Amino acid dipepetide frequency for Massilia eurypsychrophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.102AlaAla: 19.102 ± 0.185	1.284AlaCys: 1.284 ± 0.028	7.011AlaAsp: 7.011 ± 0.068	6.329AlaGlu: 6.329 ± 0.071	3.981AlaPhe: 3.981 ± 0.054	11.154AlaGly: 11.154 ± 0.095	2.569AlaHis: 2.569 ± 0.045	6.12AlaIle: 6.12 ± 0.061	4.132AlaLys: 4.132 ± 0.074	14.381AlaLeu: 14.381 ± 0.131	3.689AlaMet: 3.689 ± 0.051	3.522AlaAsn: 3.522 ± 0.049	6.561AlaPro: 6.561 ± 0.067	5.177AlaGln: 5.177 ± 0.069	8.689AlaArg: 8.689 ± 0.085	7.139AlaSer: 7.139 ± 0.077	6.285AlaThr: 6.285 ± 0.065	8.94AlaVal: 8.94 ± 0.088	1.639AlaTrp: 1.639 ± 0.034	2.641AlaTyr: 2.641 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.24CysAla: 1.24 ± 0.029	0.11CysCys: 0.11 ± 0.008	0.538CysAsp: 0.538 ± 0.016	0.454CysGlu: 0.454 ± 0.018	0.317CysPhe: 0.317 ± 0.013	0.923CysGly: 0.923 ± 0.024	0.239CysHis: 0.239 ± 0.013	0.422CysIle: 0.422 ± 0.016	0.254CysLys: 0.254 ± 0.012	0.798CysLeu: 0.798 ± 0.022	0.217CysMet: 0.217 ± 0.011	0.244CysAsn: 0.244 ± 0.013	0.408CysPro: 0.408 ± 0.016	0.249CysGln: 0.249 ± 0.012	0.567CysArg: 0.567 ± 0.017	0.498CysSer: 0.498 ± 0.014	0.449CysThr: 0.449 ± 0.017	0.655CysVal: 0.655 ± 0.019	0.128CysTrp: 0.128 ± 0.01	0.24CysTyr: 0.24 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.077AspAla: 7.077 ± 0.066	0.467AspCys: 0.467 ± 0.017	3.108AspAsp: 3.108 ± 0.044	3.054AspGlu: 3.054 ± 0.046	2.137AspPhe: 2.137 ± 0.035	4.865AspGly: 4.865 ± 0.054	1.06AspHis: 1.06 ± 0.025	2.892AspIle: 2.892 ± 0.039	2.144AspLys: 2.144 ± 0.038	5.088AspLeu: 5.088 ± 0.058	1.4AspMet: 1.4 ± 0.031	1.516AspAsn: 1.516 ± 0.031	2.827AspPro: 2.827 ± 0.044	1.937AspGln: 1.937 ± 0.029	3.019AspArg: 3.019 ± 0.051	2.734AspSer: 2.734 ± 0.036	2.656AspThr: 2.656 ± 0.041	4.061AspVal: 4.061 ± 0.051	0.836AspTrp: 0.836 ± 0.022	1.557AspTyr: 1.557 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.946GluAla: 5.946 ± 0.068	0.389GluCys: 0.389 ± 0.017	1.969GluAsp: 1.969 ± 0.041	2.454GluGlu: 2.454 ± 0.05	1.87GluPhe: 1.87 ± 0.035	3.162GluGly: 3.162 ± 0.046	1.319GluHis: 1.319 ± 0.03	2.726GluIle: 2.726 ± 0.047	2.081GluLys: 2.081 ± 0.042	5.674GluLeu: 5.674 ± 0.068	1.43GluMet: 1.43 ± 0.028	1.392GluAsn: 1.392 ± 0.029	2.198GluPro: 2.198 ± 0.046	2.748GluGln: 2.748 ± 0.045	4.335GluArg: 4.335 ± 0.057	2.553GluSer: 2.553 ± 0.043	2.459GluThr: 2.459 ± 0.039	3.684GluVal: 3.684 ± 0.053	0.72GluTrp: 0.72 ± 0.02	1.145GluTyr: 1.145 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.445PheAla: 4.445 ± 0.052	0.403PheCys: 0.403 ± 0.014	2.666PheAsp: 2.666 ± 0.036	1.964PheGlu: 1.964 ± 0.033	1.4PhePhe: 1.4 ± 0.031	3.544PheGly: 3.544 ± 0.041	0.752PheHis: 0.752 ± 0.023	1.732PheIle: 1.732 ± 0.034	1.338PheLys: 1.338 ± 0.025	3.023PheLeu: 3.023 ± 0.045	0.879PheMet: 0.879 ± 0.023	1.318PheAsn: 1.318 ± 0.031	1.448PhePro: 1.448 ± 0.028	1.076PheGln: 1.076 ± 0.026	1.946PheArg: 1.946 ± 0.036	2.401PheSer: 2.401 ± 0.039	1.964PheThr: 1.964 ± 0.034	2.699PheVal: 2.699 ± 0.041	0.483PheTrp: 0.483 ± 0.021	0.992PheTyr: 0.992 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.441GlyAla: 10.441 ± 0.092	0.823GlyCys: 0.823 ± 0.022	4.164GlyAsp: 4.164 ± 0.053	4.122GlyGlu: 4.122 ± 0.048	3.247GlyPhe: 3.247 ± 0.043	6.793GlyGly: 6.793 ± 0.084	1.774GlyHis: 1.774 ± 0.035	4.284GlyIle: 4.284 ± 0.059	3.815GlyLys: 3.815 ± 0.054	7.521GlyLeu: 7.521 ± 0.074	2.512GlyMet: 2.512 ± 0.044	2.431GlyAsn: 2.431 ± 0.043	2.722GlyPro: 2.722 ± 0.043	3.125GlyGln: 3.125 ± 0.044	4.939GlyArg: 4.939 ± 0.052	4.645GlySer: 4.645 ± 0.057	4.231GlyThr: 4.231 ± 0.059	6.424GlyVal: 6.424 ± 0.067	1.249GlyTrp: 1.249 ± 0.029	2.351GlyTyr: 2.351 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.763HisAla: 2.763 ± 0.048	0.247HisCys: 0.247 ± 0.011	1.252HisAsp: 1.252 ± 0.032	1.092HisGlu: 1.092 ± 0.027	0.895HisPhe: 0.895 ± 0.025	1.999HisGly: 1.999 ± 0.039	0.576HisHis: 0.576 ± 0.019	0.984HisIle: 0.984 ± 0.025	0.638HisLys: 0.638 ± 0.021	2.077HisLeu: 2.077 ± 0.036	0.527HisMet: 0.527 ± 0.018	0.55HisAsn: 0.55 ± 0.018	1.288HisPro: 1.288 ± 0.025	0.783HisGln: 0.783 ± 0.023	1.295HisArg: 1.295 ± 0.029	1.076HisSer: 1.076 ± 0.024	0.987HisThr: 0.987 ± 0.02	1.442HisVal: 1.442 ± 0.029	0.339HisTrp: 0.339 ± 0.014	0.612HisTyr: 0.612 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.762IleAla: 6.762 ± 0.064	0.453IleCys: 0.453 ± 0.017	3.68IleAsp: 3.68 ± 0.046	3.187IleGlu: 3.187 ± 0.053	1.496IlePhe: 1.496 ± 0.035	4.83IleGly: 4.83 ± 0.049	0.917IleHis: 0.917 ± 0.027	2.045IleIle: 2.045 ± 0.037	1.816IleLys: 1.816 ± 0.038	3.802IleLeu: 3.802 ± 0.049	0.958IleMet: 0.958 ± 0.024	1.716IleAsn: 1.716 ± 0.036	2.021IlePro: 2.021 ± 0.036	1.161IleGln: 1.161 ± 0.022	2.602IleArg: 2.602 ± 0.047	2.81IleSer: 2.81 ± 0.039	2.634IleThr: 2.634 ± 0.042	3.998IleVal: 3.998 ± 0.049	0.49IleTrp: 0.49 ± 0.017	1.068IleTyr: 1.068 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.222LysAla: 4.222 ± 0.067	0.182LysCys: 0.182 ± 0.011	1.783LysAsp: 1.783 ± 0.035	1.723LysGlu: 1.723 ± 0.037	1.216LysPhe: 1.216 ± 0.029	2.495LysGly: 2.495 ± 0.04	0.753LysHis: 0.753 ± 0.02	1.872LysIle: 1.872 ± 0.035	1.616LysLys: 1.616 ± 0.038	4.007LysLeu: 4.007 ± 0.062	1.139LysMet: 1.139 ± 0.027	1.244LysAsn: 1.244 ± 0.029	2.077LysPro: 2.077 ± 0.042	1.489LysGln: 1.489 ± 0.029	2.38LysArg: 2.38 ± 0.039	2.072LysSer: 2.072 ± 0.041	2.118LysThr: 2.118 ± 0.035	2.825LysVal: 2.825 ± 0.045	0.409LysTrp: 0.409 ± 0.016	0.821LysTyr: 0.821 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.94LeuAla: 14.94 ± 0.129	0.967LeuCys: 0.967 ± 0.024	5.752LeuAsp: 5.752 ± 0.056	5.008LeuGlu: 5.008 ± 0.053	3.594LeuPhe: 3.594 ± 0.049	7.925LeuGly: 7.925 ± 0.065	2.157LeuHis: 2.157 ± 0.034	4.497LeuIle: 4.497 ± 0.051	3.699LeuLys: 3.699 ± 0.05	10.634LeuLeu: 10.634 ± 0.108	2.554LeuMet: 2.554 ± 0.041	2.855LeuAsn: 2.855 ± 0.037	5.437LeuPro: 5.437 ± 0.063	3.632LeuGln: 3.632 ± 0.049	7.127LeuArg: 7.127 ± 0.075	6.083LeuSer: 6.083 ± 0.064	5.481LeuThr: 5.481 ± 0.056	7.544LeuVal: 7.544 ± 0.083	1.1LeuTrp: 1.1 ± 0.029	2.176LeuTyr: 2.176 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.243MetAla: 3.243 ± 0.048	0.172MetCys: 0.172 ± 0.01	1.17MetAsp: 1.17 ± 0.027	1.15MetGlu: 1.15 ± 0.025	0.91MetPhe: 0.91 ± 0.022	1.858MetGly: 1.858 ± 0.041	0.612MetHis: 0.612 ± 0.021	1.212MetIle: 1.212 ± 0.024	1.188MetLys: 1.188 ± 0.027	3.115MetLeu: 3.115 ± 0.046	0.737MetMet: 0.737 ± 0.022	0.989MetAsn: 0.989 ± 0.024	1.561MetPro: 1.561 ± 0.036	1.133MetGln: 1.133 ± 0.025	1.862MetArg: 1.862 ± 0.035	1.698MetSer: 1.698 ± 0.031	1.695MetThr: 1.695 ± 0.029	1.913MetVal: 1.913 ± 0.033	0.231MetTrp: 0.231 ± 0.012	0.506MetTyr: 0.506 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.587AsnAla: 3.587 ± 0.051	0.301AsnCys: 0.301 ± 0.014	1.535AsnAsp: 1.535 ± 0.03	1.376AsnGlu: 1.376 ± 0.026	1.151AsnPhe: 1.151 ± 0.027	2.632AsnGly: 2.632 ± 0.043	0.581AsnHis: 0.581 ± 0.017	1.497AsnIle: 1.497 ± 0.033	1.094AsnLys: 1.094 ± 0.029	3.017AsnLeu: 3.017 ± 0.047	0.723AsnMet: 0.723 ± 0.019	1.02AsnAsn: 1.02 ± 0.032	1.857AsnPro: 1.857 ± 0.038	1.002AsnGln: 1.002 ± 0.024	1.77AsnArg: 1.77 ± 0.034	1.476AsnSer: 1.476 ± 0.034	1.59AsnThr: 1.59 ± 0.036	2.258AsnVal: 2.258 ± 0.038	0.439AsnTrp: 0.439 ± 0.015	0.876AsnTyr: 0.876 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.138ProAla: 7.138 ± 0.084	0.34ProCys: 0.34 ± 0.014	2.936ProAsp: 2.936 ± 0.039	2.67ProGlu: 2.67 ± 0.042	1.785ProPhe: 1.785 ± 0.036	4.174ProGly: 4.174 ± 0.049	0.991ProHis: 0.991 ± 0.023	1.976ProIle: 1.976 ± 0.034	1.599ProLys: 1.599 ± 0.033	4.854ProLeu: 4.854 ± 0.057	1.309ProMet: 1.309 ± 0.025	1.406ProAsn: 1.406 ± 0.032	2.306ProPro: 2.306 ± 0.057	1.861ProGln: 1.861 ± 0.03	2.599ProArg: 2.599 ± 0.041	2.578ProSer: 2.578 ± 0.04	2.32ProThr: 2.32 ± 0.047	4.046ProVal: 4.046 ± 0.052	0.601ProTrp: 0.601 ± 0.022	1.064ProTyr: 1.064 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.911GlnAla: 4.911 ± 0.071	0.279GlnCys: 0.279 ± 0.013	1.548GlnAsp: 1.548 ± 0.031	1.603GlnGlu: 1.603 ± 0.036	1.537GlnPhe: 1.537 ± 0.027	2.526GlnGly: 2.526 ± 0.042	0.883GlnHis: 0.883 ± 0.021	1.835GlnIle: 1.835 ± 0.035	1.221GlnLys: 1.221 ± 0.029	4.407GlnLeu: 4.407 ± 0.054	1.087GlnMet: 1.087 ± 0.024	0.978GlnAsn: 0.978 ± 0.025	1.929GlnPro: 1.929 ± 0.034	2.032GlnGln: 2.032 ± 0.044	2.988GlnArg: 2.988 ± 0.05	2.037GlnSer: 2.037 ± 0.037	1.766GlnThr: 1.766 ± 0.034	3.006GlnVal: 3.006 ± 0.042	0.518GlnTrp: 0.518 ± 0.02	0.876GlnTyr: 0.876 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.803ArgAla: 7.803 ± 0.083	0.517ArgCys: 0.517 ± 0.018	3.573ArgAsp: 3.573 ± 0.05	3.535ArgGlu: 3.535 ± 0.053	2.702ArgPhe: 2.702 ± 0.039	4.355ArgGly: 4.355 ± 0.052	1.732ArgHis: 1.732 ± 0.031	3.509ArgIle: 3.509 ± 0.046	2.293ArgLys: 2.293 ± 0.039	7.052ArgLeu: 7.052 ± 0.081	1.921ArgMet: 1.921 ± 0.031	1.967ArgAsn: 1.967 ± 0.036	2.793ArgPro: 2.793 ± 0.04	2.851ArgGln: 2.851 ± 0.051	4.595ArgArg: 4.595 ± 0.068	3.489ArgSer: 3.489 ± 0.044	3.081ArgThr: 3.081 ± 0.035	4.518ArgVal: 4.518 ± 0.054	0.917ArgTrp: 0.917 ± 0.026	1.874ArgTyr: 1.874 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.073SerAla: 7.073 ± 0.069	0.483SerCys: 0.483 ± 0.018	2.839SerAsp: 2.839 ± 0.043	2.558SerGlu: 2.558 ± 0.036	2.198SerPhe: 2.198 ± 0.037	5.391SerGly: 5.391 ± 0.067	1.223SerHis: 1.223 ± 0.024	2.741SerIle: 2.741 ± 0.04	1.977SerLys: 1.977 ± 0.031	5.687SerLeu: 5.687 ± 0.065	1.595SerMet: 1.595 ± 0.031	1.643SerAsn: 1.643 ± 0.031	2.619SerPro: 2.619 ± 0.041	1.91SerGln: 1.91 ± 0.04	3.287SerArg: 3.287 ± 0.039	3.362SerSer: 3.362 ± 0.048	3.061SerThr: 3.061 ± 0.043	4.283SerVal: 4.283 ± 0.049	0.728SerTrp: 0.728 ± 0.023	1.498SerTyr: 1.498 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.086ThrAla: 6.086 ± 0.067	0.412ThrCys: 0.412 ± 0.016	2.706ThrAsp: 2.706 ± 0.045	2.388ThrGlu: 2.388 ± 0.04	1.864ThrPhe: 1.864 ± 0.035	4.617ThrGly: 4.617 ± 0.062	1.019ThrHis: 1.019 ± 0.02	2.721ThrIle: 2.721 ± 0.048	1.455ThrLys: 1.455 ± 0.032	5.948ThrLeu: 5.948 ± 0.056	1.372ThrMet: 1.372 ± 0.029	1.454ThrAsn: 1.454 ± 0.032	3.129ThrPro: 3.129 ± 0.046	1.632ThrGln: 1.632 ± 0.029	3.233ThrArg: 3.233 ± 0.043	2.924ThrSer: 2.924 ± 0.045	2.812ThrThr: 2.812 ± 0.053	4.267ThrVal: 4.267 ± 0.058	0.643ThrTrp: 0.643 ± 0.023	1.227ThrTyr: 1.227 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.765ValAla: 9.765 ± 0.082	0.713ValCys: 0.713 ± 0.019	4.222ValAsp: 4.222 ± 0.057	3.92ValGlu: 3.92 ± 0.048	2.623ValPhe: 2.623 ± 0.038	5.515ValGly: 5.515 ± 0.071	1.425ValHis: 1.425 ± 0.028	3.747ValIle: 3.747 ± 0.046	2.759ValLys: 2.759 ± 0.044	7.821ValLeu: 7.821 ± 0.08	1.991ValMet: 1.991 ± 0.034	2.327ValAsn: 2.327 ± 0.038	3.536ValPro: 3.536 ± 0.055	2.439ValGln: 2.439 ± 0.038	4.924ValArg: 4.924 ± 0.058	4.355ValSer: 4.355 ± 0.059	4.418ValThr: 4.418 ± 0.059	5.985ValVal: 5.985 ± 0.066	0.864ValTrp: 0.864 ± 0.024	1.657ValTyr: 1.657 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.073TrpAla: 1.073 ± 0.028	0.141TrpCys: 0.141 ± 0.009	0.617TrpAsp: 0.617 ± 0.023	0.533TrpGlu: 0.533 ± 0.02	0.534TrpPhe: 0.534 ± 0.019	0.806TrpGly: 0.806 ± 0.023	0.334TrpHis: 0.334 ± 0.014	0.664TrpIle: 0.664 ± 0.018	0.475TrpLys: 0.475 ± 0.015	1.662TrpLeu: 1.662 ± 0.04	0.421TrpMet: 0.421 ± 0.016	0.46TrpAsn: 0.46 ± 0.017	0.621TrpPro: 0.621 ± 0.017	0.673TrpGln: 0.673 ± 0.022	1.105TrpArg: 1.105 ± 0.028	0.777TrpSer: 0.777 ± 0.021	0.665TrpThr: 0.665 ± 0.02	0.809TrpVal: 0.809 ± 0.026	0.218TrpTrp: 0.218 ± 0.012	0.313TrpTyr: 0.313 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.728TyrAla: 2.728 ± 0.039	0.266TyrCys: 0.266 ± 0.015	1.366TyrAsp: 1.366 ± 0.03	1.137TyrGlu: 1.137 ± 0.023	1.017TyrPhe: 1.017 ± 0.027	2.045TyrGly: 2.045 ± 0.04	0.51TyrHis: 0.51 ± 0.015	0.97TyrIle: 0.97 ± 0.023	0.847TyrLys: 0.847 ± 0.02	2.592TyrLeu: 2.592 ± 0.038	0.494TyrMet: 0.494 ± 0.017	0.748TyrAsn: 0.748 ± 0.023	1.214TyrPro: 1.214 ± 0.028	1.058TyrGln: 1.058 ± 0.026	1.814TyrArg: 1.814 ± 0.04	1.446TyrSer: 1.446 ± 0.029	1.234TyrThr: 1.234 ± 0.028	1.651TyrVal: 1.651 ± 0.033	0.352TyrTrp: 0.352 ± 0.014	0.666TyrTyr: 0.666 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5261 proteins (1730067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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