Amino acid dipepetide frequency for Planctomycetes bacterium Pan265

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.094AlaAla: 12.094 ± 0.174	1.129AlaCys: 1.129 ± 0.035	6.828AlaAsp: 6.828 ± 0.107	7.274AlaGlu: 7.274 ± 0.115	3.38AlaPhe: 3.38 ± 0.055	9.461AlaGly: 9.461 ± 0.126	1.913AlaHis: 1.913 ± 0.054	5.476AlaIle: 5.476 ± 0.081	2.542AlaLys: 2.542 ± 0.078	10.204AlaLeu: 10.204 ± 0.132	3.063AlaMet: 3.063 ± 0.067	2.958AlaAsn: 2.958 ± 0.08	3.752AlaPro: 3.752 ± 0.061	3.56AlaGln: 3.56 ± 0.06	6.892AlaArg: 6.892 ± 0.115	6.745AlaSer: 6.745 ± 0.103	5.981AlaThr: 5.981 ± 0.089	7.696AlaVal: 7.696 ± 0.101	1.699AlaTrp: 1.699 ± 0.045	2.644AlaTyr: 2.644 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.829CysAla: 0.829 ± 0.03	0.158CysCys: 0.158 ± 0.014	0.562CysAsp: 0.562 ± 0.027	0.441CysGlu: 0.441 ± 0.023	0.327CysPhe: 0.327 ± 0.019	0.837CysGly: 0.837 ± 0.033	0.237CysHis: 0.237 ± 0.013	0.34CysIle: 0.34 ± 0.017	0.187CysLys: 0.187 ± 0.014	0.956CysLeu: 0.956 ± 0.033	0.169CysMet: 0.169 ± 0.013	0.192CysAsn: 0.192 ± 0.015	0.531CysPro: 0.531 ± 0.021	0.241CysGln: 0.241 ± 0.015	0.68CysArg: 0.68 ± 0.027	0.517CysSer: 0.517 ± 0.022	0.456CysThr: 0.456 ± 0.021	0.749CysVal: 0.749 ± 0.028	0.14CysTrp: 0.14 ± 0.012	0.216CysTyr: 0.216 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.571AspAla: 7.571 ± 0.112	0.395AspCys: 0.395 ± 0.02	4.534AspAsp: 4.534 ± 0.117	4.359AspGlu: 4.359 ± 0.085	2.395AspPhe: 2.395 ± 0.068	5.752AspGly: 5.752 ± 0.131	1.764AspHis: 1.764 ± 0.054	2.808AspIle: 2.808 ± 0.093	1.478AspLys: 1.478 ± 0.044	7.506AspLeu: 7.506 ± 0.161	1.108AspMet: 1.108 ± 0.036	2.098AspAsn: 2.098 ± 0.073	4.336AspPro: 4.336 ± 0.068	2.517AspGln: 2.517 ± 0.059	4.91AspArg: 4.91 ± 0.084	2.65AspSer: 2.65 ± 0.065	3.546AspThr: 3.546 ± 0.093	4.564AspVal: 4.564 ± 0.091	1.129AspTrp: 1.129 ± 0.037	1.732AspTyr: 1.732 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.283GluAla: 7.283 ± 0.107	0.31GluCys: 0.31 ± 0.017	3.324GluAsp: 3.324 ± 0.063	3.108GluGlu: 3.108 ± 0.081	1.523GluPhe: 1.523 ± 0.04	4.701GluGly: 4.701 ± 0.065	1.747GluHis: 1.747 ± 0.05	3.061GluIle: 3.061 ± 0.079	1.754GluLys: 1.754 ± 0.058	6.102GluLeu: 6.102 ± 0.092	1.302GluMet: 1.302 ± 0.038	1.717GluAsn: 1.717 ± 0.047	3.575GluPro: 3.575 ± 0.075	3.086GluGln: 3.086 ± 0.071	5.28GluArg: 5.28 ± 0.108	3.147GluSer: 3.147 ± 0.048	3.57GluThr: 3.57 ± 0.054	4.47GluVal: 4.47 ± 0.071	0.598GluTrp: 0.598 ± 0.025	1.141GluTyr: 1.141 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.368PheAla: 3.368 ± 0.065	0.334PheCys: 0.334 ± 0.019	2.843PheAsp: 2.843 ± 0.067	2.368PheGlu: 2.368 ± 0.047	1.205PhePhe: 1.205 ± 0.039	3.309PheGly: 3.309 ± 0.073	0.638PheHis: 0.638 ± 0.026	1.489PheIle: 1.489 ± 0.044	0.805PheLys: 0.805 ± 0.033	2.751PheLeu: 2.751 ± 0.069	0.655PheMet: 0.655 ± 0.025	1.352PheAsn: 1.352 ± 0.044	1.327PhePro: 1.327 ± 0.041	0.819PheGln: 0.819 ± 0.026	1.925PheArg: 1.925 ± 0.051	1.86PheSer: 1.86 ± 0.048	2.196PheThr: 2.196 ± 0.06	2.52PheVal: 2.52 ± 0.06	0.528PheTrp: 0.528 ± 0.024	0.976PheTyr: 0.976 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.637GlyAla: 6.637 ± 0.108	0.973GlyCys: 0.973 ± 0.037	5.485GlyAsp: 5.485 ± 0.136	4.731GlyGlu: 4.731 ± 0.071	3.316GlyPhe: 3.316 ± 0.071	7.333GlyGly: 7.333 ± 0.177	1.979GlyHis: 1.979 ± 0.048	4.276GlyIle: 4.276 ± 0.069	2.482GlyLys: 2.482 ± 0.061	8.614GlyLeu: 8.614 ± 0.14	2.281GlyMet: 2.281 ± 0.066	2.457GlyAsn: 2.457 ± 0.074	3.4GlyPro: 3.4 ± 0.059	3.156GlyGln: 3.156 ± 0.058	5.587GlyArg: 5.587 ± 0.088	5.143GlySer: 5.143 ± 0.104	4.917GlyThr: 4.917 ± 0.118	6.801GlyVal: 6.801 ± 0.108	1.515GlyTrp: 1.515 ± 0.05	2.551GlyTyr: 2.551 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.728HisAla: 2.728 ± 0.07	0.218HisCys: 0.218 ± 0.015	1.647HisAsp: 1.647 ± 0.049	1.427HisGlu: 1.427 ± 0.045	0.776HisPhe: 0.776 ± 0.027	1.939HisGly: 1.939 ± 0.056	0.81HisHis: 0.81 ± 0.031	0.888HisIle: 0.888 ± 0.03	0.535HisLys: 0.535 ± 0.026	2.362HisLeu: 2.362 ± 0.051	0.369HisMet: 0.369 ± 0.02	0.703HisAsn: 0.703 ± 0.029	1.51HisPro: 1.51 ± 0.044	0.802HisGln: 0.802 ± 0.028	1.622HisArg: 1.622 ± 0.046	0.803HisSer: 0.803 ± 0.026	1.235HisThr: 1.235 ± 0.038	1.585HisVal: 1.585 ± 0.043	0.375HisTrp: 0.375 ± 0.02	0.607HisTyr: 0.607 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.469IleAla: 5.469 ± 0.079	0.429IleCys: 0.429 ± 0.024	4.553IleAsp: 4.553 ± 0.087	4.142IleGlu: 4.142 ± 0.057	1.357IlePhe: 1.357 ± 0.036	4.111IleGly: 4.111 ± 0.073	1.078IleHis: 1.078 ± 0.031	2.265IleIle: 2.265 ± 0.05	1.293IleLys: 1.293 ± 0.037	4.475IleLeu: 4.475 ± 0.08	0.806IleMet: 0.806 ± 0.028	1.912IleAsn: 1.912 ± 0.056	2.57IlePro: 2.57 ± 0.061	1.559IleGln: 1.559 ± 0.039	3.402IleArg: 3.402 ± 0.067	2.465IleSer: 2.465 ± 0.064	3.455IleThr: 3.455 ± 0.097	3.422IleVal: 3.422 ± 0.061	0.51IleTrp: 0.51 ± 0.026	1.146IleTyr: 1.146 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.911LysAla: 2.911 ± 0.085	0.162LysCys: 0.162 ± 0.013	1.353LysAsp: 1.353 ± 0.042	1.108LysGlu: 1.108 ± 0.043	0.616LysPhe: 0.616 ± 0.027	1.709LysGly: 1.709 ± 0.043	0.682LysHis: 0.682 ± 0.029	1.315LysIle: 1.315 ± 0.048	1.078LysLys: 1.078 ± 0.059	2.791LysLeu: 2.791 ± 0.069	0.525LysMet: 0.525 ± 0.024	0.741LysAsn: 0.741 ± 0.031	1.74LysPro: 1.74 ± 0.052	1.206LysGln: 1.206 ± 0.034	2.001LysArg: 2.001 ± 0.059	1.26LysSer: 1.26 ± 0.042	1.717LysThr: 1.717 ± 0.054	1.775LysVal: 1.775 ± 0.053	0.273LysTrp: 0.273 ± 0.018	0.601LysTyr: 0.601 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.826LeuAla: 11.826 ± 0.153	0.958LeuCys: 0.958 ± 0.033	7.163LeuAsp: 7.163 ± 0.137	6.035LeuGlu: 6.035 ± 0.09	3.013LeuPhe: 3.013 ± 0.063	8.644LeuGly: 8.644 ± 0.109	1.974LeuHis: 1.974 ± 0.051	5.513LeuIle: 5.513 ± 0.09	2.603LeuLys: 2.603 ± 0.06	10.477LeuLeu: 10.477 ± 0.173	2.383LeuMet: 2.383 ± 0.066	3.063LeuAsn: 3.063 ± 0.073	5.373LeuPro: 5.373 ± 0.086	2.667LeuGln: 2.667 ± 0.063	7.129LeuArg: 7.129 ± 0.113	6.008LeuSer: 6.008 ± 0.088	6.445LeuThr: 6.445 ± 0.129	7.297LeuVal: 7.297 ± 0.106	1.318LeuTrp: 1.318 ± 0.043	2.258LeuTyr: 2.258 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.523MetAla: 2.523 ± 0.059	0.154MetCys: 0.154 ± 0.013	1.132MetAsp: 1.132 ± 0.031	0.956MetGlu: 0.956 ± 0.033	0.608MetPhe: 0.608 ± 0.026	1.616MetGly: 1.616 ± 0.054	0.474MetHis: 0.474 ± 0.022	1.379MetIle: 1.379 ± 0.039	0.743MetLys: 0.743 ± 0.03	2.388MetLeu: 2.388 ± 0.061	0.603MetMet: 0.603 ± 0.029	0.818MetAsn: 0.818 ± 0.03	1.418MetPro: 1.418 ± 0.042	0.684MetGln: 0.684 ± 0.026	1.578MetArg: 1.578 ± 0.042	1.517MetSer: 1.517 ± 0.046	1.771MetThr: 1.771 ± 0.048	1.656MetVal: 1.656 ± 0.046	0.215MetTrp: 0.215 ± 0.017	0.395MetTyr: 0.395 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.219AsnAla: 3.219 ± 0.071	0.194AsnCys: 0.194 ± 0.014	2.087AsnAsp: 2.087 ± 0.065	1.532AsnGlu: 1.532 ± 0.042	1.031AsnPhe: 1.031 ± 0.038	2.685AsnGly: 2.685 ± 0.087	0.805AsnHis: 0.805 ± 0.027	1.45AsnIle: 1.45 ± 0.042	0.739AsnLys: 0.739 ± 0.031	3.245AsnLeu: 3.245 ± 0.091	0.513AsnMet: 0.513 ± 0.022	1.198AsnAsn: 1.198 ± 0.047	2.268AsnPro: 2.268 ± 0.051	1.15AsnGln: 1.15 ± 0.035	1.808AsnArg: 1.808 ± 0.041	1.328AsnSer: 1.328 ± 0.05	2.043AsnThr: 2.043 ± 0.061	1.949AsnVal: 1.949 ± 0.059	0.493AsnTrp: 0.493 ± 0.024	0.73AsnTyr: 0.73 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.721ProAla: 5.721 ± 0.098	0.347ProCys: 0.347 ± 0.019	4.348ProAsp: 4.348 ± 0.073	4.401ProGlu: 4.401 ± 0.086	1.657ProPhe: 1.657 ± 0.044	4.751ProGly: 4.751 ± 0.086	1.124ProHis: 1.124 ± 0.036	2.353ProIle: 2.353 ± 0.042	1.255ProLys: 1.255 ± 0.036	4.368ProLeu: 4.368 ± 0.076	1.271ProMet: 1.271 ± 0.043	1.456ProAsn: 1.456 ± 0.043	2.346ProPro: 2.346 ± 0.066	1.648ProGln: 1.648 ± 0.044	2.855ProArg: 2.855 ± 0.061	2.841ProSer: 2.841 ± 0.061	3.026ProThr: 3.026 ± 0.055	4.106ProVal: 4.106 ± 0.068	0.819ProTrp: 0.819 ± 0.028	1.194ProTyr: 1.194 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.014GlnAla: 4.014 ± 0.073	0.231GlnCys: 0.231 ± 0.014	1.569GlnAsp: 1.569 ± 0.044	1.481GlnGlu: 1.481 ± 0.035	0.986GlnPhe: 0.986 ± 0.032	2.418GlnGly: 2.418 ± 0.059	0.983GlnHis: 0.983 ± 0.037	1.995GlnIle: 1.995 ± 0.045	0.937GlnLys: 0.937 ± 0.034	3.651GlnLeu: 3.651 ± 0.079	0.754GlnMet: 0.754 ± 0.032	1.027GlnAsn: 1.027 ± 0.033	2.317GlnPro: 2.317 ± 0.059	1.892GlnGln: 1.892 ± 0.053	3.003GlnArg: 3.003 ± 0.062	1.796GlnSer: 1.796 ± 0.047	2.261GlnThr: 2.261 ± 0.052	2.411GlnVal: 2.411 ± 0.056	0.503GlnTrp: 0.503 ± 0.023	0.739GlnTyr: 0.739 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.245ArgAla: 6.245 ± 0.114	0.681ArgCys: 0.681 ± 0.026	4.233ArgAsp: 4.233 ± 0.064	4.277ArgGlu: 4.277 ± 0.084	2.877ArgPhe: 2.877 ± 0.062	4.725ArgGly: 4.725 ± 0.086	1.803ArgHis: 1.803 ± 0.049	3.652ArgIle: 3.652 ± 0.073	1.985ArgLys: 1.985 ± 0.074	7.716ArgLeu: 7.716 ± 0.115	1.712ArgMet: 1.712 ± 0.038	1.789ArgAsn: 1.789 ± 0.043	3.409ArgPro: 3.409 ± 0.073	2.706ArgGln: 2.706 ± 0.063	5.451ArgArg: 5.451 ± 0.121	3.847ArgSer: 3.847 ± 0.075	3.326ArgThr: 3.326 ± 0.065	5.886ArgVal: 5.886 ± 0.097	1.345ArgTrp: 1.345 ± 0.044	1.948ArgTyr: 1.948 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.217SerAla: 5.217 ± 0.087	0.44SerCys: 0.44 ± 0.021	3.608SerAsp: 3.608 ± 0.083	3.163SerGlu: 3.163 ± 0.051	2.03SerPhe: 2.03 ± 0.055	5.455SerGly: 5.455 ± 0.097	0.999SerHis: 0.999 ± 0.032	2.883SerIle: 2.883 ± 0.06	1.254SerLys: 1.254 ± 0.039	5.806SerLeu: 5.806 ± 0.086	1.314SerMet: 1.314 ± 0.035	1.64SerAsn: 1.64 ± 0.051	2.773SerPro: 2.773 ± 0.055	1.694SerGln: 1.694 ± 0.043	3.461SerArg: 3.461 ± 0.064	3.453SerSer: 3.453 ± 0.068	3.352SerThr: 3.352 ± 0.068	4.412SerVal: 4.412 ± 0.066	0.864SerTrp: 0.864 ± 0.034	1.345SerTyr: 1.345 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.975ThrAla: 5.975 ± 0.098	0.478ThrCys: 0.478 ± 0.025	3.947ThrAsp: 3.947 ± 0.09	3.044ThrGlu: 3.044 ± 0.061	2.032ThrPhe: 2.032 ± 0.058	5.405ThrGly: 5.405 ± 0.102	1.426ThrHis: 1.426 ± 0.041	3.391ThrIle: 3.391 ± 0.092	1.165ThrLys: 1.165 ± 0.038	6.982ThrLeu: 6.982 ± 0.16	1.129ThrMet: 1.129 ± 0.037	1.759ThrAsn: 1.759 ± 0.062	3.845ThrPro: 3.845 ± 0.074	2.082ThrGln: 2.082 ± 0.053	3.851ThrArg: 3.851 ± 0.081	3.214ThrSer: 3.214 ± 0.075	4.142ThrThr: 4.142 ± 0.107	4.425ThrVal: 4.425 ± 0.12	0.877ThrTrp: 0.877 ± 0.033	1.498ThrTyr: 1.498 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.835ValAla: 7.835 ± 0.104	0.788ValCys: 0.788 ± 0.034	5.217ValAsp: 5.217 ± 0.091	4.773ValGlu: 4.773 ± 0.083	2.652ValPhe: 2.652 ± 0.056	5.666ValGly: 5.666 ± 0.083	1.452ValHis: 1.452 ± 0.036	4.167ValIle: 4.167 ± 0.068	1.754ValLys: 1.754 ± 0.049	7.426ValLeu: 7.426 ± 0.11	1.839ValMet: 1.839 ± 0.051	2.241ValAsn: 2.241 ± 0.063	3.44ValPro: 3.44 ± 0.059	1.948ValGln: 1.948 ± 0.044	5.126ValArg: 5.126 ± 0.095	4.367ValSer: 4.367 ± 0.076	4.892ValThr: 4.892 ± 0.123	6.504ValVal: 6.504 ± 0.112	1.055ValTrp: 1.055 ± 0.038	1.822ValTyr: 1.822 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.26TrpAla: 1.26 ± 0.036	0.166TrpCys: 0.166 ± 0.013	0.865TrpAsp: 0.865 ± 0.031	0.681TrpGlu: 0.681 ± 0.026	0.528TrpPhe: 0.528 ± 0.025	1.047TrpGly: 1.047 ± 0.034	0.437TrpHis: 0.437 ± 0.02	0.756TrpIle: 0.756 ± 0.026	0.383TrpLys: 0.383 ± 0.02	1.783TrpLeu: 1.783 ± 0.052	0.415TrpMet: 0.415 ± 0.023	0.498TrpAsn: 0.498 ± 0.023	0.728TrpPro: 0.728 ± 0.03	0.61TrpGln: 0.61 ± 0.024	1.096TrpArg: 1.096 ± 0.039	0.995TrpSer: 0.995 ± 0.036	0.892TrpThr: 0.892 ± 0.033	1.089TrpVal: 1.089 ± 0.039	0.367TrpTrp: 0.367 ± 0.02	0.409TrpTyr: 0.409 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.566TyrAla: 2.566 ± 0.055	0.219TyrCys: 0.219 ± 0.014	1.855TyrAsp: 1.855 ± 0.054	1.499TyrGlu: 1.499 ± 0.038	0.958TyrPhe: 0.958 ± 0.031	2.069TyrGly: 2.069 ± 0.05	0.615TyrHis: 0.615 ± 0.024	0.962TyrIle: 0.962 ± 0.026	0.594TyrLys: 0.594 ± 0.024	2.547TyrLeu: 2.547 ± 0.057	0.415TyrMet: 0.415 ± 0.019	0.848TyrAsn: 0.848 ± 0.031	1.227TyrPro: 1.227 ± 0.04	0.939TyrGln: 0.939 ± 0.034	1.959TyrArg: 1.959 ± 0.049	1.207TyrSer: 1.207 ± 0.036	1.444TyrThr: 1.444 ± 0.048	1.647TyrVal: 1.647 ± 0.046	0.381TyrTrp: 0.381 ± 0.019	0.709TyrTyr: 0.709 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2855 proteins (1052711 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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