Amino acid dipepetide frequency for Corynebacterium maris DSM 45190

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.445AlaAla: 17.445 ± 0.216	0.781AlaCys: 0.781 ± 0.033	8.342AlaAsp: 8.342 ± 0.114	9.108AlaGlu: 9.108 ± 0.136	3.37AlaPhe: 3.37 ± 0.065	11.487AlaGly: 11.487 ± 0.136	2.542AlaHis: 2.542 ± 0.059	4.764AlaIle: 4.764 ± 0.079	2.906AlaLys: 2.906 ± 0.067	11.805AlaLeu: 11.805 ± 0.159	2.655AlaMet: 2.655 ± 0.063	2.452AlaAsn: 2.452 ± 0.055	5.737AlaPro: 5.737 ± 0.107	4.235AlaGln: 4.235 ± 0.072	7.696AlaArg: 7.696 ± 0.105	5.667AlaSer: 5.667 ± 0.086	7.065AlaThr: 7.065 ± 0.102	10.994AlaVal: 10.994 ± 0.135	1.764AlaTrp: 1.764 ± 0.053	2.283AlaTyr: 2.283 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.679CysAla: 0.679 ± 0.029	0.03CysCys: 0.03 ± 0.006	0.361CysAsp: 0.361 ± 0.022	0.336CysGlu: 0.336 ± 0.02	0.198CysPhe: 0.198 ± 0.014	0.618CysGly: 0.618 ± 0.033	0.136CysHis: 0.136 ± 0.013	0.217CysIle: 0.217 ± 0.016	0.091CysLys: 0.091 ± 0.012	0.471CysLeu: 0.471 ± 0.024	0.089CysMet: 0.089 ± 0.011	0.118CysAsn: 0.118 ± 0.012	0.382CysPro: 0.382 ± 0.024	0.148CysGln: 0.148 ± 0.012	0.366CysArg: 0.366 ± 0.023	0.368CysSer: 0.368 ± 0.02	0.391CysThr: 0.391 ± 0.021	0.491CysVal: 0.491 ± 0.024	0.074CysTrp: 0.074 ± 0.01	0.115CysTyr: 0.115 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.204AspAla: 8.204 ± 0.124	0.337AspCys: 0.337 ± 0.019	4.73AspAsp: 4.73 ± 0.1	4.848AspGlu: 4.848 ± 0.081	2.121AspPhe: 2.121 ± 0.05	5.963AspGly: 5.963 ± 0.093	1.466AspHis: 1.466 ± 0.041	2.407AspIle: 2.407 ± 0.049	1.78AspLys: 1.78 ± 0.044	6.168AspLeu: 6.168 ± 0.084	1.243AspMet: 1.243 ± 0.037	1.687AspAsn: 1.687 ± 0.044	4.225AspPro: 4.225 ± 0.071	1.826AspGln: 1.826 ± 0.046	3.993AspArg: 3.993 ± 0.078	3.082AspSer: 3.082 ± 0.055	3.357AspThr: 3.357 ± 0.063	6.165AspVal: 6.165 ± 0.086	0.999AspTrp: 0.999 ± 0.038	1.692AspTyr: 1.692 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.221GluAla: 7.221 ± 0.109	0.28GluCys: 0.28 ± 0.017	4.247GluAsp: 4.247 ± 0.084	4.826GluGlu: 4.826 ± 0.092	2.097GluPhe: 2.097 ± 0.056	4.421GluGly: 4.421 ± 0.084	1.737GluHis: 1.737 ± 0.049	3.321GluIle: 3.321 ± 0.063	2.12GluLys: 2.12 ± 0.063	7.102GluLeu: 7.102 ± 0.11	1.35GluMet: 1.35 ± 0.037	1.641GluAsn: 1.641 ± 0.048	2.969GluPro: 2.969 ± 0.077	2.745GluGln: 2.745 ± 0.069	4.621GluArg: 4.621 ± 0.082	3.069GluSer: 3.069 ± 0.062	3.514GluThr: 3.514 ± 0.071	5.167GluVal: 5.167 ± 0.083	0.861GluTrp: 0.861 ± 0.036	1.362GluTyr: 1.362 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.66PheAla: 3.66 ± 0.077	0.193PheCys: 0.193 ± 0.015	2.39PheAsp: 2.39 ± 0.065	1.677PheGlu: 1.677 ± 0.045	1.217PhePhe: 1.217 ± 0.047	3.27PheGly: 3.27 ± 0.074	0.753PheHis: 0.753 ± 0.033	1.434PheIle: 1.434 ± 0.053	0.534PheLys: 0.534 ± 0.028	2.973PheLeu: 2.973 ± 0.065	0.572PheMet: 0.572 ± 0.026	0.846PheAsn: 0.846 ± 0.032	1.456PhePro: 1.456 ± 0.042	0.812PheGln: 0.812 ± 0.035	1.708PheArg: 1.708 ± 0.054	1.918PheSer: 1.918 ± 0.044	2.3PheThr: 2.3 ± 0.053	2.471PheVal: 2.471 ± 0.058	0.47PheTrp: 0.47 ± 0.022	0.793PheTyr: 0.793 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.635GlyAla: 9.635 ± 0.121	0.587GlyCys: 0.587 ± 0.032	4.95GlyAsp: 4.95 ± 0.079	5.707GlyGlu: 5.707 ± 0.085	2.924GlyPhe: 2.924 ± 0.055	7.277GlyGly: 7.277 ± 0.114	2.049GlyHis: 2.049 ± 0.048	3.542GlyIle: 3.542 ± 0.071	2.536GlyLys: 2.536 ± 0.063	8.547GlyLeu: 8.547 ± 0.12	2.267GlyMet: 2.267 ± 0.059	2.0GlyAsn: 2.0 ± 0.052	3.623GlyPro: 3.623 ± 0.066	2.972GlyGln: 2.972 ± 0.064	5.599GlyArg: 5.599 ± 0.078	4.756GlySer: 4.756 ± 0.081	4.963GlyThr: 4.963 ± 0.08	8.345GlyVal: 8.345 ± 0.101	1.549GlyTrp: 1.549 ± 0.045	2.213GlyTyr: 2.213 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.326HisAla: 2.326 ± 0.054	0.157HisCys: 0.157 ± 0.014	1.516HisAsp: 1.516 ± 0.042	1.332HisGlu: 1.332 ± 0.045	0.671HisPhe: 0.671 ± 0.027	2.041HisGly: 2.041 ± 0.05	0.612HisHis: 0.612 ± 0.029	0.877HisIle: 0.877 ± 0.036	0.422HisLys: 0.422 ± 0.02	2.193HisLeu: 2.193 ± 0.048	0.39HisMet: 0.39 ± 0.023	0.561HisAsn: 0.561 ± 0.026	1.568HisPro: 1.568 ± 0.048	0.637HisGln: 0.637 ± 0.027	1.74HisArg: 1.74 ± 0.058	1.112HisSer: 1.112 ± 0.037	1.291HisThr: 1.291 ± 0.042	1.7HisVal: 1.7 ± 0.052	0.289HisTrp: 0.289 ± 0.018	0.553HisTyr: 0.553 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.831IleAla: 5.831 ± 0.099	0.31IleCys: 0.31 ± 0.021	3.6IleAsp: 3.6 ± 0.064	2.59IleGlu: 2.59 ± 0.053	1.417IlePhe: 1.417 ± 0.054	4.144IleGly: 4.144 ± 0.074	0.909IleHis: 0.909 ± 0.035	2.115IleIle: 2.115 ± 0.055	1.034IleLys: 1.034 ± 0.038	3.738IleLeu: 3.738 ± 0.077	0.853IleMet: 0.853 ± 0.038	1.243IleAsn: 1.243 ± 0.041	2.248IlePro: 2.248 ± 0.053	1.083IleGln: 1.083 ± 0.036	2.447IleArg: 2.447 ± 0.053	2.375IleSer: 2.375 ± 0.054	2.917IleThr: 2.917 ± 0.054	3.972IleVal: 3.972 ± 0.075	0.473IleTrp: 0.473 ± 0.025	0.945IleTyr: 0.945 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.84LysAla: 2.84 ± 0.07	0.096LysCys: 0.096 ± 0.01	1.561LysAsp: 1.561 ± 0.051	1.446LysGlu: 1.446 ± 0.046	0.757LysPhe: 0.757 ± 0.03	1.67LysGly: 1.67 ± 0.046	0.57LysHis: 0.57 ± 0.025	1.407LysIle: 1.407 ± 0.048	1.323LysLys: 1.323 ± 0.056	2.411LysLeu: 2.411 ± 0.057	0.701LysMet: 0.701 ± 0.031	0.831LysAsn: 0.831 ± 0.032	1.225LysPro: 1.225 ± 0.058	0.9LysGln: 0.9 ± 0.037	1.767LysArg: 1.767 ± 0.054	1.255LysSer: 1.255 ± 0.045	1.554LysThr: 1.554 ± 0.045	2.022LysVal: 2.022 ± 0.053	0.367LysTrp: 0.367 ± 0.019	0.589LysTyr: 0.589 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.992LeuAla: 12.992 ± 0.149	0.534LeuCys: 0.534 ± 0.025	6.505LeuAsp: 6.505 ± 0.099	5.254LeuGlu: 5.254 ± 0.092	2.745LeuPhe: 2.745 ± 0.06	8.682LeuGly: 8.682 ± 0.115	2.016LeuHis: 2.016 ± 0.053	4.932LeuIle: 4.932 ± 0.087	2.138LeuLys: 2.138 ± 0.058	9.632LeuLeu: 9.632 ± 0.15	1.885LeuMet: 1.885 ± 0.043	2.432LeuAsn: 2.432 ± 0.058	5.341LeuPro: 5.341 ± 0.086	2.69LeuGln: 2.69 ± 0.055	6.678LeuArg: 6.678 ± 0.099	5.81LeuSer: 5.81 ± 0.087	6.576LeuThr: 6.576 ± 0.104	8.079LeuVal: 8.079 ± 0.12	1.202LeuTrp: 1.202 ± 0.04	1.74LeuTyr: 1.74 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.765MetAla: 2.765 ± 0.054	0.118MetCys: 0.118 ± 0.013	1.205MetAsp: 1.205 ± 0.033	0.993MetGlu: 0.993 ± 0.035	0.725MetPhe: 0.725 ± 0.03	1.602MetGly: 1.602 ± 0.048	0.403MetHis: 0.403 ± 0.024	1.141MetIle: 1.141 ± 0.039	0.606MetLys: 0.606 ± 0.024	2.097MetLeu: 2.097 ± 0.048	0.458MetMet: 0.458 ± 0.023	0.651MetAsn: 0.651 ± 0.029	1.117MetPro: 1.117 ± 0.032	0.605MetGln: 0.605 ± 0.028	1.274MetArg: 1.274 ± 0.042	1.696MetSer: 1.696 ± 0.043	1.939MetThr: 1.939 ± 0.053	1.557MetVal: 1.557 ± 0.046	0.26MetTrp: 0.26 ± 0.019	0.401MetTyr: 0.401 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.639AsnAla: 2.639 ± 0.056	0.136AsnCys: 0.136 ± 0.012	1.552AsnAsp: 1.552 ± 0.043	1.398AsnGlu: 1.398 ± 0.047	0.792AsnPhe: 0.792 ± 0.031	1.784AsnGly: 1.784 ± 0.052	0.571AsnHis: 0.571 ± 0.026	1.142AsnIle: 1.142 ± 0.038	0.66AsnLys: 0.66 ± 0.028	2.44AsnLeu: 2.44 ± 0.049	0.561AsnMet: 0.561 ± 0.028	0.673AsnAsn: 0.673 ± 0.03	1.87AsnPro: 1.87 ± 0.052	0.835AsnGln: 0.835 ± 0.036	1.563AsnArg: 1.563 ± 0.044	1.272AsnSer: 1.272 ± 0.039	1.476AsnThr: 1.476 ± 0.042	1.97AsnVal: 1.97 ± 0.053	0.37AsnTrp: 0.37 ± 0.021	0.714AsnTyr: 0.714 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.081ProAla: 7.081 ± 0.122	0.204ProCys: 0.204 ± 0.015	3.687ProAsp: 3.687 ± 0.067	4.528ProGlu: 4.528 ± 0.092	1.515ProPhe: 1.515 ± 0.04	4.89ProGly: 4.89 ± 0.087	1.088ProHis: 1.088 ± 0.032	1.778ProIle: 1.778 ± 0.043	1.344ProLys: 1.344 ± 0.051	4.385ProLeu: 4.385 ± 0.076	1.038ProMet: 1.038 ± 0.036	1.281ProAsn: 1.281 ± 0.04	2.044ProPro: 2.044 ± 0.064	1.756ProGln: 1.756 ± 0.054	2.81ProArg: 2.81 ± 0.061	2.529ProSer: 2.529 ± 0.056	3.304ProThr: 3.304 ± 0.061	4.775ProVal: 4.775 ± 0.081	0.757ProTrp: 0.757 ± 0.028	1.094ProTyr: 1.094 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.844GlnAla: 3.844 ± 0.069	0.115GlnCys: 0.115 ± 0.012	1.684GlnAsp: 1.684 ± 0.053	2.073GlnGlu: 2.073 ± 0.054	0.93GlnPhe: 0.93 ± 0.033	2.158GlnGly: 2.158 ± 0.06	0.611GlnHis: 0.611 ± 0.031	1.692GlnIle: 1.692 ± 0.046	0.803GlnLys: 0.803 ± 0.033	3.598GlnLeu: 3.598 ± 0.066	0.804GlnMet: 0.804 ± 0.03	0.776GlnAsn: 0.776 ± 0.033	1.624GlnPro: 1.624 ± 0.049	1.266GlnGln: 1.266 ± 0.043	2.511GlnArg: 2.511 ± 0.056	1.521GlnSer: 1.521 ± 0.046	1.61GlnThr: 1.61 ± 0.041	2.668GlnVal: 2.668 ± 0.052	0.551GlnTrp: 0.551 ± 0.028	0.662GlnTyr: 0.662 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.168ArgAla: 7.168 ± 0.107	0.328ArgCys: 0.328 ± 0.021	4.131ArgAsp: 4.131 ± 0.07	4.367ArgGlu: 4.367 ± 0.085	2.059ArgPhe: 2.059 ± 0.052	4.951ArgGly: 4.951 ± 0.094	1.578ArgHis: 1.578 ± 0.043	3.153ArgIle: 3.153 ± 0.075	1.828ArgLys: 1.828 ± 0.053	6.416ArgLeu: 6.416 ± 0.105	1.693ArgMet: 1.693 ± 0.049	1.527ArgAsn: 1.527 ± 0.044	3.405ArgPro: 3.405 ± 0.065	2.263ArgGln: 2.263 ± 0.047	5.755ArgArg: 5.755 ± 0.11	3.402ArgSer: 3.402 ± 0.06	3.928ArgThr: 3.928 ± 0.076	4.945ArgVal: 4.945 ± 0.084	1.009ArgTrp: 1.009 ± 0.04	1.532ArgTyr: 1.532 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.236SerAla: 6.236 ± 0.085	0.306SerCys: 0.306 ± 0.02	2.993SerAsp: 2.993 ± 0.06	2.991SerGlu: 2.991 ± 0.064	1.924SerPhe: 1.924 ± 0.046	5.182SerGly: 5.182 ± 0.08	1.137SerHis: 1.137 ± 0.037	2.169SerIle: 2.169 ± 0.051	1.258SerLys: 1.258 ± 0.039	5.225SerLeu: 5.225 ± 0.074	1.302SerMet: 1.302 ± 0.038	1.163SerAsn: 1.163 ± 0.036	3.028SerPro: 3.028 ± 0.06	1.707SerGln: 1.707 ± 0.049	3.443SerArg: 3.443 ± 0.059	3.274SerSer: 3.274 ± 0.083	3.473SerThr: 3.473 ± 0.071	4.515SerVal: 4.515 ± 0.07	0.869SerTrp: 0.869 ± 0.036	1.291SerTyr: 1.291 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	7.489ThrAla: 7.489 ± 0.1	0.352ThrCys: 0.352 ± 0.021	4.044ThrAsp: 4.044 ± 0.075	3.713ThrGlu: 3.713 ± 0.071	1.89ThrPhe: 1.89 ± 0.054	5.823ThrGly: 5.823 ± 0.078	1.28ThrHis: 1.28 ± 0.035	2.361ThrIle: 2.361 ± 0.051	1.359ThrLys: 1.359 ± 0.041	5.821ThrLeu: 5.821 ± 0.09	1.268ThrMet: 1.268 ± 0.037	1.32ThrAsn: 1.32 ± 0.039	3.915ThrPro: 3.915 ± 0.074	1.746ThrGln: 1.746 ± 0.051	3.586ThrArg: 3.586 ± 0.069	3.305ThrSer: 3.305 ± 0.064	4.151ThrThr: 4.151 ± 0.089	6.2ThrVal: 6.2 ± 0.099	0.893ThrTrp: 0.893 ± 0.037	1.326ThrTyr: 1.326 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	10.951ValAla: 10.951 ± 0.123	0.557ValCys: 0.557 ± 0.03	6.552ValAsp: 6.552 ± 0.11	5.368ValGlu: 5.368 ± 0.082	2.719ValPhe: 2.719 ± 0.072	6.961ValGly: 6.961 ± 0.11	1.777ValHis: 1.777 ± 0.042	4.407ValIle: 4.407 ± 0.08	1.825ValLys: 1.825 ± 0.053	8.632ValLeu: 8.632 ± 0.138	1.808ValMet: 1.808 ± 0.048	2.217ValAsn: 2.217 ± 0.057	4.171ValPro: 4.171 ± 0.072	2.038ValGln: 2.038 ± 0.054	5.131ValArg: 5.131 ± 0.079	4.879ValSer: 4.879 ± 0.073	6.061ValThr: 6.061 ± 0.079	7.996ValVal: 7.996 ± 0.107	1.115ValTrp: 1.115 ± 0.036	1.669ValTyr: 1.669 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.674TrpAla: 1.674 ± 0.042	0.108TrpCys: 0.108 ± 0.012	0.768TrpAsp: 0.768 ± 0.033	0.77TrpGlu: 0.77 ± 0.033	0.569TrpPhe: 0.569 ± 0.027	0.987TrpGly: 0.987 ± 0.037	0.312TrpHis: 0.312 ± 0.019	0.662TrpIle: 0.662 ± 0.029	0.347TrpLys: 0.347 ± 0.02	1.784TrpLeu: 1.784 ± 0.052	0.341TrpMet: 0.341 ± 0.021	0.425TrpAsn: 0.425 ± 0.022	0.721TrpPro: 0.721 ± 0.028	0.523TrpGln: 0.523 ± 0.024	1.131TrpArg: 1.131 ± 0.04	0.87TrpSer: 0.87 ± 0.031	0.764TrpThr: 0.764 ± 0.043	1.154TrpVal: 1.154 ± 0.038	0.368TrpTrp: 0.368 ± 0.02	0.295TrpTyr: 0.295 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.42TyrAla: 2.42 ± 0.064	0.152TyrCys: 0.152 ± 0.013	1.474TyrAsp: 1.474 ± 0.041	1.347TyrGlu: 1.347 ± 0.046	0.812TyrPhe: 0.812 ± 0.034	2.129TyrGly: 2.129 ± 0.053	0.441TyrHis: 0.441 ± 0.024	0.726TyrIle: 0.726 ± 0.03	0.377TyrLys: 0.377 ± 0.024	2.421TyrLeu: 2.421 ± 0.056	0.335TyrMet: 0.335 ± 0.02	0.573TyrAsn: 0.573 ± 0.025	1.218TyrPro: 1.218 ± 0.044	0.715TyrGln: 0.715 ± 0.033	1.617TyrArg: 1.617 ± 0.046	1.323TyrSer: 1.323 ± 0.039	1.208TyrThr: 1.208 ± 0.037	1.645TyrVal: 1.645 ± 0.04	0.334TyrTrp: 0.334 ± 0.019	0.528TyrTyr: 0.528 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2584 proteins (833534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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