Amino acid dipepetide frequency for Planctomycetes bacterium Poly30

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.659AlaAla: 15.659 ± 0.119	1.005AlaCys: 1.005 ± 0.021	6.079AlaAsp: 6.079 ± 0.054	7.657AlaGlu: 7.657 ± 0.074	4.14AlaPhe: 4.14 ± 0.044	10.335AlaGly: 10.335 ± 0.071	2.023AlaHis: 2.023 ± 0.032	4.896AlaIle: 4.896 ± 0.043	2.991AlaLys: 2.991 ± 0.046	13.087AlaLeu: 13.087 ± 0.1	2.494AlaMet: 2.494 ± 0.039	2.328AlaAsn: 2.328 ± 0.035	6.368AlaPro: 6.368 ± 0.06	3.243AlaGln: 3.243 ± 0.04	9.071AlaArg: 9.071 ± 0.086	8.12AlaSer: 8.12 ± 0.067	6.341AlaThr: 6.341 ± 0.059	7.924AlaVal: 7.924 ± 0.073	1.87AlaTrp: 1.87 ± 0.031	2.018AlaTyr: 2.018 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.024	0.111CysCys: 0.111 ± 0.011	0.472CysAsp: 0.472 ± 0.014	0.453CysGlu: 0.453 ± 0.016	0.281CysPhe: 0.281 ± 0.011	0.801CysGly: 0.801 ± 0.018	0.295CysHis: 0.295 ± 0.022	0.324CysIle: 0.324 ± 0.012	0.151CysLys: 0.151 ± 0.008	0.845CysLeu: 0.845 ± 0.02	0.142CysMet: 0.142 ± 0.007	0.185CysAsn: 0.185 ± 0.01	0.416CysPro: 0.416 ± 0.013	0.251CysGln: 0.251 ± 0.011	0.572CysArg: 0.572 ± 0.017	0.588CysSer: 0.588 ± 0.02	0.441CysThr: 0.441 ± 0.014	0.676CysVal: 0.676 ± 0.017	0.126CysTrp: 0.126 ± 0.009	0.18CysTyr: 0.18 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.113AspAla: 7.113 ± 0.056	0.408AspCys: 0.408 ± 0.016	3.51AspAsp: 3.51 ± 0.049	4.293AspGlu: 4.293 ± 0.053	2.122AspPhe: 2.122 ± 0.031	6.83AspGly: 6.83 ± 0.076	1.299AspHis: 1.299 ± 0.027	1.962AspIle: 1.962 ± 0.03	0.968AspLys: 0.968 ± 0.022	7.08AspLeu: 7.08 ± 0.059	0.951AspMet: 0.951 ± 0.022	0.902AspAsn: 0.902 ± 0.02	4.489AspPro: 4.489 ± 0.048	1.644AspGln: 1.644 ± 0.027	4.56AspArg: 4.56 ± 0.043	3.181AspSer: 3.181 ± 0.04	2.341AspThr: 2.341 ± 0.031	4.887AspVal: 4.887 ± 0.055	0.949AspTrp: 0.949 ± 0.021	1.109AspTyr: 1.109 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	8.226GluAla: 8.226 ± 0.085	0.42GluCys: 0.42 ± 0.015	3.591GluAsp: 3.591 ± 0.05	4.405GluGlu: 4.405 ± 0.064	2.146GluPhe: 2.146 ± 0.031	5.626GluGly: 5.626 ± 0.061	1.386GluHis: 1.386 ± 0.027	3.271GluIle: 3.271 ± 0.043	1.801GluLys: 1.801 ± 0.038	6.923GluLeu: 6.923 ± 0.078	1.263GluMet: 1.263 ± 0.025	1.517GluAsn: 1.517 ± 0.03	3.594GluPro: 3.594 ± 0.044	1.791GluGln: 1.791 ± 0.026	5.998GluArg: 5.998 ± 0.067	4.037GluSer: 4.037 ± 0.04	3.5GluThr: 3.5 ± 0.04	5.183GluVal: 5.183 ± 0.054	0.912GluTrp: 0.912 ± 0.021	1.065GluTyr: 1.065 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.783PheAla: 3.783 ± 0.044	0.341PheCys: 0.341 ± 0.015	2.813PheAsp: 2.813 ± 0.037	2.819PheGlu: 2.819 ± 0.038	1.297PhePhe: 1.297 ± 0.026	3.731PheGly: 3.731 ± 0.043	0.841PheHis: 0.841 ± 0.02	1.029PheIle: 1.029 ± 0.023	0.638PheLys: 0.638 ± 0.018	3.554PheLeu: 3.554 ± 0.039	0.592PheMet: 0.592 ± 0.015	0.702PheAsn: 0.702 ± 0.017	1.72PhePro: 1.72 ± 0.03	1.386PheGln: 1.386 ± 0.023	2.445PheArg: 2.445 ± 0.035	2.216PheSer: 2.216 ± 0.032	2.01PheThr: 2.01 ± 0.03	2.839PheVal: 2.839 ± 0.041	0.46PheTrp: 0.46 ± 0.015	0.665PheTyr: 0.665 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.665GlyAla: 10.665 ± 0.083	0.769GlyCys: 0.769 ± 0.02	5.734GlyAsp: 5.734 ± 0.067	5.891GlyGlu: 5.891 ± 0.058	3.496GlyPhe: 3.496 ± 0.041	8.744GlyGly: 8.744 ± 0.119	1.849GlyHis: 1.849 ± 0.032	3.643GlyIle: 3.643 ± 0.039	2.587GlyLys: 2.587 ± 0.044	8.878GlyLeu: 8.878 ± 0.067	1.923GlyMet: 1.923 ± 0.031	2.124GlyAsn: 2.124 ± 0.037	4.556GlyPro: 4.556 ± 0.05	3.103GlyGln: 3.103 ± 0.041	6.665GlyArg: 6.665 ± 0.063	6.817GlySer: 6.817 ± 0.071	5.521GlyThr: 5.521 ± 0.055	6.617GlyVal: 6.617 ± 0.054	1.49GlyTrp: 1.49 ± 0.026	1.977GlyTyr: 1.977 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.363HisAla: 2.363 ± 0.034	0.192HisCys: 0.192 ± 0.009	1.148HisAsp: 1.148 ± 0.023	1.257HisGlu: 1.257 ± 0.031	0.802HisPhe: 0.802 ± 0.021	2.118HisGly: 2.118 ± 0.034	0.521HisHis: 0.521 ± 0.016	0.605HisIle: 0.605 ± 0.015	0.352HisLys: 0.352 ± 0.013	2.092HisLeu: 2.092 ± 0.031	0.354HisMet: 0.354 ± 0.012	0.305HisAsn: 0.305 ± 0.013	1.415HisPro: 1.415 ± 0.026	0.585HisGln: 0.585 ± 0.015	1.591HisArg: 1.591 ± 0.031	1.083HisSer: 1.083 ± 0.02	0.825HisThr: 0.825 ± 0.019	1.693HisVal: 1.693 ± 0.034	0.328HisTrp: 0.328 ± 0.011	0.44HisTyr: 0.44 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.05IleAla: 5.05 ± 0.054	0.325IleCys: 0.325 ± 0.013	3.276IleAsp: 3.276 ± 0.039	3.525IleGlu: 3.525 ± 0.041	1.109IlePhe: 1.109 ± 0.021	3.798IleGly: 3.798 ± 0.04	0.934IleHis: 0.934 ± 0.018	1.04IleIle: 1.04 ± 0.023	0.843IleLys: 0.843 ± 0.024	3.589IleLeu: 3.589 ± 0.045	0.513IleMet: 0.513 ± 0.014	0.742IleAsn: 0.742 ± 0.018	2.129IlePro: 2.129 ± 0.033	1.508IleGln: 1.508 ± 0.027	2.745IleArg: 2.745 ± 0.036	2.25IleSer: 2.25 ± 0.036	2.082IleThr: 2.082 ± 0.027	3.342IleVal: 3.342 ± 0.038	0.45IleTrp: 0.45 ± 0.014	0.801IleTyr: 0.801 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.89LysAla: 2.89 ± 0.049	0.13LysCys: 0.13 ± 0.008	1.518LysAsp: 1.518 ± 0.037	1.611LysGlu: 1.611 ± 0.03	0.6LysPhe: 0.6 ± 0.018	2.139LysGly: 2.139 ± 0.035	0.469LysHis: 0.469 ± 0.014	1.122LysIle: 1.122 ± 0.026	1.162LysLys: 1.162 ± 0.034	2.438LysLeu: 2.438 ± 0.045	0.551LysMet: 0.551 ± 0.016	0.651LysAsn: 0.651 ± 0.02	1.376LysPro: 1.376 ± 0.029	0.596LysGln: 0.596 ± 0.018	2.062LysArg: 2.062 ± 0.035	1.57LysSer: 1.57 ± 0.032	1.383LysThr: 1.383 ± 0.028	1.785LysVal: 1.785 ± 0.034	0.274LysTrp: 0.274 ± 0.012	0.417LysTyr: 0.417 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	12.679LeuAla: 12.679 ± 0.093	0.995LeuCys: 0.995 ± 0.022	7.085LeuAsp: 7.085 ± 0.06	7.426LeuGlu: 7.426 ± 0.08	3.506LeuPhe: 3.506 ± 0.043	9.393LeuGly: 9.393 ± 0.077	2.062LeuHis: 2.062 ± 0.036	3.703LeuIle: 3.703 ± 0.049	2.535LeuLys: 2.535 ± 0.04	9.881LeuLeu: 9.881 ± 0.087	1.805LeuMet: 1.805 ± 0.028	1.947LeuAsn: 1.947 ± 0.032	5.776LeuPro: 5.776 ± 0.061	3.055LeuGln: 3.055 ± 0.039	8.188LeuArg: 8.188 ± 0.075	6.273LeuSer: 6.273 ± 0.059	5.364LeuThr: 5.364 ± 0.051	7.988LeuVal: 7.988 ± 0.067	1.292LeuTrp: 1.292 ± 0.025	1.87LeuTyr: 1.87 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.326MetAla: 2.326 ± 0.034	0.128MetCys: 0.128 ± 0.008	1.117MetAsp: 1.117 ± 0.023	1.269MetGlu: 1.269 ± 0.027	0.478MetPhe: 0.478 ± 0.013	1.72MetGly: 1.72 ± 0.025	0.365MetHis: 0.365 ± 0.012	0.885MetIle: 0.885 ± 0.021	0.743MetLys: 0.743 ± 0.018	1.783MetLeu: 1.783 ± 0.03	0.387MetMet: 0.387 ± 0.014	0.668MetAsn: 0.668 ± 0.016	1.157MetPro: 1.157 ± 0.025	0.601MetGln: 0.601 ± 0.017	1.421MetArg: 1.421 ± 0.024	1.283MetSer: 1.283 ± 0.025	1.437MetThr: 1.437 ± 0.026	1.294MetVal: 1.294 ± 0.023	0.178MetTrp: 0.178 ± 0.008	0.261MetTyr: 0.261 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.431AsnAla: 2.431 ± 0.037	0.197AsnCys: 0.197 ± 0.01	1.34AsnAsp: 1.34 ± 0.028	1.286AsnGlu: 1.286 ± 0.025	0.847AsnPhe: 0.847 ± 0.02	2.432AsnGly: 2.432 ± 0.045	0.422AsnHis: 0.422 ± 0.014	0.661AsnIle: 0.661 ± 0.019	0.378AsnLys: 0.378 ± 0.015	2.198AsnLeu: 2.198 ± 0.036	0.371AsnMet: 0.371 ± 0.014	0.466AsnAsn: 0.466 ± 0.018	1.479AsnPro: 1.479 ± 0.029	0.703AsnGln: 0.703 ± 0.019	1.412AsnArg: 1.412 ± 0.02	1.342AsnSer: 1.342 ± 0.032	1.041AsnThr: 1.041 ± 0.024	1.79AsnVal: 1.79 ± 0.032	0.298AsnTrp: 0.298 ± 0.012	0.48AsnTyr: 0.48 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	6.339ProAla: 6.339 ± 0.062	0.338ProCys: 0.338 ± 0.013	3.647ProAsp: 3.647 ± 0.038	4.332ProGlu: 4.332 ± 0.049	2.053ProPhe: 2.053 ± 0.033	5.901ProGly: 5.901 ± 0.059	0.996ProHis: 0.996 ± 0.02	2.323ProIle: 2.323 ± 0.031	1.456ProLys: 1.456 ± 0.028	5.223ProLeu: 5.223 ± 0.062	1.243ProMet: 1.243 ± 0.021	1.337ProAsn: 1.337 ± 0.027	2.923ProPro: 2.923 ± 0.047	1.386ProGln: 1.386 ± 0.023	3.648ProArg: 3.648 ± 0.043	3.819ProSer: 3.819 ± 0.048	3.11ProThr: 3.11 ± 0.04	4.065ProVal: 4.065 ± 0.043	0.852ProTrp: 0.852 ± 0.018	1.049ProTyr: 1.049 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.357GlnAla: 3.357 ± 0.04	0.21GlnCys: 0.21 ± 0.01	1.5GlnAsp: 1.5 ± 0.028	1.772GlnGlu: 1.772 ± 0.029	1.018GlnPhe: 1.018 ± 0.023	2.65GlnGly: 2.65 ± 0.039	0.567GlnHis: 0.567 ± 0.017	1.343GlnIle: 1.343 ± 0.026	0.797GlnLys: 0.797 ± 0.021	3.063GlnLeu: 3.063 ± 0.036	0.64GlnMet: 0.64 ± 0.015	0.789GlnAsn: 0.789 ± 0.019	1.853GlnPro: 1.853 ± 0.03	0.849GlnGln: 0.849 ± 0.024	2.64GlnArg: 2.64 ± 0.037	1.814GlnSer: 1.814 ± 0.03	1.485GlnThr: 1.485 ± 0.029	2.298GlnVal: 2.298 ± 0.03	0.4GlnTrp: 0.4 ± 0.012	0.546GlnTyr: 0.546 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	8.659ArgAla: 8.659 ± 0.086	0.627ArgCys: 0.627 ± 0.019	4.223ArgAsp: 4.223 ± 0.046	4.719ArgGlu: 4.719 ± 0.053	3.231ArgPhe: 3.231 ± 0.039	5.87ArgGly: 5.87 ± 0.059	1.481ArgHis: 1.481 ± 0.028	3.579ArgIle: 3.579 ± 0.045	1.959ArgLys: 1.959 ± 0.039	7.762ArgLeu: 7.762 ± 0.061	1.867ArgMet: 1.867 ± 0.026	1.536ArgAsn: 1.536 ± 0.026	3.829ArgPro: 3.829 ± 0.043	2.086ArgGln: 2.086 ± 0.029	6.063ArgArg: 6.063 ± 0.068	4.942ArgSer: 4.942 ± 0.046	3.928ArgThr: 3.928 ± 0.043	5.821ArgVal: 5.821 ± 0.052	1.365ArgTrp: 1.365 ± 0.028	1.783ArgTyr: 1.783 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.261SerAla: 7.261 ± 0.063	0.584SerCys: 0.584 ± 0.016	3.564SerAsp: 3.564 ± 0.048	3.652SerGlu: 3.652 ± 0.046	2.518SerPhe: 2.518 ± 0.037	6.908SerGly: 6.908 ± 0.068	1.151SerHis: 1.151 ± 0.021	2.842SerIle: 2.842 ± 0.036	1.519SerLys: 1.519 ± 0.031	6.473SerLeu: 6.473 ± 0.057	1.359SerMet: 1.359 ± 0.025	1.575SerAsn: 1.575 ± 0.029	3.694SerPro: 3.694 ± 0.041	1.823SerGln: 1.823 ± 0.028	4.054SerArg: 4.054 ± 0.043	4.637SerSer: 4.637 ± 0.054	3.816SerThr: 3.816 ± 0.049	4.816SerVal: 4.816 ± 0.047	0.993SerTrp: 0.993 ± 0.023	1.226SerTyr: 1.226 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.881ThrAla: 5.881 ± 0.052	0.446ThrCys: 0.446 ± 0.015	2.998ThrAsp: 2.998 ± 0.035	2.963ThrGlu: 2.963 ± 0.032	2.233ThrPhe: 2.233 ± 0.033	5.341ThrGly: 5.341 ± 0.062	0.953ThrHis: 0.953 ± 0.021	2.415ThrIle: 2.415 ± 0.037	1.23ThrLys: 1.23 ± 0.027	6.067ThrLeu: 6.067 ± 0.06	0.97ThrMet: 0.97 ± 0.02	1.273ThrAsn: 1.273 ± 0.027	3.338ThrPro: 3.338 ± 0.038	1.412ThrGln: 1.412 ± 0.028	3.472ThrArg: 3.472 ± 0.038	3.715ThrSer: 3.715 ± 0.053	2.987ThrThr: 2.987 ± 0.041	4.204ThrVal: 4.204 ± 0.045	0.976ThrTrp: 0.976 ± 0.022	1.191ThrTyr: 1.191 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	8.816ValAla: 8.816 ± 0.074	0.594ValCys: 0.594 ± 0.017	4.986ValAsp: 4.986 ± 0.052	5.331ValGlu: 5.331 ± 0.053	2.603ValPhe: 2.603 ± 0.036	5.952ValGly: 5.952 ± 0.053	1.69ValHis: 1.69 ± 0.028	3.014ValIle: 3.014 ± 0.04	1.779ValLys: 1.779 ± 0.034	8.18ValLeu: 8.18 ± 0.066	1.377ValMet: 1.377 ± 0.025	1.643ValAsn: 1.643 ± 0.028	4.33ValPro: 4.33 ± 0.045	2.441ValGln: 2.441 ± 0.033	5.67ValArg: 5.67 ± 0.053	4.462ValSer: 4.462 ± 0.047	4.517ValThr: 4.517 ± 0.05	5.919ValVal: 5.919 ± 0.056	0.959ValTrp: 0.959 ± 0.022	1.384ValTyr: 1.384 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.262TrpAla: 1.262 ± 0.027	0.143TrpCys: 0.143 ± 0.007	0.726TrpAsp: 0.726 ± 0.021	0.728TrpGlu: 0.728 ± 0.017	0.589TrpPhe: 0.589 ± 0.016	0.88TrpGly: 0.88 ± 0.021	0.341TrpHis: 0.341 ± 0.012	0.855TrpIle: 0.855 ± 0.02	0.501TrpLys: 0.501 ± 0.015	1.692TrpLeu: 1.692 ± 0.027	0.389TrpMet: 0.389 ± 0.013	0.507TrpAsn: 0.507 ± 0.017	0.657TrpPro: 0.657 ± 0.017	0.444TrpGln: 0.444 ± 0.014	1.265TrpArg: 1.265 ± 0.027	1.108TrpSer: 1.108 ± 0.024	1.079TrpThr: 1.079 ± 0.023	0.954TrpVal: 0.954 ± 0.021	0.25TrpTrp: 0.25 ± 0.013	0.355TrpTyr: 0.355 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.955TyrAla: 1.955 ± 0.029	0.281TyrCys: 0.281 ± 0.011	1.271TyrAsp: 1.271 ± 0.026	1.269TyrGlu: 1.269 ± 0.024	0.815TyrPhe: 0.815 ± 0.019	1.876TyrGly: 1.876 ± 0.031	0.423TyrHis: 0.423 ± 0.013	0.541TyrIle: 0.541 ± 0.017	0.352TyrLys: 0.352 ± 0.013	2.014TyrLeu: 2.014 ± 0.03	0.308TyrMet: 0.308 ± 0.013	0.379TyrAsn: 0.379 ± 0.013	0.942TyrPro: 0.942 ± 0.02	0.683TyrGln: 0.683 ± 0.018	1.788TyrArg: 1.788 ± 0.028	1.209TyrSer: 1.209 ± 0.024	0.856TyrThr: 0.856 ± 0.02	1.552TyrVal: 1.552 ± 0.025	0.303TyrTrp: 0.303 ± 0.013	0.471TyrTyr: 0.471 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5628 proteins (2299414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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