Amino acid dipepetide frequency for Streptococcus phage Javan215

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.44AlaAla: 4.44 ± 1.216
0.586AlaCys: 0.586 ± 0.308
5.613AlaAsp: 5.613 ± 0.598
6.2AlaGlu: 6.2 ± 0.735
2.765AlaPhe: 2.765 ± 0.523
5.111AlaGly: 5.111 ± 1.012
1.005AlaHis: 1.005 ± 0.262
5.362AlaIle: 5.362 ± 1.091
6.702AlaLys: 6.702 ± 0.935
5.529AlaLeu: 5.529 ± 0.741
1.508AlaMet: 1.508 ± 0.415
3.686AlaAsn: 3.686 ± 0.515
1.34AlaPro: 1.34 ± 0.366
2.011AlaGln: 2.011 ± 0.537
1.843AlaArg: 1.843 ± 0.274
3.519AlaSer: 3.519 ± 0.715
5.362AlaThr: 5.362 ± 1.061
4.44AlaVal: 4.44 ± 0.636
1.34AlaTrp: 1.34 ± 0.432
3.686AlaTyr: 3.686 ± 0.465
0.0AlaXaa: 0.0 ± 0.0
Cys
0.251CysAla: 0.251 ± 0.169
0.0CysCys: 0.0 ± 0.0
0.503CysAsp: 0.503 ± 0.203
0.922CysGlu: 0.922 ± 0.269
0.168CysPhe: 0.168 ± 0.112
0.419CysGly: 0.419 ± 0.228
0.251CysHis: 0.251 ± 0.182
0.168CysIle: 0.168 ± 0.126
0.586CysLys: 0.586 ± 0.239
0.335CysLeu: 0.335 ± 0.178
0.251CysMet: 0.251 ± 0.161
0.503CysAsn: 0.503 ± 0.221
0.251CysPro: 0.251 ± 0.131
0.251CysGln: 0.251 ± 0.171
0.251CysArg: 0.251 ± 0.188
0.838CysSer: 0.838 ± 0.271
0.419CysThr: 0.419 ± 0.18
0.168CysVal: 0.168 ± 0.117
0.168CysTrp: 0.168 ± 0.115
0.754CysTyr: 0.754 ± 0.276
0.0CysXaa: 0.0 ± 0.0
Asp
2.765AspAla: 2.765 ± 0.674
1.089AspCys: 1.089 ± 0.371
4.273AspAsp: 4.273 ± 0.795
6.2AspGlu: 6.2 ± 0.913
3.938AspPhe: 3.938 ± 0.545
5.446AspGly: 5.446 ± 0.564
0.754AspHis: 0.754 ± 0.243
3.603AspIle: 3.603 ± 0.701
5.948AspLys: 5.948 ± 0.655
4.692AspLeu: 4.692 ± 0.703
1.592AspMet: 1.592 ± 0.305
4.524AspAsn: 4.524 ± 0.507
1.508AspPro: 1.508 ± 0.314
1.676AspGln: 1.676 ± 0.543
1.927AspArg: 1.927 ± 0.437
4.273AspSer: 4.273 ± 0.605
3.686AspThr: 3.686 ± 0.453
3.854AspVal: 3.854 ± 0.479
1.005AspTrp: 1.005 ± 0.28
3.1AspTyr: 3.1 ± 0.525
0.0AspXaa: 0.0 ± 0.0
Glu
5.613GluAla: 5.613 ± 0.785
0.251GluCys: 0.251 ± 0.152
4.357GluAsp: 4.357 ± 0.725
5.194GluGlu: 5.194 ± 1.163
2.765GluPhe: 2.765 ± 0.534
3.854GluGly: 3.854 ± 0.637
0.922GluHis: 0.922 ± 0.292
4.692GluIle: 4.692 ± 0.543
5.111GluLys: 5.111 ± 0.973
7.708GluLeu: 7.708 ± 1.217
2.765GluMet: 2.765 ± 0.555
4.692GluAsn: 4.692 ± 0.815
2.095GluPro: 2.095 ± 0.547
2.849GluGln: 2.849 ± 0.531
2.011GluArg: 2.011 ± 0.441
4.021GluSer: 4.021 ± 0.657
5.529GluThr: 5.529 ± 0.537
7.038GluVal: 7.038 ± 0.891
1.005GluTrp: 1.005 ± 0.31
3.1GluTyr: 3.1 ± 0.465
0.0GluXaa: 0.0 ± 0.0
Phe
1.927PheAla: 1.927 ± 0.369
0.251PheCys: 0.251 ± 0.191
2.765PheAsp: 2.765 ± 0.522
3.603PheGlu: 3.603 ± 0.61
1.927PhePhe: 1.927 ± 0.693
2.681PheGly: 2.681 ± 0.5
0.586PheHis: 0.586 ± 0.177
1.676PheIle: 1.676 ± 0.355
3.519PheLys: 3.519 ± 0.599
2.513PheLeu: 2.513 ± 0.501
0.335PheMet: 0.335 ± 0.239
2.849PheAsn: 2.849 ± 0.606
0.922PhePro: 0.922 ± 0.336
1.089PheGln: 1.089 ± 0.28
1.759PheArg: 1.759 ± 0.336
3.435PheSer: 3.435 ± 0.971
1.759PheThr: 1.759 ± 0.336
1.927PheVal: 1.927 ± 0.451
0.922PheTrp: 0.922 ± 0.287
2.262PheTyr: 2.262 ± 0.32
0.0PheXaa: 0.0 ± 0.0
Gly
4.943GlyAla: 4.943 ± 0.945
0.335GlyCys: 0.335 ± 0.152
3.77GlyAsp: 3.77 ± 0.644
3.938GlyGlu: 3.938 ± 0.563
3.184GlyPhe: 3.184 ± 0.518
5.781GlyGly: 5.781 ± 0.97
1.173GlyHis: 1.173 ± 0.305
4.692GlyIle: 4.692 ± 1.267
5.781GlyLys: 5.781 ± 0.687
5.948GlyLeu: 5.948 ± 0.781
1.508GlyMet: 1.508 ± 0.336
3.351GlyAsn: 3.351 ± 0.583
1.005GlyPro: 1.005 ± 0.326
3.016GlyGln: 3.016 ± 0.581
2.597GlyArg: 2.597 ± 0.52
4.692GlySer: 4.692 ± 0.942
4.775GlyThr: 4.775 ± 0.838
4.692GlyVal: 4.692 ± 1.112
1.173GlyTrp: 1.173 ± 0.231
3.686GlyTyr: 3.686 ± 0.594
0.0GlyXaa: 0.0 ± 0.0
His
0.754HisAla: 0.754 ± 0.263
0.168HisCys: 0.168 ± 0.115
1.089HisAsp: 1.089 ± 0.354
0.754HisGlu: 0.754 ± 0.287
0.251HisPhe: 0.251 ± 0.137
0.922HisGly: 0.922 ± 0.215
0.084HisHis: 0.084 ± 0.081
1.005HisIle: 1.005 ± 0.273
0.419HisLys: 0.419 ± 0.197
1.759HisLeu: 1.759 ± 0.32
0.335HisMet: 0.335 ± 0.144
0.838HisAsn: 0.838 ± 0.257
0.586HisPro: 0.586 ± 0.175
0.419HisGln: 0.419 ± 0.174
0.419HisArg: 0.419 ± 0.193
0.922HisSer: 0.922 ± 0.239
0.503HisThr: 0.503 ± 0.238
0.838HisVal: 0.838 ± 0.281
0.251HisTrp: 0.251 ± 0.132
0.168HisTyr: 0.168 ± 0.1
0.0HisXaa: 0.0 ± 0.0
Ile
4.357IleAla: 4.357 ± 0.496
0.251IleCys: 0.251 ± 0.145
4.189IleAsp: 4.189 ± 0.607
4.357IleGlu: 4.357 ± 0.551
2.011IlePhe: 2.011 ± 0.407
3.351IleGly: 3.351 ± 0.509
0.838IleHis: 0.838 ± 0.213
3.603IleIle: 3.603 ± 0.607
5.781IleLys: 5.781 ± 0.796
4.189IleLeu: 4.189 ± 0.593
1.173IleMet: 1.173 ± 0.256
4.105IleAsn: 4.105 ± 0.703
1.759IlePro: 1.759 ± 0.389
2.346IleGln: 2.346 ± 0.449
2.095IleArg: 2.095 ± 0.467
4.608IleSer: 4.608 ± 0.733
4.692IleThr: 4.692 ± 0.744
2.849IleVal: 2.849 ± 0.562
0.922IleTrp: 0.922 ± 0.375
2.178IleTyr: 2.178 ± 0.498
0.0IleXaa: 0.0 ± 0.0
Lys
6.451LysAla: 6.451 ± 0.77
0.586LysCys: 0.586 ± 0.235
5.446LysAsp: 5.446 ± 0.85
6.702LysGlu: 6.702 ± 1.058
2.011LysPhe: 2.011 ± 0.447
5.697LysGly: 5.697 ± 0.644
0.922LysHis: 0.922 ± 0.278
5.027LysIle: 5.027 ± 0.786
5.362LysLys: 5.362 ± 1.089
7.205LysLeu: 7.205 ± 1.079
1.759LysMet: 1.759 ± 0.334
5.362LysAsn: 5.362 ± 0.499
1.843LysPro: 1.843 ± 0.387
3.854LysGln: 3.854 ± 0.595
3.351LysArg: 3.351 ± 0.584
4.859LysSer: 4.859 ± 0.992
6.451LysThr: 6.451 ± 0.847
5.865LysVal: 5.865 ± 0.639
1.424LysTrp: 1.424 ± 0.319
2.43LysTyr: 2.43 ± 0.44
0.0LysXaa: 0.0 ± 0.0
Leu
4.943LeuAla: 4.943 ± 0.646
0.419LeuCys: 0.419 ± 0.224
4.943LeuAsp: 4.943 ± 0.766
6.619LeuGlu: 6.619 ± 1.081
3.016LeuPhe: 3.016 ± 0.471
6.2LeuGly: 6.2 ± 0.677
1.173LeuHis: 1.173 ± 0.326
4.189LeuIle: 4.189 ± 0.719
9.551LeuLys: 9.551 ± 1.694
4.692LeuLeu: 4.692 ± 0.757
1.089LeuMet: 1.089 ± 0.31
4.357LeuAsn: 4.357 ± 0.829
2.513LeuPro: 2.513 ± 0.425
2.932LeuGln: 2.932 ± 0.513
2.765LeuArg: 2.765 ± 0.427
5.697LeuSer: 5.697 ± 0.572
5.446LeuThr: 5.446 ± 0.708
5.362LeuVal: 5.362 ± 0.565
0.838LeuTrp: 0.838 ± 0.476
1.843LeuTyr: 1.843 ± 0.356
0.0LeuXaa: 0.0 ± 0.0
Met
2.095MetAla: 2.095 ± 0.358
0.084MetCys: 0.084 ± 0.095
0.754MetAsp: 0.754 ± 0.275
1.34MetGlu: 1.34 ± 0.337
0.67MetPhe: 0.67 ± 0.25
0.67MetGly: 0.67 ± 0.249
0.084MetHis: 0.084 ± 0.083
1.34MetIle: 1.34 ± 0.355
2.178MetLys: 2.178 ± 0.474
2.178MetLeu: 2.178 ± 0.411
0.67MetMet: 0.67 ± 0.213
1.34MetAsn: 1.34 ± 0.333
0.67MetPro: 0.67 ± 0.239
1.173MetGln: 1.173 ± 0.335
0.838MetArg: 0.838 ± 0.239
1.508MetSer: 1.508 ± 0.348
2.178MetThr: 2.178 ± 0.393
0.754MetVal: 0.754 ± 0.256
0.419MetTrp: 0.419 ± 0.159
1.005MetTyr: 1.005 ± 0.279
0.0MetXaa: 0.0 ± 0.0
Asn
5.865AsnAla: 5.865 ± 0.864
0.335AsnCys: 0.335 ± 0.182
3.351AsnAsp: 3.351 ± 0.458
4.273AsnGlu: 4.273 ± 0.715
2.346AsnPhe: 2.346 ± 0.391
5.529AsnGly: 5.529 ± 1.072
0.419AsnHis: 0.419 ± 0.146
3.686AsnIle: 3.686 ± 0.462
4.859AsnLys: 4.859 ± 0.858
4.105AsnLeu: 4.105 ± 0.494
1.257AsnMet: 1.257 ± 0.416
3.77AsnAsn: 3.77 ± 0.704
2.43AsnPro: 2.43 ± 0.485
2.346AsnGln: 2.346 ± 0.418
2.178AsnArg: 2.178 ± 0.44
3.435AsnSer: 3.435 ± 0.505
3.435AsnThr: 3.435 ± 0.535
3.77AsnVal: 3.77 ± 0.468
1.257AsnTrp: 1.257 ± 0.425
2.262AsnTyr: 2.262 ± 0.377
0.0AsnXaa: 0.0 ± 0.0
Pro
2.932ProAla: 2.932 ± 0.466
0.0ProCys: 0.0 ± 0.0
1.927ProAsp: 1.927 ± 0.448
2.849ProGlu: 2.849 ± 0.619
0.922ProPhe: 0.922 ± 0.233
0.67ProGly: 0.67 ± 0.228
0.419ProHis: 0.419 ± 0.263
1.34ProIle: 1.34 ± 0.295
1.759ProLys: 1.759 ± 0.408
1.005ProLeu: 1.005 ± 0.374
0.586ProMet: 0.586 ± 0.214
1.257ProAsn: 1.257 ± 0.285
0.503ProPro: 0.503 ± 0.244
0.754ProGln: 0.754 ± 0.238
1.173ProArg: 1.173 ± 0.338
1.34ProSer: 1.34 ± 0.274
1.927ProThr: 1.927 ± 0.503
1.759ProVal: 1.759 ± 0.366
0.335ProTrp: 0.335 ± 0.178
1.257ProTyr: 1.257 ± 0.369
0.0ProXaa: 0.0 ± 0.0
Gln
3.519GlnAla: 3.519 ± 0.47
0.67GlnCys: 0.67 ± 0.24
2.011GlnAsp: 2.011 ± 0.328
3.519GlnGlu: 3.519 ± 0.544
1.676GlnPhe: 1.676 ± 0.355
2.765GlnGly: 2.765 ± 0.817
0.251GlnHis: 0.251 ± 0.14
2.262GlnIle: 2.262 ± 0.52
2.513GlnLys: 2.513 ± 0.431
2.849GlnLeu: 2.849 ± 0.361
1.173GlnMet: 1.173 ± 0.289
2.178GlnAsn: 2.178 ± 0.443
0.67GlnPro: 0.67 ± 0.189
1.843GlnGln: 1.843 ± 0.531
1.676GlnArg: 1.676 ± 0.295
1.508GlnSer: 1.508 ± 0.404
2.597GlnThr: 2.597 ± 0.459
2.346GlnVal: 2.346 ± 0.46
0.503GlnTrp: 0.503 ± 0.181
1.173GlnTyr: 1.173 ± 0.27
0.0GlnXaa: 0.0 ± 0.0
Arg
2.43ArgAla: 2.43 ± 0.565
0.251ArgCys: 0.251 ± 0.165
1.843ArgAsp: 1.843 ± 0.43
1.843ArgGlu: 1.843 ± 0.462
1.508ArgPhe: 1.508 ± 0.396
2.262ArgGly: 2.262 ± 0.522
0.503ArgHis: 0.503 ± 0.221
2.178ArgIle: 2.178 ± 0.424
3.519ArgLys: 3.519 ± 0.657
3.1ArgLeu: 3.1 ± 0.62
0.922ArgMet: 0.922 ± 0.293
2.43ArgAsn: 2.43 ± 0.418
0.754ArgPro: 0.754 ± 0.269
2.095ArgGln: 2.095 ± 0.454
2.178ArgArg: 2.178 ± 0.563
1.34ArgSer: 1.34 ± 0.248
2.597ArgThr: 2.597 ± 0.382
2.765ArgVal: 2.765 ± 0.511
0.838ArgTrp: 0.838 ± 0.285
1.759ArgTyr: 1.759 ± 0.393
0.0ArgXaa: 0.0 ± 0.0
Ser
3.938SerAla: 3.938 ± 0.574
0.503SerCys: 0.503 ± 0.187
4.859SerAsp: 4.859 ± 0.629
4.105SerGlu: 4.105 ± 0.749
2.178SerPhe: 2.178 ± 0.49
6.367SerGly: 6.367 ± 1.0
0.67SerHis: 0.67 ± 0.25
4.021SerIle: 4.021 ± 0.67
4.608SerLys: 4.608 ± 0.677
4.692SerLeu: 4.692 ± 0.477
1.34SerMet: 1.34 ± 0.347
4.44SerAsn: 4.44 ± 0.664
0.67SerPro: 0.67 ± 0.195
2.597SerGln: 2.597 ± 0.407
2.011SerArg: 2.011 ± 0.501
4.608SerSer: 4.608 ± 0.811
4.273SerThr: 4.273 ± 0.722
4.105SerVal: 4.105 ± 0.802
0.922SerTrp: 0.922 ± 0.24
2.346SerTyr: 2.346 ± 0.414
0.0SerXaa: 0.0 ± 0.0
Thr
6.284ThrAla: 6.284 ± 0.675
0.335ThrCys: 0.335 ± 0.149
4.943ThrAsp: 4.943 ± 0.81
4.105ThrGlu: 4.105 ± 0.614
2.513ThrPhe: 2.513 ± 0.488
5.111ThrGly: 5.111 ± 0.861
0.67ThrHis: 0.67 ± 0.236
5.111ThrIle: 5.111 ± 0.627
5.446ThrLys: 5.446 ± 0.777
5.362ThrLeu: 5.362 ± 0.674
1.005ThrMet: 1.005 ± 0.276
3.016ThrAsn: 3.016 ± 0.599
1.927ThrPro: 1.927 ± 0.422
2.513ThrGln: 2.513 ± 0.535
2.262ThrArg: 2.262 ± 0.446
3.938ThrSer: 3.938 ± 0.698
4.105ThrThr: 4.105 ± 0.87
6.954ThrVal: 6.954 ± 1.201
0.67ThrTrp: 0.67 ± 0.263
2.765ThrTyr: 2.765 ± 0.439
0.0ThrXaa: 0.0 ± 0.0
Val
4.943ValAla: 4.943 ± 0.949
0.503ValCys: 0.503 ± 0.175
5.529ValAsp: 5.529 ± 0.61
5.613ValGlu: 5.613 ± 0.689
2.849ValPhe: 2.849 ± 0.643
4.189ValGly: 4.189 ± 0.69
0.754ValHis: 0.754 ± 0.288
2.849ValIle: 2.849 ± 0.586
5.027ValLys: 5.027 ± 0.751
5.613ValLeu: 5.613 ± 0.632
1.592ValMet: 1.592 ± 0.401
3.351ValAsn: 3.351 ± 0.603
1.592ValPro: 1.592 ± 0.315
1.843ValGln: 1.843 ± 0.346
2.513ValArg: 2.513 ± 0.436
4.692ValSer: 4.692 ± 0.673
5.529ValThr: 5.529 ± 0.905
3.854ValVal: 3.854 ± 0.522
1.089ValTrp: 1.089 ± 0.465
2.262ValTyr: 2.262 ± 0.547
0.0ValXaa: 0.0 ± 0.0
Trp
1.424TrpAla: 1.424 ± 0.328
0.084TrpCys: 0.084 ± 0.076
0.586TrpAsp: 0.586 ± 0.222
0.838TrpGlu: 0.838 ± 0.225
0.586TrpPhe: 0.586 ± 0.207
0.754TrpGly: 0.754 ± 0.237
0.419TrpHis: 0.419 ± 0.199
0.754TrpIle: 0.754 ± 0.266
1.005TrpLys: 1.005 ± 0.282
1.508TrpLeu: 1.508 ± 0.395
0.084TrpMet: 0.084 ± 0.101
2.095TrpAsn: 2.095 ± 0.818
0.084TrpPro: 0.084 ± 0.079
0.67TrpGln: 0.67 ± 0.29
0.67TrpArg: 0.67 ± 0.295
1.424TrpSer: 1.424 ± 0.518
1.173TrpThr: 1.173 ± 0.402
1.005TrpVal: 1.005 ± 0.278
0.251TrpTrp: 0.251 ± 0.184
0.419TrpTyr: 0.419 ± 0.201
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.178TyrAla: 2.178 ± 0.385
0.754TyrCys: 0.754 ± 0.251
3.1TyrAsp: 3.1 ± 0.529
2.597TyrGlu: 2.597 ± 0.615
1.508TyrPhe: 1.508 ± 0.418
2.262TyrGly: 2.262 ± 0.428
0.586TyrHis: 0.586 ± 0.256
2.095TyrIle: 2.095 ± 0.381
2.932TyrLys: 2.932 ± 0.443
3.603TyrLeu: 3.603 ± 0.562
0.922TyrMet: 0.922 ± 0.204
2.765TyrAsn: 2.765 ± 0.445
1.592TyrPro: 1.592 ± 0.412
1.424TyrGln: 1.424 ± 0.416
2.597TyrArg: 2.597 ± 0.419
2.597TyrSer: 2.597 ± 0.459
2.597TyrThr: 2.597 ± 0.462
1.843TyrVal: 1.843 ± 0.373
0.503TyrTrp: 0.503 ± 0.173
1.843TyrTyr: 1.843 ± 0.582
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11937 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski