Amino acid dipepetide frequency for Haloprofundus marisrubri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.507AlaAla: 12.507 ± 0.157	0.67AlaCys: 0.67 ± 0.027	8.855AlaAsp: 8.855 ± 0.12	8.381AlaGlu: 8.381 ± 0.1	4.044AlaPhe: 4.044 ± 0.07	8.785AlaGly: 8.785 ± 0.119	1.807AlaHis: 1.807 ± 0.043	4.239AlaIle: 4.239 ± 0.073	2.009AlaLys: 2.009 ± 0.05	10.394AlaLeu: 10.394 ± 0.133	2.022AlaMet: 2.022 ± 0.046	2.486AlaAsn: 2.486 ± 0.051	3.673AlaPro: 3.673 ± 0.063	2.279AlaGln: 2.279 ± 0.041	5.896AlaArg: 5.896 ± 0.086	5.686AlaSer: 5.686 ± 0.084	6.473AlaThr: 6.473 ± 0.084	10.319AlaVal: 10.319 ± 0.124	1.035AlaTrp: 1.035 ± 0.035	2.748AlaTyr: 2.748 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.611CysAla: 0.611 ± 0.025	0.093CysCys: 0.093 ± 0.009	0.534CysAsp: 0.534 ± 0.026	0.569CysGlu: 0.569 ± 0.024	0.219CysPhe: 0.219 ± 0.016	0.814CysGly: 0.814 ± 0.031	0.166CysHis: 0.166 ± 0.013	0.275CysIle: 0.275 ± 0.018	0.114CysLys: 0.114 ± 0.012	0.574CysLeu: 0.574 ± 0.025	0.11CysMet: 0.11 ± 0.01	0.168CysAsn: 0.168 ± 0.014	0.473CysPro: 0.473 ± 0.021	0.136CysGln: 0.136 ± 0.01	0.459CysArg: 0.459 ± 0.022	0.399CysSer: 0.399 ± 0.02	0.388CysThr: 0.388 ± 0.02	0.497CysVal: 0.497 ± 0.024	0.074CysTrp: 0.074 ± 0.009	0.197CysTyr: 0.197 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.785AspAla: 9.785 ± 0.132	0.648AspCys: 0.648 ± 0.028	7.88AspAsp: 7.88 ± 0.118	8.259AspGlu: 8.259 ± 0.109	1.846AspPhe: 1.846 ± 0.044	7.592AspGly: 7.592 ± 0.103	1.762AspHis: 1.762 ± 0.042	3.257AspIle: 3.257 ± 0.063	1.0AspLys: 1.0 ± 0.036	5.931AspLeu: 5.931 ± 0.07	1.161AspMet: 1.161 ± 0.031	1.422AspAsn: 1.422 ± 0.046	4.047AspPro: 4.047 ± 0.067	1.429AspGln: 1.429 ± 0.043	5.241AspArg: 5.241 ± 0.077	4.426AspSer: 4.426 ± 0.076	4.153AspThr: 4.153 ± 0.064	7.289AspVal: 7.289 ± 0.097	0.974AspTrp: 0.974 ± 0.032	1.859AspTyr: 1.859 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.826GluAla: 7.826 ± 0.091	0.456GluCys: 0.456 ± 0.022	4.697GluAsp: 4.697 ± 0.08	6.505GluGlu: 6.505 ± 0.099	3.364GluPhe: 3.364 ± 0.059	5.046GluGly: 5.046 ± 0.075	1.837GluHis: 1.837 ± 0.048	3.379GluIle: 3.379 ± 0.061	2.228GluLys: 2.228 ± 0.056	7.863GluLeu: 7.863 ± 0.097	2.012GluMet: 2.012 ± 0.044	2.83GluAsn: 2.83 ± 0.057	3.103GluPro: 3.103 ± 0.052	2.767GluGln: 2.767 ± 0.054	7.26GluArg: 7.26 ± 0.091	5.78GluSer: 5.78 ± 0.085	6.894GluThr: 6.894 ± 0.1	5.377GluVal: 5.377 ± 0.076	1.157GluTrp: 1.157 ± 0.033	2.612GluTyr: 2.612 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.866PheAla: 3.866 ± 0.073	0.302PheCys: 0.302 ± 0.015	3.47PheAsp: 3.47 ± 0.058	3.337PheGlu: 3.337 ± 0.065	1.232PhePhe: 1.232 ± 0.036	3.678PheGly: 3.678 ± 0.065	0.619PheHis: 0.619 ± 0.024	1.051PheIle: 1.051 ± 0.033	0.504PheLys: 0.504 ± 0.024	3.034PheLeu: 3.034 ± 0.058	0.491PheMet: 0.491 ± 0.02	0.723PheAsn: 0.723 ± 0.028	1.437PhePro: 1.437 ± 0.037	0.747PheGln: 0.747 ± 0.023	1.905PheArg: 1.905 ± 0.041	2.051PheSer: 2.051 ± 0.041	1.889PheThr: 1.889 ± 0.042	3.888PheVal: 3.888 ± 0.073	0.427PheTrp: 0.427 ± 0.02	0.883PheTyr: 0.883 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	7.616GlyAla: 7.616 ± 0.108	0.695GlyCys: 0.695 ± 0.03	6.532GlyAsp: 6.532 ± 0.09	6.922GlyGlu: 6.922 ± 0.087	3.31GlyPhe: 3.31 ± 0.064	7.42GlyGly: 7.42 ± 0.115	1.67GlyHis: 1.67 ± 0.041	3.941GlyIle: 3.941 ± 0.07	1.952GlyLys: 1.952 ± 0.044	7.316GlyLeu: 7.316 ± 0.092	1.645GlyMet: 1.645 ± 0.04	2.134GlyAsn: 2.134 ± 0.055	3.212GlyPro: 3.212 ± 0.058	2.097GlyGln: 2.097 ± 0.05	5.034GlyArg: 5.034 ± 0.068	5.27GlySer: 5.27 ± 0.088	5.305GlyThr: 5.305 ± 0.075	8.251GlyVal: 8.251 ± 0.107	1.114GlyTrp: 1.114 ± 0.037	2.831GlyTyr: 2.831 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.02HisAla: 2.02 ± 0.053	0.192HisCys: 0.192 ± 0.013	1.79HisAsp: 1.79 ± 0.043	1.652HisGlu: 1.652 ± 0.039	0.502HisPhe: 0.502 ± 0.026	1.887HisGly: 1.887 ± 0.05	0.549HisHis: 0.549 ± 0.024	0.763HisIle: 0.763 ± 0.027	0.301HisLys: 0.301 ± 0.02	1.774HisLeu: 1.774 ± 0.04	0.237HisMet: 0.237 ± 0.015	0.435HisAsn: 0.435 ± 0.02	1.249HisPro: 1.249 ± 0.036	0.43HisGln: 0.43 ± 0.022	1.295HisArg: 1.295 ± 0.039	0.932HisSer: 0.932 ± 0.032	1.088HisThr: 1.088 ± 0.035	1.881HisVal: 1.881 ± 0.039	0.243HisTrp: 0.243 ± 0.015	0.557HisTyr: 0.557 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.101IleAla: 4.101 ± 0.067	0.233IleCys: 0.233 ± 0.016	3.422IleAsp: 3.422 ± 0.06	3.474IleGlu: 3.474 ± 0.06	1.014IlePhe: 1.014 ± 0.038	3.394IleGly: 3.394 ± 0.061	0.796IleHis: 0.796 ± 0.027	1.233IleIle: 1.233 ± 0.038	0.644IleLys: 0.644 ± 0.027	3.137IleLeu: 3.137 ± 0.063	0.436IleMet: 0.436 ± 0.022	0.881IleAsn: 0.881 ± 0.028	2.13IlePro: 2.13 ± 0.046	0.998IleGln: 0.998 ± 0.032	2.611IleArg: 2.611 ± 0.053	2.187IleSer: 2.187 ± 0.052	2.051IleThr: 2.051 ± 0.043	3.496IleVal: 3.496 ± 0.067	0.304IleTrp: 0.304 ± 0.018	0.841IleTyr: 0.841 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	1.877LysAla: 1.877 ± 0.049	0.122LysCys: 0.122 ± 0.011	1.069LysAsp: 1.069 ± 0.036	1.441LysGlu: 1.441 ± 0.045	0.609LysPhe: 0.609 ± 0.023	1.39LysGly: 1.39 ± 0.041	0.531LysHis: 0.531 ± 0.024	0.794LysIle: 0.794 ± 0.031	0.594LysLys: 0.594 ± 0.03	1.925LysLeu: 1.925 ± 0.046	0.429LysMet: 0.429 ± 0.021	0.677LysAsn: 0.677 ± 0.029	1.043LysPro: 1.043 ± 0.035	0.89LysGln: 0.89 ± 0.029	1.796LysArg: 1.796 ± 0.038	1.278LysSer: 1.278 ± 0.033	1.484LysThr: 1.484 ± 0.034	1.226LysVal: 1.226 ± 0.03	0.235LysTrp: 0.235 ± 0.014	0.588LysTyr: 0.588 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.404LeuAla: 10.404 ± 0.113	0.636LeuCys: 0.636 ± 0.027	7.596LeuAsp: 7.596 ± 0.108	5.919LeuGlu: 5.919 ± 0.08	3.533LeuPhe: 3.533 ± 0.073	7.865LeuGly: 7.865 ± 0.095	1.551LeuHis: 1.551 ± 0.044	2.586LeuIle: 2.586 ± 0.064	1.648LeuLys: 1.648 ± 0.043	9.03LeuLeu: 9.03 ± 0.122	1.336LeuMet: 1.336 ± 0.037	1.942LeuAsn: 1.942 ± 0.046	4.186LeuPro: 4.186 ± 0.064	2.174LeuGln: 2.174 ± 0.046	5.973LeuArg: 5.973 ± 0.082	6.783LeuSer: 6.783 ± 0.086	5.552LeuThr: 5.552 ± 0.073	9.461LeuVal: 9.461 ± 0.116	0.954LeuTrp: 0.954 ± 0.032	2.477LeuTyr: 2.477 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.738MetAla: 1.738 ± 0.042	0.113MetCys: 0.113 ± 0.011	1.219MetAsp: 1.219 ± 0.036	1.175MetGlu: 1.175 ± 0.033	0.557MetPhe: 0.557 ± 0.024	1.382MetGly: 1.382 ± 0.035	0.358MetHis: 0.358 ± 0.018	0.504MetIle: 0.504 ± 0.021	0.472MetLys: 0.472 ± 0.023	1.696MetLeu: 1.696 ± 0.042	0.299MetMet: 0.299 ± 0.016	0.638MetAsn: 0.638 ± 0.025	0.826MetPro: 0.826 ± 0.027	0.601MetGln: 0.601 ± 0.025	1.201MetArg: 1.201 ± 0.032	1.541MetSer: 1.541 ± 0.038	1.443MetThr: 1.443 ± 0.033	1.385MetVal: 1.385 ± 0.035	0.162MetTrp: 0.162 ± 0.013	0.433MetTyr: 0.433 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.791AsnAla: 2.791 ± 0.056	0.234AsnCys: 0.234 ± 0.014	1.828AsnAsp: 1.828 ± 0.042	1.877AsnGlu: 1.877 ± 0.046	0.722AsnPhe: 0.722 ± 0.028	2.313AsnGly: 2.313 ± 0.058	0.503AsnHis: 0.503 ± 0.025	0.986AsnIle: 0.986 ± 0.033	0.438AsnLys: 0.438 ± 0.021	2.18AsnLeu: 2.18 ± 0.042	0.468AsnMet: 0.468 ± 0.019	0.626AsnAsn: 0.626 ± 0.032	1.689AsnPro: 1.689 ± 0.04	0.693AsnGln: 0.693 ± 0.033	1.841AsnArg: 1.841 ± 0.043	1.269AsnSer: 1.269 ± 0.036	1.411AsnThr: 1.411 ± 0.032	2.572AsnVal: 2.572 ± 0.059	0.33AsnTrp: 0.33 ± 0.019	0.787AsnTyr: 0.787 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.138ProAla: 4.138 ± 0.064	0.213ProCys: 0.213 ± 0.013	4.043ProAsp: 4.043 ± 0.068	4.557ProGlu: 4.557 ± 0.075	1.654ProPhe: 1.654 ± 0.04	3.512ProGly: 3.512 ± 0.066	0.881ProHis: 0.881 ± 0.032	1.683ProIle: 1.683 ± 0.042	1.043ProLys: 1.043 ± 0.03	3.835ProLeu: 3.835 ± 0.071	0.883ProMet: 0.883 ± 0.028	1.298ProAsn: 1.298 ± 0.036	2.02ProPro: 2.02 ± 0.04	1.143ProGln: 1.143 ± 0.037	2.23ProArg: 2.23 ± 0.045	2.717ProSer: 2.717 ± 0.05	3.372ProThr: 3.372 ± 0.062	4.021ProVal: 4.021 ± 0.066	0.528ProTrp: 0.528 ± 0.023	1.162ProTyr: 1.162 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.336GlnAla: 2.336 ± 0.047	0.141GlnCys: 0.141 ± 0.01	1.103GlnAsp: 1.103 ± 0.034	1.638GlnGlu: 1.638 ± 0.046	1.281GlnPhe: 1.281 ± 0.036	1.457GlnGly: 1.457 ± 0.038	0.533GlnHis: 0.533 ± 0.022	1.041GlnIle: 1.041 ± 0.032	0.691GlnLys: 0.691 ± 0.026	2.511GlnLeu: 2.511 ± 0.057	0.648GlnMet: 0.648 ± 0.026	0.88GlnAsn: 0.88 ± 0.035	1.079GlnPro: 1.079 ± 0.034	1.184GlnGln: 1.184 ± 0.041	2.07GlnArg: 2.07 ± 0.049	1.969GlnSer: 1.969 ± 0.046	1.86GlnThr: 1.86 ± 0.041	1.811GlnVal: 1.811 ± 0.04	0.419GlnTrp: 0.419 ± 0.021	0.943GlnTyr: 0.943 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.089ArgAla: 6.089 ± 0.084	0.45ArgCys: 0.45 ± 0.023	4.693ArgAsp: 4.693 ± 0.077	6.371ArgGlu: 6.371 ± 0.087	2.416ArgPhe: 2.416 ± 0.047	4.575ArgGly: 4.575 ± 0.066	1.248ArgHis: 1.248 ± 0.033	2.892ArgIle: 2.892 ± 0.053	1.511ArgLys: 1.511 ± 0.04	6.32ArgLeu: 6.32 ± 0.09	1.373ArgMet: 1.373 ± 0.037	1.808ArgAsn: 1.808 ± 0.042	2.649ArgPro: 2.649 ± 0.049	1.896ArgGln: 1.896 ± 0.049	5.272ArgArg: 5.272 ± 0.086	3.593ArgSer: 3.593 ± 0.055	4.11ArgThr: 4.11 ± 0.064	5.54ArgVal: 5.54 ± 0.076	0.781ArgTrp: 0.781 ± 0.03	1.985ArgTyr: 1.985 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.86SerAla: 5.86 ± 0.066	0.319SerCys: 0.319 ± 0.019	4.747SerAsp: 4.747 ± 0.072	4.886SerGlu: 4.886 ± 0.072	2.189SerPhe: 2.189 ± 0.049	5.85SerGly: 5.85 ± 0.072	1.085SerHis: 1.085 ± 0.034	2.343SerIle: 2.343 ± 0.046	1.359SerLys: 1.359 ± 0.038	5.825SerLeu: 5.825 ± 0.078	1.143SerMet: 1.143 ± 0.033	1.691SerAsn: 1.691 ± 0.044	2.786SerPro: 2.786 ± 0.059	1.568SerGln: 1.568 ± 0.041	3.478SerArg: 3.478 ± 0.052	3.638SerSer: 3.638 ± 0.076	3.928SerThr: 3.928 ± 0.07	5.715SerVal: 5.715 ± 0.083	0.662SerTrp: 0.662 ± 0.025	1.61SerTyr: 1.61 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.509ThrAla: 6.509 ± 0.086	0.328ThrCys: 0.328 ± 0.018	5.274ThrAsp: 5.274 ± 0.083	4.975ThrGlu: 4.975 ± 0.082	2.304ThrPhe: 2.304 ± 0.05	5.428ThrGly: 5.428 ± 0.07	1.222ThrHis: 1.222 ± 0.034	2.509ThrIle: 2.509 ± 0.054	1.242ThrLys: 1.242 ± 0.036	6.248ThrLeu: 6.248 ± 0.084	1.069ThrMet: 1.069 ± 0.031	1.693ThrAsn: 1.693 ± 0.039	3.484ThrPro: 3.484 ± 0.078	1.52ThrGln: 1.52 ± 0.045	3.527ThrArg: 3.527 ± 0.054	3.112ThrSer: 3.112 ± 0.055	4.511ThrThr: 4.511 ± 0.081	6.883ThrVal: 6.883 ± 0.09	0.685ThrTrp: 0.685 ± 0.024	1.75ThrTyr: 1.75 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.472ValAla: 10.472 ± 0.134	0.735ValCys: 0.735 ± 0.03	7.861ValAsp: 7.861 ± 0.097	7.751ValGlu: 7.751 ± 0.092	3.277ValPhe: 3.277 ± 0.057	8.583ValGly: 8.583 ± 0.108	1.735ValHis: 1.735 ± 0.04	2.719ValIle: 2.719 ± 0.062	1.5ValLys: 1.5 ± 0.036	8.13ValLeu: 8.13 ± 0.101	1.347ValMet: 1.347 ± 0.038	2.127ValAsn: 2.127 ± 0.046	4.086ValPro: 4.086 ± 0.064	1.909ValGln: 1.909 ± 0.047	5.554ValArg: 5.554 ± 0.087	5.986ValSer: 5.986 ± 0.08	6.034ValThr: 6.034 ± 0.084	10.635ValVal: 10.635 ± 0.127	0.834ValTrp: 0.834 ± 0.03	2.339ValTyr: 2.339 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.96TrpAla: 0.96 ± 0.031	0.089TrpCys: 0.089 ± 0.01	0.691TrpAsp: 0.691 ± 0.025	0.865TrpGlu: 0.865 ± 0.031	0.516TrpPhe: 0.516 ± 0.022	0.823TrpGly: 0.823 ± 0.029	0.235TrpHis: 0.235 ± 0.017	0.377TrpIle: 0.377 ± 0.019	0.289TrpLys: 0.289 ± 0.016	1.189TrpLeu: 1.189 ± 0.039	0.231TrpMet: 0.231 ± 0.014	0.43TrpAsn: 0.43 ± 0.018	0.477TrpPro: 0.477 ± 0.02	0.42TrpGln: 0.42 ± 0.019	0.895TrpArg: 0.895 ± 0.033	0.679TrpSer: 0.679 ± 0.026	0.808TrpThr: 0.808 ± 0.025	0.905TrpVal: 0.905 ± 0.029	0.209TrpTrp: 0.209 ± 0.014	0.382TrpTyr: 0.382 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.805TyrAla: 2.805 ± 0.047	0.203TyrCys: 0.203 ± 0.014	2.653TyrAsp: 2.653 ± 0.053	2.443TyrGlu: 2.443 ± 0.052	0.949TyrPhe: 0.949 ± 0.031	2.471TyrGly: 2.471 ± 0.046	0.686TyrHis: 0.686 ± 0.022	0.812TyrIle: 0.812 ± 0.03	0.455TyrLys: 0.455 ± 0.02	2.694TyrLeu: 2.694 ± 0.053	0.4TyrMet: 0.4 ± 0.023	0.667TyrAsn: 0.667 ± 0.027	1.286TyrPro: 1.286 ± 0.031	0.715TyrGln: 0.715 ± 0.029	2.034TyrArg: 2.034 ± 0.045	1.386TyrSer: 1.386 ± 0.036	1.522TyrThr: 1.522 ± 0.04	2.46TyrVal: 2.46 ± 0.051	0.343TyrTrp: 0.343 ± 0.016	0.875TyrTyr: 0.875 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3761 proteins (1074478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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