Amino acid dipepetide frequency for Halomonas chromatireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.236AlaAla: 12.236 ± 0.145	1.178AlaCys: 1.178 ± 0.038	5.893AlaAsp: 5.893 ± 0.078	7.745AlaGlu: 7.745 ± 0.102	4.062AlaPhe: 4.062 ± 0.069	9.329AlaGly: 9.329 ± 0.102	2.32AlaHis: 2.32 ± 0.045	5.527AlaIle: 5.527 ± 0.089	2.612AlaLys: 2.612 ± 0.053	13.724AlaLeu: 13.724 ± 0.146	3.538AlaMet: 3.538 ± 0.056	2.562AlaAsn: 2.562 ± 0.045	4.644AlaPro: 4.644 ± 0.08	3.709AlaGln: 3.709 ± 0.059	8.117AlaArg: 8.117 ± 0.103	6.362AlaSer: 6.362 ± 0.08	5.211AlaThr: 5.211 ± 0.068	7.495AlaVal: 7.495 ± 0.072	1.918AlaTrp: 1.918 ± 0.05	2.282AlaTyr: 2.282 ± 0.047	0.003AlaXaa: 0.003 ± 0.001
Cys	0.84CysAla: 0.84 ± 0.029	0.129CysCys: 0.129 ± 0.01	0.565CysAsp: 0.565 ± 0.023	0.525CysGlu: 0.525 ± 0.024	0.305CysPhe: 0.305 ± 0.017	0.886CysGly: 0.886 ± 0.029	0.366CysHis: 0.366 ± 0.019	0.375CysIle: 0.375 ± 0.02	0.194CysLys: 0.194 ± 0.014	1.077CysLeu: 1.077 ± 0.035	0.202CysMet: 0.202 ± 0.01	0.213CysAsn: 0.213 ± 0.014	0.525CysPro: 0.525 ± 0.022	0.376CysGln: 0.376 ± 0.018	0.794CysArg: 0.794 ± 0.026	0.471CysSer: 0.471 ± 0.023	0.391CysThr: 0.391 ± 0.018	0.655CysVal: 0.655 ± 0.023	0.134CysTrp: 0.134 ± 0.013	0.261CysTyr: 0.261 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.33AspAla: 6.33 ± 0.09	0.471AspCys: 0.471 ± 0.022	3.743AspAsp: 3.743 ± 0.068	4.41AspGlu: 4.41 ± 0.071	2.126AspPhe: 2.126 ± 0.051	4.664AspGly: 4.664 ± 0.076	1.394AspHis: 1.394 ± 0.041	2.933AspIle: 2.933 ± 0.057	1.434AspLys: 1.434 ± 0.042	5.603AspLeu: 5.603 ± 0.084	1.407AspMet: 1.407 ± 0.038	1.433AspAsn: 1.433 ± 0.038	3.117AspPro: 3.117 ± 0.055	1.935AspGln: 1.935 ± 0.046	3.82AspArg: 3.82 ± 0.071	2.828AspSer: 2.828 ± 0.054	2.871AspThr: 2.871 ± 0.053	3.835AspVal: 3.835 ± 0.059	0.961AspTrp: 0.961 ± 0.028	1.663AspTyr: 1.663 ± 0.038	0.002AspXaa: 0.002 ± 0.001
Glu	8.706GluAla: 8.706 ± 0.124	0.474GluCys: 0.474 ± 0.02	2.964GluAsp: 2.964 ± 0.055	4.665GluGlu: 4.665 ± 0.086	1.71GluPhe: 1.71 ± 0.036	5.134GluGly: 5.134 ± 0.067	1.784GluHis: 1.784 ± 0.04	3.118GluIle: 3.118 ± 0.054	1.861GluLys: 1.861 ± 0.048	7.508GluLeu: 7.508 ± 0.092	1.611GluMet: 1.611 ± 0.039	1.519GluAsn: 1.519 ± 0.032	3.087GluPro: 3.087 ± 0.067	3.306GluGln: 3.306 ± 0.065	6.313GluArg: 6.313 ± 0.091	3.436GluSer: 3.436 ± 0.059	3.337GluThr: 3.337 ± 0.054	4.816GluVal: 4.816 ± 0.077	0.957GluTrp: 0.957 ± 0.03	1.28GluTyr: 1.28 ± 0.04	0.003GluXaa: 0.003 ± 0.002
Phe	3.537PheAla: 3.537 ± 0.058	0.406PheCys: 0.406 ± 0.021	2.455PheAsp: 2.455 ± 0.041	2.198PheGlu: 2.198 ± 0.042	1.383PhePhe: 1.383 ± 0.037	3.179PheGly: 3.179 ± 0.054	0.908PheHis: 0.908 ± 0.03	1.729PheIle: 1.729 ± 0.044	0.891PheLys: 0.891 ± 0.027	3.308PheLeu: 3.308 ± 0.061	0.905PheMet: 0.905 ± 0.027	1.021PheAsn: 1.021 ± 0.03	1.517PhePro: 1.517 ± 0.033	1.17PheGln: 1.17 ± 0.034	2.073PheArg: 2.073 ± 0.047	2.189PheSer: 2.189 ± 0.05	1.947PheThr: 1.947 ± 0.042	2.38PheVal: 2.38 ± 0.051	0.493PheTrp: 0.493 ± 0.025	0.925PheTyr: 0.925 ± 0.03	0.004PheXaa: 0.004 ± 0.002
Gly	7.312GlyAla: 7.312 ± 0.098	0.951GlyCys: 0.951 ± 0.031	4.583GlyAsp: 4.583 ± 0.071	6.121GlyGlu: 6.121 ± 0.085	3.18GlyPhe: 3.18 ± 0.051	6.733GlyGly: 6.733 ± 0.099	2.2GlyHis: 2.2 ± 0.053	4.567GlyIle: 4.567 ± 0.069	2.67GlyLys: 2.67 ± 0.06	9.396GlyLeu: 9.396 ± 0.119	2.569GlyMet: 2.569 ± 0.054	2.103GlyAsn: 2.103 ± 0.047	2.883GlyPro: 2.883 ± 0.054	3.236GlyGln: 3.236 ± 0.061	5.882GlyArg: 5.882 ± 0.083	4.525GlySer: 4.525 ± 0.062	3.73GlyThr: 3.73 ± 0.054	6.256GlyVal: 6.256 ± 0.077	1.359GlyTrp: 1.359 ± 0.032	2.328GlyTyr: 2.328 ± 0.041	0.005GlyXaa: 0.005 ± 0.002
His	2.554HisAla: 2.554 ± 0.049	0.33HisCys: 0.33 ± 0.018	1.626HisAsp: 1.626 ± 0.043	1.496HisGlu: 1.496 ± 0.042	1.068HisPhe: 1.068 ± 0.029	2.349HisGly: 2.349 ± 0.053	0.82HisHis: 0.82 ± 0.031	0.964HisIle: 0.964 ± 0.031	0.528HisLys: 0.528 ± 0.022	2.724HisLeu: 2.724 ± 0.046	0.509HisMet: 0.509 ± 0.018	0.576HisAsn: 0.576 ± 0.024	1.573HisPro: 1.573 ± 0.038	0.968HisGln: 0.968 ± 0.027	1.931HisArg: 1.931 ± 0.049	1.157HisSer: 1.157 ± 0.031	0.98HisThr: 0.98 ± 0.032	1.51HisVal: 1.51 ± 0.039	0.436HisTrp: 0.436 ± 0.019	0.811HisTyr: 0.811 ± 0.028	0.005HisXaa: 0.005 ± 0.002
Ile	5.63IleAla: 5.63 ± 0.081	0.449IleCys: 0.449 ± 0.021	3.467IleAsp: 3.467 ± 0.054	3.665IleGlu: 3.665 ± 0.065	1.55IlePhe: 1.55 ± 0.046	4.341IleGly: 4.341 ± 0.072	1.141IleHis: 1.141 ± 0.031	2.043IleIle: 2.043 ± 0.057	1.307IleLys: 1.307 ± 0.041	4.229IleLeu: 4.229 ± 0.072	0.994IleMet: 0.994 ± 0.031	1.497IleAsn: 1.497 ± 0.037	2.282IlePro: 2.282 ± 0.055	1.513IleGln: 1.513 ± 0.035	3.094IleArg: 3.094 ± 0.056	2.632IleSer: 2.632 ± 0.052	2.578IleThr: 2.578 ± 0.046	3.341IleVal: 3.341 ± 0.06	0.475IleTrp: 0.475 ± 0.022	1.034IleTyr: 1.034 ± 0.032	0.004IleXaa: 0.004 ± 0.002
Lys	3.101LysAla: 3.101 ± 0.063	0.158LysCys: 0.158 ± 0.013	1.22LysAsp: 1.22 ± 0.035	1.503LysGlu: 1.503 ± 0.043	0.582LysPhe: 0.582 ± 0.023	2.147LysGly: 2.147 ± 0.047	0.569LysHis: 0.569 ± 0.021	1.113LysIle: 1.113 ± 0.033	0.928LysLys: 0.928 ± 0.04	2.692LysLeu: 2.692 ± 0.052	0.596LysMet: 0.596 ± 0.024	0.598LysAsn: 0.598 ± 0.024	1.514LysPro: 1.514 ± 0.046	1.155LysGln: 1.155 ± 0.035	2.33LysArg: 2.33 ± 0.052	1.432LysSer: 1.432 ± 0.036	1.313LysThr: 1.313 ± 0.042	2.048LysVal: 2.048 ± 0.047	0.279LysTrp: 0.279 ± 0.016	0.472LysTyr: 0.472 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.057LeuAla: 15.057 ± 0.155	1.095LeuCys: 1.095 ± 0.031	7.168LeuAsp: 7.168 ± 0.093	7.77LeuGlu: 7.77 ± 0.105	3.853LeuPhe: 3.853 ± 0.06	9.522LeuGly: 9.522 ± 0.116	2.461LeuHis: 2.461 ± 0.05	5.358LeuIle: 5.358 ± 0.077	3.177LeuLys: 3.177 ± 0.059	12.841LeuLeu: 12.841 ± 0.16	3.017LeuMet: 3.017 ± 0.059	2.752LeuAsn: 2.752 ± 0.051	6.254LeuPro: 6.254 ± 0.083	3.408LeuGln: 3.408 ± 0.059	7.255LeuArg: 7.255 ± 0.094	6.769LeuSer: 6.769 ± 0.09	5.95LeuThr: 5.95 ± 0.079	8.317LeuVal: 8.317 ± 0.097	1.468LeuTrp: 1.468 ± 0.044	2.416LeuTyr: 2.416 ± 0.043	0.006LeuXaa: 0.006 ± 0.002
Met	3.424MetAla: 3.424 ± 0.05	0.146MetCys: 0.146 ± 0.01	1.151MetAsp: 1.151 ± 0.034	1.369MetGlu: 1.369 ± 0.033	0.675MetPhe: 0.675 ± 0.028	2.042MetGly: 2.042 ± 0.048	0.527MetHis: 0.527 ± 0.021	1.288MetIle: 1.288 ± 0.035	0.847MetLys: 0.847 ± 0.026	2.974MetLeu: 2.974 ± 0.058	0.689MetMet: 0.689 ± 0.024	0.785MetAsn: 0.785 ± 0.027	1.561MetPro: 1.561 ± 0.038	1.002MetGln: 1.002 ± 0.032	1.702MetArg: 1.702 ± 0.032	1.789MetSer: 1.789 ± 0.04	1.783MetThr: 1.783 ± 0.043	1.882MetVal: 1.882 ± 0.04	0.194MetTrp: 0.194 ± 0.014	0.338MetTyr: 0.338 ± 0.017	0.002MetXaa: 0.002 ± 0.001
Asn	2.733AsnAla: 2.733 ± 0.055	0.222AsnCys: 0.222 ± 0.015	1.394AsnAsp: 1.394 ± 0.036	1.424AsnGlu: 1.424 ± 0.034	0.804AsnPhe: 0.804 ± 0.033	2.008AsnGly: 2.008 ± 0.042	0.62AsnHis: 0.62 ± 0.024	1.207AsnIle: 1.207 ± 0.036	0.578AsnLys: 0.578 ± 0.026	2.662AsnLeu: 2.662 ± 0.052	0.584AsnMet: 0.584 ± 0.025	0.629AsnAsn: 0.629 ± 0.027	1.608AsnPro: 1.608 ± 0.038	0.939AsnGln: 0.939 ± 0.03	1.934AsnArg: 1.934 ± 0.038	1.096AsnSer: 1.096 ± 0.032	1.194AsnThr: 1.194 ± 0.031	1.79AsnVal: 1.79 ± 0.043	0.361AsnTrp: 0.361 ± 0.015	0.639AsnTyr: 0.639 ± 0.024	0.002AsnXaa: 0.002 ± 0.001
Pro	5.233ProAla: 5.233 ± 0.074	0.373ProCys: 0.373 ± 0.019	3.365ProAsp: 3.365 ± 0.052	4.108ProGlu: 4.108 ± 0.061	1.808ProPhe: 1.808 ± 0.036	4.474ProGly: 4.474 ± 0.071	1.157ProHis: 1.157 ± 0.034	2.034ProIle: 2.034 ± 0.048	1.153ProLys: 1.153 ± 0.037	5.703ProLeu: 5.703 ± 0.073	1.325ProMet: 1.325 ± 0.035	1.153ProAsn: 1.153 ± 0.032	2.491ProPro: 2.491 ± 0.058	1.769ProGln: 1.769 ± 0.042	3.121ProArg: 3.121 ± 0.054	2.67ProSer: 2.67 ± 0.053	2.259ProThr: 2.259 ± 0.05	3.8ProVal: 3.8 ± 0.053	0.835ProTrp: 0.835 ± 0.03	1.06ProTyr: 1.06 ± 0.032	0.003ProXaa: 0.003 ± 0.001
Gln	5.153GlnAla: 5.153 ± 0.07	0.271GlnCys: 0.271 ± 0.015	1.698GlnAsp: 1.698 ± 0.044	2.237GlnGlu: 2.237 ± 0.054	0.991GlnPhe: 0.991 ± 0.025	3.198GlnGly: 3.198 ± 0.052	0.98GlnHis: 0.98 ± 0.029	1.43GlnIle: 1.43 ± 0.044	0.88GlnLys: 0.88 ± 0.03	4.284GlnLeu: 4.284 ± 0.08	0.834GlnMet: 0.834 ± 0.028	0.733GlnAsn: 0.733 ± 0.026	1.965GlnPro: 1.965 ± 0.043	2.084GlnGln: 2.084 ± 0.056	3.537GlnArg: 3.537 ± 0.06	1.753GlnSer: 1.753 ± 0.037	1.494GlnThr: 1.494 ± 0.037	2.982GlnVal: 2.982 ± 0.053	0.555GlnTrp: 0.555 ± 0.02	0.702GlnTyr: 0.702 ± 0.027	0.002GlnXaa: 0.002 ± 0.001
Arg	6.523ArgAla: 6.523 ± 0.078	0.653ArgCys: 0.653 ± 0.024	4.36ArgAsp: 4.36 ± 0.066	5.521ArgGlu: 5.521 ± 0.09	2.964ArgPhe: 2.964 ± 0.053	4.8ArgGly: 4.8 ± 0.068	2.474ArgHis: 2.474 ± 0.057	3.598ArgIle: 3.598 ± 0.058	1.8ArgLys: 1.8 ± 0.036	10.186ArgLeu: 10.186 ± 0.142	1.939ArgMet: 1.939 ± 0.037	1.697ArgAsn: 1.697 ± 0.04	3.269ArgPro: 3.269 ± 0.057	3.461ArgGln: 3.461 ± 0.071	6.088ArgArg: 6.088 ± 0.1	3.514ArgSer: 3.514 ± 0.06	2.971ArgThr: 2.971 ± 0.055	5.003ArgVal: 5.003 ± 0.075	1.155ArgTrp: 1.155 ± 0.036	2.156ArgTyr: 2.156 ± 0.047	0.002ArgXaa: 0.002 ± 0.001
Ser	5.375SerAla: 5.375 ± 0.064	0.458SerCys: 0.458 ± 0.019	3.053SerAsp: 3.053 ± 0.047	3.211SerGlu: 3.211 ± 0.06	1.865SerPhe: 1.865 ± 0.046	5.117SerGly: 5.117 ± 0.068	1.375SerHis: 1.375 ± 0.038	2.427SerIle: 2.427 ± 0.05	1.197SerLys: 1.197 ± 0.035	6.892SerLeu: 6.892 ± 0.084	1.443SerMet: 1.443 ± 0.037	1.238SerAsn: 1.238 ± 0.031	3.028SerPro: 3.028 ± 0.052	2.097SerGln: 2.097 ± 0.045	4.502SerArg: 4.502 ± 0.069	2.962SerSer: 2.962 ± 0.066	2.442SerThr: 2.442 ± 0.045	3.718SerVal: 3.718 ± 0.069	0.785SerTrp: 0.785 ± 0.027	1.141SerTyr: 1.141 ± 0.03	0.003SerXaa: 0.003 ± 0.001
Thr	5.012ThrAla: 5.012 ± 0.069	0.446ThrCys: 0.446 ± 0.019	2.399ThrAsp: 2.399 ± 0.049	2.618ThrGlu: 2.618 ± 0.05	1.813ThrPhe: 1.813 ± 0.044	4.306ThrGly: 4.306 ± 0.07	1.215ThrHis: 1.215 ± 0.03	2.142ThrIle: 2.142 ± 0.045	0.9ThrLys: 0.9 ± 0.029	7.042ThrLeu: 7.042 ± 0.084	1.092ThrMet: 1.092 ± 0.029	1.128ThrAsn: 1.128 ± 0.029	3.201ThrPro: 3.201 ± 0.055	1.633ThrGln: 1.633 ± 0.044	3.59ThrArg: 3.59 ± 0.059	2.506ThrSer: 2.506 ± 0.049	2.56ThrThr: 2.56 ± 0.058	3.451ThrVal: 3.451 ± 0.055	0.673ThrTrp: 0.673 ± 0.03	1.009ThrTyr: 1.009 ± 0.028	0.002ThrXaa: 0.002 ± 0.001
Val	8.248ValAla: 8.248 ± 0.091	0.631ValCys: 0.631 ± 0.021	4.065ValAsp: 4.065 ± 0.066	5.035ValGlu: 5.035 ± 0.071	2.474ValPhe: 2.474 ± 0.048	5.511ValGly: 5.511 ± 0.076	1.485ValHis: 1.485 ± 0.032	3.887ValIle: 3.887 ± 0.067	1.944ValLys: 1.944 ± 0.051	7.774ValLeu: 7.774 ± 0.102	2.096ValMet: 2.096 ± 0.044	1.926ValAsn: 1.926 ± 0.041	3.41ValPro: 3.41 ± 0.049	2.078ValGln: 2.078 ± 0.044	4.549ValArg: 4.549 ± 0.068	4.249ValSer: 4.249 ± 0.065	4.069ValThr: 4.069 ± 0.063	5.811ValVal: 5.811 ± 0.089	0.881ValTrp: 0.881 ± 0.029	1.434ValTyr: 1.434 ± 0.036	0.002ValXaa: 0.002 ± 0.001
Trp	1.201TrpAla: 1.201 ± 0.037	0.177TrpCys: 0.177 ± 0.012	0.571TrpAsp: 0.571 ± 0.021	0.744TrpGlu: 0.744 ± 0.031	0.504TrpPhe: 0.504 ± 0.023	0.907TrpGly: 0.907 ± 0.028	0.454TrpHis: 0.454 ± 0.021	0.65TrpIle: 0.65 ± 0.026	0.371TrpLys: 0.371 ± 0.019	2.445TrpLeu: 2.445 ± 0.058	0.386TrpMet: 0.386 ± 0.018	0.34TrpAsn: 0.34 ± 0.018	0.74TrpPro: 0.74 ± 0.03	0.94TrpGln: 0.94 ± 0.025	1.265TrpArg: 1.265 ± 0.04	0.739TrpSer: 0.739 ± 0.026	0.56TrpThr: 0.56 ± 0.021	1.005TrpVal: 1.005 ± 0.029	0.306TrpTrp: 0.306 ± 0.018	0.324TrpTyr: 0.324 ± 0.018	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.255TyrAla: 2.255 ± 0.046	0.261TyrCys: 0.261 ± 0.016	1.242TyrAsp: 1.242 ± 0.036	1.222TyrGlu: 1.222 ± 0.032	0.901TyrPhe: 0.901 ± 0.024	1.94TyrGly: 1.94 ± 0.046	0.664TyrHis: 0.664 ± 0.023	0.871TyrIle: 0.871 ± 0.028	0.475TyrLys: 0.475 ± 0.019	2.844TyrLeu: 2.844 ± 0.062	0.433TyrMet: 0.433 ± 0.02	0.523TyrAsn: 0.523 ± 0.023	1.221TyrPro: 1.221 ± 0.031	0.983TyrGln: 0.983 ± 0.028	2.229TyrArg: 2.229 ± 0.048	1.245TyrSer: 1.245 ± 0.038	1.096TyrThr: 1.096 ± 0.035	1.462TyrVal: 1.462 ± 0.032	0.405TyrTrp: 0.405 ± 0.018	0.658TyrTyr: 0.658 ± 0.026	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.006XaaAla: 0.006 ± 0.002	0.003XaaCys: 0.003 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.003XaaIle: 0.003 ± 0.002	0.003XaaLys: 0.003 ± 0.002	0.005XaaLeu: 0.005 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.003XaaPro: 0.003 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.008XaaArg: 0.008 ± 0.003	0.005XaaSer: 0.005 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3678 proteins (1174037 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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