Amino acid dipepetide frequency for Fusobacterium nucleatum subsp. animalis ATCC 51191

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.529AlaAla: 3.529 ± 0.107
0.586AlaCys: 0.586 ± 0.032
2.831AlaAsp: 2.831 ± 0.07
3.611AlaGlu: 3.611 ± 0.089
2.591AlaPhe: 2.591 ± 0.062
4.187AlaGly: 4.187 ± 0.107
0.813AlaHis: 0.813 ± 0.036
5.541AlaIle: 5.541 ± 0.097
5.422AlaLys: 5.422 ± 0.11
5.372AlaLeu: 5.372 ± 0.111
1.502AlaMet: 1.502 ± 0.051
3.083AlaAsn: 3.083 ± 0.096
1.466AlaPro: 1.466 ± 0.053
1.304AlaGln: 1.304 ± 0.051
1.88AlaArg: 1.88 ± 0.055
3.126AlaSer: 3.126 ± 0.083
3.157AlaThr: 3.157 ± 0.082
3.703AlaVal: 3.703 ± 0.084
0.342AlaTrp: 0.342 ± 0.028
2.278AlaTyr: 2.278 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.343CysAla: 0.343 ± 0.025
0.131CysCys: 0.131 ± 0.014
0.435CysAsp: 0.435 ± 0.025
0.458CysGlu: 0.458 ± 0.028
0.375CysPhe: 0.375 ± 0.023
0.803CysGly: 0.803 ± 0.04
0.131CysHis: 0.131 ± 0.014
0.753CysIle: 0.753 ± 0.038
0.632CysLys: 0.632 ± 0.027
0.674CysLeu: 0.674 ± 0.031
0.234CysMet: 0.234 ± 0.019
0.387CysAsn: 0.387 ± 0.025
0.317CysPro: 0.317 ± 0.027
0.181CysGln: 0.181 ± 0.017
0.231CysArg: 0.231 ± 0.018
0.556CysSer: 0.556 ± 0.027
0.342CysThr: 0.342 ± 0.023
0.437CysVal: 0.437 ± 0.029
0.067CysTrp: 0.067 ± 0.01
0.345CysTyr: 0.345 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.332AspAla: 2.332 ± 0.061
0.414AspCys: 0.414 ± 0.024
2.524AspAsp: 2.524 ± 0.064
4.758AspGlu: 4.758 ± 0.099
3.011AspPhe: 3.011 ± 0.073
3.556AspGly: 3.556 ± 0.088
0.402AspHis: 0.402 ± 0.023
6.126AspIle: 6.126 ± 0.106
5.883AspLys: 5.883 ± 0.115
5.012AspLeu: 5.012 ± 0.105
1.372AspMet: 1.372 ± 0.049
3.327AspAsn: 3.327 ± 0.079
1.233AspPro: 1.233 ± 0.044
0.571AspGln: 0.571 ± 0.033
1.986AspArg: 1.986 ± 0.061
2.828AspSer: 2.828 ± 0.066
2.624AspThr: 2.624 ± 0.067
3.245AspVal: 3.245 ± 0.088
0.432AspTrp: 0.432 ± 0.027
2.757AspTyr: 2.757 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.439GluAla: 4.439 ± 0.093
0.469GluCys: 0.469 ± 0.028
4.235GluAsp: 4.235 ± 0.088
6.977GluGlu: 6.977 ± 0.143
3.071GluPhe: 3.071 ± 0.068
3.564GluGly: 3.564 ± 0.071
0.837GluHis: 0.837 ± 0.034
8.207GluIle: 8.207 ± 0.136
9.651GluLys: 9.651 ± 0.142
6.694GluLeu: 6.694 ± 0.129
1.877GluMet: 1.877 ± 0.053
6.616GluAsn: 6.616 ± 0.109
1.259GluPro: 1.259 ± 0.05
1.685GluGln: 1.685 ± 0.045
2.71GluArg: 2.71 ± 0.081
3.071GluSer: 3.071 ± 0.068
3.16GluThr: 3.16 ± 0.065
4.879GluVal: 4.879 ± 0.093
0.517GluTrp: 0.517 ± 0.028
3.307GluTyr: 3.307 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
2.281PheAla: 2.281 ± 0.058
0.413PheCys: 0.413 ± 0.024
2.517PheAsp: 2.517 ± 0.075
3.147PheGlu: 3.147 ± 0.084
2.514PhePhe: 2.514 ± 0.082
3.058PheGly: 3.058 ± 0.077
0.514PheHis: 0.514 ± 0.028
4.429PheIle: 4.429 ± 0.1
4.134PheLys: 4.134 ± 0.074
4.899PheLeu: 4.899 ± 0.106
1.258PheMet: 1.258 ± 0.043
2.638PheAsn: 2.638 ± 0.064
1.271PhePro: 1.271 ± 0.051
1.02PheGln: 1.02 ± 0.043
1.395PheArg: 1.395 ± 0.051
3.768PheSer: 3.768 ± 0.083
2.229PheThr: 2.229 ± 0.059
2.69PheVal: 2.69 ± 0.064
0.331PheTrp: 0.331 ± 0.024
2.211PheTyr: 2.211 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.317GlyAla: 4.317 ± 0.118
0.55GlyCys: 0.55 ± 0.027
3.263GlyAsp: 3.263 ± 0.081
4.471GlyGlu: 4.471 ± 0.103
2.799GlyPhe: 2.799 ± 0.06
4.58GlyGly: 4.58 ± 0.114
0.984GlyHis: 0.984 ± 0.046
6.978GlyIle: 6.978 ± 0.128
6.567GlyLys: 6.567 ± 0.124
5.354GlyLeu: 5.354 ± 0.113
1.779GlyMet: 1.779 ± 0.068
3.789GlyAsn: 3.789 ± 0.129
1.138GlyPro: 1.138 ± 0.047
1.36GlyGln: 1.36 ± 0.051
2.313GlyArg: 2.313 ± 0.068
3.705GlySer: 3.705 ± 0.095
3.971GlyThr: 3.971 ± 0.162
4.745GlyVal: 4.745 ± 0.114
0.42GlyTrp: 0.42 ± 0.024
2.916GlyTyr: 2.916 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
0.561HisAla: 0.561 ± 0.032
0.122HisCys: 0.122 ± 0.014
0.52HisAsp: 0.52 ± 0.028
0.635HisGlu: 0.635 ± 0.033
0.614HisPhe: 0.614 ± 0.036
0.859HisGly: 0.859 ± 0.037
0.221HisHis: 0.221 ± 0.018
1.283HisIle: 1.283 ± 0.049
0.995HisLys: 0.995 ± 0.037
1.067HisLeu: 1.067 ± 0.046
0.274HisMet: 0.274 ± 0.022
0.724HisAsn: 0.724 ± 0.031
0.55HisPro: 0.55 ± 0.029
0.37HisGln: 0.37 ± 0.025
0.497HisArg: 0.497 ± 0.029
0.831HisSer: 0.831 ± 0.041
0.674HisThr: 0.674 ± 0.033
0.526HisVal: 0.526 ± 0.033
0.089HisTrp: 0.089 ± 0.01
0.55HisTyr: 0.55 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.875IleAla: 5.875 ± 0.117
0.88IleCys: 0.88 ± 0.043
5.552IleAsp: 5.552 ± 0.095
7.586IleGlu: 7.586 ± 0.117
4.991IlePhe: 4.991 ± 0.121
6.326IleGly: 6.326 ± 0.124
1.087IleHis: 1.087 ± 0.04
8.637IleIle: 8.637 ± 0.157
9.218IleLys: 9.218 ± 0.137
9.586IleLeu: 9.586 ± 0.158
2.092IleMet: 2.092 ± 0.055
5.79IleAsn: 5.79 ± 0.116
3.159IlePro: 3.159 ± 0.08
2.071IleGln: 2.071 ± 0.059
2.872IleArg: 2.872 ± 0.075
6.602IleSer: 6.602 ± 0.104
4.782IleThr: 4.782 ± 0.102
5.995IleVal: 5.995 ± 0.101
0.544IleTrp: 0.544 ± 0.031
3.871IleTyr: 3.871 ± 0.083
0.0IleXaa: 0.0 ± 0.0
Lys
4.915LysAla: 4.915 ± 0.103
0.467LysCys: 0.467 ± 0.027
6.507LysAsp: 6.507 ± 0.116
9.751LysGlu: 9.751 ± 0.145
3.983LysPhe: 3.983 ± 0.086
5.287LysGly: 5.287 ± 0.11
0.985LysHis: 0.985 ± 0.04
10.085LysIle: 10.085 ± 0.133
10.576LysLys: 10.576 ± 0.181
8.144LysLeu: 8.144 ± 0.117
2.817LysMet: 2.817 ± 0.081
8.231LysAsn: 8.231 ± 0.15
1.87LysPro: 1.87 ± 0.054
1.994LysGln: 1.994 ± 0.059
3.165LysArg: 3.165 ± 0.076
4.921LysSer: 4.921 ± 0.09
4.46LysThr: 4.46 ± 0.086
6.115LysVal: 6.115 ± 0.1
0.659LysTrp: 0.659 ± 0.035
4.735LysTyr: 4.735 ± 0.107
0.0LysXaa: 0.0 ± 0.0
Leu
5.443LeuAla: 5.443 ± 0.097
0.713LeuCys: 0.713 ± 0.036
5.141LeuAsp: 5.141 ± 0.094
7.403LeuGlu: 7.403 ± 0.111
4.06LeuPhe: 4.06 ± 0.096
6.264LeuGly: 6.264 ± 0.097
1.055LeuHis: 1.055 ± 0.038
7.858LeuIle: 7.858 ± 0.145
9.785LeuLys: 9.785 ± 0.162
7.997LeuLeu: 7.997 ± 0.162
2.243LeuMet: 2.243 ± 0.062
5.558LeuAsn: 5.558 ± 0.104
2.69LeuPro: 2.69 ± 0.072
2.001LeuGln: 2.001 ± 0.062
2.913LeuArg: 2.913 ± 0.077
6.356LeuSer: 6.356 ± 0.117
4.648LeuThr: 4.648 ± 0.077
5.165LeuVal: 5.165 ± 0.096
0.494LeuTrp: 0.494 ± 0.03
3.074LeuTyr: 3.074 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.613MetAla: 1.613 ± 0.046
0.144MetCys: 0.144 ± 0.017
1.25MetAsp: 1.25 ± 0.048
1.988MetGlu: 1.988 ± 0.06
0.979MetPhe: 0.979 ± 0.039
1.839MetGly: 1.839 ± 0.064
0.24MetHis: 0.24 ± 0.017
2.078MetIle: 2.078 ± 0.06
2.796MetLys: 2.796 ± 0.065
2.329MetLeu: 2.329 ± 0.065
0.645MetMet: 0.645 ± 0.036
1.504MetAsn: 1.504 ± 0.045
0.757MetPro: 0.757 ± 0.035
0.544MetGln: 0.544 ± 0.028
0.809MetArg: 0.809 ± 0.039
1.563MetSer: 1.563 ± 0.049
1.235MetThr: 1.235 ± 0.045
1.344MetVal: 1.344 ± 0.046
0.148MetTrp: 0.148 ± 0.016
0.889MetTyr: 0.889 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.789AsnAla: 2.789 ± 0.087
0.416AsnCys: 0.416 ± 0.024
2.904AsnAsp: 2.904 ± 0.072
4.141AsnGlu: 4.141 ± 0.076
3.295AsnPhe: 3.295 ± 0.067
4.273AsnGly: 4.273 ± 0.146
0.653AsnHis: 0.653 ± 0.037
7.378AsnIle: 7.378 ± 0.158
6.368AsnLys: 6.368 ± 0.11
6.226AsnLeu: 6.226 ± 0.105
1.604AsnMet: 1.604 ± 0.051
4.324AsnAsn: 4.324 ± 0.125
2.276AsnPro: 2.276 ± 0.064
1.498AsnGln: 1.498 ± 0.05
2.093AsnArg: 2.093 ± 0.061
4.113AsnSer: 4.113 ± 0.132
3.099AsnThr: 3.099 ± 0.1
3.561AsnVal: 3.561 ± 0.098
0.431AsnTrp: 0.431 ± 0.027
2.949AsnTyr: 2.949 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
1.596ProAla: 1.596 ± 0.047
0.237ProCys: 0.237 ± 0.02
1.422ProAsp: 1.422 ± 0.049
2.255ProGlu: 2.255 ± 0.069
1.366ProPhe: 1.366 ± 0.051
1.371ProGly: 1.371 ± 0.046
0.423ProHis: 0.423 ± 0.027
2.527ProIle: 2.527 ± 0.06
2.264ProLys: 2.264 ± 0.059
2.335ProLeu: 2.335 ± 0.063
0.627ProMet: 0.627 ± 0.033
1.67ProAsn: 1.67 ± 0.052
0.574ProPro: 0.574 ± 0.031
0.691ProGln: 0.691 ± 0.029
0.741ProArg: 0.741 ± 0.039
1.472ProSer: 1.472 ± 0.049
1.578ProThr: 1.578 ± 0.053
2.0ProVal: 2.0 ± 0.06
0.209ProTrp: 0.209 ± 0.017
1.303ProTyr: 1.303 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
1.409GlnAla: 1.409 ± 0.047
0.178GlnCys: 0.178 ± 0.016
1.135GlnAsp: 1.135 ± 0.043
1.779GlnGlu: 1.779 ± 0.057
0.901GlnPhe: 0.901 ± 0.037
1.418GlnGly: 1.418 ± 0.043
0.243GlnHis: 0.243 ± 0.018
2.093GlnIle: 2.093 ± 0.058
2.294GlnLys: 2.294 ± 0.059
1.838GlnLeu: 1.838 ± 0.052
0.617GlnMet: 0.617 ± 0.026
1.549GlnAsn: 1.549 ± 0.045
0.472GlnPro: 0.472 ± 0.027
0.606GlnGln: 0.606 ± 0.033
0.863GlnArg: 0.863 ± 0.038
1.053GlnSer: 1.053 ± 0.041
1.084GlnThr: 1.084 ± 0.039
1.354GlnVal: 1.354 ± 0.041
0.147GlnTrp: 0.147 ± 0.014
0.954GlnTyr: 0.954 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.095ArgAla: 2.095 ± 0.058
0.255ArgCys: 0.255 ± 0.02
1.808ArgAsp: 1.808 ± 0.052
3.056ArgGlu: 3.056 ± 0.07
1.403ArgPhe: 1.403 ± 0.047
2.077ArgGly: 2.077 ± 0.067
0.384ArgHis: 0.384 ± 0.022
3.13ArgIle: 3.13 ± 0.067
3.422ArgLys: 3.422 ± 0.096
2.681ArgLeu: 2.681 ± 0.066
0.854ArgMet: 0.854 ± 0.04
2.018ArgAsn: 2.018 ± 0.054
0.787ArgPro: 0.787 ± 0.036
0.795ArgGln: 0.795 ± 0.032
1.261ArgArg: 1.261 ± 0.05
1.282ArgSer: 1.282 ± 0.046
1.457ArgThr: 1.457 ± 0.047
2.105ArgVal: 2.105 ± 0.06
0.213ArgTrp: 0.213 ± 0.017
1.439ArgTyr: 1.439 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
3.272SerAla: 3.272 ± 0.086
0.503SerCys: 0.503 ± 0.024
2.932SerAsp: 2.932 ± 0.07
3.925SerGlu: 3.925 ± 0.066
3.011SerPhe: 3.011 ± 0.071
4.628SerGly: 4.628 ± 0.127
0.807SerHis: 0.807 ± 0.037
5.597SerIle: 5.597 ± 0.1
5.546SerLys: 5.546 ± 0.094
5.759SerLeu: 5.759 ± 0.088
1.359SerMet: 1.359 ± 0.048
3.44SerAsn: 3.44 ± 0.098
1.709SerPro: 1.709 ± 0.048
1.56SerGln: 1.56 ± 0.045
1.808SerArg: 1.808 ± 0.052
3.989SerSer: 3.989 ± 0.099
3.177SerThr: 3.177 ± 0.102
3.614SerVal: 3.614 ± 0.076
0.441SerTrp: 0.441 ± 0.026
2.642SerTyr: 2.642 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
3.04ThrAla: 3.04 ± 0.084
0.382ThrCys: 0.382 ± 0.024
2.807ThrAsp: 2.807 ± 0.066
3.126ThrGlu: 3.126 ± 0.066
2.29ThrPhe: 2.29 ± 0.059
3.984ThrGly: 3.984 ± 0.142
0.712ThrHis: 0.712 ± 0.034
4.728ThrIle: 4.728 ± 0.117
4.193ThrLys: 4.193 ± 0.083
4.64ThrLeu: 4.64 ± 0.084
1.146ThrMet: 1.146 ± 0.037
3.003ThrAsn: 3.003 ± 0.121
1.737ThrPro: 1.737 ± 0.061
1.131ThrGln: 1.131 ± 0.038
1.49ThrArg: 1.49 ± 0.043
3.021ThrSer: 3.021 ± 0.082
2.828ThrThr: 2.828 ± 0.089
3.389ThrVal: 3.389 ± 0.084
0.388ThrTrp: 0.388 ± 0.025
2.074ThrTyr: 2.074 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.03ValAla: 4.03 ± 0.091
0.515ValCys: 0.515 ± 0.031
3.685ValAsp: 3.685 ± 0.079
4.787ValGlu: 4.787 ± 0.087
2.737ValPhe: 2.737 ± 0.072
4.584ValGly: 4.584 ± 0.128
0.757ValHis: 0.757 ± 0.037
5.529ValIle: 5.529 ± 0.106
5.417ValLys: 5.417 ± 0.112
5.481ValLeu: 5.481 ± 0.105
1.248ValMet: 1.248 ± 0.045
3.51ValAsn: 3.51 ± 0.095
1.932ValPro: 1.932 ± 0.058
1.265ValGln: 1.265 ± 0.043
1.838ValArg: 1.838 ± 0.057
4.033ValSer: 4.033 ± 0.09
3.225ValThr: 3.225 ± 0.078
4.338ValVal: 4.338 ± 0.102
0.357ValTrp: 0.357 ± 0.025
2.436ValTyr: 2.436 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.385TrpAla: 0.385 ± 0.024
0.068TrpCys: 0.068 ± 0.01
0.375TrpAsp: 0.375 ± 0.026
0.505TrpGlu: 0.505 ± 0.03
0.269TrpPhe: 0.269 ± 0.02
0.422TrpGly: 0.422 ± 0.026
0.101TrpHis: 0.101 ± 0.012
0.62TrpIle: 0.62 ± 0.035
0.611TrpLys: 0.611 ± 0.03
0.605TrpLeu: 0.605 ± 0.032
0.172TrpMet: 0.172 ± 0.017
0.416TrpAsn: 0.416 ± 0.028
0.107TrpPro: 0.107 ± 0.014
0.246TrpGln: 0.246 ± 0.019
0.274TrpArg: 0.274 ± 0.019
0.337TrpSer: 0.337 ± 0.028
0.316TrpThr: 0.316 ± 0.02
0.384TrpVal: 0.384 ± 0.025
0.089TrpTrp: 0.089 ± 0.01
0.313TrpTyr: 0.313 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.062TyrAla: 2.062 ± 0.073
0.387TyrCys: 0.387 ± 0.026
2.553TyrAsp: 2.553 ± 0.072
2.869TyrGlu: 2.869 ± 0.081
2.456TyrPhe: 2.456 ± 0.068
2.92TyrGly: 2.92 ± 0.083
0.611TyrHis: 0.611 ± 0.031
3.937TyrIle: 3.937 ± 0.082
3.895TyrLys: 3.895 ± 0.083
4.169TyrLeu: 4.169 ± 0.086
0.972TyrMet: 0.972 ± 0.041
2.811TyrAsn: 2.811 ± 0.07
1.357TyrPro: 1.357 ± 0.047
1.093TyrGln: 1.093 ± 0.043
1.385TyrArg: 1.385 ± 0.047
3.092TyrSer: 3.092 ± 0.072
2.062TyrThr: 2.062 ± 0.062
2.116TyrVal: 2.116 ± 0.051
0.296TyrTrp: 0.296 ± 0.02
2.057TyrTyr: 2.057 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2777 proteins (661607 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski