Amino acid dipepetide frequency for Escherichia phage vB_EcoP_PhAPEC7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.378AlaAla: 8.378 ± 1.284
0.683AlaCys: 0.683 ± 0.2
5.054AlaAsp: 5.054 ± 0.545
5.601AlaGlu: 5.601 ± 0.393
2.368AlaPhe: 2.368 ± 0.304
6.921AlaGly: 6.921 ± 0.684
1.047AlaHis: 1.047 ± 0.194
4.644AlaIle: 4.644 ± 0.515
5.282AlaLys: 5.282 ± 0.592
7.467AlaLeu: 7.467 ± 0.91
2.96AlaMet: 2.96 ± 0.562
5.191AlaAsn: 5.191 ± 0.572
2.595AlaPro: 2.595 ± 0.418
4.417AlaGln: 4.417 ± 0.9
3.643AlaArg: 3.643 ± 0.311
4.963AlaSer: 4.963 ± 0.452
6.329AlaThr: 6.329 ± 0.653
5.464AlaVal: 5.464 ± 0.464
0.865AlaTrp: 0.865 ± 0.191
3.369AlaTyr: 3.369 ± 0.371
0.0AlaXaa: 0.0 ± 0.0
Cys
0.637CysAla: 0.637 ± 0.209
0.046CysCys: 0.046 ± 0.046
0.637CysAsp: 0.637 ± 0.212
0.774CysGlu: 0.774 ± 0.217
0.364CysPhe: 0.364 ± 0.139
0.501CysGly: 0.501 ± 0.18
0.228CysHis: 0.228 ± 0.096
0.774CysIle: 0.774 ± 0.217
0.774CysLys: 0.774 ± 0.197
0.592CysLeu: 0.592 ± 0.177
0.455CysMet: 0.455 ± 0.159
0.501CysAsn: 0.501 ± 0.165
0.41CysPro: 0.41 ± 0.153
0.091CysGln: 0.091 ± 0.063
0.182CysArg: 0.182 ± 0.1
0.501CysSer: 0.501 ± 0.128
0.546CysThr: 0.546 ± 0.207
0.729CysVal: 0.729 ± 0.236
0.182CysTrp: 0.182 ± 0.083
0.273CysTyr: 0.273 ± 0.111
0.0CysXaa: 0.0 ± 0.0
Asp
4.872AspAla: 4.872 ± 0.57
0.956AspCys: 0.956 ± 0.245
3.096AspAsp: 3.096 ± 0.336
3.825AspGlu: 3.825 ± 0.476
2.686AspPhe: 2.686 ± 0.35
3.051AspGly: 3.051 ± 0.313
0.865AspHis: 0.865 ± 0.211
4.644AspIle: 4.644 ± 0.594
3.324AspLys: 3.324 ± 0.406
4.69AspLeu: 4.69 ± 0.562
1.594AspMet: 1.594 ± 0.267
2.823AspAsn: 2.823 ± 0.264
2.641AspPro: 2.641 ± 0.315
1.821AspGln: 1.821 ± 0.362
2.277AspArg: 2.277 ± 0.281
3.734AspSer: 3.734 ± 0.327
4.007AspThr: 4.007 ± 0.402
3.734AspVal: 3.734 ± 0.386
0.865AspTrp: 0.865 ± 0.201
2.14AspTyr: 2.14 ± 0.387
0.0AspXaa: 0.0 ± 0.0
Glu
6.739GluAla: 6.739 ± 0.97
0.455GluCys: 0.455 ± 0.189
3.961GluAsp: 3.961 ± 0.592
5.737GluGlu: 5.737 ± 0.709
2.413GluPhe: 2.413 ± 0.375
3.552GluGly: 3.552 ± 0.457
0.774GluHis: 0.774 ± 0.186
3.233GluIle: 3.233 ± 0.381
3.643GluLys: 3.643 ± 0.494
5.692GluLeu: 5.692 ± 0.506
2.095GluMet: 2.095 ± 0.277
3.096GluAsn: 3.096 ± 0.405
3.369GluPro: 3.369 ± 0.452
2.96GluGln: 2.96 ± 0.431
2.049GluArg: 2.049 ± 0.25
3.415GluSer: 3.415 ± 0.386
3.051GluThr: 3.051 ± 0.324
4.735GluVal: 4.735 ± 0.476
0.911GluTrp: 0.911 ± 0.183
2.869GluTyr: 2.869 ± 0.397
0.0GluXaa: 0.0 ± 0.0
Phe
2.778PheAla: 2.778 ± 0.331
0.455PheCys: 0.455 ± 0.158
2.55PheAsp: 2.55 ± 0.325
1.867PheGlu: 1.867 ± 0.205
1.184PhePhe: 1.184 ± 0.284
2.96PheGly: 2.96 ± 0.271
0.637PheHis: 0.637 ± 0.155
2.869PheIle: 2.869 ± 0.37
1.958PheLys: 1.958 ± 0.325
2.55PheLeu: 2.55 ± 0.342
1.594PheMet: 1.594 ± 0.287
2.368PheAsn: 2.368 ± 0.44
1.093PhePro: 1.093 ± 0.201
1.503PheGln: 1.503 ± 0.247
1.821PheArg: 1.821 ± 0.3
2.14PheSer: 2.14 ± 0.292
2.914PheThr: 2.914 ± 0.308
1.958PheVal: 1.958 ± 0.384
0.364PheTrp: 0.364 ± 0.133
1.32PheTyr: 1.32 ± 0.216
0.0PheXaa: 0.0 ± 0.0
Gly
5.464GlyAla: 5.464 ± 0.696
0.774GlyCys: 0.774 ± 0.211
3.278GlyAsp: 3.278 ± 0.447
4.007GlyGlu: 4.007 ± 0.351
2.869GlyPhe: 2.869 ± 0.405
4.144GlyGly: 4.144 ± 0.702
1.138GlyHis: 1.138 ± 0.234
4.007GlyIle: 4.007 ± 0.438
5.646GlyLys: 5.646 ± 0.545
5.692GlyLeu: 5.692 ± 0.568
2.049GlyMet: 2.049 ± 0.27
4.872GlyAsn: 4.872 ± 0.453
0.865GlyPro: 0.865 ± 0.174
2.322GlyGln: 2.322 ± 0.303
2.732GlyArg: 2.732 ± 0.402
5.009GlySer: 5.009 ± 0.448
4.508GlyThr: 4.508 ± 0.438
4.69GlyVal: 4.69 ± 0.555
1.093GlyTrp: 1.093 ± 0.264
3.005GlyTyr: 3.005 ± 0.459
0.0GlyXaa: 0.0 ± 0.0
His
1.275HisAla: 1.275 ± 0.226
0.182HisCys: 0.182 ± 0.079
0.82HisAsp: 0.82 ± 0.244
1.229HisGlu: 1.229 ± 0.254
0.729HisPhe: 0.729 ± 0.203
0.82HisGly: 0.82 ± 0.245
0.546HisHis: 0.546 ± 0.192
1.184HisIle: 1.184 ± 0.25
1.184HisLys: 1.184 ± 0.273
2.003HisLeu: 2.003 ± 0.383
0.364HisMet: 0.364 ± 0.105
0.865HisAsn: 0.865 ± 0.158
0.82HisPro: 0.82 ± 0.221
0.455HisGln: 0.455 ± 0.141
0.546HisArg: 0.546 ± 0.133
1.366HisSer: 1.366 ± 0.235
0.82HisThr: 0.82 ± 0.222
0.911HisVal: 0.911 ± 0.212
0.319HisTrp: 0.319 ± 0.125
0.911HisTyr: 0.911 ± 0.196
0.0HisXaa: 0.0 ± 0.0
Ile
4.144IleAla: 4.144 ± 0.408
0.455IleCys: 0.455 ± 0.152
3.779IleAsp: 3.779 ± 0.528
3.552IleGlu: 3.552 ± 0.353
1.958IlePhe: 1.958 ± 0.345
3.597IleGly: 3.597 ± 0.37
1.093IleHis: 1.093 ± 0.218
3.369IleIle: 3.369 ± 0.555
4.144IleLys: 4.144 ± 0.507
3.825IleLeu: 3.825 ± 0.385
1.275IleMet: 1.275 ± 0.17
3.278IleAsn: 3.278 ± 0.401
3.233IlePro: 3.233 ± 0.482
2.504IleGln: 2.504 ± 0.302
3.278IleArg: 3.278 ± 0.365
3.187IleSer: 3.187 ± 0.382
4.735IleThr: 4.735 ± 0.49
3.506IleVal: 3.506 ± 0.425
0.455IleTrp: 0.455 ± 0.178
2.504IleTyr: 2.504 ± 0.413
0.0IleXaa: 0.0 ± 0.0
Lys
6.83LysAla: 6.83 ± 0.484
0.41LysCys: 0.41 ± 0.154
2.869LysAsp: 2.869 ± 0.338
4.735LysGlu: 4.735 ± 0.549
2.595LysPhe: 2.595 ± 0.353
4.371LysGly: 4.371 ± 0.523
1.503LysHis: 1.503 ± 0.365
2.778LysIle: 2.778 ± 0.329
3.187LysLys: 3.187 ± 0.476
6.238LysLeu: 6.238 ± 0.581
2.003LysMet: 2.003 ± 0.27
3.506LysAsn: 3.506 ± 0.384
3.051LysPro: 3.051 ± 0.481
2.823LysGln: 2.823 ± 0.354
2.778LysArg: 2.778 ± 0.289
4.007LysSer: 4.007 ± 0.532
4.28LysThr: 4.28 ± 0.404
4.144LysVal: 4.144 ± 0.43
0.683LysTrp: 0.683 ± 0.23
1.73LysTyr: 1.73 ± 0.359
0.0LysXaa: 0.0 ± 0.0
Leu
7.194LeuAla: 7.194 ± 0.63
0.637LeuCys: 0.637 ± 0.189
4.872LeuAsp: 4.872 ± 0.457
4.417LeuGlu: 4.417 ± 0.405
2.914LeuPhe: 2.914 ± 0.34
6.693LeuGly: 6.693 ± 0.422
1.548LeuHis: 1.548 ± 0.287
4.144LeuIle: 4.144 ± 0.361
5.1LeuLys: 5.1 ± 0.432
5.646LeuLeu: 5.646 ± 0.539
2.504LeuMet: 2.504 ± 0.415
5.145LeuAsn: 5.145 ± 0.476
4.189LeuPro: 4.189 ± 0.358
3.233LeuGln: 3.233 ± 0.436
3.597LeuArg: 3.597 ± 0.464
5.145LeuSer: 5.145 ± 0.572
5.373LeuThr: 5.373 ± 0.438
5.874LeuVal: 5.874 ± 0.535
0.82LeuTrp: 0.82 ± 0.174
2.322LeuTyr: 2.322 ± 0.296
0.0LeuXaa: 0.0 ± 0.0
Met
2.641MetAla: 2.641 ± 0.449
0.137MetCys: 0.137 ± 0.08
1.32MetAsp: 1.32 ± 0.24
2.049MetGlu: 2.049 ± 0.298
0.592MetPhe: 0.592 ± 0.176
1.776MetGly: 1.776 ± 0.302
0.455MetHis: 0.455 ± 0.119
1.594MetIle: 1.594 ± 0.259
2.277MetLys: 2.277 ± 0.307
2.413MetLeu: 2.413 ± 0.417
0.683MetMet: 0.683 ± 0.17
2.277MetAsn: 2.277 ± 0.296
1.047MetPro: 1.047 ± 0.262
1.548MetGln: 1.548 ± 0.329
1.184MetArg: 1.184 ± 0.17
2.686MetSer: 2.686 ± 0.36
1.73MetThr: 1.73 ± 0.318
1.912MetVal: 1.912 ± 0.341
0.319MetTrp: 0.319 ± 0.104
0.865MetTyr: 0.865 ± 0.179
0.0MetXaa: 0.0 ± 0.0
Asn
4.371AsnAla: 4.371 ± 0.604
0.364AsnCys: 0.364 ± 0.138
2.96AsnAsp: 2.96 ± 0.359
3.324AsnGlu: 3.324 ± 0.462
2.049AsnPhe: 2.049 ± 0.304
3.961AsnGly: 3.961 ± 0.563
1.366AsnHis: 1.366 ± 0.257
3.415AsnIle: 3.415 ± 0.331
3.825AsnLys: 3.825 ± 0.416
4.599AsnLeu: 4.599 ± 0.506
1.412AsnMet: 1.412 ± 0.268
2.914AsnAsn: 2.914 ± 0.264
3.278AsnPro: 3.278 ± 0.43
3.552AsnGln: 3.552 ± 0.459
3.187AsnArg: 3.187 ± 0.316
2.914AsnSer: 2.914 ± 0.463
3.369AsnThr: 3.369 ± 0.465
3.187AsnVal: 3.187 ± 0.361
0.774AsnTrp: 0.774 ± 0.153
2.277AsnTyr: 2.277 ± 0.397
0.0AsnXaa: 0.0 ± 0.0
Pro
3.506ProAla: 3.506 ± 0.41
0.273ProCys: 0.273 ± 0.107
2.686ProAsp: 2.686 ± 0.394
4.052ProGlu: 4.052 ± 0.5
1.776ProPhe: 1.776 ± 0.269
2.869ProGly: 2.869 ± 0.433
0.41ProHis: 0.41 ± 0.138
2.277ProIle: 2.277 ± 0.238
2.003ProLys: 2.003 ± 0.245
3.096ProLeu: 3.096 ± 0.38
1.184ProMet: 1.184 ± 0.213
1.867ProAsn: 1.867 ± 0.268
0.911ProPro: 0.911 ± 0.301
1.32ProGln: 1.32 ± 0.271
1.412ProArg: 1.412 ± 0.324
2.55ProSer: 2.55 ± 0.312
3.142ProThr: 3.142 ± 0.337
3.688ProVal: 3.688 ± 0.508
0.683ProTrp: 0.683 ± 0.177
1.412ProTyr: 1.412 ± 0.273
0.0ProXaa: 0.0 ± 0.0
Gln
5.145GlnAla: 5.145 ± 0.908
0.455GlnCys: 0.455 ± 0.185
2.003GlnAsp: 2.003 ± 0.352
3.051GlnGlu: 3.051 ± 0.378
1.639GlnPhe: 1.639 ± 0.226
2.778GlnGly: 2.778 ± 0.431
0.364GlnHis: 0.364 ± 0.116
2.049GlnIle: 2.049 ± 0.246
2.732GlnLys: 2.732 ± 0.474
3.324GlnLeu: 3.324 ± 0.424
1.093GlnMet: 1.093 ± 0.218
2.186GlnAsn: 2.186 ± 0.431
0.956GlnPro: 0.956 ± 0.218
1.548GlnGln: 1.548 ± 0.35
1.958GlnArg: 1.958 ± 0.271
2.595GlnSer: 2.595 ± 0.322
2.914GlnThr: 2.914 ± 0.412
3.051GlnVal: 3.051 ± 0.319
0.455GlnTrp: 0.455 ± 0.141
1.776GlnTyr: 1.776 ± 0.287
0.0GlnXaa: 0.0 ± 0.0
Arg
3.552ArgAla: 3.552 ± 0.44
0.592ArgCys: 0.592 ± 0.161
2.049ArgAsp: 2.049 ± 0.253
2.96ArgGlu: 2.96 ± 0.423
1.639ArgPhe: 1.639 ± 0.234
2.641ArgGly: 2.641 ± 0.296
0.774ArgHis: 0.774 ± 0.188
2.732ArgIle: 2.732 ± 0.355
3.005ArgLys: 3.005 ± 0.426
4.007ArgLeu: 4.007 ± 0.496
1.457ArgMet: 1.457 ± 0.241
2.869ArgAsn: 2.869 ± 0.341
1.548ArgPro: 1.548 ± 0.272
1.958ArgGln: 1.958 ± 0.345
1.776ArgArg: 1.776 ± 0.296
2.595ArgSer: 2.595 ± 0.311
2.368ArgThr: 2.368 ± 0.318
2.277ArgVal: 2.277 ± 0.306
0.455ArgTrp: 0.455 ± 0.122
1.503ArgTyr: 1.503 ± 0.267
0.0ArgXaa: 0.0 ± 0.0
Ser
4.827SerAla: 4.827 ± 0.592
0.546SerCys: 0.546 ± 0.186
3.87SerAsp: 3.87 ± 0.379
3.87SerGlu: 3.87 ± 0.367
2.095SerPhe: 2.095 ± 0.416
4.599SerGly: 4.599 ± 0.391
0.956SerHis: 0.956 ± 0.197
3.597SerIle: 3.597 ± 0.372
4.007SerLys: 4.007 ± 0.563
5.692SerLeu: 5.692 ± 0.473
1.776SerMet: 1.776 ± 0.376
2.823SerAsn: 2.823 ± 0.387
2.595SerPro: 2.595 ± 0.464
2.368SerGln: 2.368 ± 0.417
2.459SerArg: 2.459 ± 0.475
3.87SerSer: 3.87 ± 0.548
3.825SerThr: 3.825 ± 0.578
4.007SerVal: 4.007 ± 0.451
0.637SerTrp: 0.637 ± 0.179
2.413SerTyr: 2.413 ± 0.372
0.0SerXaa: 0.0 ± 0.0
Thr
4.599ThrAla: 4.599 ± 0.568
0.364ThrCys: 0.364 ± 0.163
3.415ThrAsp: 3.415 ± 0.347
3.324ThrGlu: 3.324 ± 0.447
2.96ThrPhe: 2.96 ± 0.284
4.918ThrGly: 4.918 ± 0.523
0.865ThrHis: 0.865 ± 0.268
4.644ThrIle: 4.644 ± 0.489
4.644ThrLys: 4.644 ± 0.368
5.692ThrLeu: 5.692 ± 0.385
1.366ThrMet: 1.366 ± 0.272
4.144ThrAsn: 4.144 ± 0.438
3.734ThrPro: 3.734 ± 0.385
2.322ThrGln: 2.322 ± 0.243
2.504ThrArg: 2.504 ± 0.385
3.506ThrSer: 3.506 ± 0.382
3.643ThrThr: 3.643 ± 0.518
4.644ThrVal: 4.644 ± 0.474
0.774ThrTrp: 0.774 ± 0.204
2.186ThrTyr: 2.186 ± 0.378
0.0ThrXaa: 0.0 ± 0.0
Val
6.329ValAla: 6.329 ± 0.704
0.501ValCys: 0.501 ± 0.167
4.553ValAsp: 4.553 ± 0.39
3.825ValGlu: 3.825 ± 0.303
2.277ValPhe: 2.277 ± 0.34
4.963ValGly: 4.963 ± 0.571
1.457ValHis: 1.457 ± 0.204
3.142ValIle: 3.142 ± 0.54
3.916ValLys: 3.916 ± 0.417
4.644ValLeu: 4.644 ± 0.427
2.322ValMet: 2.322 ± 0.328
3.734ValAsn: 3.734 ± 0.417
2.869ValPro: 2.869 ± 0.41
3.233ValGln: 3.233 ± 0.394
3.324ValArg: 3.324 ± 0.348
3.825ValSer: 3.825 ± 0.502
4.599ValThr: 4.599 ± 0.536
5.1ValVal: 5.1 ± 0.521
0.637ValTrp: 0.637 ± 0.166
2.914ValTyr: 2.914 ± 0.445
0.0ValXaa: 0.0 ± 0.0
Trp
0.956TrpAla: 0.956 ± 0.215
0.228TrpCys: 0.228 ± 0.099
1.138TrpAsp: 1.138 ± 0.287
0.501TrpGlu: 0.501 ± 0.175
0.273TrpPhe: 0.273 ± 0.125
0.546TrpGly: 0.546 ± 0.131
0.319TrpHis: 0.319 ± 0.106
0.455TrpIle: 0.455 ± 0.151
0.774TrpLys: 0.774 ± 0.167
1.275TrpLeu: 1.275 ± 0.284
0.319TrpMet: 0.319 ± 0.1
0.546TrpAsn: 0.546 ± 0.182
0.319TrpPro: 0.319 ± 0.118
0.592TrpGln: 0.592 ± 0.158
0.455TrpArg: 0.455 ± 0.112
0.683TrpSer: 0.683 ± 0.144
0.41TrpThr: 0.41 ± 0.145
1.503TrpVal: 1.503 ± 0.254
0.046TrpTrp: 0.046 ± 0.046
0.455TrpTyr: 0.455 ± 0.178
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.005TyrAla: 3.005 ± 0.344
0.683TyrCys: 0.683 ± 0.23
2.732TyrAsp: 2.732 ± 0.34
2.049TyrGlu: 2.049 ± 0.282
1.503TyrPhe: 1.503 ± 0.327
2.504TyrGly: 2.504 ± 0.35
1.002TyrHis: 1.002 ± 0.265
2.322TyrIle: 2.322 ± 0.395
3.096TyrLys: 3.096 ± 0.529
2.231TyrLeu: 2.231 ± 0.271
0.956TyrMet: 0.956 ± 0.168
2.14TyrAsn: 2.14 ± 0.356
1.594TyrPro: 1.594 ± 0.308
1.503TyrGln: 1.503 ± 0.24
1.594TyrArg: 1.594 ± 0.319
2.14TyrSer: 2.14 ± 0.333
1.685TyrThr: 1.685 ± 0.303
3.051TyrVal: 3.051 ± 0.461
0.455TyrTrp: 0.455 ± 0.14
1.184TyrTyr: 1.184 ± 0.235
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (21963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski