Amino acid dipepetide frequency for Acinetobacter larvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.004AlaAla: 10.004 ± 0.148
1.044AlaCys: 1.044 ± 0.036
4.935AlaAsp: 4.935 ± 0.084
5.858AlaGlu: 5.858 ± 0.102
3.357AlaPhe: 3.357 ± 0.061
6.303AlaGly: 6.303 ± 0.12
2.158AlaHis: 2.158 ± 0.057
6.382AlaIle: 6.382 ± 0.093
4.839AlaLys: 4.839 ± 0.094
11.113AlaLeu: 11.113 ± 0.146
2.682AlaMet: 2.682 ± 0.057
3.403AlaAsn: 3.403 ± 0.076
3.246AlaPro: 3.246 ± 0.099
6.556AlaGln: 6.556 ± 0.108
3.845AlaArg: 3.845 ± 0.058
5.228AlaSer: 5.228 ± 0.084
5.237AlaThr: 5.237 ± 0.13
6.419AlaVal: 6.419 ± 0.089
1.342AlaTrp: 1.342 ± 0.041
2.993AlaTyr: 2.993 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.82CysAla: 0.82 ± 0.033
0.204CysCys: 0.204 ± 0.015
0.502CysAsp: 0.502 ± 0.024
0.444CysGlu: 0.444 ± 0.023
0.505CysPhe: 0.505 ± 0.023
0.758CysGly: 0.758 ± 0.026
0.309CysHis: 0.309 ± 0.018
0.731CysIle: 0.731 ± 0.03
0.341CysLys: 0.341 ± 0.022
1.128CysLeu: 1.128 ± 0.038
0.265CysMet: 0.265 ± 0.018
0.306CysAsn: 0.306 ± 0.019
0.398CysPro: 0.398 ± 0.022
0.601CysGln: 0.601 ± 0.025
0.438CysArg: 0.438 ± 0.023
0.667CysSer: 0.667 ± 0.026
0.431CysThr: 0.431 ± 0.025
0.668CysVal: 0.668 ± 0.028
0.119CysTrp: 0.119 ± 0.011
0.38CysTyr: 0.38 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.154AspAla: 5.154 ± 0.118
0.481AspCys: 0.481 ± 0.023
2.653AspAsp: 2.653 ± 0.068
2.878AspGlu: 2.878 ± 0.066
2.541AspPhe: 2.541 ± 0.05
3.439AspGly: 3.439 ± 0.173
1.494AspHis: 1.494 ± 0.044
3.725AspIle: 3.725 ± 0.068
2.236AspLys: 2.236 ± 0.069
5.716AspLeu: 5.716 ± 0.085
1.135AspMet: 1.135 ± 0.035
1.798AspAsn: 1.798 ± 0.058
2.257AspPro: 2.257 ± 0.082
3.269AspGln: 3.269 ± 0.061
2.412AspArg: 2.412 ± 0.052
2.623AspSer: 2.623 ± 0.055
2.108AspThr: 2.108 ± 0.071
3.548AspVal: 3.548 ± 0.084
0.826AspTrp: 0.826 ± 0.027
2.218AspTyr: 2.218 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
4.478GluAla: 4.478 ± 0.085
0.34GluCys: 0.34 ± 0.02
2.427GluAsp: 2.427 ± 0.057
2.277GluGlu: 2.277 ± 0.053
1.788GluPhe: 1.788 ± 0.053
2.589GluGly: 2.589 ± 0.053
1.661GluHis: 1.661 ± 0.041
3.764GluIle: 3.764 ± 0.07
3.188GluLys: 3.188 ± 0.058
5.269GluLeu: 5.269 ± 0.085
1.246GluMet: 1.246 ± 0.037
2.459GluAsn: 2.459 ± 0.053
1.452GluPro: 1.452 ± 0.051
4.722GluGln: 4.722 ± 0.092
2.654GluArg: 2.654 ± 0.058
2.639GluSer: 2.639 ± 0.059
2.297GluThr: 2.297 ± 0.061
3.226GluVal: 3.226 ± 0.065
0.606GluTrp: 0.606 ± 0.03
1.613GluTyr: 1.613 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
4.024PheAla: 4.024 ± 0.072
0.508PheCys: 0.508 ± 0.022
2.571PheAsp: 2.571 ± 0.056
2.237PheGlu: 2.237 ± 0.055
1.673PhePhe: 1.673 ± 0.063
2.724PheGly: 2.724 ± 0.063
0.835PheHis: 0.835 ± 0.029
2.907PheIle: 2.907 ± 0.066
2.299PheLys: 2.299 ± 0.052
3.512PheLeu: 3.512 ± 0.084
1.058PheMet: 1.058 ± 0.032
2.069PheAsn: 2.069 ± 0.048
1.327PhePro: 1.327 ± 0.044
1.808PheGln: 1.808 ± 0.046
1.412PheArg: 1.412 ± 0.04
3.021PheSer: 3.021 ± 0.066
1.717PheThr: 1.717 ± 0.041
2.331PheVal: 2.331 ± 0.062
0.555PheTrp: 0.555 ± 0.028
1.545PheTyr: 1.545 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.272GlyAla: 5.272 ± 0.103
0.764GlyCys: 0.764 ± 0.028
3.05GlyAsp: 3.05 ± 0.109
3.288GlyGlu: 3.288 ± 0.065
2.923GlyPhe: 2.923 ± 0.06
4.402GlyGly: 4.402 ± 0.094
1.561GlyHis: 1.561 ± 0.038
4.628GlyIle: 4.628 ± 0.076
3.207GlyLys: 3.207 ± 0.111
7.014GlyLeu: 7.014 ± 0.116
1.529GlyMet: 1.529 ± 0.043
2.37GlyAsn: 2.37 ± 0.111
1.573GlyPro: 1.573 ± 0.045
3.512GlyGln: 3.512 ± 0.062
3.06GlyArg: 3.06 ± 0.059
3.792GlySer: 3.792 ± 0.132
3.227GlyThr: 3.227 ± 0.119
4.624GlyVal: 4.624 ± 0.122
0.868GlyTrp: 0.868 ± 0.032
2.425GlyTyr: 2.425 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.549HisAla: 2.549 ± 0.054
0.356HisCys: 0.356 ± 0.019
1.33HisAsp: 1.33 ± 0.037
1.064HisGlu: 1.064 ± 0.038
1.204HisPhe: 1.204 ± 0.038
1.64HisGly: 1.64 ± 0.041
0.89HisHis: 0.89 ± 0.031
1.792HisIle: 1.792 ± 0.046
0.968HisLys: 0.968 ± 0.031
2.736HisLeu: 2.736 ± 0.064
0.587HisMet: 0.587 ± 0.024
0.996HisAsn: 0.996 ± 0.033
1.371HisPro: 1.371 ± 0.036
1.652HisGln: 1.652 ± 0.045
1.217HisArg: 1.217 ± 0.035
1.608HisSer: 1.608 ± 0.045
1.046HisThr: 1.046 ± 0.033
1.446HisVal: 1.446 ± 0.036
0.451HisTrp: 0.451 ± 0.023
1.305HisTyr: 1.305 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
7.451IleAla: 7.451 ± 0.096
0.778IleCys: 0.778 ± 0.026
4.306IleAsp: 4.306 ± 0.07
4.179IleGlu: 4.179 ± 0.068
2.764IlePhe: 2.764 ± 0.068
4.533IleGly: 4.533 ± 0.088
1.504IleHis: 1.504 ± 0.041
4.006IleIle: 4.006 ± 0.076
3.078IleLys: 3.078 ± 0.063
6.49IleLeu: 6.49 ± 0.121
1.351IleMet: 1.351 ± 0.042
2.8IleAsn: 2.8 ± 0.062
2.775IlePro: 2.775 ± 0.063
3.7IleGln: 3.7 ± 0.073
3.039IleArg: 3.039 ± 0.06
4.307IleSer: 4.307 ± 0.071
3.271IleThr: 3.271 ± 0.091
4.031IleVal: 4.031 ± 0.074
0.72IleTrp: 0.72 ± 0.028
2.207IleTyr: 2.207 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.619LysAla: 4.619 ± 0.102
0.256LysCys: 0.256 ± 0.016
2.627LysAsp: 2.627 ± 0.112
2.168LysGlu: 2.168 ± 0.052
1.637LysPhe: 1.637 ± 0.043
2.633LysGly: 2.633 ± 0.071
1.195LysHis: 1.195 ± 0.037
3.643LysIle: 3.643 ± 0.068
2.824LysLys: 2.824 ± 0.064
4.704LysLeu: 4.704 ± 0.071
1.186LysMet: 1.186 ± 0.04
2.492LysAsn: 2.492 ± 0.06
1.975LysPro: 1.975 ± 0.046
3.284LysGln: 3.284 ± 0.068
2.344LysArg: 2.344 ± 0.054
2.902LysSer: 2.902 ± 0.063
2.913LysThr: 2.913 ± 0.063
3.276LysVal: 3.276 ± 0.075
0.492LysTrp: 0.492 ± 0.024
1.527LysTyr: 1.527 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
10.841LeuAla: 10.841 ± 0.147
1.283LeuCys: 1.283 ± 0.039
5.81LeuAsp: 5.81 ± 0.079
5.315LeuGlu: 5.315 ± 0.098
4.028LeuPhe: 4.028 ± 0.1
7.01LeuGly: 7.01 ± 0.098
2.377LeuHis: 2.377 ± 0.055
6.517LeuIle: 6.517 ± 0.105
5.978LeuLys: 5.978 ± 0.076
11.062LeuLeu: 11.062 ± 0.193
2.518LeuMet: 2.518 ± 0.058
5.09LeuAsn: 5.09 ± 0.074
4.518LeuPro: 4.518 ± 0.079
6.28LeuGln: 6.28 ± 0.119
4.388LeuArg: 4.388 ± 0.072
8.203LeuSer: 8.203 ± 0.103
5.285LeuThr: 5.285 ± 0.072
5.838LeuVal: 5.838 ± 0.097
1.33LeuTrp: 1.33 ± 0.042
3.122LeuTyr: 3.122 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.171MetAla: 2.171 ± 0.053
0.209MetCys: 0.209 ± 0.014
0.949MetAsp: 0.949 ± 0.032
0.738MetGlu: 0.738 ± 0.029
0.746MetPhe: 0.746 ± 0.032
1.579MetGly: 1.579 ± 0.048
0.596MetHis: 0.596 ± 0.024
1.49MetIle: 1.49 ± 0.046
1.106MetLys: 1.106 ± 0.031
2.71MetLeu: 2.71 ± 0.064
0.674MetMet: 0.674 ± 0.028
1.091MetAsn: 1.091 ± 0.034
1.137MetPro: 1.137 ± 0.033
1.655MetGln: 1.655 ± 0.043
1.165MetArg: 1.165 ± 0.035
1.793MetSer: 1.793 ± 0.042
1.474MetThr: 1.474 ± 0.042
1.466MetVal: 1.466 ± 0.039
0.204MetTrp: 0.204 ± 0.015
0.54MetTyr: 0.54 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.775AsnAla: 3.775 ± 0.093
0.354AsnCys: 0.354 ± 0.017
2.085AsnAsp: 2.085 ± 0.054
1.713AsnGlu: 1.713 ± 0.042
1.769AsnPhe: 1.769 ± 0.046
2.564AsnGly: 2.564 ± 0.08
1.082AsnHis: 1.082 ± 0.03
3.379AsnIle: 3.379 ± 0.081
2.163AsnLys: 2.163 ± 0.053
4.186AsnLeu: 4.186 ± 0.081
0.882AsnMet: 0.882 ± 0.033
2.043AsnAsn: 2.043 ± 0.065
2.263AsnPro: 2.263 ± 0.059
2.351AsnGln: 2.351 ± 0.052
1.776AsnArg: 1.776 ± 0.04
2.554AsnSer: 2.554 ± 0.057
2.404AsnThr: 2.404 ± 0.071
2.395AsnVal: 2.395 ± 0.07
0.495AsnTrp: 0.495 ± 0.021
1.548AsnTyr: 1.548 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.622ProAla: 3.622 ± 0.072
0.288ProCys: 0.288 ± 0.019
2.207ProAsp: 2.207 ± 0.073
2.805ProGlu: 2.805 ± 0.059
1.593ProPhe: 1.593 ± 0.047
1.669ProGly: 1.669 ± 0.082
1.022ProHis: 1.022 ± 0.031
2.594ProIle: 2.594 ± 0.06
1.968ProLys: 1.968 ± 0.045
3.894ProLeu: 3.894 ± 0.073
0.922ProMet: 0.922 ± 0.034
1.823ProAsn: 1.823 ± 0.049
1.156ProPro: 1.156 ± 0.052
2.295ProGln: 2.295 ± 0.057
1.525ProArg: 1.525 ± 0.041
2.555ProSer: 2.555 ± 0.051
2.21ProThr: 2.21 ± 0.066
2.801ProVal: 2.801 ± 0.071
0.487ProTrp: 0.487 ± 0.025
1.397ProTyr: 1.397 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
6.357GlnAla: 6.357 ± 0.115
0.556GlnCys: 0.556 ± 0.027
3.017GlnAsp: 3.017 ± 0.066
2.321GlnGlu: 2.321 ± 0.059
2.3GlnPhe: 2.3 ± 0.054
3.507GlnGly: 3.507 ± 0.06
2.929GlnHis: 2.929 ± 0.07
3.695GlnIle: 3.695 ± 0.06
2.737GlnLys: 2.737 ± 0.056
7.56GlnLeu: 7.56 ± 0.12
1.22GlnMet: 1.22 ± 0.037
2.354GlnAsn: 2.354 ± 0.049
2.298GlnPro: 2.298 ± 0.053
7.605GlnGln: 7.605 ± 0.212
3.593GlnArg: 3.593 ± 0.075
3.682GlnSer: 3.682 ± 0.069
2.589GlnThr: 2.589 ± 0.049
3.804GlnVal: 3.804 ± 0.065
0.933GlnTrp: 0.933 ± 0.032
2.301GlnTyr: 2.301 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
3.726ArgAla: 3.726 ± 0.081
0.473ArgCys: 0.473 ± 0.023
2.372ArgAsp: 2.372 ± 0.062
2.405ArgGlu: 2.405 ± 0.059
2.183ArgPhe: 2.183 ± 0.052
2.559ArgGly: 2.559 ± 0.056
1.272ArgHis: 1.272 ± 0.04
3.156ArgIle: 3.156 ± 0.062
2.058ArgLys: 2.058 ± 0.051
5.234ArgLeu: 5.234 ± 0.091
1.152ArgMet: 1.152 ± 0.035
1.706ArgAsn: 1.706 ± 0.045
1.846ArgPro: 1.846 ± 0.047
2.908ArgGln: 2.908 ± 0.056
2.354ArgArg: 2.354 ± 0.061
2.462ArgSer: 2.462 ± 0.051
1.814ArgThr: 1.814 ± 0.041
2.951ArgVal: 2.951 ± 0.055
0.658ArgTrp: 0.658 ± 0.025
2.071ArgTyr: 2.071 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.782SerAla: 5.782 ± 0.093
0.561SerCys: 0.561 ± 0.022
2.948SerAsp: 2.948 ± 0.062
2.808SerGlu: 2.808 ± 0.051
2.736SerPhe: 2.736 ± 0.056
4.058SerGly: 4.058 ± 0.07
1.587SerHis: 1.587 ± 0.043
4.433SerIle: 4.433 ± 0.071
2.963SerLys: 2.963 ± 0.059
6.579SerLeu: 6.579 ± 0.102
1.525SerMet: 1.525 ± 0.044
2.897SerAsn: 2.897 ± 0.078
2.422SerPro: 2.422 ± 0.061
3.245SerGln: 3.245 ± 0.063
2.59SerArg: 2.59 ± 0.048
4.207SerSer: 4.207 ± 0.085
3.541SerThr: 3.541 ± 0.091
3.591SerVal: 3.591 ± 0.084
0.763SerTrp: 0.763 ± 0.043
2.287SerTyr: 2.287 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
5.583ThrAla: 5.583 ± 0.135
0.382ThrCys: 0.382 ± 0.02
2.654ThrAsp: 2.654 ± 0.116
2.781ThrGlu: 2.781 ± 0.063
1.627ThrPhe: 1.627 ± 0.048
3.964ThrGly: 3.964 ± 0.113
1.163ThrHis: 1.163 ± 0.037
3.055ThrIle: 3.055 ± 0.061
1.765ThrLys: 1.765 ± 0.045
5.418ThrLeu: 5.418 ± 0.075
0.928ThrMet: 0.928 ± 0.034
1.536ThrAsn: 1.536 ± 0.063
2.566ThrPro: 2.566 ± 0.054
2.999ThrGln: 2.999 ± 0.062
2.164ThrArg: 2.164 ± 0.047
2.571ThrSer: 2.571 ± 0.061
3.036ThrThr: 3.036 ± 0.088
3.844ThrVal: 3.844 ± 0.183
0.691ThrTrp: 0.691 ± 0.042
1.351ThrTyr: 1.351 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.499ValAla: 6.499 ± 0.125
0.632ValCys: 0.632 ± 0.026
3.675ValAsp: 3.675 ± 0.08
3.595ValGlu: 3.595 ± 0.066
2.569ValPhe: 2.569 ± 0.06
4.196ValGly: 4.196 ± 0.148
1.308ValHis: 1.308 ± 0.037
4.461ValIle: 4.461 ± 0.072
3.047ValLys: 3.047 ± 0.074
6.918ValLeu: 6.918 ± 0.097
1.653ValMet: 1.653 ± 0.043
2.652ValAsn: 2.652 ± 0.084
2.392ValPro: 2.392 ± 0.045
3.141ValGln: 3.141 ± 0.062
2.624ValArg: 2.624 ± 0.051
3.737ValSer: 3.737 ± 0.065
3.343ValThr: 3.343 ± 0.135
4.766ValVal: 4.766 ± 0.127
0.781ValTrp: 0.781 ± 0.029
1.865ValTyr: 1.865 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.936TrpAla: 0.936 ± 0.034
0.168TrpCys: 0.168 ± 0.014
0.554TrpAsp: 0.554 ± 0.024
0.41TrpGlu: 0.41 ± 0.02
0.584TrpPhe: 0.584 ± 0.023
0.779TrpGly: 0.779 ± 0.029
0.386TrpHis: 0.386 ± 0.021
0.813TrpIle: 0.813 ± 0.031
0.501TrpLys: 0.501 ± 0.019
1.796TrpLeu: 1.796 ± 0.055
0.387TrpMet: 0.387 ± 0.022
0.495TrpAsn: 0.495 ± 0.021
0.373TrpPro: 0.373 ± 0.018
1.208TrpGln: 1.208 ± 0.04
0.793TrpArg: 0.793 ± 0.028
0.852TrpSer: 0.852 ± 0.031
0.54TrpThr: 0.54 ± 0.038
0.859TrpVal: 0.859 ± 0.028
0.156TrpTrp: 0.156 ± 0.014
0.424TrpTyr: 0.424 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.278TyrAla: 3.278 ± 0.057
0.38TyrCys: 0.38 ± 0.019
1.843TyrAsp: 1.843 ± 0.043
1.408TyrGlu: 1.408 ± 0.035
1.605TyrPhe: 1.605 ± 0.049
2.182TyrGly: 2.182 ± 0.051
0.879TyrHis: 0.879 ± 0.029
2.123TyrIle: 2.123 ± 0.049
1.434TyrLys: 1.434 ± 0.042
3.751TyrLeu: 3.751 ± 0.066
0.594TyrMet: 0.594 ± 0.026
1.401TyrAsn: 1.401 ± 0.044
1.487TyrPro: 1.487 ± 0.046
2.57TyrGln: 2.57 ± 0.059
1.966TyrArg: 1.966 ± 0.048
2.12TyrSer: 2.12 ± 0.049
1.595TyrThr: 1.595 ± 0.056
1.968TyrVal: 1.968 ± 0.05
0.537TyrTrp: 0.537 ± 0.024
1.214TyrTyr: 1.214 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3108 proteins (1021974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski