Amino acid dipepetide frequency for Lutibacter agarilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.099AlaAla: 4.099 ± 0.08	0.549AlaCys: 0.549 ± 0.023	3.041AlaAsp: 3.041 ± 0.05	3.777AlaGlu: 3.777 ± 0.068	3.129AlaPhe: 3.129 ± 0.047	3.95AlaGly: 3.95 ± 0.063	0.998AlaHis: 0.998 ± 0.03	5.61AlaIle: 5.61 ± 0.076	4.528AlaLys: 4.528 ± 0.072	5.611AlaLeu: 5.611 ± 0.081	1.422AlaMet: 1.422 ± 0.04	3.513AlaAsn: 3.513 ± 0.063	1.943AlaPro: 1.943 ± 0.047	2.201AlaGln: 2.201 ± 0.04	1.736AlaArg: 1.736 ± 0.043	4.197AlaSer: 4.197 ± 0.069	3.846AlaThr: 3.846 ± 0.074	4.103AlaVal: 4.103 ± 0.056	0.617AlaTrp: 0.617 ± 0.022	2.488AlaTyr: 2.488 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.418CysAla: 0.418 ± 0.019	0.095CysCys: 0.095 ± 0.008	0.474CysAsp: 0.474 ± 0.024	0.505CysGlu: 0.505 ± 0.024	0.401CysPhe: 0.401 ± 0.021	0.609CysGly: 0.609 ± 0.031	0.209CysHis: 0.209 ± 0.019	0.583CysIle: 0.583 ± 0.023	0.55CysLys: 0.55 ± 0.02	0.621CysLeu: 0.621 ± 0.025	0.148CysMet: 0.148 ± 0.011	0.461CysAsn: 0.461 ± 0.021	0.333CysPro: 0.333 ± 0.02	0.195CysGln: 0.195 ± 0.013	0.189CysArg: 0.189 ± 0.014	0.528CysSer: 0.528 ± 0.026	0.467CysThr: 0.467 ± 0.019	0.414CysVal: 0.414 ± 0.018	0.091CysTrp: 0.091 ± 0.012	0.299CysTyr: 0.299 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.557AspAla: 3.557 ± 0.057	0.404AspCys: 0.404 ± 0.017	2.692AspAsp: 2.692 ± 0.06	3.779AspGlu: 3.779 ± 0.057	3.629AspPhe: 3.629 ± 0.052	3.591AspGly: 3.591 ± 0.068	0.778AspHis: 0.778 ± 0.028	4.453AspIle: 4.453 ± 0.066	3.894AspLys: 3.894 ± 0.067	5.018AspLeu: 5.018 ± 0.074	1.017AspMet: 1.017 ± 0.03	3.107AspAsn: 3.107 ± 0.062	1.623AspPro: 1.623 ± 0.043	1.269AspGln: 1.269 ± 0.036	1.606AspArg: 1.606 ± 0.044	2.886AspSer: 2.886 ± 0.052	2.733AspThr: 2.733 ± 0.056	3.59AspVal: 3.59 ± 0.059	0.792AspTrp: 0.792 ± 0.027	2.696AspTyr: 2.696 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.292GluAla: 4.292 ± 0.068	0.38GluCys: 0.38 ± 0.019	3.553GluAsp: 3.553 ± 0.055	4.742GluGlu: 4.742 ± 0.083	3.239GluPhe: 3.239 ± 0.045	3.983GluGly: 3.983 ± 0.063	1.147GluHis: 1.147 ± 0.027	6.136GluIle: 6.136 ± 0.073	5.898GluLys: 5.898 ± 0.087	6.473GluLeu: 6.473 ± 0.092	1.584GluMet: 1.584 ± 0.039	5.275GluAsn: 5.275 ± 0.077	1.565GluPro: 1.565 ± 0.036	2.254GluGln: 2.254 ± 0.043	2.237GluArg: 2.237 ± 0.043	3.301GluSer: 3.301 ± 0.048	3.81GluThr: 3.81 ± 0.063	4.461GluVal: 4.461 ± 0.066	0.681GluTrp: 0.681 ± 0.026	2.34GluTyr: 2.34 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.677PheAla: 2.677 ± 0.054	0.421PheCys: 0.421 ± 0.023	3.171PheAsp: 3.171 ± 0.051	3.735PheGlu: 3.735 ± 0.058	2.62PhePhe: 2.62 ± 0.061	3.566PheGly: 3.566 ± 0.061	0.811PheHis: 0.811 ± 0.026	4.244PheIle: 4.244 ± 0.071	4.179PheLys: 4.179 ± 0.07	4.593PheLeu: 4.593 ± 0.085	1.146PheMet: 1.146 ± 0.032	3.745PheAsn: 3.745 ± 0.065	1.655PhePro: 1.655 ± 0.04	1.487PheGln: 1.487 ± 0.033	1.433PheArg: 1.433 ± 0.036	4.101PheSer: 4.101 ± 0.066	3.077PheThr: 3.077 ± 0.064	3.083PheVal: 3.083 ± 0.049	0.616PheTrp: 0.616 ± 0.025	2.241PheTyr: 2.241 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.176GlyAla: 4.176 ± 0.071	0.579GlyCys: 0.579 ± 0.028	3.325GlyAsp: 3.325 ± 0.067	3.888GlyGlu: 3.888 ± 0.064	3.586GlyPhe: 3.586 ± 0.057	4.57GlyGly: 4.57 ± 0.086	1.003GlyHis: 1.003 ± 0.031	5.552GlyIle: 5.552 ± 0.085	4.965GlyLys: 4.965 ± 0.069	5.581GlyLeu: 5.581 ± 0.068	1.538GlyMet: 1.538 ± 0.038	3.69GlyAsn: 3.69 ± 0.067	1.344GlyPro: 1.344 ± 0.036	1.665GlyGln: 1.665 ± 0.039	1.959GlyArg: 1.959 ± 0.051	3.951GlySer: 3.951 ± 0.066	3.932GlyThr: 3.932 ± 0.081	4.699GlyVal: 4.699 ± 0.072	0.833GlyTrp: 0.833 ± 0.031	2.953GlyTyr: 2.953 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.891HisAla: 0.891 ± 0.031	0.151HisCys: 0.151 ± 0.011	0.753HisAsp: 0.753 ± 0.027	0.876HisGlu: 0.876 ± 0.029	1.088HisPhe: 1.088 ± 0.035	1.02HisGly: 1.02 ± 0.029	0.439HisHis: 0.439 ± 0.022	1.406HisIle: 1.406 ± 0.037	1.355HisLys: 1.355 ± 0.038	1.743HisLeu: 1.743 ± 0.039	0.301HisMet: 0.301 ± 0.015	0.99HisAsn: 0.99 ± 0.025	0.866HisPro: 0.866 ± 0.027	0.66HisGln: 0.66 ± 0.023	0.639HisArg: 0.639 ± 0.024	1.059HisSer: 1.059 ± 0.034	0.961HisThr: 0.961 ± 0.031	0.828HisVal: 0.828 ± 0.026	0.224HisTrp: 0.224 ± 0.014	0.794HisTyr: 0.794 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.595IleAla: 5.595 ± 0.075	0.63IleCys: 0.63 ± 0.023	5.116IleAsp: 5.116 ± 0.069	6.13IleGlu: 6.13 ± 0.075	3.67IlePhe: 3.67 ± 0.061	5.21IleGly: 5.21 ± 0.077	1.423IleHis: 1.423 ± 0.038	6.632IleIle: 6.632 ± 0.087	6.3IleLys: 6.3 ± 0.071	7.006IleLeu: 7.006 ± 0.094	1.419IleMet: 1.419 ± 0.036	5.164IleAsn: 5.164 ± 0.066	3.351IlePro: 3.351 ± 0.049	2.69IleGln: 2.69 ± 0.041	2.334IleArg: 2.334 ± 0.044	6.311IleSer: 6.311 ± 0.082	5.046IleThr: 5.046 ± 0.088	5.19IleVal: 5.19 ± 0.069	0.742IleTrp: 0.742 ± 0.025	3.02IleTyr: 3.02 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.744LysAla: 4.744 ± 0.07	0.388LysCys: 0.388 ± 0.018	4.251LysAsp: 4.251 ± 0.075	6.377LysGlu: 6.377 ± 0.084	3.258LysPhe: 3.258 ± 0.058	4.844LysGly: 4.844 ± 0.063	1.444LysHis: 1.444 ± 0.035	6.728LysIle: 6.728 ± 0.08	7.145LysLys: 7.145 ± 0.099	6.954LysLeu: 6.954 ± 0.091	1.977LysMet: 1.977 ± 0.042	6.105LysAsn: 6.105 ± 0.092	2.548LysPro: 2.548 ± 0.052	2.747LysGln: 2.747 ± 0.056	2.701LysArg: 2.701 ± 0.05	4.677LysSer: 4.677 ± 0.062	4.864LysThr: 4.864 ± 0.073	4.903LysVal: 4.903 ± 0.067	0.825LysTrp: 0.825 ± 0.03	3.267LysTyr: 3.267 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	5.448LeuAla: 5.448 ± 0.08	0.625LeuCys: 0.625 ± 0.025	4.688LeuAsp: 4.688 ± 0.066	5.871LeuGlu: 5.871 ± 0.083	5.023LeuPhe: 5.023 ± 0.09	5.658LeuGly: 5.658 ± 0.075	1.392LeuHis: 1.392 ± 0.037	7.343LeuIle: 7.343 ± 0.086	8.252LeuLys: 8.252 ± 0.103	8.522LeuLeu: 8.522 ± 0.106	1.898LeuMet: 1.898 ± 0.041	6.376LeuAsn: 6.376 ± 0.091	3.392LeuPro: 3.392 ± 0.052	2.85LeuGln: 2.85 ± 0.056	2.72LeuArg: 2.72 ± 0.047	6.084LeuSer: 6.084 ± 0.08	5.201LeuThr: 5.201 ± 0.074	5.431LeuVal: 5.431 ± 0.074	0.77LeuTrp: 0.77 ± 0.03	3.155LeuTyr: 3.155 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.481MetAla: 1.481 ± 0.042	0.151MetCys: 0.151 ± 0.011	1.053MetAsp: 1.053 ± 0.035	1.241MetGlu: 1.241 ± 0.027	0.893MetPhe: 0.893 ± 0.028	1.427MetGly: 1.427 ± 0.036	0.425MetHis: 0.425 ± 0.017	1.427MetIle: 1.427 ± 0.038	2.17MetLys: 2.17 ± 0.044	1.917MetLeu: 1.917 ± 0.043	0.507MetMet: 0.507 ± 0.022	1.37MetAsn: 1.37 ± 0.032	0.818MetPro: 0.818 ± 0.024	0.721MetGln: 0.721 ± 0.026	0.784MetArg: 0.784 ± 0.026	1.385MetSer: 1.385 ± 0.034	1.036MetThr: 1.036 ± 0.031	1.33MetVal: 1.33 ± 0.036	0.19MetTrp: 0.19 ± 0.011	0.777MetTyr: 0.777 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.905AsnAla: 3.905 ± 0.056	0.561AsnCys: 0.561 ± 0.025	3.362AsnAsp: 3.362 ± 0.063	4.352AsnGlu: 4.352 ± 0.061	3.421AsnPhe: 3.421 ± 0.061	4.162AsnGly: 4.162 ± 0.065	1.071AsnHis: 1.071 ± 0.03	5.266AsnIle: 5.266 ± 0.082	5.095AsnLys: 5.095 ± 0.079	5.955AsnLeu: 5.955 ± 0.099	1.31AsnMet: 1.31 ± 0.034	4.692AsnAsn: 4.692 ± 0.09	2.812AsnPro: 2.812 ± 0.055	2.116AsnGln: 2.116 ± 0.048	1.949AsnArg: 1.949 ± 0.042	4.472AsnSer: 4.472 ± 0.077	4.053AsnThr: 4.053 ± 0.067	3.727AsnVal: 3.727 ± 0.066	0.877AsnTrp: 0.877 ± 0.027	3.315AsnTyr: 3.315 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.877ProAla: 1.877 ± 0.046	0.188ProCys: 0.188 ± 0.012	1.792ProAsp: 1.792 ± 0.039	2.672ProGlu: 2.672 ± 0.047	1.948ProPhe: 1.948 ± 0.04	1.852ProGly: 1.852 ± 0.046	0.609ProHis: 0.609 ± 0.023	2.788ProIle: 2.788 ± 0.055	2.58ProLys: 2.58 ± 0.047	2.846ProLeu: 2.846 ± 0.05	0.677ProMet: 0.677 ± 0.026	2.358ProAsn: 2.358 ± 0.045	0.819ProPro: 0.819 ± 0.032	0.989ProGln: 0.989 ± 0.028	0.885ProArg: 0.885 ± 0.029	2.332ProSer: 2.332 ± 0.052	2.191ProThr: 2.191 ± 0.051	2.297ProVal: 2.297 ± 0.044	0.414ProTrp: 0.414 ± 0.017	1.389ProTyr: 1.389 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.772GlnAla: 1.772 ± 0.039	0.178GlnCys: 0.178 ± 0.012	1.388GlnAsp: 1.388 ± 0.033	2.121GlnGlu: 2.121 ± 0.047	1.665GlnPhe: 1.665 ± 0.037	1.713GlnGly: 1.713 ± 0.04	0.657GlnHis: 0.657 ± 0.028	2.472GlnIle: 2.472 ± 0.046	2.733GlnLys: 2.733 ± 0.045	3.516GlnLeu: 3.516 ± 0.061	0.739GlnMet: 0.739 ± 0.027	2.105GlnAsn: 2.105 ± 0.044	1.058GlnPro: 1.058 ± 0.031	1.487GlnGln: 1.487 ± 0.04	1.034GlnArg: 1.034 ± 0.029	1.682GlnSer: 1.682 ± 0.036	1.718GlnThr: 1.718 ± 0.048	1.822GlnVal: 1.822 ± 0.04	0.345GlnTrp: 0.345 ± 0.017	1.229GlnTyr: 1.229 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.911ArgAla: 1.911 ± 0.047	0.202ArgCys: 0.202 ± 0.013	1.58ArgAsp: 1.58 ± 0.043	1.86ArgGlu: 1.86 ± 0.037	1.686ArgPhe: 1.686 ± 0.038	1.815ArgGly: 1.815 ± 0.045	0.51ArgHis: 0.51 ± 0.024	2.612ArgIle: 2.612 ± 0.05	2.53ArgLys: 2.53 ± 0.056	2.814ArgLeu: 2.814 ± 0.05	0.788ArgMet: 0.788 ± 0.027	1.955ArgAsn: 1.955 ± 0.046	1.033ArgPro: 1.033 ± 0.04	0.818ArgGln: 0.818 ± 0.026	1.061ArgArg: 1.061 ± 0.035	1.706ArgSer: 1.706 ± 0.039	1.817ArgThr: 1.817 ± 0.043	1.925ArgVal: 1.925 ± 0.046	0.399ArgTrp: 0.399 ± 0.019	1.334ArgTyr: 1.334 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	3.529SerAla: 3.529 ± 0.056	0.681SerCys: 0.681 ± 0.025	3.346SerAsp: 3.346 ± 0.064	4.604SerGlu: 4.604 ± 0.062	3.739SerPhe: 3.739 ± 0.061	4.358SerGly: 4.358 ± 0.076	1.098SerHis: 1.098 ± 0.037	5.482SerIle: 5.482 ± 0.07	5.453SerLys: 5.453 ± 0.074	5.682SerLeu: 5.682 ± 0.079	1.29SerMet: 1.29 ± 0.033	4.298SerAsn: 4.298 ± 0.066	1.951SerPro: 1.951 ± 0.041	1.942SerGln: 1.942 ± 0.037	1.854SerArg: 1.854 ± 0.04	4.373SerSer: 4.373 ± 0.071	3.811SerThr: 3.811 ± 0.072	3.92SerVal: 3.92 ± 0.059	0.787SerTrp: 0.787 ± 0.028	2.873SerTyr: 2.873 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.76ThrAla: 3.76 ± 0.068	0.411ThrCys: 0.411 ± 0.023	3.117ThrAsp: 3.117 ± 0.051	3.488ThrGlu: 3.488 ± 0.061	3.018ThrPhe: 3.018 ± 0.056	3.987ThrGly: 3.987 ± 0.072	0.999ThrHis: 0.999 ± 0.03	5.468ThrIle: 5.468 ± 0.08	4.242ThrLys: 4.242 ± 0.053	5.016ThrLeu: 5.016 ± 0.076	0.986ThrMet: 0.986 ± 0.027	3.717ThrAsn: 3.717 ± 0.063	2.494ThrPro: 2.494 ± 0.05	1.745ThrGln: 1.745 ± 0.041	1.578ThrArg: 1.578 ± 0.036	4.203ThrSer: 4.203 ± 0.073	3.922ThrThr: 3.922 ± 0.083	3.791ThrVal: 3.791 ± 0.069	0.66ThrTrp: 0.66 ± 0.028	2.513ThrTyr: 2.513 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.114ValAla: 4.114 ± 0.061	0.545ValCys: 0.545 ± 0.023	3.549ValAsp: 3.549 ± 0.062	4.229ValGlu: 4.229 ± 0.066	3.443ValPhe: 3.443 ± 0.06	4.02ValGly: 4.02 ± 0.067	0.999ValHis: 0.999 ± 0.028	5.067ValIle: 5.067 ± 0.066	4.623ValLys: 4.623 ± 0.06	6.002ValLeu: 6.002 ± 0.079	1.239ValMet: 1.239 ± 0.032	3.807ValAsn: 3.807 ± 0.06	2.087ValPro: 2.087 ± 0.044	1.825ValGln: 1.825 ± 0.037	1.887ValArg: 1.887 ± 0.042	4.414ValSer: 4.414 ± 0.067	3.579ValThr: 3.579 ± 0.065	4.356ValVal: 4.356 ± 0.069	0.685ValTrp: 0.685 ± 0.025	2.391ValTyr: 2.391 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.672TrpAla: 0.672 ± 0.025	0.114TrpCys: 0.114 ± 0.009	0.681TrpAsp: 0.681 ± 0.027	0.733TrpGlu: 0.733 ± 0.027	0.587TrpPhe: 0.587 ± 0.023	0.811TrpGly: 0.811 ± 0.027	0.222TrpHis: 0.222 ± 0.015	0.756TrpIle: 0.756 ± 0.023	0.88TrpLys: 0.88 ± 0.03	0.948TrpLeu: 0.948 ± 0.028	0.333TrpMet: 0.333 ± 0.015	0.834TrpAsn: 0.834 ± 0.029	0.278TrpPro: 0.278 ± 0.017	0.377TrpGln: 0.377 ± 0.019	0.39TrpArg: 0.39 ± 0.016	0.681TrpSer: 0.681 ± 0.024	0.579TrpThr: 0.579 ± 0.025	0.727TrpVal: 0.727 ± 0.027	0.184TrpTrp: 0.184 ± 0.014	0.5TrpTyr: 0.5 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.438TyrAla: 2.438 ± 0.044	0.337TyrCys: 0.337 ± 0.016	2.181TyrAsp: 2.181 ± 0.045	2.37TyrGlu: 2.37 ± 0.046	2.559TyrPhe: 2.559 ± 0.053	2.645TyrGly: 2.645 ± 0.059	0.812TyrHis: 0.812 ± 0.029	2.954TyrIle: 2.954 ± 0.049	3.376TyrLys: 3.376 ± 0.054	3.879TyrLeu: 3.879 ± 0.065	0.783TyrMet: 0.783 ± 0.024	2.914TyrAsn: 2.914 ± 0.055	1.531TyrPro: 1.531 ± 0.039	1.398TyrGln: 1.398 ± 0.035	1.381TyrArg: 1.381 ± 0.039	2.726TyrSer: 2.726 ± 0.052	2.47TyrThr: 2.47 ± 0.057	2.267TyrVal: 2.267 ± 0.045	0.556TyrTrp: 0.556 ± 0.022	1.936TyrTyr: 1.936 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.011XaaXaa: 0.011 ± 0.01

Statistics based on 3391 proteins (1235752 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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