Amino acid dipepetide frequency for Marine Group I thaumarchaeote SCGC AAA799-B03

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.219AlaAla: 4.219 ± 0.216
0.651AlaCys: 0.651 ± 0.051
2.933AlaAsp: 2.933 ± 0.111
3.971AlaGlu: 3.971 ± 0.155
2.417AlaPhe: 2.417 ± 0.076
3.903AlaGly: 3.903 ± 0.131
1.03AlaHis: 1.03 ± 0.05
5.454AlaIle: 5.454 ± 0.148
5.79AlaLys: 5.79 ± 0.167
5.145AlaLeu: 5.145 ± 0.173
1.588AlaMet: 1.588 ± 0.084
2.561AlaAsn: 2.561 ± 0.099
1.916AlaPro: 1.916 ± 0.088
1.796AlaGln: 1.796 ± 0.089
2.326AlaArg: 2.326 ± 0.093
3.833AlaSer: 3.833 ± 0.12
3.383AlaThr: 3.383 ± 0.119
3.779AlaVal: 3.779 ± 0.133
0.574AlaTrp: 0.574 ± 0.047
1.745AlaTyr: 1.745 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.631CysAla: 0.631 ± 0.046
0.144CysCys: 0.144 ± 0.023
0.668CysAsp: 0.668 ± 0.045
0.654CysGlu: 0.654 ± 0.05
0.346CysPhe: 0.346 ± 0.033
1.061CysGly: 1.061 ± 0.07
0.218CysHis: 0.218 ± 0.025
0.819CysIle: 0.819 ± 0.049
0.99CysLys: 0.99 ± 0.064
0.665CysLeu: 0.665 ± 0.051
0.258CysMet: 0.258 ± 0.031
0.594CysAsn: 0.594 ± 0.039
0.607CysPro: 0.607 ± 0.054
0.366CysGln: 0.366 ± 0.031
0.389CysArg: 0.389 ± 0.034
0.738CysSer: 0.738 ± 0.044
0.594CysThr: 0.594 ± 0.054
0.631CysVal: 0.631 ± 0.05
0.094CysTrp: 0.094 ± 0.018
0.282CysTyr: 0.282 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.628AspAla: 3.628 ± 0.121
0.661AspCys: 0.661 ± 0.045
3.561AspAsp: 3.561 ± 0.125
4.934AspGlu: 4.934 ± 0.168
3.071AspPhe: 3.071 ± 0.112
3.682AspGly: 3.682 ± 0.132
0.92AspHis: 0.92 ± 0.052
4.544AspIle: 4.544 ± 0.122
4.393AspLys: 4.393 ± 0.143
4.786AspLeu: 4.786 ± 0.134
1.591AspMet: 1.591 ± 0.079
2.433AspAsn: 2.433 ± 0.102
2.245AspPro: 2.245 ± 0.083
1.517AspGln: 1.517 ± 0.076
1.822AspArg: 1.822 ± 0.08
4.4AspSer: 4.4 ± 0.122
2.863AspThr: 2.863 ± 0.126
4.4AspVal: 4.4 ± 0.131
0.631AspTrp: 0.631 ± 0.043
2.313AspTyr: 2.313 ± 0.11
0.0AspXaa: 0.0 ± 0.0
Glu
3.538GluAla: 3.538 ± 0.139
0.665GluCys: 0.665 ± 0.047
3.578GluAsp: 3.578 ± 0.113
5.555GluGlu: 5.555 ± 0.193
3.665GluPhe: 3.665 ± 0.121
3.665GluGly: 3.665 ± 0.119
1.406GluHis: 1.406 ± 0.065
7.626GluIle: 7.626 ± 0.178
8.257GluLys: 8.257 ± 0.203
6.558GluLeu: 6.558 ± 0.162
2.017GluMet: 2.017 ± 0.081
4.638GluAsn: 4.638 ± 0.13
2.349GluPro: 2.349 ± 0.118
2.675GluGln: 2.675 ± 0.099
2.386GluArg: 2.386 ± 0.097
4.967GluSer: 4.967 ± 0.147
3.521GluThr: 3.521 ± 0.127
3.813GluVal: 3.813 ± 0.121
0.641GluTrp: 0.641 ± 0.045
2.561GluTyr: 2.561 ± 0.084
0.003GluXaa: 0.003 ± 0.004
Phe
2.913PheAla: 2.913 ± 0.105
0.681PheCys: 0.681 ± 0.053
3.303PheAsp: 3.303 ± 0.128
3.437PheGlu: 3.437 ± 0.103
1.923PhePhe: 1.923 ± 0.092
3.282PheGly: 3.282 ± 0.109
0.812PheHis: 0.812 ± 0.05
2.621PheIle: 2.621 ± 0.1
2.688PheLys: 2.688 ± 0.092
4.061PheLeu: 4.061 ± 0.136
1.034PheMet: 1.034 ± 0.061
1.816PheAsn: 1.816 ± 0.074
1.561PhePro: 1.561 ± 0.072
1.198PheGln: 1.198 ± 0.063
1.396PheArg: 1.396 ± 0.074
3.732PheSer: 3.732 ± 0.107
2.43PheThr: 2.43 ± 0.097
3.504PheVal: 3.504 ± 0.106
0.446PheTrp: 0.446 ± 0.048
1.544PheTyr: 1.544 ± 0.081
0.0PheXaa: 0.0 ± 0.0
Gly
3.793GlyAla: 3.793 ± 0.145
0.641GlyCys: 0.641 ± 0.047
3.457GlyAsp: 3.457 ± 0.128
3.672GlyGlu: 3.672 ± 0.13
3.081GlyPhe: 3.081 ± 0.109
4.437GlyGly: 4.437 ± 0.171
1.272GlyHis: 1.272 ± 0.063
6.444GlyIle: 6.444 ± 0.153
5.766GlyLys: 5.766 ± 0.146
5.525GlyLeu: 5.525 ± 0.155
2.031GlyMet: 2.031 ± 0.079
2.823GlyAsn: 2.823 ± 0.121
1.92GlyPro: 1.92 ± 0.237
1.745GlyGln: 1.745 ± 0.076
2.323GlyArg: 2.323 ± 0.09
3.94GlySer: 3.94 ± 0.132
3.809GlyThr: 3.809 ± 0.114
4.531GlyVal: 4.531 ± 0.136
0.607GlyTrp: 0.607 ± 0.044
2.252GlyTyr: 2.252 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
1.151HisAla: 1.151 ± 0.072
0.242HisCys: 0.242 ± 0.029
1.185HisAsp: 1.185 ± 0.058
1.309HisGlu: 1.309 ± 0.066
0.785HisPhe: 0.785 ± 0.052
1.259HisGly: 1.259 ± 0.061
0.463HisHis: 0.463 ± 0.043
1.379HisIle: 1.379 ± 0.065
1.225HisLys: 1.225 ± 0.063
1.638HisLeu: 1.638 ± 0.08
0.48HisMet: 0.48 ± 0.039
0.816HisAsn: 0.816 ± 0.057
1.0HisPro: 1.0 ± 0.054
0.638HisGln: 0.638 ± 0.043
0.691HisArg: 0.691 ± 0.054
1.208HisSer: 1.208 ± 0.073
0.916HisThr: 0.916 ± 0.052
1.332HisVal: 1.332 ± 0.068
0.154HisTrp: 0.154 ± 0.022
0.621HisTyr: 0.621 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
5.649IleAla: 5.649 ± 0.147
0.943IleCys: 0.943 ± 0.056
5.182IleAsp: 5.182 ± 0.154
6.219IleGlu: 6.219 ± 0.16
3.638IlePhe: 3.638 ± 0.131
5.803IleGly: 5.803 ± 0.149
1.594IleHis: 1.594 ± 0.067
7.122IleIle: 7.122 ± 0.191
6.652IleLys: 6.652 ± 0.172
7.444IleLeu: 7.444 ± 0.18
2.091IleMet: 2.091 ± 0.076
3.813IleAsn: 3.813 ± 0.112
4.065IlePro: 4.065 ± 0.131
3.101IleGln: 3.101 ± 0.106
3.249IleArg: 3.249 ± 0.098
6.79IleSer: 6.79 ± 0.171
5.051IleThr: 5.051 ± 0.132
5.585IleVal: 5.585 ± 0.14
0.631IleTrp: 0.631 ± 0.049
2.135IleTyr: 2.135 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
4.32LysAla: 4.32 ± 0.157
0.873LysCys: 0.873 ± 0.054
4.625LysAsp: 4.625 ± 0.14
6.518LysGlu: 6.518 ± 0.179
3.87LysPhe: 3.87 ± 0.116
4.417LysGly: 4.417 ± 0.185
1.577LysHis: 1.577 ± 0.089
9.384LysIle: 9.384 ± 0.22
9.327LysLys: 9.327 ± 0.269
7.068LysLeu: 7.068 ± 0.165
2.511LysMet: 2.511 ± 0.092
5.655LysAsn: 5.655 ± 0.164
2.819LysPro: 2.819 ± 0.124
2.91LysGln: 2.91 ± 0.12
3.128LysArg: 3.128 ± 0.149
5.592LysSer: 5.592 ± 0.169
5.102LysThr: 5.102 ± 0.13
4.685LysVal: 4.685 ± 0.143
0.712LysTrp: 0.712 ± 0.057
2.635LysTyr: 2.635 ± 0.092
0.003LysXaa: 0.003 ± 0.003
Leu
5.333LeuAla: 5.333 ± 0.148
0.849LeuCys: 0.849 ± 0.055
5.384LeuAsp: 5.384 ± 0.149
7.125LeuGlu: 7.125 ± 0.167
3.534LeuPhe: 3.534 ± 0.121
5.682LeuGly: 5.682 ± 0.154
1.41LeuHis: 1.41 ± 0.072
6.354LeuIle: 6.354 ± 0.144
7.582LeuLys: 7.582 ± 0.174
6.669LeuLeu: 6.669 ± 0.177
1.923LeuMet: 1.923 ± 0.076
4.118LeuAsn: 4.118 ± 0.139
3.148LeuPro: 3.148 ± 0.116
2.866LeuGln: 2.866 ± 0.099
3.39LeuArg: 3.39 ± 0.105
6.508LeuSer: 6.508 ± 0.173
4.367LeuThr: 4.367 ± 0.126
5.582LeuVal: 5.582 ± 0.141
0.654LeuTrp: 0.654 ± 0.052
2.386LeuTyr: 2.386 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
1.863MetAla: 1.863 ± 0.073
0.175MetCys: 0.175 ± 0.023
1.487MetAsp: 1.487 ± 0.075
1.648MetGlu: 1.648 ± 0.077
1.04MetPhe: 1.04 ± 0.067
1.916MetGly: 1.916 ± 0.101
0.46MetHis: 0.46 ± 0.041
2.346MetIle: 2.346 ± 0.086
2.403MetLys: 2.403 ± 0.097
2.114MetLeu: 2.114 ± 0.084
0.832MetMet: 0.832 ± 0.059
1.225MetAsn: 1.225 ± 0.067
0.997MetPro: 0.997 ± 0.059
0.802MetGln: 0.802 ± 0.052
0.953MetArg: 0.953 ± 0.058
1.95MetSer: 1.95 ± 0.077
1.611MetThr: 1.611 ± 0.075
1.567MetVal: 1.567 ± 0.074
0.275MetTrp: 0.275 ± 0.032
0.725MetTyr: 0.725 ± 0.051
0.003MetXaa: 0.003 ± 0.003
Asn
2.893AsnAla: 2.893 ± 0.101
0.651AsnCys: 0.651 ± 0.049
2.574AsnAsp: 2.574 ± 0.097
3.497AsnGlu: 3.497 ± 0.103
2.44AsnPhe: 2.44 ± 0.09
2.635AsnGly: 2.635 ± 0.098
0.987AsnHis: 0.987 ± 0.06
4.007AsnIle: 4.007 ± 0.128
3.608AsnLys: 3.608 ± 0.127
4.521AsnLeu: 4.521 ± 0.159
1.46AsnMet: 1.46 ± 0.078
2.531AsnAsn: 2.531 ± 0.106
2.611AsnPro: 2.611 ± 0.093
2.027AsnGln: 2.027 ± 0.078
1.517AsnArg: 1.517 ± 0.065
3.833AsnSer: 3.833 ± 0.118
2.568AsnThr: 2.568 ± 0.099
3.192AsnVal: 3.192 ± 0.11
0.47AsnTrp: 0.47 ± 0.046
1.759AsnTyr: 1.759 ± 0.083
0.0AsnXaa: 0.0 ± 0.0
Pro
1.977ProAla: 1.977 ± 0.102
0.279ProCys: 0.279 ± 0.032
2.266ProAsp: 2.266 ± 0.098
3.487ProGlu: 3.487 ± 0.13
1.655ProPhe: 1.655 ± 0.069
2.272ProGly: 2.272 ± 0.131
0.755ProHis: 0.755 ± 0.052
3.242ProIle: 3.242 ± 0.125
3.178ProLys: 3.178 ± 0.114
2.843ProLeu: 2.843 ± 0.084
0.916ProMet: 0.916 ± 0.062
1.91ProAsn: 1.91 ± 0.079
1.306ProPro: 1.306 ± 0.081
1.356ProGln: 1.356 ± 0.091
1.259ProArg: 1.259 ± 0.071
2.39ProSer: 2.39 ± 0.096
2.225ProThr: 2.225 ± 0.108
2.517ProVal: 2.517 ± 0.096
0.349ProTrp: 0.349 ± 0.033
1.118ProTyr: 1.118 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
1.638GlnAla: 1.638 ± 0.074
0.342GlnCys: 0.342 ± 0.036
1.571GlnAsp: 1.571 ± 0.075
2.42GlnGlu: 2.42 ± 0.095
1.289GlnPhe: 1.289 ± 0.062
1.799GlnGly: 1.799 ± 0.104
0.631GlnHis: 0.631 ± 0.047
3.215GlnIle: 3.215 ± 0.105
3.578GlnLys: 3.578 ± 0.122
2.584GlnLeu: 2.584 ± 0.096
0.936GlnMet: 0.936 ± 0.055
2.125GlnAsn: 2.125 ± 0.082
0.755GlnPro: 0.755 ± 0.052
1.134GlnGln: 1.134 ± 0.064
1.188GlnArg: 1.188 ± 0.063
1.98GlnSer: 1.98 ± 0.079
1.873GlnThr: 1.873 ± 0.089
1.91GlnVal: 1.91 ± 0.081
0.262GlnTrp: 0.262 ± 0.031
1.081GlnTyr: 1.081 ± 0.063
0.003GlnXaa: 0.003 ± 0.003
Arg
2.034ArgAla: 2.034 ± 0.086
0.376ArgCys: 0.376 ± 0.041
2.138ArgAsp: 2.138 ± 0.1
2.695ArgGlu: 2.695 ± 0.124
1.524ArgPhe: 1.524 ± 0.081
2.225ArgGly: 2.225 ± 0.094
0.665ArgHis: 0.665 ± 0.052
3.195ArgIle: 3.195 ± 0.108
3.564ArgLys: 3.564 ± 0.149
3.185ArgLeu: 3.185 ± 0.115
1.014ArgMet: 1.014 ± 0.055
1.792ArgAsn: 1.792 ± 0.071
1.155ArgPro: 1.155 ± 0.07
1.158ArgGln: 1.158 ± 0.066
1.561ArgArg: 1.561 ± 0.093
2.111ArgSer: 2.111 ± 0.087
1.822ArgThr: 1.822 ± 0.09
2.225ArgVal: 2.225 ± 0.097
0.349ArgTrp: 0.349 ± 0.033
1.202ArgTyr: 1.202 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
3.826SerAla: 3.826 ± 0.13
0.779SerCys: 0.779 ± 0.057
4.491SerAsp: 4.491 ± 0.131
5.511SerGlu: 5.511 ± 0.141
3.158SerPhe: 3.158 ± 0.101
5.024SerGly: 5.024 ± 0.144
1.306SerHis: 1.306 ± 0.064
5.565SerIle: 5.565 ± 0.167
6.313SerLys: 6.313 ± 0.185
5.957SerLeu: 5.957 ± 0.152
1.873SerMet: 1.873 ± 0.078
3.393SerAsn: 3.393 ± 0.142
2.406SerPro: 2.406 ± 0.093
2.262SerGln: 2.262 ± 0.078
2.484SerArg: 2.484 ± 0.085
4.914SerSer: 4.914 ± 0.199
3.581SerThr: 3.581 ± 0.095
4.501SerVal: 4.501 ± 0.112
0.701SerTrp: 0.701 ± 0.052
1.967SerTyr: 1.967 ± 0.088
0.003SerXaa: 0.003 ± 0.004
Thr
3.276ThrAla: 3.276 ± 0.119
0.54ThrCys: 0.54 ± 0.035
2.933ThrAsp: 2.933 ± 0.112
3.853ThrGlu: 3.853 ± 0.105
2.339ThrPhe: 2.339 ± 0.096
3.86ThrGly: 3.86 ± 0.135
0.957ThrHis: 0.957 ± 0.057
5.068ThrIle: 5.068 ± 0.134
4.659ThrLys: 4.659 ± 0.135
4.779ThrLeu: 4.779 ± 0.121
1.272ThrMet: 1.272 ± 0.073
2.665ThrAsn: 2.665 ± 0.136
2.396ThrPro: 2.396 ± 0.1
1.755ThrGln: 1.755 ± 0.08
2.034ThrArg: 2.034 ± 0.084
3.611ThrSer: 3.611 ± 0.125
2.927ThrThr: 2.927 ± 0.107
3.571ThrVal: 3.571 ± 0.111
0.48ThrTrp: 0.48 ± 0.042
1.645ThrTyr: 1.645 ± 0.071
0.003ThrXaa: 0.003 ± 0.004
Val
3.954ValAla: 3.954 ± 0.139
0.728ValCys: 0.728 ± 0.049
4.118ValAsp: 4.118 ± 0.134
4.732ValGlu: 4.732 ± 0.13
2.839ValPhe: 2.839 ± 0.094
4.353ValGly: 4.353 ± 0.142
1.151ValHis: 1.151 ± 0.059
5.635ValIle: 5.635 ± 0.159
5.028ValLys: 5.028 ± 0.141
5.716ValLeu: 5.716 ± 0.131
1.685ValMet: 1.685 ± 0.088
2.729ValAsn: 2.729 ± 0.098
2.437ValPro: 2.437 ± 0.088
1.594ValGln: 1.594 ± 0.078
2.286ValArg: 2.286 ± 0.092
4.719ValSer: 4.719 ± 0.12
3.957ValThr: 3.957 ± 0.121
4.32ValVal: 4.32 ± 0.146
0.537ValTrp: 0.537 ± 0.046
1.913ValTyr: 1.913 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.52TrpAla: 0.52 ± 0.043
0.084TrpCys: 0.084 ± 0.017
0.561TrpAsp: 0.561 ± 0.043
0.611TrpGlu: 0.611 ± 0.053
0.416TrpPhe: 0.416 ± 0.043
0.564TrpGly: 0.564 ± 0.043
0.181TrpHis: 0.181 ± 0.024
0.856TrpIle: 0.856 ± 0.056
0.738TrpLys: 0.738 ± 0.052
0.738TrpLeu: 0.738 ± 0.045
0.235TrpMet: 0.235 ± 0.027
0.641TrpAsn: 0.641 ± 0.048
0.258TrpPro: 0.258 ± 0.03
0.269TrpGln: 0.269 ± 0.031
0.376TrpArg: 0.376 ± 0.035
0.527TrpSer: 0.527 ± 0.038
0.423TrpThr: 0.423 ± 0.042
0.574TrpVal: 0.574 ± 0.044
0.171TrpTrp: 0.171 ± 0.027
0.342TrpTyr: 0.342 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.859TyrAla: 1.859 ± 0.081
0.443TyrCys: 0.443 ± 0.037
2.383TyrAsp: 2.383 ± 0.1
2.235TyrGlu: 2.235 ± 0.089
1.346TyrPhe: 1.346 ± 0.057
2.229TyrGly: 2.229 ± 0.078
0.698TyrHis: 0.698 ± 0.057
1.88TyrIle: 1.88 ± 0.076
1.987TyrLys: 1.987 ± 0.089
2.866TyrLeu: 2.866 ± 0.108
0.648TyrMet: 0.648 ± 0.043
1.504TyrAsn: 1.504 ± 0.073
1.349TyrPro: 1.349 ± 0.075
1.141TyrGln: 1.141 ± 0.06
1.232TyrArg: 1.232 ± 0.061
2.269TyrSer: 2.269 ± 0.098
1.598TyrThr: 1.598 ± 0.067
2.212TyrVal: 2.212 ± 0.093
0.346TyrTrp: 0.346 ± 0.036
1.175TyrTyr: 1.175 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.007XaaPhe: 0.007 ± 0.006
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.003XaaLys: 0.003 ± 0.003
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.003XaaGln: 0.003 ± 0.003
0.0XaaArg: 0.0 ± 0.0
0.003XaaSer: 0.003 ± 0.004
0.003XaaThr: 0.003 ± 0.003
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.101XaaXaa: 0.101 ± 0.056
Statistics based on 1339 proteins (297946 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski