Amino acid dipepetide frequency for Raineya orbicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.099AlaAla: 3.099 ± 0.075	0.818AlaCys: 0.818 ± 0.029	3.293AlaAsp: 3.293 ± 0.06	5.576AlaGlu: 5.576 ± 0.104	3.812AlaPhe: 3.812 ± 0.07	4.545AlaGly: 4.545 ± 0.082	1.14AlaHis: 1.14 ± 0.038	5.58AlaIle: 5.58 ± 0.097	5.067AlaLys: 5.067 ± 0.087	6.781AlaLeu: 6.781 ± 0.108	1.627AlaMet: 1.627 ± 0.043	3.487AlaAsn: 3.487 ± 0.077	2.079AlaPro: 2.079 ± 0.055	3.731AlaGln: 3.731 ± 0.062	2.596AlaArg: 2.596 ± 0.057	4.248AlaSer: 4.248 ± 0.071	3.828AlaThr: 3.828 ± 0.072	4.137AlaVal: 4.137 ± 0.069	0.83AlaTrp: 0.83 ± 0.034	2.905AlaTyr: 2.905 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.452CysAla: 0.452 ± 0.023	0.103CysCys: 0.103 ± 0.011	0.351CysAsp: 0.351 ± 0.02	0.587CysGlu: 0.587 ± 0.026	0.493CysPhe: 0.493 ± 0.022	0.609CysGly: 0.609 ± 0.025	0.174CysHis: 0.174 ± 0.016	0.643CysIle: 0.643 ± 0.027	0.682CysLys: 0.682 ± 0.027	0.809CysLeu: 0.809 ± 0.028	0.151CysMet: 0.151 ± 0.012	0.477CysAsn: 0.477 ± 0.026	0.41CysPro: 0.41 ± 0.033	0.327CysGln: 0.327 ± 0.018	0.285CysArg: 0.285 ± 0.017	0.563CysSer: 0.563 ± 0.024	0.453CysThr: 0.453 ± 0.024	0.554CysVal: 0.554 ± 0.022	0.086CysTrp: 0.086 ± 0.01	0.33CysTyr: 0.33 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.89AspAla: 2.89 ± 0.054	0.401AspCys: 0.401 ± 0.022	1.883AspAsp: 1.883 ± 0.047	3.588AspGlu: 3.588 ± 0.062	3.442AspPhe: 3.442 ± 0.058	2.447AspGly: 2.447 ± 0.065	0.472AspHis: 0.472 ± 0.023	3.607AspIle: 3.607 ± 0.062	3.759AspLys: 3.759 ± 0.069	4.746AspLeu: 4.746 ± 0.075	0.942AspMet: 0.942 ± 0.035	2.273AspAsn: 2.273 ± 0.061	1.182AspPro: 1.182 ± 0.044	0.804AspGln: 0.804 ± 0.029	1.478AspArg: 1.478 ± 0.035	2.395AspSer: 2.395 ± 0.056	2.439AspThr: 2.439 ± 0.052	2.719AspVal: 2.719 ± 0.055	0.608AspTrp: 0.608 ± 0.024	2.109AspTyr: 2.109 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.044GluAla: 5.044 ± 0.098	0.407GluCys: 0.407 ± 0.021	2.403GluAsp: 2.403 ± 0.06	4.604GluGlu: 4.604 ± 0.105	3.096GluPhe: 3.096 ± 0.052	3.689GluGly: 3.689 ± 0.067	1.162GluHis: 1.162 ± 0.041	6.535GluIle: 6.535 ± 0.091	8.562GluLys: 8.562 ± 0.142	6.209GluLeu: 6.209 ± 0.091	1.765GluMet: 1.765 ± 0.043	5.566GluAsn: 5.566 ± 0.1	1.976GluPro: 1.976 ± 0.049	3.35GluGln: 3.35 ± 0.07	3.037GluArg: 3.037 ± 0.06	2.956GluSer: 2.956 ± 0.057	3.435GluThr: 3.435 ± 0.064	4.399GluVal: 4.399 ± 0.073	0.864GluTrp: 0.864 ± 0.034	2.654GluTyr: 2.654 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	4.289PheAla: 4.289 ± 0.069	0.61PheCys: 0.61 ± 0.03	2.477PheAsp: 2.477 ± 0.054	3.907PheGlu: 3.907 ± 0.064	3.315PhePhe: 3.315 ± 0.077	3.388PheGly: 3.388 ± 0.07	0.9PheHis: 0.9 ± 0.03	3.577PheIle: 3.577 ± 0.067	2.803PheLys: 2.803 ± 0.054	6.126PheLeu: 6.126 ± 0.093	0.975PheMet: 0.975 ± 0.037	2.493PheAsn: 2.493 ± 0.06	1.99PhePro: 1.99 ± 0.049	2.316PheGln: 2.316 ± 0.053	2.394PheArg: 2.394 ± 0.05	3.87PheSer: 3.87 ± 0.078	2.96PheThr: 2.96 ± 0.077	3.607PheVal: 3.607 ± 0.076	0.985PheTrp: 0.985 ± 0.037	2.394PheTyr: 2.394 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	3.791GlyAla: 3.791 ± 0.079	0.511GlyCys: 0.511 ± 0.028	2.459GlyAsp: 2.459 ± 0.051	3.699GlyGlu: 3.699 ± 0.069	3.554GlyPhe: 3.554 ± 0.064	4.29GlyGly: 4.29 ± 0.123	0.937GlyHis: 0.937 ± 0.035	5.036GlyIle: 5.036 ± 0.087	5.601GlyLys: 5.601 ± 0.092	5.394GlyLeu: 5.394 ± 0.084	1.3GlyMet: 1.3 ± 0.042	3.274GlyAsn: 3.274 ± 0.084	0.766GlyPro: 0.766 ± 0.033	1.777GlyGln: 1.777 ± 0.05	2.178GlyArg: 2.178 ± 0.054	3.542GlySer: 3.542 ± 0.077	3.586GlyThr: 3.586 ± 0.101	4.135GlyVal: 4.135 ± 0.076	0.718GlyTrp: 0.718 ± 0.031	2.59GlyTyr: 2.59 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.769HisAla: 0.769 ± 0.03	0.207HisCys: 0.207 ± 0.013	0.494HisAsp: 0.494 ± 0.026	0.841HisGlu: 0.841 ± 0.026	1.315HisPhe: 1.315 ± 0.041	0.691HisGly: 0.691 ± 0.03	0.486HisHis: 0.486 ± 0.028	1.553HisIle: 1.553 ± 0.043	1.239HisLys: 1.239 ± 0.037	2.151HisLeu: 2.151 ± 0.05	0.144HisMet: 0.144 ± 0.013	0.869HisAsn: 0.869 ± 0.034	0.931HisPro: 0.931 ± 0.035	0.963HisGln: 0.963 ± 0.034	0.683HisArg: 0.683 ± 0.027	1.108HisSer: 1.108 ± 0.042	1.031HisThr: 1.031 ± 0.036	0.599HisVal: 0.599 ± 0.024	0.301HisTrp: 0.301 ± 0.02	0.893HisTyr: 0.893 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.445IleAla: 6.445 ± 0.097	0.8IleCys: 0.8 ± 0.032	3.821IleAsp: 3.821 ± 0.069	5.38IleGlu: 5.38 ± 0.097	4.48IlePhe: 4.48 ± 0.086	4.591IleGly: 4.591 ± 0.075	1.354IleHis: 1.354 ± 0.041	5.263IleIle: 5.263 ± 0.084	4.609IleLys: 4.609 ± 0.081	7.864IleLeu: 7.864 ± 0.104	1.178IleMet: 1.178 ± 0.042	3.576IleAsn: 3.576 ± 0.071	3.098IlePro: 3.098 ± 0.057	3.195IleGln: 3.195 ± 0.067	3.67IleArg: 3.67 ± 0.061	5.216IleSer: 5.216 ± 0.067	4.233IleThr: 4.233 ± 0.068	4.618IleVal: 4.618 ± 0.083	0.91IleTrp: 0.91 ± 0.03	2.874IleTyr: 2.874 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.353LysAla: 5.353 ± 0.093	0.376LysCys: 0.376 ± 0.021	3.856LysAsp: 3.856 ± 0.074	6.38LysGlu: 6.38 ± 0.132	3.164LysPhe: 3.164 ± 0.053	4.446LysGly: 4.446 ± 0.073	1.447LysHis: 1.447 ± 0.043	7.118LysIle: 7.118 ± 0.095	7.252LysLys: 7.252 ± 0.153	6.305LysLeu: 6.305 ± 0.09	2.05LysMet: 2.05 ± 0.049	5.644LysAsn: 5.644 ± 0.09	2.889LysPro: 2.889 ± 0.061	3.26LysGln: 3.26 ± 0.068	2.958LysArg: 2.958 ± 0.063	3.764LysSer: 3.764 ± 0.07	4.075LysThr: 4.075 ± 0.074	4.817LysVal: 4.817 ± 0.076	0.805LysTrp: 0.805 ± 0.033	3.068LysTyr: 3.068 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	7.492LeuAla: 7.492 ± 0.117	0.89LeuCys: 0.89 ± 0.036	4.239LeuAsp: 4.239 ± 0.067	6.822LeuGlu: 6.822 ± 0.098	4.84LeuPhe: 4.84 ± 0.086	5.997LeuGly: 5.997 ± 0.086	1.987LeuHis: 1.987 ± 0.048	6.519LeuIle: 6.519 ± 0.099	7.384LeuLys: 7.384 ± 0.103	10.211LeuLeu: 10.211 ± 0.132	2.03LeuMet: 2.03 ± 0.046	4.843LeuAsn: 4.843 ± 0.068	4.29LeuPro: 4.29 ± 0.065	6.479LeuGln: 6.479 ± 0.108	4.048LeuArg: 4.048 ± 0.063	6.048LeuSer: 6.048 ± 0.074	4.556LeuThr: 4.556 ± 0.085	5.369LeuVal: 5.369 ± 0.084	1.115LeuTrp: 1.115 ± 0.039	3.444LeuTyr: 3.444 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.447MetAla: 1.447 ± 0.04	0.135MetCys: 0.135 ± 0.012	0.764MetAsp: 0.764 ± 0.027	1.211MetGlu: 1.211 ± 0.037	0.858MetPhe: 0.858 ± 0.031	1.348MetGly: 1.348 ± 0.043	0.376MetHis: 0.376 ± 0.02	1.451MetIle: 1.451 ± 0.042	1.832MetLys: 1.832 ± 0.048	2.263MetLeu: 2.263 ± 0.046	0.507MetMet: 0.507 ± 0.025	1.053MetAsn: 1.053 ± 0.034	1.013MetPro: 1.013 ± 0.035	1.285MetGln: 1.285 ± 0.043	1.054MetArg: 1.054 ± 0.035	1.137MetSer: 1.137 ± 0.036	0.866MetThr: 0.866 ± 0.033	1.144MetVal: 1.144 ± 0.03	0.148MetTrp: 0.148 ± 0.014	0.676MetTyr: 0.676 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.931AsnAla: 3.931 ± 0.076	0.449AsnCys: 0.449 ± 0.021	2.319AsnAsp: 2.319 ± 0.069	3.726AsnGlu: 3.726 ± 0.072	3.632AsnPhe: 3.632 ± 0.063	3.169AsnGly: 3.169 ± 0.091	0.858AsnHis: 0.858 ± 0.037	4.31AsnIle: 4.31 ± 0.072	3.332AsnLys: 3.332 ± 0.068	6.223AsnLeu: 6.223 ± 0.092	0.865AsnMet: 0.865 ± 0.031	2.936AsnAsn: 2.936 ± 0.076	3.222AsnPro: 3.222 ± 0.07	2.422AsnGln: 2.422 ± 0.052	2.088AsnArg: 2.088 ± 0.049	2.963AsnSer: 2.963 ± 0.067	3.066AsnThr: 3.066 ± 0.065	3.099AsnVal: 3.099 ± 0.076	0.706AsnTrp: 0.706 ± 0.031	2.566AsnTyr: 2.566 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.643ProAla: 2.643 ± 0.061	0.293ProCys: 0.293 ± 0.018	2.077ProAsp: 2.077 ± 0.054	2.835ProGlu: 2.835 ± 0.063	2.068ProPhe: 2.068 ± 0.05	1.299ProGly: 1.299 ± 0.048	0.739ProHis: 0.739 ± 0.027	2.781ProIle: 2.781 ± 0.055	2.621ProLys: 2.621 ± 0.055	3.391ProLeu: 3.391 ± 0.06	0.66ProMet: 0.66 ± 0.025	2.492ProAsn: 2.492 ± 0.065	1.165ProPro: 1.165 ± 0.045	1.907ProGln: 1.907 ± 0.048	1.237ProArg: 1.237 ± 0.039	1.889ProSer: 1.889 ± 0.048	2.354ProThr: 2.354 ± 0.054	2.076ProVal: 2.076 ± 0.056	0.29ProTrp: 0.29 ± 0.018	1.622ProTyr: 1.622 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.225GlnAla: 3.225 ± 0.062	0.236GlnCys: 0.236 ± 0.02	2.001GlnAsp: 2.001 ± 0.048	4.326GlnGlu: 4.326 ± 0.081	1.69GlnPhe: 1.69 ± 0.045	2.435GlnGly: 2.435 ± 0.061	0.598GlnHis: 0.598 ± 0.026	4.102GlnIle: 4.102 ± 0.081	5.585GlnLys: 5.585 ± 0.094	3.174GlnLeu: 3.174 ± 0.067	1.182GlnMet: 1.182 ± 0.037	3.573GlnAsn: 3.573 ± 0.077	1.254GlnPro: 1.254 ± 0.037	1.715GlnGln: 1.715 ± 0.049	1.782GlnArg: 1.782 ± 0.041	2.246GlnSer: 2.246 ± 0.053	2.549GlnThr: 2.549 ± 0.05	2.627GlnVal: 2.627 ± 0.062	0.482GlnTrp: 0.482 ± 0.026	1.399GlnTyr: 1.399 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.211ArgAla: 2.211 ± 0.052	0.261ArgCys: 0.261 ± 0.019	1.595ArgAsp: 1.595 ± 0.045	2.883ArgGlu: 2.883 ± 0.067	2.357ArgPhe: 2.357 ± 0.051	1.973ArgGly: 1.973 ± 0.047	0.635ArgHis: 0.635 ± 0.025	3.259ArgIle: 3.259 ± 0.061	3.948ArgLys: 3.948 ± 0.076	3.992ArgLeu: 3.992 ± 0.063	1.034ArgMet: 1.034 ± 0.035	2.538ArgAsn: 2.538 ± 0.055	1.236ArgPro: 1.236 ± 0.042	1.709ArgGln: 1.709 ± 0.043	1.733ArgArg: 1.733 ± 0.042	1.841ArgSer: 1.841 ± 0.049	1.91ArgThr: 1.91 ± 0.048	2.278ArgVal: 2.278 ± 0.051	0.472ArgTrp: 0.472 ± 0.024	1.817ArgTyr: 1.817 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.815SerAla: 3.815 ± 0.076	0.522SerCys: 0.522 ± 0.027	2.441SerAsp: 2.441 ± 0.052	3.882SerGlu: 3.882 ± 0.072	3.547SerPhe: 3.547 ± 0.061	3.547SerGly: 3.547 ± 0.085	0.942SerHis: 0.942 ± 0.029	4.019SerIle: 4.019 ± 0.067	4.037SerLys: 4.037 ± 0.069	5.852SerLeu: 5.852 ± 0.097	1.083SerMet: 1.083 ± 0.033	2.838SerAsn: 2.838 ± 0.068	2.382SerPro: 2.382 ± 0.055	2.736SerGln: 2.736 ± 0.06	1.986SerArg: 1.986 ± 0.047	3.092SerSer: 3.092 ± 0.078	2.84SerThr: 2.84 ± 0.065	3.761SerVal: 3.761 ± 0.073	0.724SerTrp: 0.724 ± 0.035	2.501SerTyr: 2.501 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.952ThrAla: 3.952 ± 0.085	0.453ThrCys: 0.453 ± 0.024	2.653ThrAsp: 2.653 ± 0.057	3.598ThrGlu: 3.598 ± 0.059	3.128ThrPhe: 3.128 ± 0.068	3.526ThrGly: 3.526 ± 0.077	1.076ThrHis: 1.076 ± 0.037	4.206ThrIle: 4.206 ± 0.086	3.03ThrLys: 3.03 ± 0.061	5.675ThrLeu: 5.675 ± 0.084	0.949ThrMet: 0.949 ± 0.029	2.684ThrAsn: 2.684 ± 0.071	2.568ThrPro: 2.568 ± 0.075	2.499ThrGln: 2.499 ± 0.064	1.72ThrArg: 1.72 ± 0.041	2.957ThrSer: 2.957 ± 0.064	3.031ThrThr: 3.031 ± 0.085	1.877ThrVal: 1.877 ± 0.064	0.66ThrTrp: 0.66 ± 0.028	2.249ThrTyr: 2.249 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	4.656ValAla: 4.656 ± 0.083	0.612ValCys: 0.612 ± 0.028	2.536ValAsp: 2.536 ± 0.053	4.076ValGlu: 4.076 ± 0.07	3.458ValPhe: 3.458 ± 0.066	3.995ValGly: 3.995 ± 0.08	0.804ValHis: 0.804 ± 0.03	4.269ValIle: 4.269 ± 0.073	4.121ValLys: 4.121 ± 0.07	5.933ValLeu: 5.933 ± 0.082	1.368ValMet: 1.368 ± 0.039	2.456ValAsn: 2.456 ± 0.057	2.276ValPro: 2.276 ± 0.052	2.348ValGln: 2.348 ± 0.048	2.487ValArg: 2.487 ± 0.054	3.997ValSer: 3.997 ± 0.072	2.683ValThr: 2.683 ± 0.086	4.194ValVal: 4.194 ± 0.081	0.799ValTrp: 0.799 ± 0.029	2.087ValTyr: 2.087 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.864TrpAla: 0.864 ± 0.035	0.103TrpCys: 0.103 ± 0.012	0.539TrpAsp: 0.539 ± 0.023	0.788TrpGlu: 0.788 ± 0.031	0.563TrpPhe: 0.563 ± 0.027	0.881TrpGly: 0.881 ± 0.035	0.278TrpHis: 0.278 ± 0.018	0.96TrpIle: 0.96 ± 0.034	0.864TrpLys: 0.864 ± 0.037	1.401TrpLeu: 1.401 ± 0.046	0.162TrpMet: 0.162 ± 0.014	0.678TrpAsn: 0.678 ± 0.036	0.073TrpPro: 0.073 ± 0.009	1.03TrpGln: 1.03 ± 0.039	0.524TrpArg: 0.524 ± 0.027	0.552TrpSer: 0.552 ± 0.023	0.461TrpThr: 0.461 ± 0.026	0.903TrpVal: 0.903 ± 0.03	0.18TrpTrp: 0.18 ± 0.017	0.482TrpTyr: 0.482 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.81TyrAla: 2.81 ± 0.056	0.351TyrCys: 0.351 ± 0.019	1.985TyrAsp: 1.985 ± 0.054	3.004TyrGlu: 3.004 ± 0.065	2.564TyrPhe: 2.564 ± 0.053	2.271TyrGly: 2.271 ± 0.054	0.902TyrHis: 0.902 ± 0.035	2.387TyrIle: 2.387 ± 0.053	2.699TyrLys: 2.699 ± 0.056	4.104TyrLeu: 4.104 ± 0.071	0.598TyrMet: 0.598 ± 0.028	2.131TyrAsn: 2.131 ± 0.055	1.64TyrPro: 1.64 ± 0.043	2.328TyrGln: 2.328 ± 0.063	1.743TyrArg: 1.743 ± 0.049	2.165TyrSer: 2.165 ± 0.051	2.136TyrThr: 2.136 ± 0.064	2.241TyrVal: 2.241 ± 0.05	0.602TyrTrp: 0.602 ± 0.03	1.912TyrTyr: 1.912 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2684 proteins (933702 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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