Amino acid dipepetide frequency for Mycoplasma verecundum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.795AlaAla: 2.795 ± 0.123
0.285AlaCys: 0.285 ± 0.039
3.046AlaAsp: 3.046 ± 0.13
3.039AlaGlu: 3.039 ± 0.131
2.46AlaPhe: 2.46 ± 0.111
2.498AlaGly: 2.498 ± 0.126
0.834AlaHis: 0.834 ± 0.072
5.589AlaIle: 5.589 ± 0.204
6.457AlaLys: 6.457 ± 0.38
6.202AlaLeu: 6.202 ± 0.283
1.176AlaMet: 1.176 ± 0.074
4.74AlaAsn: 4.74 ± 0.254
1.333AlaPro: 1.333 ± 0.08
2.667AlaGln: 2.667 ± 0.144
1.784AlaArg: 1.784 ± 0.098
3.929AlaSer: 3.929 ± 0.16
3.351AlaThr: 3.351 ± 0.127
2.693AlaVal: 2.693 ± 0.116
0.394AlaTrp: 0.394 ± 0.041
2.306AlaTyr: 2.306 ± 0.107
0.0AlaXaa: 0.0 ± 0.0
Cys
0.263CysAla: 0.263 ± 0.033
0.06CysCys: 0.06 ± 0.018
0.368CysAsp: 0.368 ± 0.039
0.255CysGlu: 0.255 ± 0.037
0.312CysPhe: 0.312 ± 0.037
0.331CysGly: 0.331 ± 0.042
0.079CysHis: 0.079 ± 0.019
0.394CysIle: 0.394 ± 0.044
0.368CysLys: 0.368 ± 0.043
0.406CysLeu: 0.406 ± 0.044
0.071CysMet: 0.071 ± 0.018
0.282CysAsn: 0.282 ± 0.034
0.158CysPro: 0.158 ± 0.024
0.154CysGln: 0.154 ± 0.028
0.146CysArg: 0.146 ± 0.026
0.364CysSer: 0.364 ± 0.036
0.188CysThr: 0.188 ± 0.032
0.218CysVal: 0.218 ± 0.034
0.075CysTrp: 0.075 ± 0.016
0.195CysTyr: 0.195 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.407AspAla: 3.407 ± 0.209
0.21AspCys: 0.21 ± 0.03
3.343AspAsp: 3.343 ± 0.145
4.451AspGlu: 4.451 ± 0.143
3.478AspPhe: 3.478 ± 0.123
2.524AspGly: 2.524 ± 0.109
0.654AspHis: 0.654 ± 0.051
5.631AspIle: 5.631 ± 0.17
6.765AspLys: 6.765 ± 0.319
5.894AspLeu: 5.894 ± 0.206
0.898AspMet: 0.898 ± 0.067
4.808AspAsn: 4.808 ± 0.235
1.469AspPro: 1.469 ± 0.084
1.765AspGln: 1.765 ± 0.1
1.446AspArg: 1.446 ± 0.075
3.636AspSer: 3.636 ± 0.162
2.96AspThr: 2.96 ± 0.107
3.651AspVal: 3.651 ± 0.1
0.477AspTrp: 0.477 ± 0.042
2.877AspTyr: 2.877 ± 0.121
0.0AspXaa: 0.0 ± 0.0
Glu
4.019GluAla: 4.019 ± 0.217
0.237GluCys: 0.237 ± 0.034
2.723GluAsp: 2.723 ± 0.117
4.519GluGlu: 4.519 ± 0.177
3.193GluPhe: 3.193 ± 0.116
2.175GluGly: 2.175 ± 0.113
0.774GluHis: 0.774 ± 0.054
6.754GluIle: 6.754 ± 0.17
6.637GluLys: 6.637 ± 0.204
7.325GluLeu: 7.325 ± 0.211
1.367GluMet: 1.367 ± 0.081
4.977GluAsn: 4.977 ± 0.163
1.39GluPro: 1.39 ± 0.078
3.182GluGln: 3.182 ± 0.126
1.657GluArg: 1.657 ± 0.088
3.208GluSer: 3.208 ± 0.115
3.291GluThr: 3.291 ± 0.119
3.681GluVal: 3.681 ± 0.131
