Amino acid dipepetide frequency for Charleville virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.275AlaAla: 2.275 ± 1.022
1.137AlaCys: 1.137 ± 0.597
2.559AlaAsp: 2.559 ± 1.223
2.275AlaGlu: 2.275 ± 1.194
1.99AlaPhe: 1.99 ± 1.226
1.99AlaGly: 1.99 ± 0.96
0.853AlaHis: 0.853 ± 0.793
3.412AlaIle: 3.412 ± 0.803
1.99AlaLys: 1.99 ± 1.041
3.128AlaLeu: 3.128 ± 0.6
0.569AlaMet: 0.569 ± 0.603
0.853AlaAsn: 0.853 ± 0.964
0.569AlaPro: 0.569 ± 0.758
1.706AlaGln: 1.706 ± 0.99
3.412AlaArg: 3.412 ± 0.976
3.128AlaSer: 3.128 ± 0.806
1.99AlaThr: 1.99 ± 0.763
2.275AlaVal: 2.275 ± 1.438
1.137AlaTrp: 1.137 ± 0.982
0.569AlaTyr: 0.569 ± 0.341
0.0AlaXaa: 0.0 ± 0.0
Cys
0.284CysAla: 0.284 ± 0.165
0.0CysCys: 0.0 ± 0.0
0.284CysAsp: 0.284 ± 0.379
1.99CysGlu: 1.99 ± 1.154
1.137CysPhe: 1.137 ± 0.66
0.569CysGly: 0.569 ± 0.33
0.569CysHis: 0.569 ± 0.694
0.853CysIle: 0.853 ± 0.495
2.559CysLys: 2.559 ± 1.554
1.99CysLeu: 1.99 ± 0.902
1.706CysMet: 1.706 ± 0.878
1.137CysAsn: 1.137 ± 0.66
0.853CysPro: 0.853 ± 0.772
1.422CysGln: 1.422 ± 0.557
0.853CysArg: 0.853 ± 0.697
2.275CysSer: 2.275 ± 0.752
0.569CysThr: 0.569 ± 0.491
0.569CysVal: 0.569 ± 0.404
0.569CysTrp: 0.569 ± 0.33
1.137CysTyr: 1.137 ± 0.597
0.0CysXaa: 0.0 ± 0.0
Asp
1.422AspAla: 1.422 ± 0.747
1.137AspCys: 1.137 ± 0.482
1.99AspAsp: 1.99 ± 0.492
1.706AspGlu: 1.706 ± 0.949
2.843AspPhe: 2.843 ± 0.561
2.559AspGly: 2.559 ± 1.152
0.0AspHis: 0.0 ± 0.0
3.128AspIle: 3.128 ± 1.154
3.696AspLys: 3.696 ± 1.512
5.687AspLeu: 5.687 ± 1.099
1.137AspMet: 1.137 ± 0.472
2.275AspAsn: 2.275 ± 0.94
3.412AspPro: 3.412 ± 0.838
1.706AspGln: 1.706 ± 0.767
1.706AspArg: 1.706 ± 0.711
5.118AspSer: 5.118 ± 1.06
3.128AspThr: 3.128 ± 1.109
1.99AspVal: 1.99 ± 0.427
0.853AspTrp: 0.853 ± 0.383
2.275AspTyr: 2.275 ± 0.94
0.0AspXaa: 0.0 ± 0.0
Glu
2.559GluAla: 2.559 ± 1.642
1.137GluCys: 1.137 ± 0.586
3.412GluAsp: 3.412 ± 0.731
7.393GluGlu: 7.393 ± 2.478
3.128GluPhe: 3.128 ± 0.824
4.549GluGly: 4.549 ± 0.904
0.853GluHis: 0.853 ± 0.364
7.393GluIle: 7.393 ± 2.404
5.971GluLys: 5.971 ± 1.253
7.677GluLeu: 7.677 ± 1.502
3.128GluMet: 3.128 ± 0.881
3.412GluAsn: 3.412 ± 2.095
1.422GluPro: 1.422 ± 0.545
0.853GluGln: 0.853 ± 0.495
3.128GluArg: 3.128 ± 0.777
5.118GluSer: 5.118 ± 3.463
3.696GluThr: 3.696 ± 1.261
2.843GluVal: 2.843 ± 1.369
1.99GluTrp: 1.99 ± 0.427
1.422GluTyr: 1.422 ± 0.734
0.0GluXaa: 0.0 ± 0.0
Phe
1.137PheAla: 1.137 ± 1.032
1.137PheCys: 1.137 ± 1.065
0.853PheAsp: 0.853 ± 0.53
2.843PheGlu: 2.843 ± 1.167
1.706PhePhe: 1.706 ± 0.461
1.99PheGly: 1.99 ± 0.709
0.853PheHis: 0.853 ± 0.41
3.128PheIle: 3.128 ± 1.109
3.696PheLys: 3.696 ± 1.097
5.687PheLeu: 5.687 ± 1.49
0.853PheMet: 0.853 ± 0.383
2.559PheAsn: 2.559 ± 0.779
3.412PhePro: 3.412 ± 1.059
2.843PheGln: 2.843 ± 0.971
0.853PheArg: 0.853 ± 0.495
2.275PheSer: 2.275 ± 0.872
3.412PheThr: 3.412 ± 0.858
2.559PheVal: 2.559 ± 0.895
1.422PheTrp: 1.422 ± 0.809
1.706PheTyr: 1.706 ± 0.89
0.0PheXaa: 0.0 ± 0.0
Gly
1.99GlyAla: 1.99 ± 0.918
0.569GlyCys: 0.569 ± 0.33
1.99GlyAsp: 1.99 ± 0.708
3.981GlyGlu: 3.981 ± 1.419
3.981GlyPhe: 3.981 ± 0.816
4.834GlyGly: 4.834 ± 1.436
0.853GlyHis: 0.853 ± 0.383
4.834GlyIle: 4.834 ± 1.204
4.834GlyLys: 4.834 ± 1.679
7.393GlyLeu: 7.393 ± 2.016
1.422GlyMet: 1.422 ± 0.462
1.706GlyAsn: 1.706 ± 0.99
1.137GlyPro: 1.137 ± 0.449
2.275GlyGln: 2.275 ± 0.963
2.843GlyArg: 2.843 ± 0.86
5.118GlySer: 5.118 ± 1.73
3.696GlyThr: 3.696 ± 1.723
4.834GlyVal: 4.834 ± 1.818
1.422GlyTrp: 1.422 ± 0.405
1.99GlyTyr: 1.99 ± 0.628
0.0GlyXaa: 0.0 ± 0.0
His
0.853HisAla: 0.853 ± 0.697
0.569HisCys: 0.569 ± 0.404
1.422HisAsp: 1.422 ± 0.557
1.422HisGlu: 1.422 ± 0.722
0.853HisPhe: 0.853 ± 0.495
0.569HisGly: 0.569 ± 0.607
1.422HisHis: 1.422 ± 0.825
1.137HisIle: 1.137 ± 0.366
1.99HisLys: 1.99 ± 0.502
1.706HisLeu: 1.706 ± 0.541
0.284HisMet: 0.284 ± 0.165
0.284HisAsn: 0.284 ± 0.165
2.559HisPro: 2.559 ± 1.526
0.853HisGln: 0.853 ± 0.364
1.137HisArg: 1.137 ± 0.482
2.275HisSer: 2.275 ± 0.762
0.569HisThr: 0.569 ± 0.293
1.137HisVal: 1.137 ± 0.682
0.569HisTrp: 0.569 ± 0.293
1.422HisTyr: 1.422 ± 0.583
0.0HisXaa: 0.0 ± 0.0
Ile
3.981IleAla: 3.981 ± 0.664
1.422IleCys: 1.422 ± 0.489
3.981IleAsp: 3.981 ± 0.985
5.402IleGlu: 5.402 ± 0.973
2.559IlePhe: 2.559 ± 0.534
4.265IleGly: 4.265 ± 1.137
0.853IleHis: 0.853 ± 0.657
5.687IleIle: 5.687 ± 1.535
7.677IleLys: 7.677 ± 1.711
9.383IleLeu: 9.383 ± 1.275
1.422IleMet: 1.422 ± 0.825
3.981IleAsn: 3.981 ± 1.59
3.696IlePro: 3.696 ± 1.148
2.275IleGln: 2.275 ± 0.962
5.118IleArg: 5.118 ± 0.918
6.824IleSer: 6.824 ± 1.807
5.402IleThr: 5.402 ± 1.067
2.275IleVal: 2.275 ± 0.701
1.706IleTrp: 1.706 ± 0.461
3.412IleTyr: 3.412 ± 1.264
0.0IleXaa: 0.0 ± 0.0
Lys
1.706LysAla: 1.706 ± 0.461
1.422LysCys: 1.422 ± 0.489
3.412LysAsp: 3.412 ± 0.404
5.971LysGlu: 5.971 ± 1.325
2.559LysPhe: 2.559 ± 1.222
5.118LysGly: 5.118 ± 1.811
1.706LysHis: 1.706 ± 0.713
9.667LysIle: 9.667 ± 2.22
5.118LysLys: 5.118 ± 1.125
5.118LysLeu: 5.118 ± 1.744
1.99LysMet: 1.99 ± 0.784
4.834LysAsn: 4.834 ± 1.017
2.843LysPro: 2.843 ± 0.523
0.853LysGln: 0.853 ± 0.657
1.99LysArg: 1.99 ± 0.87
4.549LysSer: 4.549 ± 1.504
5.687LysThr: 5.687 ± 0.868
4.834LysVal: 4.834 ± 1.497
1.422LysTrp: 1.422 ± 0.609
1.137LysTyr: 1.137 ± 1.225
0.0LysXaa: 0.0 ± 0.0
Leu
4.265LeuAla: 4.265 ± 0.777
2.559LeuCys: 2.559 ± 1.052
5.971LeuAsp: 5.971 ± 1.148
6.255LeuGlu: 6.255 ± 0.728
3.128LeuPhe: 3.128 ± 0.841
6.255LeuGly: 6.255 ± 1.252
1.99LeuHis: 1.99 ± 0.899
6.255LeuIle: 6.255 ± 1.196
6.255LeuLys: 6.255 ± 1.264
10.805LeuLeu: 10.805 ± 5.157
3.412LeuMet: 3.412 ± 1.345
4.834LeuAsn: 4.834 ± 1.041
3.128LeuPro: 3.128 ± 1.265
2.559LeuGln: 2.559 ± 0.962
7.108LeuArg: 7.108 ± 1.477
9.667LeuSer: 9.667 ± 3.904
5.687LeuThr: 5.687 ± 1.64
2.843LeuVal: 2.843 ± 0.729
1.137LeuTrp: 1.137 ± 0.449
3.412LeuTyr: 3.412 ± 0.838
0.0LeuXaa: 0.0 ± 0.0
Met
1.422MetAla: 1.422 ± 0.746
0.569MetCys: 0.569 ± 0.33
0.853MetAsp: 0.853 ± 0.288
1.99MetGlu: 1.99 ± 0.68
1.137MetPhe: 1.137 ± 0.698
2.275MetGly: 2.275 ± 1.084
0.284MetHis: 0.284 ± 0.165
3.128MetIle: 3.128 ± 0.593
1.706MetLys: 1.706 ± 0.99
1.422MetLeu: 1.422 ± 1.42
0.569MetMet: 0.569 ± 0.33
1.99MetAsn: 1.99 ± 0.576
0.284MetPro: 0.284 ± 0.165
1.137MetGln: 1.137 ± 0.586
0.853MetArg: 0.853 ± 0.495
2.275MetSer: 2.275 ± 0.952
1.706MetThr: 1.706 ± 0.767
1.137MetVal: 1.137 ± 0.472
0.0MetTrp: 0.0 ± 0.0
1.422MetTyr: 1.422 ± 0.28
0.0MetXaa: 0.0 ± 0.0
Asn
1.706AsnAla: 1.706 ± 1.023
1.99AsnCys: 1.99 ± 0.845
2.275AsnAsp: 2.275 ± 0.614
2.275AsnGlu: 2.275 ± 0.885
2.559AsnPhe: 2.559 ± 1.098
1.137AsnGly: 1.137 ± 0.64
1.422AsnHis: 1.422 ± 0.489
2.843AsnIle: 2.843 ± 1.258
3.696AsnLys: 3.696 ± 1.349
5.687AsnLeu: 5.687 ± 1.495
1.422AsnMet: 1.422 ± 0.746
4.834AsnAsn: 4.834 ± 1.012
3.696AsnPro: 3.696 ± 1.244
2.843AsnGln: 2.843 ± 1.258
2.559AsnArg: 2.559 ± 0.815
3.128AsnSer: 3.128 ± 0.511
2.559AsnThr: 2.559 ± 0.691
1.137AsnVal: 1.137 ± 0.586
0.853AsnTrp: 0.853 ± 0.495
2.275AsnTyr: 2.275 ± 0.455
0.0AsnXaa: 0.0 ± 0.0
Pro
1.706ProAla: 1.706 ± 1.215
0.0ProCys: 0.0 ± 0.0
2.275ProAsp: 2.275 ± 0.637
3.412ProGlu: 3.412 ± 0.512
1.137ProPhe: 1.137 ± 0.449
3.412ProGly: 3.412 ± 1.29
1.137ProHis: 1.137 ± 0.586
2.843ProIle: 2.843 ± 0.352
2.843ProLys: 2.843 ± 0.841
2.843ProLeu: 2.843 ± 0.835
0.569ProMet: 0.569 ± 0.375
2.843ProAsn: 2.843 ± 1.369
1.422ProPro: 1.422 ± 0.825
1.422ProGln: 1.422 ± 0.722
1.706ProArg: 1.706 ± 0.723
3.696ProSer: 3.696 ± 1.066
2.843ProThr: 2.843 ± 1.583
1.99ProVal: 1.99 ± 0.571
0.569ProTrp: 0.569 ± 0.33
1.706ProTyr: 1.706 ± 0.461
0.0ProXaa: 0.0 ± 0.0
Gln
1.422GlnAla: 1.422 ± 0.557
0.284GlnCys: 0.284 ± 0.165
2.275GlnAsp: 2.275 ± 0.333
3.128GlnGlu: 3.128 ± 1.804
1.99GlnPhe: 1.99 ± 0.845
1.99GlnGly: 1.99 ± 0.845
1.422GlnHis: 1.422 ± 0.609
1.422GlnIle: 1.422 ± 0.489
0.853GlnLys: 0.853 ± 0.697
2.275GlnLeu: 2.275 ± 1.004
0.853GlnMet: 0.853 ± 0.657
1.706GlnAsn: 1.706 ± 0.688
0.853GlnPro: 0.853 ± 0.41
1.422GlnGln: 1.422 ± 0.545
1.99GlnArg: 1.99 ± 0.492
1.422GlnSer: 1.422 ± 0.489
0.853GlnThr: 0.853 ± 0.59
3.412GlnVal: 3.412 ± 1.23
0.284GlnTrp: 0.284 ± 0.379
0.853GlnTyr: 0.853 ± 0.59
0.0GlnXaa: 0.0 ± 0.0
Arg
1.422ArgAla: 1.422 ± 0.489
1.706ArgCys: 1.706 ± 0.632
3.128ArgAsp: 3.128 ± 0.593
4.265ArgGlu: 4.265 ± 0.955
3.696ArgPhe: 3.696 ± 0.83
2.559ArgGly: 2.559 ± 1.034
0.0ArgHis: 0.0 ± 0.0
4.265ArgIle: 4.265 ± 1.099
4.549ArgLys: 4.549 ± 1.909
2.559ArgLeu: 2.559 ± 1.19
1.706ArgMet: 1.706 ± 0.765
1.422ArgAsn: 1.422 ± 0.825
0.853ArgPro: 0.853 ± 0.288
0.853ArgGln: 0.853 ± 0.891
2.275ArgArg: 2.275 ± 1.419
3.412ArgSer: 3.412 ± 1.069
3.981ArgThr: 3.981 ± 1.108
3.412ArgVal: 3.412 ± 0.921
0.0ArgTrp: 0.0 ± 0.0
1.706ArgTyr: 1.706 ± 0.365
0.0ArgXaa: 0.0 ± 0.0
Ser
3.128SerAla: 3.128 ± 0.772
2.275SerCys: 2.275 ± 0.893
3.696SerAsp: 3.696 ± 0.564
5.971SerGlu: 5.971 ± 0.966
3.412SerPhe: 3.412 ± 0.512
4.834SerGly: 4.834 ± 2.276
3.981SerHis: 3.981 ± 1.18
6.824SerIle: 6.824 ± 1.893
4.265SerLys: 4.265 ± 2.029
7.393SerLeu: 7.393 ± 0.844
0.853SerMet: 0.853 ± 0.53
4.265SerAsn: 4.265 ± 1.4
3.128SerPro: 3.128 ± 1.675
1.422SerGln: 1.422 ± 1.128
1.99SerArg: 1.99 ± 0.784
6.54SerSer: 6.54 ± 2.477
4.834SerThr: 4.834 ± 1.034
4.265SerVal: 4.265 ± 1.309
1.99SerTrp: 1.99 ± 0.827
2.843SerTyr: 2.843 ± 1.268
0.0SerXaa: 0.0 ± 0.0
Thr
2.275ThrAla: 2.275 ± 0.932
1.137ThrCys: 1.137 ± 0.366
3.128ThrAsp: 3.128 ± 0.64
4.549ThrGlu: 4.549 ± 1.269
1.422ThrPhe: 1.422 ± 1.08
3.981ThrGly: 3.981 ± 1.331
1.99ThrHis: 1.99 ± 0.64
4.834ThrIle: 4.834 ± 1.401
3.981ThrLys: 3.981 ± 0.963
7.108ThrLeu: 7.108 ± 1.884
2.275ThrMet: 2.275 ± 0.597
3.412ThrAsn: 3.412 ± 1.039
1.706ThrPro: 1.706 ± 0.632
1.706ThrGln: 1.706 ± 0.825
3.128ThrArg: 3.128 ± 1.084
5.118ThrSer: 5.118 ± 0.773
3.981ThrThr: 3.981 ± 1.835
3.981ThrVal: 3.981 ± 0.925
1.422ThrTrp: 1.422 ± 0.545
2.275ThrTyr: 2.275 ± 1.041
0.0ThrXaa: 0.0 ± 0.0
Val
2.275ValAla: 2.275 ± 1.342
1.706ValCys: 1.706 ± 0.97
2.275ValAsp: 2.275 ± 1.151
3.981ValGlu: 3.981 ± 1.031
1.706ValPhe: 1.706 ± 0.548
3.981ValGly: 3.981 ± 1.518
1.422ValHis: 1.422 ± 0.28
5.118ValIle: 5.118 ± 0.72
2.559ValLys: 2.559 ± 1.199
4.834ValLeu: 4.834 ± 0.711
0.569ValMet: 0.569 ± 0.341
1.99ValAsn: 1.99 ± 0.784
2.559ValPro: 2.559 ± 1.132
1.422ValGln: 1.422 ± 1.289
2.275ValArg: 2.275 ± 1.531
3.412ValSer: 3.412 ± 0.85
3.412ValThr: 3.412 ± 1.913
1.706ValVal: 1.706 ± 0.551
0.569ValTrp: 0.569 ± 0.341
2.275ValTyr: 2.275 ± 1.764
0.0ValXaa: 0.0 ± 0.0
Trp
1.137TrpAla: 1.137 ± 0.586
0.0TrpCys: 0.0 ± 0.0
0.569TrpAsp: 0.569 ± 0.33
1.137TrpGlu: 1.137 ± 0.464
1.137TrpPhe: 1.137 ± 0.482
0.284TrpGly: 0.284 ± 0.379
1.137TrpHis: 1.137 ± 0.905
1.422TrpIle: 1.422 ± 0.609
1.422TrpLys: 1.422 ± 0.557
1.137TrpLeu: 1.137 ± 0.482
0.284TrpMet: 0.284 ± 0.165
0.569TrpAsn: 0.569 ± 0.293
0.284TrpPro: 0.284 ± 0.165
0.284TrpGln: 0.284 ± 0.165
1.137TrpArg: 1.137 ± 0.28
0.853TrpSer: 0.853 ± 0.53
3.128TrpThr: 3.128 ± 0.592
0.853TrpVal: 0.853 ± 0.793
0.0TrpTrp: 0.0 ± 0.0
1.422TrpTyr: 1.422 ± 0.28
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.853TyrAla: 0.853 ± 0.657
0.853TyrCys: 0.853 ± 0.288
1.422TyrAsp: 1.422 ± 0.557
1.137TyrGlu: 1.137 ± 0.366
2.843TyrPhe: 2.843 ± 1.19
4.549TyrGly: 4.549 ± 0.857
0.284TyrHis: 0.284 ± 0.165
3.128TyrIle: 3.128 ± 0.865
2.275TyrLys: 2.275 ± 0.871
3.696TyrLeu: 3.696 ± 1.032
0.853TyrMet: 0.853 ± 0.3
1.99TyrAsn: 1.99 ± 0.637
2.559TyrPro: 2.559 ± 0.618
0.853TyrGln: 0.853 ± 1.009
1.706TyrArg: 1.706 ± 0.954
1.706TyrSer: 1.706 ± 0.365
2.275TyrThr: 2.275 ± 1.846
1.99TyrVal: 1.99 ± 0.831
0.284TyrTrp: 0.284 ± 0.379
0.853TyrTyr: 0.853 ± 0.697
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (3518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski