Amino acid dipepetide frequency for Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.524AlaAla: 3.524 ± 0.126
0.328AlaCys: 0.328 ± 0.032
2.305AlaAsp: 2.305 ± 0.084
4.091AlaGlu: 4.091 ± 0.115
2.984AlaPhe: 2.984 ± 0.097
4.072AlaGly: 4.072 ± 0.124
0.855AlaHis: 0.855 ± 0.044
6.469AlaIle: 6.469 ± 0.142
4.463AlaLys: 4.463 ± 0.128
7.067AlaLeu: 7.067 ± 0.154
1.552AlaMet: 1.552 ± 0.058
2.09AlaAsn: 2.09 ± 0.07
1.697AlaPro: 1.697 ± 0.069
1.243AlaGln: 1.243 ± 0.062
2.822AlaArg: 2.822 ± 0.091
4.828AlaSer: 4.828 ± 0.121
2.829AlaThr: 2.829 ± 0.106
4.534AlaVal: 4.534 ± 0.12
0.627AlaTrp: 0.627 ± 0.038
2.53AlaTyr: 2.53 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
0.344CysAla: 0.344 ± 0.028
0.071CysCys: 0.071 ± 0.013
0.299CysAsp: 0.299 ± 0.031
0.511CysGlu: 0.511 ± 0.036
0.291CysPhe: 0.291 ± 0.027
0.802CysGly: 0.802 ± 0.055
0.076CysHis: 0.076 ± 0.014
0.564CysIle: 0.564 ± 0.046
0.522CysLys: 0.522 ± 0.038
0.477CysLeu: 0.477 ± 0.036
0.173CysMet: 0.173 ± 0.021
0.33CysAsn: 0.33 ± 0.03
0.603CysPro: 0.603 ± 0.05
0.123CysGln: 0.123 ± 0.016
0.312CysArg: 0.312 ± 0.03
0.582CysSer: 0.582 ± 0.04
0.357CysThr: 0.357 ± 0.031
0.315CysVal: 0.315 ± 0.031
0.087CysTrp: 0.087 ± 0.014
0.33CysTyr: 0.33 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
2.963AspAla: 2.963 ± 0.096
0.265AspCys: 0.265 ± 0.032
1.87AspAsp: 1.87 ± 0.079
3.962AspGlu: 3.962 ± 0.115
2.247AspPhe: 2.247 ± 0.079
2.517AspGly: 2.517 ± 0.078
0.532AspHis: 0.532 ± 0.036
4.557AspIle: 4.557 ± 0.106
3.031AspLys: 3.031 ± 0.092
4.717AspLeu: 4.717 ± 0.106
1.015AspMet: 1.015 ± 0.048
1.5AspAsn: 1.5 ± 0.062
2.462AspPro: 2.462 ± 0.079
0.658AspGln: 0.658 ± 0.039
1.838AspArg: 1.838 ± 0.074
2.586AspSer: 2.586 ± 0.088
1.631AspThr: 1.631 ± 0.056
3.655AspVal: 3.655 ± 0.105
0.472AspTrp: 0.472 ± 0.037
1.93AspTyr: 1.93 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.662GluAla: 4.662 ± 0.112
0.427GluCys: 0.427 ± 0.037
3.608GluAsp: 3.608 ± 0.091
7.62GluGlu: 7.62 ± 0.187
2.612GluPhe: 2.612 ± 0.093
4.39GluGly: 4.39 ± 0.109
1.004GluHis: 1.004 ± 0.058
7.452GluIle: 7.452 ± 0.165
9.097GluLys: 9.097 ± 0.186
7.657GluLeu: 7.657 ± 0.169
1.796GluMet: 1.796 ± 0.073
3.878GluAsn: 3.878 ± 0.116
2.087GluPro: 2.087 ± 0.094
1.361GluGln: 1.361 ± 0.065
4.279GluArg: 4.279 ± 0.113
4.298GluSer: 4.298 ± 0.122
2.638GluThr: 2.638 ± 0.092
5.226GluVal: 5.226 ± 0.123
0.645GluTrp: 0.645 ± 0.044
2.795GluTyr: 2.795 ± 0.104
0.0GluXaa: 0.0 ± 0.0
Phe
2.457PheAla: 2.457 ± 0.086
0.338PheCys: 0.338 ± 0.031
1.99PheAsp: 1.99 ± 0.068
2.916PheGlu: 2.916 ± 0.082
2.352PhePhe: 2.352 ± 0.079
3.044PheGly: 3.044 ± 0.091
0.64PheHis: 0.64 ± 0.034
3.91PheIle: 3.91 ± 0.112
3.06PheLys: 3.06 ± 0.087
5.011PheLeu: 5.011 ± 0.142
1.086PheMet: 1.086 ± 0.054
1.857PheAsn: 1.857 ± 0.076
1.741PhePro: 1.741 ± 0.075
0.829PheGln: 0.829 ± 0.048
1.471PheArg: 1.471 ± 0.059
4.083PheSer: 4.083 ± 0.123
2.095PheThr: 2.095 ± 0.087
2.759PheVal: 2.759 ± 0.087
0.451PheTrp: 0.451 ± 0.032
2.079PheTyr: 2.079 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
4.007GlyAla: 4.007 ± 0.097
0.598GlyCys: 0.598 ± 0.05
2.89GlyAsp: 2.89 ± 0.099
4.838GlyGlu: 4.838 ± 0.109
3.113GlyPhe: 3.113 ± 0.089
4.801GlyGly: 4.801 ± 0.132
0.923GlyHis: 0.923 ± 0.053
7.573GlyIle: 7.573 ± 0.16
5.737GlyLys: 5.737 ± 0.144
5.984GlyLeu: 5.984 ± 0.133
1.778GlyMet: 1.778 ± 0.073
2.468GlyAsn: 2.468 ± 0.082
1.862GlyPro: 1.862 ± 0.08
0.923GlyGln: 0.923 ± 0.051
3.113GlyArg: 3.113 ± 0.091
4.599GlySer: 4.599 ± 0.129
3.262GlyThr: 3.262 ± 0.1
4.314GlyVal: 4.314 ± 0.106
0.789GlyTrp: 0.789 ± 0.046
3.131GlyTyr: 3.131 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.871HisAla: 0.871 ± 0.053
0.092HisCys: 0.092 ± 0.015
0.572HisAsp: 0.572 ± 0.043
0.941HisGlu: 0.941 ± 0.047
0.574HisPhe: 0.574 ± 0.043
0.983HisGly: 0.983 ± 0.047
0.291HisHis: 0.291 ± 0.028
1.143HisIle: 1.143 ± 0.047
0.766HisLys: 0.766 ± 0.049
1.285HisLeu: 1.285 ± 0.057
0.33HisMet: 0.33 ± 0.03
0.396HisAsn: 0.396 ± 0.036
0.863HisPro: 0.863 ± 0.052
0.27HisGln: 0.27 ± 0.025
0.559HisArg: 0.559 ± 0.04
0.873HisSer: 0.873 ± 0.048
0.569HisThr: 0.569 ± 0.042
0.934HisVal: 0.934 ± 0.046
0.121HisTrp: 0.121 ± 0.019
0.614HisTyr: 0.614 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
7.13IleAla: 7.13 ± 0.147
0.656IleCys: 0.656 ± 0.046
5.056IleAsp: 5.056 ± 0.12
7.649IleGlu: 7.649 ± 0.168
4.379IlePhe: 4.379 ± 0.116
6.43IleGly: 6.43 ± 0.149
1.096IleHis: 1.096 ± 0.046
8.656IleIle: 8.656 ± 0.215
7.193IleLys: 7.193 ± 0.161
9.073IleLeu: 9.073 ± 0.172
2.066IleMet: 2.066 ± 0.08
4.217IleAsn: 4.217 ± 0.111
4.117IlePro: 4.117 ± 0.099
1.691IleGln: 1.691 ± 0.074
3.705IleArg: 3.705 ± 0.104
8.124IleSer: 8.124 ± 0.167
4.161IleThr: 4.161 ± 0.113
6.569IleVal: 6.569 ± 0.148
0.721IleTrp: 0.721 ± 0.045
4.078IleTyr: 4.078 ± 0.106
0.0IleXaa: 0.0 ± 0.0
Lys
4.919LysAla: 4.919 ± 0.119
0.653LysCys: 0.653 ± 0.052
4.002LysAsp: 4.002 ± 0.112
7.785LysGlu: 7.785 ± 0.166
2.551LysPhe: 2.551 ± 0.085
4.796LysGly: 4.796 ± 0.12
0.816LysHis: 0.816 ± 0.054
8.299LysIle: 8.299 ± 0.189
8.43LysLys: 8.43 ± 0.199
7.57LysLeu: 7.57 ± 0.153
2.381LysMet: 2.381 ± 0.077
4.337LysAsn: 4.337 ± 0.123
2.599LysPro: 2.599 ± 0.087
1.508LysGln: 1.508 ± 0.063
4.122LysArg: 4.122 ± 0.108
4.618LysSer: 4.618 ± 0.122
3.335LysThr: 3.335 ± 0.1
5.583LysVal: 5.583 ± 0.126
0.682LysTrp: 0.682 ± 0.045
3.246LysTyr: 3.246 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
6.181LeuAla: 6.181 ± 0.144
0.598LeuCys: 0.598 ± 0.043
4.321LeuAsp: 4.321 ± 0.12
7.135LeuGlu: 7.135 ± 0.157
4.439LeuPhe: 4.439 ± 0.136
6.668LeuGly: 6.668 ± 0.128
1.353LeuHis: 1.353 ± 0.06
9.007LeuIle: 9.007 ± 0.194
9.086LeuLys: 9.086 ± 0.164
9.844LeuLeu: 9.844 ± 0.2
2.46LeuMet: 2.46 ± 0.087
5.022LeuAsn: 5.022 ± 0.149
3.831LeuPro: 3.831 ± 0.1
1.94LeuGln: 1.94 ± 0.081
4.628LeuArg: 4.628 ± 0.111
9.125LeuSer: 9.125 ± 0.192
4.303LeuThr: 4.303 ± 0.112
5.824LeuVal: 5.824 ± 0.138
0.847LeuTrp: 0.847 ± 0.048
3.773LeuTyr: 3.773 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
1.371MetAla: 1.371 ± 0.062
0.126MetCys: 0.126 ± 0.02
0.907MetAsp: 0.907 ± 0.055
1.652MetGlu: 1.652 ± 0.069
0.873MetPhe: 0.873 ± 0.057
1.676MetGly: 1.676 ± 0.061
0.396MetHis: 0.396 ± 0.034
2.174MetIle: 2.174 ± 0.073
2.216MetLys: 2.216 ± 0.08
2.751MetLeu: 2.751 ± 0.096
0.548MetMet: 0.548 ± 0.039
1.293MetAsn: 1.293 ± 0.059
0.991MetPro: 0.991 ± 0.048
0.611MetGln: 0.611 ± 0.043
1.274MetArg: 1.274 ± 0.056
2.127MetSer: 2.127 ± 0.073
1.01MetThr: 1.01 ± 0.054
1.406MetVal: 1.406 ± 0.063
0.194MetTrp: 0.194 ± 0.023
0.69MetTyr: 0.69 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.73AsnAla: 2.73 ± 0.093
0.406AsnCys: 0.406 ± 0.03
1.859AsnAsp: 1.859 ± 0.063
3.642AsnGlu: 3.642 ± 0.091
1.896AsnPhe: 1.896 ± 0.076
2.945AsnGly: 2.945 ± 0.097
0.441AsnHis: 0.441 ± 0.038
4.552AsnIle: 4.552 ± 0.113
3.018AsnLys: 3.018 ± 0.09
4.474AsnLeu: 4.474 ± 0.12
0.994AsnMet: 0.994 ± 0.049
1.822AsnAsn: 1.822 ± 0.08
2.111AsnPro: 2.111 ± 0.069
0.768AsnGln: 0.768 ± 0.063
1.668AsnArg: 1.668 ± 0.061
3.128AsnSer: 3.128 ± 0.108
1.951AsnThr: 1.951 ± 0.08
3.178AsnVal: 3.178 ± 0.11
0.443AsnTrp: 0.443 ± 0.033
1.938AsnTyr: 1.938 ± 0.079
0.0AsnXaa: 0.0 ± 0.0
Pro
1.906ProAla: 1.906 ± 0.078
0.312ProCys: 0.312 ± 0.029
1.689ProAsp: 1.689 ± 0.081
3.17ProGlu: 3.17 ± 0.085
2.032ProPhe: 2.032 ± 0.079
2.572ProGly: 2.572 ± 0.107
0.76ProHis: 0.76 ± 0.045
3.498ProIle: 3.498 ± 0.101
2.646ProLys: 2.646 ± 0.095
3.689ProLeu: 3.689 ± 0.112
0.789ProMet: 0.789 ± 0.046
1.55ProAsn: 1.55 ± 0.061
1.977ProPro: 1.977 ± 0.081
0.975ProGln: 0.975 ± 0.053
1.5ProArg: 1.5 ± 0.062
3.081ProSer: 3.081 ± 0.09
1.702ProThr: 1.702 ± 0.07
2.706ProVal: 2.706 ± 0.098
0.462ProTrp: 0.462 ± 0.04
1.946ProTyr: 1.946 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
1.293GlnAla: 1.293 ± 0.055
0.131GlnCys: 0.131 ± 0.02
0.687GlnAsp: 0.687 ± 0.044
1.369GlnGlu: 1.369 ± 0.058
0.663GlnPhe: 0.663 ± 0.032
1.13GlnGly: 1.13 ± 0.06
0.275GlnHis: 0.275 ± 0.025
1.762GlnIle: 1.762 ± 0.07
1.571GlnLys: 1.571 ± 0.071
2.106GlnLeu: 2.106 ± 0.084
0.543GlnMet: 0.543 ± 0.036
1.002GlnAsn: 1.002 ± 0.06
0.65GlnPro: 0.65 ± 0.04
0.572GlnGln: 0.572 ± 0.05
0.918GlnArg: 0.918 ± 0.056
1.295GlnSer: 1.295 ± 0.063
0.868GlnThr: 0.868 ± 0.057
1.358GlnVal: 1.358 ± 0.064
0.157GlnTrp: 0.157 ± 0.024
0.892GlnTyr: 0.892 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
2.774ArgAla: 2.774 ± 0.091
0.393ArgCys: 0.393 ± 0.038
1.985ArgAsp: 1.985 ± 0.076
4.285ArgGlu: 4.285 ± 0.122
1.697ArgPhe: 1.697 ± 0.066
3.412ArgGly: 3.412 ± 0.111
0.501ArgHis: 0.501 ± 0.035
4.222ArgIle: 4.222 ± 0.117
4.099ArgLys: 4.099 ± 0.108
3.981ArgLeu: 3.981 ± 0.118
1.067ArgMet: 1.067 ± 0.054
1.93ArgAsn: 1.93 ± 0.063
1.458ArgPro: 1.458 ± 0.064
0.721ArgGln: 0.721 ± 0.035
2.386ArgArg: 2.386 ± 0.09
2.436ArgSer: 2.436 ± 0.077
1.749ArgThr: 1.749 ± 0.072
2.911ArgVal: 2.911 ± 0.097
0.456ArgTrp: 0.456 ± 0.029
1.699ArgTyr: 1.699 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
3.747SerAla: 3.747 ± 0.123
0.551SerCys: 0.551 ± 0.043
3.162SerAsp: 3.162 ± 0.092
5.048SerGlu: 5.048 ± 0.126
3.891SerPhe: 3.891 ± 0.112
5.066SerGly: 5.066 ± 0.144
0.907SerHis: 0.907 ± 0.048
7.696SerIle: 7.696 ± 0.159
5.549SerLys: 5.549 ± 0.119
8.323SerLeu: 8.323 ± 0.199
1.725SerMet: 1.725 ± 0.069
3.102SerAsn: 3.102 ± 0.104
3.008SerPro: 3.008 ± 0.075
1.783SerGln: 1.783 ± 0.08
2.777SerArg: 2.777 ± 0.082
6.55SerSer: 6.55 ± 0.166
3.155SerThr: 3.155 ± 0.107
4.421SerVal: 4.421 ± 0.115
0.755SerTrp: 0.755 ± 0.051
3.425SerTyr: 3.425 ± 0.1
0.0SerXaa: 0.0 ± 0.0
Thr
2.646ThrAla: 2.646 ± 0.097
0.294ThrCys: 0.294 ± 0.029
1.718ThrAsp: 1.718 ± 0.071
2.384ThrGlu: 2.384 ± 0.082
2.176ThrPhe: 2.176 ± 0.074
3.485ThrGly: 3.485 ± 0.11
0.698ThrHis: 0.698 ± 0.038
4.117ThrIle: 4.117 ± 0.103
2.727ThrLys: 2.727 ± 0.085
4.476ThrLeu: 4.476 ± 0.129
1.007ThrMet: 1.007 ± 0.054
1.841ThrAsn: 1.841 ± 0.08
1.954ThrPro: 1.954 ± 0.062
0.975ThrGln: 0.975 ± 0.056
1.636ThrArg: 1.636 ± 0.059
3.267ThrSer: 3.267 ± 0.118
2.121ThrThr: 2.121 ± 0.106
2.984ThrVal: 2.984 ± 0.104
0.417ThrTrp: 0.417 ± 0.039
1.888ThrTyr: 1.888 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
4.397ValAla: 4.397 ± 0.126
0.506ValCys: 0.506 ± 0.037
3.144ValAsp: 3.144 ± 0.1
5.179ValGlu: 5.179 ± 0.133
2.905ValPhe: 2.905 ± 0.101
4.143ValGly: 4.143 ± 0.11
0.821ValHis: 0.821 ± 0.043
6.126ValIle: 6.126 ± 0.115
5.47ValLys: 5.47 ± 0.12
6.789ValLeu: 6.789 ± 0.125
1.555ValMet: 1.555 ± 0.063
2.801ValAsn: 2.801 ± 0.087
2.85ValPro: 2.85 ± 0.08
1.28ValGln: 1.28 ± 0.062
2.782ValArg: 2.782 ± 0.094
4.982ValSer: 4.982 ± 0.138
2.853ValThr: 2.853 ± 0.096
5.006ValVal: 5.006 ± 0.127
0.642ValTrp: 0.642 ± 0.045
2.785ValTyr: 2.785 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.488TrpAla: 0.488 ± 0.039
0.06TrpCys: 0.06 ± 0.012
0.417TrpAsp: 0.417 ± 0.036
0.561TrpGlu: 0.561 ± 0.039
0.438TrpPhe: 0.438 ± 0.033
0.726TrpGly: 0.726 ± 0.052
0.142TrpHis: 0.142 ± 0.022
1.012TrpIle: 1.012 ± 0.05
0.779TrpLys: 0.779 ± 0.047
0.996TrpLeu: 0.996 ± 0.05
0.323TrpMet: 0.323 ± 0.028
0.545TrpAsn: 0.545 ± 0.039
0.307TrpPro: 0.307 ± 0.029
0.186TrpGln: 0.186 ± 0.024
0.532TrpArg: 0.532 ± 0.04
0.684TrpSer: 0.684 ± 0.042
0.307TrpThr: 0.307 ± 0.032
0.509TrpVal: 0.509 ± 0.035
0.139TrpTrp: 0.139 ± 0.023
0.378TrpTyr: 0.378 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.499TyrAla: 2.499 ± 0.081
0.364TyrCys: 0.364 ± 0.031
1.93TyrAsp: 1.93 ± 0.079
2.795TyrGlu: 2.795 ± 0.09
2.053TyrPhe: 2.053 ± 0.077
3.042TyrGly: 3.042 ± 0.087
0.519TyrHis: 0.519 ± 0.037
3.975TyrIle: 3.975 ± 0.114
2.774TyrLys: 2.774 ± 0.084
4.117TyrLeu: 4.117 ± 0.107
1.093TyrMet: 1.093 ± 0.053
1.985TyrAsn: 1.985 ± 0.077
1.796TyrPro: 1.796 ± 0.067
0.823TyrGln: 0.823 ± 0.051
1.838TyrArg: 1.838 ± 0.067
3.375TyrSer: 3.375 ± 0.12
1.914TyrThr: 1.914 ± 0.078
2.827TyrVal: 2.827 ± 0.09
0.425TyrTrp: 0.425 ± 0.037
1.917TyrTyr: 1.917 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1384 proteins (381356 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski