Amino acid dipepetide frequency for Pseudorhodobacter sp. MZDSW-24AT

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.201AlaAla: 20.201 ± 0.203	1.253AlaCys: 1.253 ± 0.038	7.03AlaAsp: 7.03 ± 0.085	8.93AlaGlu: 8.93 ± 0.11	4.583AlaPhe: 4.583 ± 0.076	11.417AlaGly: 11.417 ± 0.101	2.674AlaHis: 2.674 ± 0.053	5.755AlaIle: 5.755 ± 0.075	3.722AlaLys: 3.722 ± 0.069	16.167AlaLeu: 16.167 ± 0.169	4.002AlaMet: 4.002 ± 0.058	2.536AlaAsn: 2.536 ± 0.043	6.843AlaPro: 6.843 ± 0.098	5.428AlaGln: 5.428 ± 0.07	10.471AlaArg: 10.471 ± 0.118	5.7AlaSer: 5.7 ± 0.069	6.272AlaThr: 6.272 ± 0.069	9.423AlaVal: 9.423 ± 0.099	1.6AlaTrp: 1.6 ± 0.039	2.583AlaTyr: 2.583 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.135CysAla: 1.135 ± 0.036	0.103CysCys: 0.103 ± 0.01	0.564CysAsp: 0.564 ± 0.022	0.402CysGlu: 0.402 ± 0.021	0.328CysPhe: 0.328 ± 0.017	0.944CysGly: 0.944 ± 0.029	0.252CysHis: 0.252 ± 0.015	0.396CysIle: 0.396 ± 0.021	0.158CysLys: 0.158 ± 0.012	0.928CysLeu: 0.928 ± 0.029	0.158CysMet: 0.158 ± 0.011	0.189CysAsn: 0.189 ± 0.012	0.512CysPro: 0.512 ± 0.024	0.23CysGln: 0.23 ± 0.014	0.568CysArg: 0.568 ± 0.021	0.372CysSer: 0.372 ± 0.018	0.446CysThr: 0.446 ± 0.02	0.596CysVal: 0.596 ± 0.023	0.119CysTrp: 0.119 ± 0.009	0.186CysTyr: 0.186 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.984AspAla: 6.984 ± 0.088	0.49AspCys: 0.49 ± 0.023	2.652AspAsp: 2.652 ± 0.079	2.785AspGlu: 2.785 ± 0.056	2.18AspPhe: 2.18 ± 0.048	4.935AspGly: 4.935 ± 0.077	1.375AspHis: 1.375 ± 0.039	2.486AspIle: 2.486 ± 0.049	1.262AspLys: 1.262 ± 0.034	6.752AspLeu: 6.752 ± 0.088	1.425AspMet: 1.425 ± 0.037	0.966AspAsn: 0.966 ± 0.032	3.675AspPro: 3.675 ± 0.062	1.885AspGln: 1.885 ± 0.037	4.225AspArg: 4.225 ± 0.06	2.085AspSer: 2.085 ± 0.048	2.617AspThr: 2.617 ± 0.065	3.967AspVal: 3.967 ± 0.056	1.251AspTrp: 1.251 ± 0.034	1.381AspTyr: 1.381 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.629GluAla: 8.629 ± 0.117	0.287GluCys: 0.287 ± 0.017	2.962GluAsp: 2.962 ± 0.057	2.904GluGlu: 2.904 ± 0.06	1.583GluPhe: 1.583 ± 0.037	4.736GluGly: 4.736 ± 0.07	0.923GluHis: 0.923 ± 0.026	3.057GluIle: 3.057 ± 0.057	1.677GluLys: 1.677 ± 0.046	4.441GluLeu: 4.441 ± 0.073	1.622GluMet: 1.622 ± 0.034	1.302GluAsn: 1.302 ± 0.031	2.362GluPro: 2.362 ± 0.043	1.729GluGln: 1.729 ± 0.038	4.047GluArg: 4.047 ± 0.068	2.186GluSer: 2.186 ± 0.047	3.325GluThr: 3.325 ± 0.061	4.328GluVal: 4.328 ± 0.067	0.619GluTrp: 0.619 ± 0.021	0.843GluTyr: 0.843 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.958PheAla: 4.958 ± 0.079	0.398PheCys: 0.398 ± 0.019	2.621PheAsp: 2.621 ± 0.056	1.824PheGlu: 1.824 ± 0.042	1.385PhePhe: 1.385 ± 0.039	3.751PheGly: 3.751 ± 0.058	0.8PheHis: 0.8 ± 0.03	1.511PheIle: 1.511 ± 0.035	0.767PheLys: 0.767 ± 0.027	3.551PheLeu: 3.551 ± 0.059	0.79PheMet: 0.79 ± 0.028	0.925PheAsn: 0.925 ± 0.026	1.597PhePro: 1.597 ± 0.042	0.993PheGln: 0.993 ± 0.025	2.321PheArg: 2.321 ± 0.043	1.961PheSer: 1.961 ± 0.048	2.059PheThr: 2.059 ± 0.041	2.703PheVal: 2.703 ± 0.054	0.626PheTrp: 0.626 ± 0.025	0.839PheTyr: 0.839 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.898GlyAla: 10.898 ± 0.119	0.828GlyCys: 0.828 ± 0.027	4.221GlyAsp: 4.221 ± 0.085	4.2GlyGlu: 4.2 ± 0.058	3.822GlyPhe: 3.822 ± 0.067	7.441GlyGly: 7.441 ± 0.123	2.013GlyHis: 2.013 ± 0.045	4.234GlyIle: 4.234 ± 0.061	2.875GlyLys: 2.875 ± 0.053	10.046GlyLeu: 10.046 ± 0.112	2.65GlyMet: 2.65 ± 0.054	1.916GlyAsn: 1.916 ± 0.056	4.051GlyPro: 4.051 ± 0.061	3.451GlyGln: 3.451 ± 0.059	6.172GlyArg: 6.172 ± 0.077	4.03GlySer: 4.03 ± 0.059	4.71GlyThr: 4.71 ± 0.077	6.712GlyVal: 6.712 ± 0.079	1.623GlyTrp: 1.623 ± 0.039	2.144GlyTyr: 2.144 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.646HisAla: 2.646 ± 0.054	0.238HisCys: 0.238 ± 0.015	1.276HisAsp: 1.276 ± 0.034	0.955HisGlu: 0.955 ± 0.029	0.83HisPhe: 0.83 ± 0.028	2.044HisGly: 2.044 ± 0.042	0.579HisHis: 0.579 ± 0.025	0.944HisIle: 0.944 ± 0.032	0.452HisLys: 0.452 ± 0.019	2.393HisLeu: 2.393 ± 0.044	0.517HisMet: 0.517 ± 0.021	0.402HisAsn: 0.402 ± 0.02	1.563HisPro: 1.563 ± 0.044	0.643HisGln: 0.643 ± 0.023	1.428HisArg: 1.428 ± 0.043	0.96HisSer: 0.96 ± 0.029	0.758HisThr: 0.758 ± 0.028	1.442HisVal: 1.442 ± 0.036	0.404HisTrp: 0.404 ± 0.019	0.529HisTyr: 0.529 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.983IleAla: 6.983 ± 0.08	0.564IleCys: 0.564 ± 0.025	3.126IleAsp: 3.126 ± 0.057	2.904IleGlu: 2.904 ± 0.056	1.609IlePhe: 1.609 ± 0.042	4.721IleGly: 4.721 ± 0.066	0.918IleHis: 0.918 ± 0.028	1.994IleIle: 1.994 ± 0.047	1.209IleLys: 1.209 ± 0.035	4.843IleLeu: 4.843 ± 0.06	0.996IleMet: 0.996 ± 0.033	1.147IleAsn: 1.147 ± 0.037	2.195IlePro: 2.195 ± 0.045	1.015IleGln: 1.015 ± 0.031	3.166IleArg: 3.166 ± 0.054	2.688IleSer: 2.688 ± 0.052	2.912IleThr: 2.912 ± 0.053	3.465IleVal: 3.465 ± 0.065	0.724IleTrp: 0.724 ± 0.03	0.993IleTyr: 0.993 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.754LysAla: 3.754 ± 0.072	0.159LysCys: 0.159 ± 0.011	1.453LysAsp: 1.453 ± 0.038	1.2LysGlu: 1.2 ± 0.041	0.724LysPhe: 0.724 ± 0.029	2.594LysGly: 2.594 ± 0.057	0.483LysHis: 0.483 ± 0.024	1.466LysIle: 1.466 ± 0.037	0.878LysLys: 0.878 ± 0.038	2.6LysLeu: 2.6 ± 0.056	0.777LysMet: 0.777 ± 0.028	0.618LysAsn: 0.618 ± 0.027	1.621LysPro: 1.621 ± 0.043	0.724LysGln: 0.724 ± 0.028	1.908LysArg: 1.908 ± 0.041	1.518LysSer: 1.518 ± 0.039	1.634LysThr: 1.634 ± 0.042	2.082LysVal: 2.082 ± 0.048	0.339LysTrp: 0.339 ± 0.019	0.509LysTyr: 0.509 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.132LeuAla: 15.132 ± 0.149	1.042LeuCys: 1.042 ± 0.029	5.683LeuAsp: 5.683 ± 0.082	4.976LeuGlu: 4.976 ± 0.071	3.638LeuPhe: 3.638 ± 0.066	8.945LeuGly: 8.945 ± 0.102	2.195LeuHis: 2.195 ± 0.05	5.543LeuIle: 5.543 ± 0.083	2.762LeuLys: 2.762 ± 0.056	9.642LeuLeu: 9.642 ± 0.128	2.925LeuMet: 2.925 ± 0.054	2.592LeuAsn: 2.592 ± 0.044	6.558LeuPro: 6.558 ± 0.088	2.885LeuGln: 2.885 ± 0.056	8.065LeuArg: 8.065 ± 0.096	6.647LeuSer: 6.647 ± 0.084	6.581LeuThr: 6.581 ± 0.076	7.121LeuVal: 7.121 ± 0.082	1.514LeuTrp: 1.514 ± 0.043	1.928LeuTyr: 1.928 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.922MetAla: 3.922 ± 0.06	0.157MetCys: 0.157 ± 0.01	1.352MetAsp: 1.352 ± 0.035	1.279MetGlu: 1.279 ± 0.033	0.764MetPhe: 0.764 ± 0.027	2.337MetGly: 2.337 ± 0.046	0.458MetHis: 0.458 ± 0.02	1.441MetIle: 1.441 ± 0.034	0.882MetLys: 0.882 ± 0.03	2.649MetLeu: 2.649 ± 0.046	0.769MetMet: 0.769 ± 0.03	0.72MetAsn: 0.72 ± 0.029	1.544MetPro: 1.544 ± 0.044	1.007MetGln: 1.007 ± 0.028	1.918MetArg: 1.918 ± 0.041	1.467MetSer: 1.467 ± 0.04	2.137MetThr: 2.137 ± 0.046	1.985MetVal: 1.985 ± 0.043	0.242MetTrp: 0.242 ± 0.015	0.318MetTyr: 0.318 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.929AsnAla: 2.929 ± 0.053	0.216AsnCys: 0.216 ± 0.014	1.229AsnAsp: 1.229 ± 0.05	0.887AsnGlu: 0.887 ± 0.028	0.848AsnPhe: 0.848 ± 0.028	2.068AsnGly: 2.068 ± 0.049	0.473AsnHis: 0.473 ± 0.018	1.176AsnIle: 1.176 ± 0.036	0.525AsnLys: 0.525 ± 0.028	2.386AsnLeu: 2.386 ± 0.048	0.582AsnMet: 0.582 ± 0.022	0.573AsnAsn: 0.573 ± 0.026	1.832AsnPro: 1.832 ± 0.046	0.593AsnGln: 0.593 ± 0.025	1.665AsnArg: 1.665 ± 0.042	0.974AsnSer: 0.974 ± 0.032	1.154AsnThr: 1.154 ± 0.036	1.569AsnVal: 1.569 ± 0.04	0.369AsnTrp: 0.369 ± 0.018	0.533AsnTyr: 0.533 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.885ProAla: 6.885 ± 0.103	0.386ProCys: 0.386 ± 0.017	3.85ProAsp: 3.85 ± 0.061	4.122ProGlu: 4.122 ± 0.071	2.043ProPhe: 2.043 ± 0.04	5.011ProGly: 5.011 ± 0.081	1.158ProHis: 1.158 ± 0.028	2.104ProIle: 2.104 ± 0.044	1.569ProLys: 1.569 ± 0.041	5.3ProLeu: 5.3 ± 0.079	1.428ProMet: 1.428 ± 0.032	1.245ProAsn: 1.245 ± 0.039	2.665ProPro: 2.665 ± 0.058	1.898ProGln: 1.898 ± 0.043	3.178ProArg: 3.178 ± 0.058	2.53ProSer: 2.53 ± 0.052	2.419ProThr: 2.419 ± 0.049	4.657ProVal: 4.657 ± 0.07	0.725ProTrp: 0.725 ± 0.03	1.106ProTyr: 1.106 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.751GlnAla: 4.751 ± 0.067	0.202GlnCys: 0.202 ± 0.012	1.744GlnAsp: 1.744 ± 0.041	1.414GlnGlu: 1.414 ± 0.04	1.051GlnPhe: 1.051 ± 0.03	3.128GlnGly: 3.128 ± 0.053	0.65GlnHis: 0.65 ± 0.027	2.082GlnIle: 2.082 ± 0.05	0.938GlnLys: 0.938 ± 0.033	2.679GlnLeu: 2.679 ± 0.048	1.109GlnMet: 1.109 ± 0.029	0.835GlnAsn: 0.835 ± 0.027	1.711GlnPro: 1.711 ± 0.042	0.943GlnGln: 0.943 ± 0.031	2.421GlnArg: 2.421 ± 0.044	1.866GlnSer: 1.866 ± 0.041	1.8GlnThr: 1.8 ± 0.041	2.592GlnVal: 2.592 ± 0.053	0.399GlnTrp: 0.399 ± 0.017	0.492GlnTyr: 0.492 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.744ArgAla: 9.744 ± 0.121	0.475ArgCys: 0.475 ± 0.022	4.125ArgAsp: 4.125 ± 0.068	3.532ArgGlu: 3.532 ± 0.057	2.827ArgPhe: 2.827 ± 0.049	4.977ArgGly: 4.977 ± 0.066	1.755ArgHis: 1.755 ± 0.038	3.77ArgIle: 3.77 ± 0.056	2.035ArgLys: 2.035 ± 0.048	8.388ArgLeu: 8.388 ± 0.107	2.168ArgMet: 2.168 ± 0.04	1.613ArgAsn: 1.613 ± 0.036	3.69ArgPro: 3.69 ± 0.073	2.388ArgGln: 2.388 ± 0.046	5.199ArgArg: 5.199 ± 0.079	3.267ArgSer: 3.267 ± 0.056	2.84ArgThr: 2.84 ± 0.048	5.207ArgVal: 5.207 ± 0.08	0.974ArgTrp: 0.974 ± 0.036	1.468ArgTyr: 1.468 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.019SerAla: 6.019 ± 0.064	0.439SerCys: 0.439 ± 0.019	2.815SerAsp: 2.815 ± 0.048	2.461SerGlu: 2.461 ± 0.044	2.137SerPhe: 2.137 ± 0.042	5.313SerGly: 5.313 ± 0.073	1.01SerHis: 1.01 ± 0.031	2.092SerIle: 2.092 ± 0.052	1.17SerLys: 1.17 ± 0.034	5.247SerLeu: 5.247 ± 0.069	1.218SerMet: 1.218 ± 0.033	1.129SerAsn: 1.129 ± 0.033	2.62SerPro: 2.62 ± 0.051	1.49SerGln: 1.49 ± 0.041	3.213SerArg: 3.213 ± 0.043	2.271SerSer: 2.271 ± 0.044	2.402SerThr: 2.402 ± 0.048	3.821SerVal: 3.821 ± 0.06	0.654SerTrp: 0.654 ± 0.027	1.139SerTyr: 1.139 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.844ThrAla: 6.844 ± 0.093	0.443ThrCys: 0.443 ± 0.019	2.817ThrAsp: 2.817 ± 0.047	2.849ThrGlu: 2.849 ± 0.051	1.869ThrPhe: 1.869 ± 0.042	5.34ThrGly: 5.34 ± 0.074	1.157ThrHis: 1.157 ± 0.031	2.477ThrIle: 2.477 ± 0.052	1.279ThrLys: 1.279 ± 0.04	6.354ThrLeu: 6.354 ± 0.089	1.179ThrMet: 1.179 ± 0.032	1.125ThrAsn: 1.125 ± 0.034	3.507ThrPro: 3.507 ± 0.057	1.627ThrGln: 1.627 ± 0.036	3.551ThrArg: 3.551 ± 0.06	2.401ThrSer: 2.401 ± 0.048	2.755ThrThr: 2.755 ± 0.061	4.283ThrVal: 4.283 ± 0.067	0.676ThrTrp: 0.676 ± 0.025	1.124ThrTyr: 1.124 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.903ValAla: 9.903 ± 0.121	0.558ValCys: 0.558 ± 0.022	3.786ValAsp: 3.786 ± 0.056	4.215ValGlu: 4.215 ± 0.062	2.828ValPhe: 2.828 ± 0.057	5.35ValGly: 5.35 ± 0.085	1.302ValHis: 1.302 ± 0.036	4.194ValIle: 4.194 ± 0.066	2.002ValLys: 2.002 ± 0.048	8.071ValLeu: 8.071 ± 0.097	2.19ValMet: 2.19 ± 0.041	1.827ValAsn: 1.827 ± 0.041	3.909ValPro: 3.909 ± 0.059	2.542ValGln: 2.542 ± 0.05	4.276ValArg: 4.276 ± 0.065	4.012ValSer: 4.012 ± 0.06	4.973ValThr: 4.973 ± 0.075	5.967ValVal: 5.967 ± 0.092	1.065ValTrp: 1.065 ± 0.031	1.394ValTyr: 1.394 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.638TrpAla: 1.638 ± 0.039	0.142TrpCys: 0.142 ± 0.011	0.721TrpAsp: 0.721 ± 0.027	0.651TrpGlu: 0.651 ± 0.026	0.556TrpPhe: 0.556 ± 0.024	1.061TrpGly: 1.061 ± 0.035	0.358TrpHis: 0.358 ± 0.019	0.626TrpIle: 0.626 ± 0.027	0.396TrpLys: 0.396 ± 0.02	1.795TrpLeu: 1.795 ± 0.042	0.413TrpMet: 0.413 ± 0.019	0.393TrpAsn: 0.393 ± 0.019	0.802TrpPro: 0.802 ± 0.032	0.702TrpGln: 0.702 ± 0.028	1.183TrpArg: 1.183 ± 0.031	0.755TrpSer: 0.755 ± 0.025	0.751TrpThr: 0.751 ± 0.026	1.055TrpVal: 1.055 ± 0.035	0.242TrpTrp: 0.242 ± 0.015	0.25TrpTyr: 0.25 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.637TyrAla: 2.637 ± 0.047	0.206TyrCys: 0.206 ± 0.013	1.352TyrAsp: 1.352 ± 0.036	1.073TyrGlu: 1.073 ± 0.03	0.773TyrPhe: 0.773 ± 0.028	1.922TyrGly: 1.922 ± 0.047	0.471TyrHis: 0.471 ± 0.02	0.825TyrIle: 0.825 ± 0.027	0.48TyrLys: 0.48 ± 0.021	2.144TyrLeu: 2.144 ± 0.046	0.43TyrMet: 0.43 ± 0.021	0.529TyrAsn: 0.529 ± 0.022	1.022TyrPro: 1.022 ± 0.032	0.633TyrGln: 0.633 ± 0.026	1.467TyrArg: 1.467 ± 0.037	0.97TyrSer: 0.97 ± 0.028	1.112TyrThr: 1.112 ± 0.036	1.387TyrVal: 1.387 ± 0.034	0.325TyrTrp: 0.325 ± 0.017	0.493TyrTyr: 0.493 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3602 proteins (1155149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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