0.575GluTrp: 0.575 ± 0.053
2.956GluTyr: 2.956 ± 0.118
0.0GluXaa: 0.0 ± 0.0
Phe
2.738PheAla: 2.738 ± 0.109
0.342PheCys: 0.342 ± 0.031
3.599PheAsp: 3.599 ± 0.117
2.69PheGlu: 2.69 ± 0.117
1.998PhePhe: 1.998 ± 0.134
2.434PheGly: 2.434 ± 0.127
0.507PheHis: 0.507 ± 0.043
5.026PheIle: 5.026 ± 0.233
4.455PheLys: 4.455 ± 0.142
3.873PheLeu: 3.873 ± 0.165
0.879PheMet: 0.879 ± 0.062
4.061PheAsn: 4.061 ± 0.136
1.172PhePro: 1.172 ± 0.075
1.21PheGln: 1.21 ± 0.075
1.315PheArg: 1.315 ± 0.079
3.189PheSer: 3.189 ± 0.143
2.641PheThr: 2.641 ± 0.114
2.753PheVal: 2.753 ± 0.122
0.53PheTrp: 0.53 ± 0.041
2.051PheTyr: 2.051 ± 0.117
0.0PheXaa: 0.0 ± 0.0
Gly
2.344GlyAla: 2.344 ± 0.108
0.177GlyCys: 0.177 ± 0.028
2.325GlyAsp: 2.325 ± 0.103
2.186GlyGlu: 2.186 ± 0.092
2.487GlyPhe: 2.487 ± 0.118
2.498GlyGly: 2.498 ± 0.148
0.774GlyHis: 0.774 ± 0.056
4.267GlyIle: 4.267 ± 0.175
4.027GlyLys: 4.027 ± 0.155
3.764GlyLeu: 3.764 ± 0.142
0.962GlyMet: 0.962 ± 0.068
2.731GlyAsn: 2.731 ± 0.116
0.766GlyPro: 0.766 ± 0.058
1.54GlyGln: 1.54 ± 0.101
1.476GlyArg: 1.476 ± 0.102
2.738GlySer: 2.738 ± 0.132
2.622GlyThr: 2.622 ± 0.116
2.907GlyVal: 2.907 ± 0.134
0.394GlyTrp: 0.394 ± 0.044
2.201GlyTyr: 2.201 ± 0.107
0.0GlyXaa: 0.0 ± 0.0
His
0.627HisAla: 0.627 ± 0.059
0.083HisCys: 0.083 ± 0.016
0.736HisAsp: 0.736 ± 0.057
0.838HisGlu: 0.838 ± 0.058
0.732HisPhe: 0.732 ± 0.059
0.691HisGly: 0.691 ± 0.051
0.207HisHis: 0.207 ± 0.029
1.296HisIle: 1.296 ± 0.079
1.345HisLys: 1.345 ± 0.069
1.258HisLeu: 1.258 ± 0.073
0.255HisMet: 0.255 ± 0.037
1.266HisAsn: 1.266 ± 0.08
0.597HisPro: 0.597 ± 0.046
0.518HisGln: 0.518 ± 0.045
0.443HisArg: 0.443 ± 0.045
0.905HisSer: 0.905 ± 0.064
0.654HisThr: 0.654 ± 0.049
0.65HisVal: 0.65 ± 0.044
0.154HisTrp: 0.154 ± 0.024
0.548HisTyr: 0.548 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
5.36IleAla: 5.36 ± 0.156
0.526IleCys: 0.526 ± 0.055
5.988IleAsp: 5.988 ± 0.186
5.465IleGlu: 5.465 ± 0.141
4.132IlePhe: 4.132 ± 0.213
3.869IleGly: 3.869 ± 0.179
1.108IleHis: 1.108 ± 0.087
7.595IleIle: 7.595 ± 0.29
8.782IleLys: 8.782 ± 0.223
7.794IleLeu: 7.794 ± 0.298
1.45IleMet: 1.45 ± 0.091
8.782IleAsn: 8.782 ± 0.279
2.84IlePro: 2.84 ± 0.136
3.148IleGln: 3.148 ± 0.11
2.295IleArg: 2.295 ± 0.118
6.893IleSer: 6.893 ± 0.192
5.24IleThr: 5.24 ± 0.162
4.932IleVal: 4.932 ± 0.186
0.699IleTrp: 0.699 ± 0.059
3.659IleTyr: 3.659 ± 0.172
0.0IleXaa: 0.0 ± 0.0
Lys
6.066LysAla: 6.066 ± 0.457
0.368LysCys: 0.368 ± 0.046
6.269LysAsp: 6.269 ± 0.276
7.569LysGlu: 7.569 ± 0.297
3.952LysPhe: 3.952 ± 0.136
3.294LysGly: 3.294 ± 0.124
1.379LysHis: 1.379 ± 0.078
8.177LysIle: 8.177 ± 0.234
7.757LysLys: 7.757 ± 0.194
9.755LysLeu: 9.755 ± 0.325
2.265LysMet: 2.265 ± 0.112
7.783LysAsn: 7.783 ± 0.206
2.415LysPro: 2.415 ± 0.119
4.222LysGln: 4.222 ± 0.201
2.603LysArg: 2.603 ± 0.124
5.71LysSer: 5.71 ± 0.194
5.236LysThr: 5.236 ± 0.209
5.172LysVal: 5.172 ± 0.157
0.86LysTrp: 0.86 ± 0.063
5.477LysTyr: 5.477 ± 0.16
0.0LysXaa: 0.0 ± 0.0
Leu
5.74LeuAla: 5.74 ± 0.165
0.552LeuCys: 0.552 ± 0.05
6.205LeuAsp: 6.205 ± 0.285
5.984LeuGlu: 5.984 ± 0.178
4.387LeuPhe: 4.387 ± 0.183
4.079LeuGly: 4.079 ± 0.162
1.345LeuHis: 1.345 ± 0.088
8.467LeuIle: 8.467 ± 0.226
8.516LeuLys: 8.516 ± 0.223
8.14LeuLeu: 8.14 ± 0.201
1.548LeuMet: 1.548 ± 0.088
9.011LeuAsn: 9.011 ± 0.402
2.825LeuPro: 2.825 ± 0.129
3.584LeuGln: 3.584 ± 0.147
2.614LeuArg: 2.614 ± 0.116
7.362LeuSer: 7.362 ± 0.173
5.079LeuThr: 5.079 ± 0.187
5.278LeuVal: 5.278 ± 0.154
0.669LeuTrp: 0.669 ± 0.052
3.287LeuTyr: 3.287 ± 0.147
0.0LeuXaa: 0.0 ± 0.0
Met
0.917MetAla: 0.917 ± 0.068
0.09MetCys: 0.09 ± 0.021
0.973MetAsp: 0.973 ± 0.067
0.958MetGlu: 0.958 ± 0.067
1.056MetPhe: 1.056 ± 0.074
0.774MetGly: 0.774 ± 0.059
0.301MetHis: 0.301 ± 0.038
1.57MetIle: 1.57 ± 0.103
1.867MetLys: 1.867 ± 0.092
1.69MetLeu: 1.69 ± 0.084
0.409MetMet: 0.409 ± 0.042
1.277MetAsn: 1.277 ± 0.079
0.706MetPro: 0.706 ± 0.055
0.913MetGln: 0.913 ± 0.059
0.552MetArg: 0.552 ± 0.05
1.356MetSer: 1.356 ± 0.078
0.841MetThr: 0.841 ± 0.062
0.992MetVal: 0.992 ± 0.074
0.124MetTrp: 0.124 ± 0.019
0.744MetTyr: 0.744 ± 0.053
0.0MetXaa: 0.0 ± 0.0
Asn
4.616AsnAla: 4.616 ± 0.308
0.312AsnCys: 0.312 ± 0.039
5.417AsnAsp: 5.417 ± 0.261
6.081AsnGlu: 6.081 ± 0.219
3.317AsnPhe: 3.317 ± 0.118
3.445AsnGly: 3.445 ± 0.119
1.138AsnHis: 1.138 ± 0.074
7.637AsnIle: 7.637 ± 0.255
9.372AsnLys: 9.372 ± 0.325
7.28AsnLeu: 7.28 ± 0.284
1.198AsnMet: 1.198 ± 0.076
8.23AsnAsn: 8.23 ± 0.399
2.697AsnPro: 2.697 ± 0.136
3.144AsnGln: 3.144 ± 0.156
2.081AsnArg: 2.081 ± 0.11
5.526AsnSer: 5.526 ± 0.216
4.417AsnThr: 4.417 ± 0.192
4.301AsnVal: 4.301 ± 0.126
0.778AsnTrp: 0.778 ± 0.048
3.749AsnTyr: 3.749 ± 0.146
0.0AsnXaa: 0.0 ± 0.0
Pro
1.619ProAla: 1.619 ± 0.108
0.098ProCys: 0.098 ± 0.019
1.439ProAsp: 1.439 ± 0.074
2.1ProGlu: 2.1 ± 0.101
1.431ProPhe: 1.431 ± 0.071
1.292ProGly: 1.292 ± 0.088
0.466ProHis: 0.466 ± 0.043
2.314ProIle: 2.314 ± 0.108
2.299ProLys: 2.299 ± 0.109
2.363ProLeu: 2.363 ± 0.091
0.439ProMet: 0.439 ± 0.037
2.344ProAsn: 2.344 ± 0.083
0.522ProPro: 0.522 ± 0.058
1.01ProGln: 1.01 ± 0.064
0.706ProArg: 0.706 ± 0.053
1.972ProSer: 1.972 ± 0.097
1.604ProThr: 1.604 ± 0.094
1.724ProVal: 1.724 ± 0.122
0.278ProTrp: 0.278 ± 0.036
1.461ProTyr: 1.461 ± 0.082
0.0ProXaa: 0.0 ± 0.0
Gln
2.69GlnAla: 2.69 ± 0.166
0.124GlnCys: 0.124 ± 0.024
2.502GlnAsp: 2.502 ± 0.135
2.505GlnGlu: 2.505 ± 0.127
1.581GlnPhe: 1.581 ± 0.07
1.416GlnGly: 1.416 ± 0.074
0.597GlnHis: 0.597 ± 0.039
3.445GlnIle: 3.445 ± 0.131
3.696GlnLys: 3.696 ± 0.187
3.715GlnLeu: 3.715 ± 0.137
0.639GlnMet: 0.639 ± 0.053
3.591GlnAsn: 3.591 ± 0.151
1.007GlnPro: 1.007 ± 0.076
1.773GlnGln: 1.773 ± 0.114
1.116GlnArg: 1.116 ± 0.066
2.171GlnSer: 2.171 ± 0.106
1.919GlnThr: 1.919 ± 0.105
2.055GlnVal: 2.055 ± 0.111
0.402GlnTrp: 0.402 ± 0.045
2.021GlnTyr: 2.021 ± 0.098
0.0GlnXaa: 0.0 ± 0.0
Arg
1.54ArgAla: 1.54 ± 0.093
0.135ArgCys: 0.135 ± 0.025
1.672ArgAsp: 1.672 ± 0.09
1.878ArgGlu: 1.878 ± 0.118
1.307ArgPhe: 1.307 ± 0.071
1.3ArgGly: 1.3 ± 0.095
0.379ArgHis: 0.379 ± 0.037
2.374ArgIle: 2.374 ± 0.114
2.528ArgLys: 2.528 ± 0.121
2.622ArgLeu: 2.622 ± 0.118
0.665ArgMet: 0.665 ± 0.047
2.303ArgAsn: 2.303 ± 0.114
0.789ArgPro: 0.789 ± 0.052
0.977ArgGln: 0.977 ± 0.075
1.01ArgArg: 1.01 ± 0.076
1.442ArgSer: 1.442 ± 0.071
1.491ArgThr: 1.491 ± 0.075
1.657ArgVal: 1.657 ± 0.093
0.316ArgTrp: 0.316 ± 0.038
1.326ArgTyr: 1.326 ± 0.079
0.0ArgXaa: 0.0 ± 0.0
Ser
3.493SerAla: 3.493 ± 0.123
0.372SerCys: 0.372 ± 0.039
4.098SerAsp: 4.098 ± 0.175
4.327SerGlu: 4.327 ± 0.148
3.351SerPhe: 3.351 ± 0.13
3.167SerGly: 3.167 ± 0.136
0.92SerHis: 0.92 ± 0.072
5.71SerIle: 5.71 ± 0.159
6.461SerLys: 6.461 ± 0.224
6.656SerLeu: 6.656 ± 0.155
1.033SerMet: 1.033 ± 0.074
5.559SerAsn: 5.559 ± 0.218
1.551SerPro: 1.551 ± 0.071
2.674SerGln: 2.674 ± 0.106
1.728SerArg: 1.728 ± 0.09
4.346SerSer: 4.346 ± 0.153
3.557SerThr: 3.557 ± 0.127
3.26SerVal: 3.26 ± 0.108
0.624SerTrp: 0.624 ± 0.048
3.013SerTyr: 3.013 ± 0.105
0.0SerXaa: 0.0 ± 0.0
Thr
2.795ThrAla: 2.795 ± 0.121
0.207ThrCys: 0.207 ± 0.031
2.806ThrAsp: 2.806 ± 0.128
2.941ThrGlu: 2.941 ± 0.139
2.697ThrPhe: 2.697 ± 0.106
2.644ThrGly: 2.644 ± 0.128
0.856ThrHis: 0.856 ± 0.057
4.823ThrIle: 4.823 ± 0.134
5.112ThrLys: 5.112 ± 0.207
5.409ThrLeu: 5.409 ± 0.165
0.796ThrMet: 0.796 ± 0.055
4.538ThrAsn: 4.538 ± 0.201
2.186ThrPro: 2.186 ± 0.091
2.205ThrGln: 2.205 ± 0.151
1.559ThrArg: 1.559 ± 0.079
3.662ThrSer: 3.662 ± 0.131
3.493ThrThr: 3.493 ± 0.128
2.994ThrVal: 2.994 ± 0.105
0.466ThrTrp: 0.466 ± 0.043
2.449ThrTyr: 2.449 ± 0.121
0.0ThrXaa: 0.0 ± 0.0
Val
3.753ValAla: 3.753 ± 0.157
0.255ValCys: 0.255 ± 0.032
3.493ValAsp: 3.493 ± 0.122
3.659ValGlu: 3.659 ± 0.143
2.611ValPhe: 2.611 ± 0.135
2.363ValGly: 2.363 ± 0.126
0.661ValHis: 0.661 ± 0.056
4.898ValIle: 4.898 ± 0.182
4.778ValLys: 4.778 ± 0.167
5.086ValLeu: 5.086 ± 0.161
1.044ValMet: 1.044 ± 0.072
3.959ValAsn: 3.959 ± 0.145
1.679ValPro: 1.679 ± 0.086
1.95ValGln: 1.95 ± 0.091
1.533ValArg: 1.533 ± 0.077
4.143ValSer: 4.143 ± 0.133
3.332ValThr: 3.332 ± 0.115
3.505ValVal: 3.505 ± 0.139
0.439ValTrp: 0.439 ± 0.049
2.179ValTyr: 2.179 ± 0.087
0.0ValXaa: 0.0 ± 0.0
Trp
0.424TrpAla: 0.424 ± 0.043
0.045TrpCys: 0.045 ± 0.013
0.533TrpAsp: 0.533 ± 0.051
0.537TrpGlu: 0.537 ± 0.046
0.605TrpPhe: 0.605 ± 0.057
0.331TrpGly: 0.331 ± 0.035
0.109TrpHis: 0.109 ± 0.022
0.905TrpIle: 0.905 ± 0.068
0.755TrpLys: 0.755 ± 0.055
0.793TrpLeu: 0.793 ± 0.064
0.252TrpMet: 0.252 ± 0.028
0.864TrpAsn: 0.864 ± 0.053
0.21TrpPro: 0.21 ± 0.026
0.289TrpGln: 0.289 ± 0.038
0.255TrpArg: 0.255 ± 0.03
0.451TrpSer: 0.451 ± 0.044
0.481TrpThr: 0.481 ± 0.043
0.47TrpVal: 0.47 ± 0.051
0.135TrpTrp: 0.135 ± 0.022
0.515TrpTyr: 0.515 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.374TyrAla: 2.374 ± 0.088
0.21TyrCys: 0.21 ± 0.03
2.81TyrAsp: 2.81 ± 0.113
2.656TyrGlu: 2.656 ± 0.118
2.374TyrPhe: 2.374 ± 0.133
2.062TyrGly: 2.062 ± 0.094
0.717TyrHis: 0.717 ± 0.055
3.685TyrIle: 3.685 ± 0.175
4.357TyrLys: 4.357 ± 0.155
4.647TyrLeu: 4.647 ± 0.155
0.759TyrMet: 0.759 ± 0.059
3.629TyrAsn: 3.629 ± 0.161
1.168TyrPro: 1.168 ± 0.071
2.04TyrGln: 2.04 ± 0.089
1.39TyrArg: 1.39 ± 0.077
2.896TyrSer: 2.896 ± 0.113
2.243TyrThr: 2.243 ± 0.092
2.427TyrVal: 2.427 ± 0.109
0.571TyrTrp: 0.571 ± 0.045
1.912TyrTyr: 1.912 ± 0.117
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 671 proteins (266221 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski