn: 3.234 ± 0.035
2.438GluPro: 2.438 ± 0.033
2.479GluGln: 2.479 ± 0.036
3.253GluArg: 3.253 ± 0.038
5.408GluSer: 5.408 ± 0.052
4.026GluThr: 4.026 ± 0.048
4.019GluVal: 4.019 ± 0.039
0.689GluTrp: 0.689 ± 0.017
2.145GluTyr: 2.145 ± 0.026
0.001GluXaa: 0.001 ± 0.001
Phe
3.026PheAla: 3.026 ± 0.039
0.604PheCys: 0.604 ± 0.017
2.828PheAsp: 2.828 ± 0.03
3.013PheGlu: 3.013 ± 0.034
2.13PhePhe: 2.13 ± 0.037
3.167PheGly: 3.167 ± 0.048
0.922PheHis: 0.922 ± 0.018
2.324PheIle: 2.324 ± 0.034
2.748PheLys: 2.748 ± 0.032
4.211PheLeu: 4.211 ± 0.043
0.962PheMet: 0.962 ± 0.019
2.015PheAsn: 2.015 ± 0.025
1.853PhePro: 1.853 ± 0.026
1.711PheGln: 1.711 ± 0.025
1.87PheArg: 1.87 ± 0.024
3.785PheSer: 3.785 ± 0.039
2.365PheThr: 2.365 ± 0.031
3.106PheVal: 3.106 ± 0.036
0.574PheTrp: 0.574 ± 0.016
1.488PheTyr: 1.488 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
3.836GlyAla: 3.836 ± 0.054
0.776GlyCys: 0.776 ± 0.018
3.287GlyAsp: 3.287 ± 0.035
3.382GlyGlu: 3.382 ± 0.039
2.982GlyPhe: 2.982 ± 0.039
3.755GlyGly: 3.755 ± 0.057
1.192GlyHis: 1.192 ± 0.023
3.581GlyIle: 3.581 ± 0.04
3.657GlyLys: 3.657 ± 0.039
5.766GlyLeu: 5.766 ± 0.047
1.242GlyMet: 1.242 ± 0.023
2.444GlyAsn: 2.444 ± 0.033
1.97GlyPro: 1.97 ± 0.028
1.773GlyGln: 1.773 ± 0.027
2.494GlyArg: 2.494 ± 0.034
5.522GlySer: 5.522 ± 0.046
3.231GlyThr: 3.231 ± 0.042
3.995GlyVal: 3.995 ± 0.044
0.747GlyTrp: 0.747 ± 0.015
2.146GlyTyr: 2.146 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
1.175HisAla: 1.175 ± 0.018
0.279HisCys: 0.279 ± 0.01
1.109HisAsp: 1.109 ± 0.024
1.245HisGlu: 1.245 ± 0.022
0.907HisPhe: 0.907 ± 0.019
1.242HisGly: 1.242 ± 0.021
0.673HisHis: 0.673 ± 0.019
1.177HisIle: 1.177 ± 0.023
1.096HisLys: 1.096 ± 0.022
2.038HisLeu: 2.038 ± 0.026
0.406HisMet: 0.406 ± 0.011
0.857HisAsn: 0.857 ± 0.02
1.14HisPro: 1.14 ± 0.021
0.868HisGln: 0.868 ± 0.021
1.129HisArg: 1.129 ± 0.021
1.817HisSer: 1.817 ± 0.03
1.048HisThr: 1.048 ± 0.019
1.234HisVal: 1.234 ± 0.024
0.24HisTrp: 0.24 ± 0.009
0.706HisTyr: 0.706 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
3.986IleAla: 3.986 ± 0.042
0.791IleCys: 0.791 ± 0.017
3.507IleAsp: 3.507 ± 0.036
3.604IleGlu: 3.604 ± 0.036
2.389IlePhe: 2.389 ± 0.035
3.336IleGly: 3.336 ± 0.04
1.208IleHis: 1.208 ± 0.023
2.989IleIle: 2.989 ± 0.038
3.211IleLys: 3.211 ± 0.036
5.405IleLeu: 5.405 ± 0.045
1.211IleMet: 1.211 ± 0.02
2.364IleAsn: 2.364 ± 0.031
3.226IlePro: 3.226 ± 0.035
2.099IleGln: 2.099 ± 0.027
2.769IleArg: 2.769 ± 0.035
5.252IleSer: 5.252 ± 0.047
3.176IleThr: 3.176 ± 0.035
3.798IleVal: 3.798 ± 0.038
0.677IleTrp: 0.677 ± 0.018
1.74IleTyr: 1.74 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.287LysAla: 4.287 ± 0.047
0.662LysCys: 0.662 ± 0.019
3.581LysAsp: 3.581 ± 0.037
4.461LysGlu: 4.461 ± 0.05
2.667LysPhe: 2.667 ± 0.036
3.054LysGly: 3.054 ± 0.036
1.28LysHis: 1.28 ± 0.02
3.649LysIle: 3.649 ± 0.039
4.956LysLys: 4.956 ± 0.063
6.308LysLeu: 6.308 ± 0.054
1.349LysMet: 1.349 ± 0.024
2.896LysAsn: 2.896 ± 0.033
2.934LysPro: 2.934 ± 0.038
2.414LysGln: 2.414 ± 0.033
3.635LysArg: 3.635 ± 0.045
5.098LysSer: 5.098 ± 0.048
3.823LysThr: 3.823 ± 0.038
4.145LysVal: 4.145 ± 0.041
0.713LysTrp: 0.713 ± 0.018
2.152LysTyr: 2.152 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
6.78LeuAla: 6.78 ± 0.047
1.239LeuCys: 1.239 ± 0.025
5.588LeuAsp: 5.588 ± 0.049
6.648LeuGlu: 6.648 ± 0.058
4.11LeuPhe: 4.11 ± 0.047
5.517LeuGly: 5.517 ± 0.052
1.925LeuHis: 1.925 ± 0.026
5.134LeuIle: 5.134 ± 0.054
6.964LeuLys: 6.964 ± 0.065
9.383LeuLeu: 9.383 ± 0.082
2.021LeuMet: 2.021 ± 0.027
4.566LeuAsn: 4.566 ± 0.039
4.541LeuPro: 4.541 ± 0.041
3.962LeuGln: 3.962 ± 0.042
4.932LeuArg: 4.932 ± 0.046
8.403LeuSer: 8.403 ± 0.065
5.311LeuThr: 5.311 ± 0.045
6.477LeuVal: 6.477 ± 0.056
0.997LeuTrp: 0.997 ± 0.022
2.854LeuTyr: 2.854 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
1.63MetAla: 1.63 ± 0.025
0.251MetCys: 0.251 ± 0.009
1.26MetAsp: 1.26 ± 0.023
1.278MetGlu: 1.278 ± 0.019
0.961MetPhe: 0.961 ± 0.017
1.271MetGly: 1.271 ± 0.022
0.346MetHis: 0.346 ± 0.011
1.177MetIle: 1.177 ± 0.019
1.317MetLys: 1.317 ± 0.023
1.994MetLeu: 1.994 ± 0.028
0.571MetMet: 0.571 ± 0.014
0.992MetAsn: 0.992 ± 0.018
0.888MetPro: 0.888 ± 0.021
0.641MetGln: 0.641 ± 0.015
1.023MetArg: 1.023 ± 0.021
2.107MetSer: 2.107 ± 0.027
1.284MetThr: 1.284 ± 0.022
1.479MetVal: 1.479 ± 0.026
0.2MetTrp: 0.2 ± 0.008
0.611MetTyr: 0.611 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.893AsnAla: 2.893 ± 0.029
0.544AsnCys: 0.544 ± 0.015
2.604AsnAsp: 2.604 ± 0.032
2.843AsnGlu: 2.843 ± 0.035
2.025AsnPhe: 2.025 ± 0.032
2.985AsnGly: 2.985 ± 0.037
0.914AsnHis: 0.914 ± 0.018
2.424AsnIle: 2.424 ± 0.029
2.347AsnLys: 2.347 ± 0.032
4.185AsnLeu: 4.185 ± 0.037
0.966AsnMet: 0.966 ± 0.02
1.875AsnAsn: 1.875 ± 0.033
2.293AsnPro: 2.293 ± 0.035
1.559AsnGln: 1.559 ± 0.027
2.003AsnArg: 2.003 ± 0.029
3.974AsnSer: 3.974 ± 0.039
2.327AsnThr: 2.327 ± 0.031
2.892AsnVal: 2.892 ± 0.029
0.586AsnTrp: 0.586 ± 0.014
1.551AsnTyr: 1.551 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
3.142ProAla: 3.142 ± 0.052
0.346ProCys: 0.346 ± 0.013
2.471ProAsp: 2.471 ± 0.029
3.581ProGlu: 3.581 ± 0.038
2.012ProPhe: 2.012 ± 0.027
2.45ProGly: 2.45 ± 0.03
0.971ProHis: 0.971 ± 0.02
2.557ProIle: 2.557 ± 0.032
3.015ProLys: 3.015 ± 0.039
4.173ProLeu: 4.173 ± 0.043
0.869ProMet: 0.869 ± 0.019
1.984ProAsn: 1.984 ± 0.029
2.613ProPro: 2.613 ± 0.055
2.108ProGln: 2.108 ± 0.041
2.147ProArg: 2.147 ± 0.028
4.274ProSer: 4.274 ± 0.05
2.774ProThr: 2.774 ± 0.029
3.415ProVal: 3.415 ± 0.043
0.461ProTrp: 0.461 ± 0.012
1.368ProTyr: 1.368 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
2.355GlnAla: 2.355 ± 0.036
0.387GlnCys: 0.387 ± 0.013
1.957GlnAsp: 1.957 ± 0.024
2.419GlnGlu: 2.419 ± 0.032
1.635GlnPhe: 1.635 ± 0.026
1.763GlnGly: 1.763 ± 0.035
0.844GlnHis: 0.844 ± 0.02
2.297GlnIle: 2.297 ± 0.03
2.503GlnLys: 2.503 ± 0.031
3.834GlnLeu: 3.834 ± 0.04
0.884GlnMet: 0.884 ± 0.019
1.822GlnAsn: 1.822 ± 0.028
1.828GlnPro: 1.828 ± 0.04
2.649GlnGln: 2.649 ± 0.075
2.024GlnArg: 2.024 ± 0.028
3.114GlnSer: 3.114 ± 0.044
2.146GlnThr: 2.146 ± 0.031
2.221GlnVal: 2.221 ± 0.029
0.405GlnTrp: 0.405 ± 0.014
1.174GlnTyr: 1.174 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
3.016ArgAla: 3.016 ± 0.037
0.6ArgCys: 0.6 ± 0.015
2.626ArgAsp: 2.626 ± 0.037
3.095ArgGlu: 3.095 ± 0.04
2.278ArgPhe: 2.278 ± 0.034
2.548ArgGly: 2.548 ± 0.036
1.058ArgHis: 1.058 ± 0.021
2.733ArgIle: 2.733 ± 0.031
3.413ArgLys: 3.413 ± 0.044
5.055ArgLeu: 5.055 ± 0.046
1.065ArgMet: 1.065 ± 0.019
2.16ArgAsn: 2.16 ± 0.029
2.134ArgPro: 2.134 ± 0.029
1.881ArgGln: 1.881 ± 0.029
3.181ArgArg: 3.181 ± 0.045
4.088ArgSer: 4.088 ± 0.046
2.5ArgThr: 2.5 ± 0.031
2.89ArgVal: 2.89 ± 0.031
0.567ArgTrp: 0.567 ± 0.015
1.593ArgTyr: 1.593 ± 0.021
0.0ArgXaa: 0.0 ± 0.0
Ser
5.872SerAla: 5.872 ± 0.058
0.962SerCys: 0.962 ± 0.022
4.899SerAsp: 4.899 ± 0.052
5.458SerGlu: 5.458 ± 0.048
3.938SerPhe: 3.938 ± 0.036
5.318SerGly: 5.318 ± 0.046
1.846SerHis: 1.846 ± 0.025
4.846SerIle: 4.846 ± 0.046
5.649SerLys: 5.649 ± 0.044
8.645SerLeu: 8.645 ± 0.073
1.816SerMet: 1.816 ± 0.026
3.806SerAsn: 3.806 ± 0.037
4.331SerPro: 4.331 ± 0.052
3.491SerGln: 3.491 ± 0.04
4.334SerArg: 4.334 ± 0.044
9.788SerSer: 9.788 ± 0.126
5.351SerThr: 5.351 ± 0.057
5.595SerVal: 5.595 ± 0.046
0.971SerTrp: 0.971 ± 0.02
2.517SerTyr: 2.517 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
3.916ThrAla: 3.916 ± 0.045
0.617ThrCys: 0.617 ± 0.014
2.842ThrAsp: 2.842 ± 0.034
3.468ThrGlu: 3.468 ± 0.038
2.376ThrPhe: 2.376 ± 0.031
3.626ThrGly: 3.626 ± 0.045
1.056ThrHis: 1.056 ± 0.023
3.224ThrIle: 3.224 ± 0.036
3.551ThrLys: 3.551 ± 0.039
5.253ThrLeu: 5.253 ± 0.044
1.146ThrMet: 1.146 ± 0.02
2.404ThrAsn: 2.404 ± 0.03
3.248ThrPro: 3.248 ± 0.043
1.91ThrGln: 1.91 ± 0.027
2.6ThrArg: 2.6 ± 0.032
5.13ThrSer: 5.13 ± 0.058
3.491ThrThr: 3.491 ± 0.048
3.84ThrVal: 3.84 ± 0.041
0.593ThrTrp: 0.593 ± 0.017
1.643ThrTyr: 1.643 ± 0.025
0.001ThrXaa: 0.001 ± 0.0
Val
4.572ValAla: 4.572 ± 0.043
0.88ValCys: 0.88 ± 0.019
3.975ValAsp: 3.975 ± 0.042
4.45ValGlu: 4.45 ± 0.041
3.091ValPhe: 3.091 ± 0.035
3.8ValGly: 3.8 ± 0.048
1.237ValHis: 1.237 ± 0.021
3.685ValIle: 3.685 ± 0.043
4.074ValLys: 4.074 ± 0.044
6.398ValLeu: 6.398 ± 0.052
1.372ValMet: 1.372 ± 0.022
2.737ValAsn: 2.737 ± 0.031
3.224ValPro: 3.224 ± 0.04
2.254ValGln: 2.254 ± 0.025
2.868ValArg: 2.868 ± 0.03
5.943ValSer: 5.943 ± 0.046
3.508ValThr: 3.508 ± 0.037
4.7ValVal: 4.7 ± 0.045
0.721ValTrp: 0.721 ± 0.019
2.168ValTyr: 2.168 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
0.642TrpAla: 0.642 ± 0.015
0.208TrpCys: 0.208 ± 0.01
0.72TrpAsp: 0.72 ± 0.018
0.635TrpGlu: 0.635 ± 0.017
0.554TrpPhe: 0.554 ± 0.017
0.676TrpGly: 0.676 ± 0.02
0.223TrpHis: 0.223 ± 0.009
0.689TrpIle: 0.689 ± 0.015
0.845TrpLys: 0.845 ± 0.019
1.075TrpLeu: 1.075 ± 0.021
0.275TrpMet: 0.275 ± 0.01
0.582TrpAsn: 0.582 ± 0.017
0.36TrpPro: 0.36 ± 0.012
0.351TrpGln: 0.351 ± 0.011
0.639TrpArg: 0.639 ± 0.016
0.923TrpSer: 0.923 ± 0.019
0.627TrpThr: 0.627 ± 0.016
0.658TrpVal: 0.658 ± 0.018
0.179TrpTrp: 0.179 ± 0.009
0.379TrpTyr: 0.379 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.063TyrAla: 2.063 ± 0.028
0.501TyrCys: 0.501 ± 0.016
2.067TyrAsp: 2.067 ± 0.03
1.999TyrGlu: 1.999 ± 0.025
1.539TyrPhe: 1.539 ± 0.028
2.116TyrGly: 2.116 ± 0.034
0.767TyrHis: 0.767 ± 0.017
1.692TyrIle: 1.692 ± 0.025
1.714TyrLys: 1.714 ± 0.027
3.25TyrLeu: 3.25 ± 0.034
0.684TyrMet: 0.684 ± 0.016
1.474TyrAsn: 1.474 ± 0.021
1.376TyrPro: 1.376 ± 0.024
1.242TyrGln: 1.242 ± 0.023
1.532TyrArg: 1.532 ± 0.024
2.675TyrSer: 2.675 ± 0.033
1.686TyrThr: 1.686 ± 0.026
2.032TyrVal: 2.032 ± 0.031
0.413TyrTrp: 0.413 ± 0.014
1.26TyrTyr: 1.26 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.066XaaXaa: 0.066 ± 0.031
Statistics based on 6027 proteins (2778337 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski