Amino acid dipepetide frequency for Domibacillus enclensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.943AlaAla: 9.943 ± 0.117
0.649AlaCys: 0.649 ± 0.024
4.785AlaAsp: 4.785 ± 0.066
6.22AlaGlu: 6.22 ± 0.079
4.056AlaPhe: 4.056 ± 0.063
7.252AlaGly: 7.252 ± 0.085
1.584AlaHis: 1.584 ± 0.039
5.826AlaIle: 5.826 ± 0.077
4.575AlaLys: 4.575 ± 0.075
8.344AlaLeu: 8.344 ± 0.101
2.437AlaMet: 2.437 ± 0.049
2.574AlaAsn: 2.574 ± 0.048
2.626AlaPro: 2.626 ± 0.052
2.585AlaGln: 2.585 ± 0.049
3.448AlaArg: 3.448 ± 0.057
5.035AlaSer: 5.035 ± 0.076
3.273AlaThr: 3.273 ± 0.055
7.394AlaVal: 7.394 ± 0.087
0.647AlaTrp: 0.647 ± 0.026
2.439AlaTyr: 2.439 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.512CysAla: 0.512 ± 0.022
0.083CysCys: 0.083 ± 0.009
0.347CysAsp: 0.347 ± 0.017
0.475CysGlu: 0.475 ± 0.019
0.315CysPhe: 0.315 ± 0.018
0.705CysGly: 0.705 ± 0.03
0.184CysHis: 0.184 ± 0.012
0.414CysIle: 0.414 ± 0.016
0.253CysLys: 0.253 ± 0.014
0.625CysLeu: 0.625 ± 0.024
0.184CysMet: 0.184 ± 0.013
0.224CysAsn: 0.224 ± 0.014
0.344CysPro: 0.344 ± 0.021
0.233CysGln: 0.233 ± 0.014
0.379CysArg: 0.379 ± 0.021
0.505CysSer: 0.505 ± 0.02
0.418CysThr: 0.418 ± 0.021
0.416CysVal: 0.416 ± 0.021
0.076CysTrp: 0.076 ± 0.007
0.191CysTyr: 0.191 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.988AspAla: 3.988 ± 0.065
0.37AspCys: 0.37 ± 0.017
2.562AspAsp: 2.562 ± 0.073
4.597AspGlu: 4.597 ± 0.078
2.315AspPhe: 2.315 ± 0.053
3.858AspGly: 3.858 ± 0.067
1.313AspHis: 1.313 ± 0.036
3.947AspIle: 3.947 ± 0.057
2.37AspLys: 2.37 ± 0.045
4.853AspLeu: 4.853 ± 0.068
1.479AspMet: 1.479 ± 0.037
1.391AspAsn: 1.391 ± 0.038
2.141AspPro: 2.141 ± 0.042
2.319AspGln: 2.319 ± 0.048
2.618AspArg: 2.618 ± 0.051
2.684AspSer: 2.684 ± 0.052
2.502AspThr: 2.502 ± 0.046
4.44AspVal: 4.44 ± 0.07
0.663AspTrp: 0.663 ± 0.024
2.084AspTyr: 2.084 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.977GluAla: 6.977 ± 0.079
0.378GluCys: 0.378 ± 0.019
3.601GluAsp: 3.601 ± 0.062
7.361GluGlu: 7.361 ± 0.113
2.309GluPhe: 2.309 ± 0.045
4.515GluGly: 4.515 ± 0.063
1.547GluHis: 1.547 ± 0.043
4.286GluIle: 4.286 ± 0.066
6.261GluLys: 6.261 ± 0.08
6.917GluLeu: 6.917 ± 0.089
2.37GluMet: 2.37 ± 0.048
3.073GluAsn: 3.073 ± 0.052
2.312GluPro: 2.312 ± 0.058
4.042GluGln: 4.042 ± 0.069
3.861GluArg: 3.861 ± 0.066
3.745GluSer: 3.745 ± 0.056
4.513GluThr: 4.513 ± 0.066
4.513GluVal: 4.513 ± 0.066
1.0GluTrp: 1.0 ± 0.029
2.06GluTyr: 2.06 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.289PheAla: 3.289 ± 0.06
0.327PheCys: 0.327 ± 0.017
2.517PheAsp: 2.517 ± 0.047
2.778PheGlu: 2.778 ± 0.046
2.59PhePhe: 2.59 ± 0.059
3.32PheGly: 3.32 ± 0.063
1.065PheHis: 1.065 ± 0.037
3.406PheIle: 3.406 ± 0.07
2.177PheLys: 2.177 ± 0.046
4.533PheLeu: 4.533 ± 0.082
1.326PheMet: 1.326 ± 0.034
1.613PheAsn: 1.613 ± 0.044
1.648PhePro: 1.648 ± 0.035
1.632PheGln: 1.632 ± 0.043
1.649PheArg: 1.649 ± 0.042
3.234PheSer: 3.234 ± 0.06
2.628PheThr: 2.628 ± 0.046
3.188PheVal: 3.188 ± 0.054
0.485PheTrp: 0.485 ± 0.024
1.614PheTyr: 1.614 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
5.805GlyAla: 5.805 ± 0.097
0.645GlyCys: 0.645 ± 0.024
3.466GlyAsp: 3.466 ± 0.061
4.77GlyGlu: 4.77 ± 0.076
3.491GlyPhe: 3.491 ± 0.052
5.255GlyGly: 5.255 ± 0.088
1.513GlyHis: 1.513 ± 0.038
5.622GlyIle: 5.622 ± 0.078
4.45GlyLys: 4.45 ± 0.067
6.897GlyLeu: 6.897 ± 0.095
2.319GlyMet: 2.319 ± 0.054
2.318GlyAsn: 2.318 ± 0.043
1.896GlyPro: 1.896 ± 0.042
2.457GlyGln: 2.457 ± 0.059
3.218GlyArg: 3.218 ± 0.054
4.409GlySer: 4.409 ± 0.074
4.498GlyThr: 4.498 ± 0.068
5.403GlyVal: 5.403 ± 0.073
0.871GlyTrp: 0.871 ± 0.029
2.587GlyTyr: 2.587 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.545HisAla: 1.545 ± 0.038
0.195HisCys: 0.195 ± 0.013
1.093HisAsp: 1.093 ± 0.035
1.467HisGlu: 1.467 ± 0.038
1.107HisPhe: 1.107 ± 0.03
1.537HisGly: 1.537 ± 0.036
0.697HisHis: 0.697 ± 0.03
1.571HisIle: 1.571 ± 0.039
0.876HisLys: 0.876 ± 0.025
2.128HisLeu: 2.128 ± 0.05
0.563HisMet: 0.563 ± 0.021
0.647HisAsn: 0.647 ± 0.027
1.217HisPro: 1.217 ± 0.034
0.797HisGln: 0.797 ± 0.031
0.941HisArg: 0.941 ± 0.03
1.23HisSer: 1.23 ± 0.035
1.126HisThr: 1.126 ± 0.033
1.636HisVal: 1.636 ± 0.038
0.246HisTrp: 0.246 ± 0.016
0.852HisTyr: 0.852 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.156IleAla: 6.156 ± 0.09
0.547IleCys: 0.547 ± 0.022
4.153IleAsp: 4.153 ± 0.064
5.3IleGlu: 5.3 ± 0.067
2.59IlePhe: 2.59 ± 0.057
5.822IleGly: 5.822 ± 0.086
1.643IleHis: 1.643 ± 0.038
4.454IleIle: 4.454 ± 0.081
3.282IleLys: 3.282 ± 0.056
5.85IleLeu: 5.85 ± 0.086
1.704IleMet: 1.704 ± 0.04
2.447IleAsn: 2.447 ± 0.047
3.072IlePro: 3.072 ± 0.061
2.921IleGln: 2.921 ± 0.054
3.13IleArg: 3.13 ± 0.054
4.255IleSer: 4.255 ± 0.069
3.746IleThr: 3.746 ± 0.056
5.262IleVal: 5.262 ± 0.073
0.639IleTrp: 0.639 ± 0.025
1.844IleTyr: 1.844 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
5.096LysAla: 5.096 ± 0.074
0.263LysCys: 0.263 ± 0.015
2.987LysAsp: 2.987 ± 0.056
6.254LysGlu: 6.254 ± 0.089
1.403LysPhe: 1.403 ± 0.035
4.188LysGly: 4.188 ± 0.071
1.123LysHis: 1.123 ± 0.032
3.324LysIle: 3.324 ± 0.063
5.298LysLys: 5.298 ± 0.075
4.639LysLeu: 4.639 ± 0.069
2.156LysMet: 2.156 ± 0.042
2.401LysAsn: 2.401 ± 0.052
2.331LysPro: 2.331 ± 0.049
3.055LysGln: 3.055 ± 0.059
3.211LysArg: 3.211 ± 0.06
2.975LysSer: 2.975 ± 0.05
3.646LysThr: 3.646 ± 0.056
3.804LysVal: 3.804 ± 0.071
0.856LysTrp: 0.856 ± 0.029
1.525LysTyr: 1.525 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
8.193LeuAla: 8.193 ± 0.097
0.621LeuCys: 0.621 ± 0.024
4.783LeuAsp: 4.783 ± 0.069
5.933LeuGlu: 5.933 ± 0.072
5.195LeuPhe: 5.195 ± 0.09
5.848LeuGly: 5.848 ± 0.077
1.992LeuHis: 1.992 ± 0.047
6.405LeuIle: 6.405 ± 0.104
5.89LeuLys: 5.89 ± 0.089
10.149LeuLeu: 10.149 ± 0.119
2.561LeuMet: 2.561 ± 0.049
3.787LeuAsn: 3.787 ± 0.059
4.038LeuPro: 4.038 ± 0.063
3.638LeuGln: 3.638 ± 0.059
3.553LeuArg: 3.553 ± 0.06
6.755LeuSer: 6.755 ± 0.086
5.733LeuThr: 5.733 ± 0.073
5.954LeuVal: 5.954 ± 0.076
0.795LeuTrp: 0.795 ± 0.031
3.181LeuTyr: 3.181 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.602MetAla: 2.602 ± 0.05
0.155MetCys: 0.155 ± 0.012
1.679MetAsp: 1.679 ± 0.038
2.126MetGlu: 2.126 ± 0.042
0.994MetPhe: 0.994 ± 0.031
1.754MetGly: 1.754 ± 0.039
0.43MetHis: 0.43 ± 0.02
2.251MetIle: 2.251 ± 0.046
2.626MetLys: 2.626 ± 0.049
2.632MetLeu: 2.632 ± 0.055
1.069MetMet: 1.069 ± 0.033
1.739MetAsn: 1.739 ± 0.042
1.166MetPro: 1.166 ± 0.032
0.98MetGln: 0.98 ± 0.03
1.173MetArg: 1.173 ± 0.031
1.722MetSer: 1.722 ± 0.039
2.098MetThr: 2.098 ± 0.04
1.667MetVal: 1.667 ± 0.045
0.217MetTrp: 0.217 ± 0.015
0.735MetTyr: 0.735 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.781AsnAla: 2.781 ± 0.053
0.243AsnCys: 0.243 ± 0.015
1.957AsnAsp: 1.957 ± 0.04
3.339AsnGlu: 3.339 ± 0.056
1.138AsnPhe: 1.138 ± 0.033
3.421AsnGly: 3.421 ± 0.054
0.733AsnHis: 0.733 ± 0.026
2.574AsnIle: 2.574 ± 0.05
1.973AsnLys: 1.973 ± 0.043
2.853AsnLeu: 2.853 ± 0.051
1.128AsnMet: 1.128 ± 0.03
1.295AsnAsn: 1.295 ± 0.043
1.823AsnPro: 1.823 ± 0.044
1.414AsnGln: 1.414 ± 0.039
1.894AsnArg: 1.894 ± 0.047
1.838AsnSer: 1.838 ± 0.04
1.823AsnThr: 1.823 ± 0.041
2.886AsnVal: 2.886 ± 0.055
0.501AsnTrp: 0.501 ± 0.023
1.117AsnTyr: 1.117 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
3.489ProAla: 3.489 ± 0.063
0.229ProCys: 0.229 ± 0.015
2.59ProAsp: 2.59 ± 0.053
3.263ProGlu: 3.263 ± 0.056
2.165ProPhe: 2.165 ± 0.044
2.614ProGly: 2.614 ± 0.05
0.882ProHis: 0.882 ± 0.032
2.456ProIle: 2.456 ± 0.05
1.777ProLys: 1.777 ± 0.041
3.765ProLeu: 3.765 ± 0.057
0.925ProMet: 0.925 ± 0.033
1.405ProAsn: 1.405 ± 0.038
1.113ProPro: 1.113 ± 0.034
1.039ProGln: 1.039 ± 0.03
1.073ProArg: 1.073 ± 0.032
2.283ProSer: 2.283 ± 0.051
1.564ProThr: 1.564 ± 0.037
3.612ProVal: 3.612 ± 0.058
0.378ProTrp: 0.378 ± 0.022
1.341ProTyr: 1.341 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.42GlnAla: 3.42 ± 0.059
0.196GlnCys: 0.196 ± 0.012
1.637GlnAsp: 1.637 ± 0.042
3.018GlnGlu: 3.018 ± 0.059
1.716GlnPhe: 1.716 ± 0.042
2.109GlnGly: 2.109 ± 0.041
0.822GlnHis: 0.822 ± 0.03
2.236GlnIle: 2.236 ± 0.045
2.794GlnLys: 2.794 ± 0.059
4.003GlnLeu: 4.003 ± 0.067
1.299GlnMet: 1.299 ± 0.032
1.535GlnAsn: 1.535 ± 0.038
1.476GlnPro: 1.476 ± 0.038
1.801GlnGln: 1.801 ± 0.047
1.5GlnArg: 1.5 ± 0.035
2.437GlnSer: 2.437 ± 0.047
2.286GlnThr: 2.286 ± 0.053
2.337GlnVal: 2.337 ± 0.052
0.419GlnTrp: 0.419 ± 0.018
1.251GlnTyr: 1.251 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.147ArgAla: 3.147 ± 0.052
0.262ArgCys: 0.262 ± 0.015
2.235ArgAsp: 2.235 ± 0.047
3.147ArgGlu: 3.147 ± 0.059
2.138ArgPhe: 2.138 ± 0.042
2.491ArgGly: 2.491 ± 0.049
1.012ArgHis: 1.012 ± 0.033
3.126ArgIle: 3.126 ± 0.059
2.95ArgLys: 2.95 ± 0.055
4.451ArgLeu: 4.451 ± 0.065
1.507ArgMet: 1.507 ± 0.035
1.662ArgAsn: 1.662 ± 0.041
1.626ArgPro: 1.626 ± 0.035
1.773ArgGln: 1.773 ± 0.043
2.133ArgArg: 2.133 ± 0.051
2.535ArgSer: 2.535 ± 0.047
2.417ArgThr: 2.417 ± 0.044
2.845ArgVal: 2.845 ± 0.054
0.44ArgTrp: 0.44 ± 0.02
1.565ArgTyr: 1.565 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.866SerAla: 4.866 ± 0.074
0.46SerCys: 0.46 ± 0.022
2.873SerAsp: 2.873 ± 0.049
3.83SerGlu: 3.83 ± 0.061
3.427SerPhe: 3.427 ± 0.06
5.108SerGly: 5.108 ± 0.071
1.22SerHis: 1.22 ± 0.032
4.64SerIle: 4.64 ± 0.059
3.036SerLys: 3.036 ± 0.047
5.895SerLeu: 5.895 ± 0.088
1.815SerMet: 1.815 ± 0.04
2.013SerAsn: 2.013 ± 0.056
2.198SerPro: 2.198 ± 0.051
1.758SerGln: 1.758 ± 0.044
2.658SerArg: 2.658 ± 0.054
4.008SerSer: 4.008 ± 0.07
2.978SerThr: 2.978 ± 0.061
4.525SerVal: 4.525 ± 0.061
0.66SerTrp: 0.66 ± 0.027
2.018SerTyr: 2.018 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.419ThrAla: 5.419 ± 0.078
0.347ThrCys: 0.347 ± 0.019
3.193ThrAsp: 3.193 ± 0.054
3.787ThrGlu: 3.787 ± 0.064
2.685ThrPhe: 2.685 ± 0.055
4.787ThrGly: 4.787 ± 0.063
1.074ThrHis: 1.074 ± 0.032
4.17ThrIle: 4.17 ± 0.063
2.974ThrLys: 2.974 ± 0.053
4.96ThrLeu: 4.96 ± 0.064
1.491ThrMet: 1.491 ± 0.036
2.003ThrAsn: 2.003 ± 0.048
2.242ThrPro: 2.242 ± 0.041
1.363ThrGln: 1.363 ± 0.033
2.003ThrArg: 2.003 ± 0.043
2.97ThrSer: 2.97 ± 0.045
2.626ThrThr: 2.626 ± 0.05
4.67ThrVal: 4.67 ± 0.071
0.53ThrTrp: 0.53 ± 0.024
1.794ThrTyr: 1.794 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
5.3ValAla: 5.3 ± 0.079
0.602ValCys: 0.602 ± 0.026
3.785ValAsp: 3.785 ± 0.055
4.806ValGlu: 4.806 ± 0.059
3.379ValPhe: 3.379 ± 0.062
4.213ValGly: 4.213 ± 0.079
1.653ValHis: 1.653 ± 0.04
5.331ValIle: 5.331 ± 0.076
4.561ValLys: 4.561 ± 0.065
7.428ValLeu: 7.428 ± 0.082
2.154ValMet: 2.154 ± 0.045
2.906ValAsn: 2.906 ± 0.056
3.04ValPro: 3.04 ± 0.048
2.875ValGln: 2.875 ± 0.06
2.994ValArg: 2.994 ± 0.047
4.72ValSer: 4.72 ± 0.071
4.618ValThr: 4.618 ± 0.073
5.103ValVal: 5.103 ± 0.077
0.723ValTrp: 0.723 ± 0.025
2.361ValTyr: 2.361 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.726TrpAla: 0.726 ± 0.025
0.071TrpCys: 0.071 ± 0.008
0.509TrpAsp: 0.509 ± 0.023
0.641TrpGlu: 0.641 ± 0.024
0.476TrpPhe: 0.476 ± 0.02
0.675TrpGly: 0.675 ± 0.024
0.259TrpHis: 0.259 ± 0.015
0.733TrpIle: 0.733 ± 0.025
0.72TrpLys: 0.72 ± 0.024
1.207TrpLeu: 1.207 ± 0.034
0.426TrpMet: 0.426 ± 0.019
0.48TrpAsn: 0.48 ± 0.019
0.306TrpPro: 0.306 ± 0.017
0.427TrpGln: 0.427 ± 0.023
0.463TrpArg: 0.463 ± 0.024
0.662TrpSer: 0.662 ± 0.029
0.734TrpThr: 0.734 ± 0.024
0.699TrpVal: 0.699 ± 0.024
0.134TrpTrp: 0.134 ± 0.012
0.286TrpTyr: 0.286 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.44TyrAla: 2.44 ± 0.049
0.242TyrCys: 0.242 ± 0.015
1.745TyrAsp: 1.745 ± 0.043
2.529TyrGlu: 2.529 ± 0.058
1.527TyrPhe: 1.527 ± 0.036
2.418TyrGly: 2.418 ± 0.046
0.72TyrHis: 0.72 ± 0.023
2.045TyrIle: 2.045 ± 0.046
1.689TyrLys: 1.689 ± 0.043
2.876TyrLeu: 2.876 ± 0.054
0.9TyrMet: 0.9 ± 0.029
1.218TyrAsn: 1.218 ± 0.033
1.351TyrPro: 1.351 ± 0.034
1.186TyrGln: 1.186 ± 0.036
1.563TyrArg: 1.563 ± 0.037
1.984TyrSer: 1.984 ± 0.05
1.859TyrThr: 1.859 ± 0.04
2.197TyrVal: 2.197 ± 0.044
0.356TyrTrp: 0.356 ± 0.018
1.188TyrTyr: 1.188 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3765 proteins (1138485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski