Amino acid dipepetide frequency for Enterobacteria phage mEp043 c-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.338AlaAla: 10.338 ± 1.371
1.064AlaCys: 1.064 ± 0.319
5.549AlaAsp: 5.549 ± 0.56
6.994AlaGlu: 6.994 ± 1.394
3.649AlaPhe: 3.649 ± 0.69
7.906AlaGly: 7.906 ± 1.091
1.748AlaHis: 1.748 ± 0.433
6.309AlaIle: 6.309 ± 0.711
6.157AlaLys: 6.157 ± 1.002
7.602AlaLeu: 7.602 ± 0.77
3.573AlaMet: 3.573 ± 0.623
3.573AlaAsn: 3.573 ± 0.438
2.661AlaPro: 2.661 ± 0.467
5.169AlaGln: 5.169 ± 1.014
5.853AlaArg: 5.853 ± 0.741
6.081AlaSer: 6.081 ± 0.707
5.777AlaThr: 5.777 ± 0.817
5.093AlaVal: 5.093 ± 0.642
1.9AlaTrp: 1.9 ± 0.33
2.128AlaTyr: 2.128 ± 0.455
0.0AlaXaa: 0.0 ± 0.0
Cys
0.836CysAla: 0.836 ± 0.31
0.152CysCys: 0.152 ± 0.116
0.532CysAsp: 0.532 ± 0.208
0.684CysGlu: 0.684 ± 0.227
0.076CysPhe: 0.076 ± 0.071
1.368CysGly: 1.368 ± 0.368
0.38CysHis: 0.38 ± 0.19
0.684CysIle: 0.684 ± 0.223
0.76CysLys: 0.76 ± 0.235
0.988CysLeu: 0.988 ± 0.245
0.38CysMet: 0.38 ± 0.137
0.228CysAsn: 0.228 ± 0.112
0.38CysPro: 0.38 ± 0.183
0.304CysGln: 0.304 ± 0.146
0.912CysArg: 0.912 ± 0.285
0.988CysSer: 0.988 ± 0.247
0.228CysThr: 0.228 ± 0.132
0.456CysVal: 0.456 ± 0.188
0.152CysTrp: 0.152 ± 0.105
0.152CysTyr: 0.152 ± 0.116
0.0CysXaa: 0.0 ± 0.0
Asp
5.321AspAla: 5.321 ± 0.522
0.836AspCys: 0.836 ± 0.267
3.497AspAsp: 3.497 ± 0.663
4.257AspGlu: 4.257 ± 0.584
1.216AspPhe: 1.216 ± 0.284
5.549AspGly: 5.549 ± 0.823
1.14AspHis: 1.14 ± 0.286
2.737AspIle: 2.737 ± 0.398
3.117AspLys: 3.117 ± 0.463
4.257AspLeu: 4.257 ± 0.51
2.128AspMet: 2.128 ± 0.29
2.509AspAsn: 2.509 ± 0.455
2.204AspPro: 2.204 ± 0.49
1.52AspGln: 1.52 ± 0.265
3.725AspArg: 3.725 ± 0.8
4.333AspSer: 4.333 ± 0.653
1.976AspThr: 1.976 ± 0.428
4.485AspVal: 4.485 ± 0.527
1.292AspTrp: 1.292 ± 0.398
2.433AspTyr: 2.433 ± 0.409
0.0AspXaa: 0.0 ± 0.0
Glu
5.929GluAla: 5.929 ± 1.287
0.456GluCys: 0.456 ± 0.16
2.737GluAsp: 2.737 ± 0.411
5.929GluGlu: 5.929 ± 1.018
2.128GluPhe: 2.128 ± 0.395
3.953GluGly: 3.953 ± 0.474
0.684GluHis: 0.684 ± 0.189
3.573GluIle: 3.573 ± 0.621
4.713GluLys: 4.713 ± 0.717
6.461GluLeu: 6.461 ± 0.652
2.052GluMet: 2.052 ± 0.391
2.661GluAsn: 2.661 ± 0.374
1.672GluPro: 1.672 ± 0.359
3.801GluGln: 3.801 ± 0.599
4.105GluArg: 4.105 ± 0.943
4.409GluSer: 4.409 ± 0.478
3.345GluThr: 3.345 ± 0.558
3.269GluVal: 3.269 ± 0.566
1.672GluTrp: 1.672 ± 0.426
2.509GluTyr: 2.509 ± 0.365
0.0GluXaa: 0.0 ± 0.0
Phe
2.965PheAla: 2.965 ± 0.528
0.38PheCys: 0.38 ± 0.177
2.281PheAsp: 2.281 ± 0.474
1.596PheGlu: 1.596 ± 0.362
0.684PhePhe: 0.684 ± 0.289
2.357PheGly: 2.357 ± 0.418
0.456PheHis: 0.456 ± 0.18
1.976PheIle: 1.976 ± 0.405
1.14PheLys: 1.14 ± 0.284
2.433PheLeu: 2.433 ± 0.433
0.608PheMet: 0.608 ± 0.2
1.368PheAsn: 1.368 ± 0.398
0.912PhePro: 0.912 ± 0.252
0.76PheGln: 0.76 ± 0.238
2.433PheArg: 2.433 ± 0.379
2.433PheSer: 2.433 ± 0.404
2.965PheThr: 2.965 ± 0.455
2.052PheVal: 2.052 ± 0.344
0.76PheTrp: 0.76 ± 0.256
0.988PheTyr: 0.988 ± 0.314
0.0PheXaa: 0.0 ± 0.0
Gly
6.613GlyAla: 6.613 ± 0.981
0.608GlyCys: 0.608 ± 0.179
4.561GlyAsp: 4.561 ± 0.601
4.029GlyGlu: 4.029 ± 0.536
2.737GlyPhe: 2.737 ± 0.508
5.549GlyGly: 5.549 ± 1.118
1.216GlyHis: 1.216 ± 0.312
4.181GlyIle: 4.181 ± 0.631
5.473GlyLys: 5.473 ± 0.736
4.181GlyLeu: 4.181 ± 0.52
2.889GlyMet: 2.889 ± 0.425
4.485GlyAsn: 4.485 ± 0.624
1.064GlyPro: 1.064 ± 0.328
3.269GlyGln: 3.269 ± 0.555
3.801GlyArg: 3.801 ± 0.558
3.953GlySer: 3.953 ± 0.473
5.245GlyThr: 5.245 ± 0.946
5.549GlyVal: 5.549 ± 0.663
1.824GlyTrp: 1.824 ± 0.344
2.052GlyTyr: 2.052 ± 0.419
0.0GlyXaa: 0.0 ± 0.0
His
0.836HisAla: 0.836 ± 0.268
0.304HisCys: 0.304 ± 0.148
0.836HisAsp: 0.836 ± 0.267
1.064HisGlu: 1.064 ± 0.318
0.912HisPhe: 0.912 ± 0.303
0.988HisGly: 0.988 ± 0.238
0.38HisHis: 0.38 ± 0.173
0.836HisIle: 0.836 ± 0.265
1.292HisLys: 1.292 ± 0.337
1.368HisLeu: 1.368 ± 0.342
0.304HisMet: 0.304 ± 0.131
0.456HisAsn: 0.456 ± 0.18
0.76HisPro: 0.76 ± 0.262
0.76HisGln: 0.76 ± 0.259
1.064HisArg: 1.064 ± 0.237
1.064HisSer: 1.064 ± 0.311
0.836HisThr: 0.836 ± 0.257
0.684HisVal: 0.684 ± 0.265
0.228HisTrp: 0.228 ± 0.122
0.456HisTyr: 0.456 ± 0.16
0.0HisXaa: 0.0 ± 0.0
Ile
4.941IleAla: 4.941 ± 0.546
0.836IleCys: 0.836 ± 0.254
4.029IleAsp: 4.029 ± 0.679
3.953IleGlu: 3.953 ± 0.73
1.292IlePhe: 1.292 ± 0.329
3.649IleGly: 3.649 ± 0.563
0.988IleHis: 0.988 ± 0.327
3.345IleIle: 3.345 ± 0.626
3.725IleLys: 3.725 ± 0.481
3.421IleLeu: 3.421 ± 0.401
1.064IleMet: 1.064 ± 0.356
2.737IleAsn: 2.737 ± 0.544
1.444IlePro: 1.444 ± 0.453
2.889IleGln: 2.889 ± 0.592
4.181IleArg: 4.181 ± 0.505
3.953IleSer: 3.953 ± 0.791
4.333IleThr: 4.333 ± 0.515
2.813IleVal: 2.813 ± 0.432
1.064IleTrp: 1.064 ± 0.283
1.14IleTyr: 1.14 ± 0.284
0.0IleXaa: 0.0 ± 0.0
Lys
7.45LysAla: 7.45 ± 1.084
0.456LysCys: 0.456 ± 0.192
2.889LysAsp: 2.889 ± 0.542
4.789LysGlu: 4.789 ± 0.648
1.9LysPhe: 1.9 ± 0.318
4.485LysGly: 4.485 ± 0.424
1.216LysHis: 1.216 ± 0.375
2.585LysIle: 2.585 ± 0.463
3.497LysLys: 3.497 ± 0.675
4.409LysLeu: 4.409 ± 0.605
2.204LysMet: 2.204 ± 0.348
2.813LysAsn: 2.813 ± 0.549
3.193LysPro: 3.193 ± 0.524
2.737LysGln: 2.737 ± 0.437
2.965LysArg: 2.965 ± 0.652
3.649LysSer: 3.649 ± 0.492
4.105LysThr: 4.105 ± 0.536
3.573LysVal: 3.573 ± 0.505
1.064LysTrp: 1.064 ± 0.312
1.748LysTyr: 1.748 ± 0.386
0.0LysXaa: 0.0 ± 0.0
Leu
8.514LeuAla: 8.514 ± 1.243
0.608LeuCys: 0.608 ± 0.243
4.789LeuAsp: 4.789 ± 0.541
5.777LeuGlu: 5.777 ± 0.739
2.128LeuPhe: 2.128 ± 0.37
3.117LeuGly: 3.117 ± 0.42
0.988LeuHis: 0.988 ± 0.323
4.333LeuIle: 4.333 ± 0.543
5.017LeuLys: 5.017 ± 0.709
5.169LeuLeu: 5.169 ± 0.593
2.052LeuMet: 2.052 ± 0.495
3.953LeuAsn: 3.953 ± 0.568
3.269LeuPro: 3.269 ± 0.499
3.877LeuGln: 3.877 ± 0.604
4.409LeuArg: 4.409 ± 0.761
6.689LeuSer: 6.689 ± 0.751
4.789LeuThr: 4.789 ± 0.556
4.029LeuVal: 4.029 ± 0.483
0.912LeuTrp: 0.912 ± 0.28
2.509LeuTyr: 2.509 ± 0.333
0.0LeuXaa: 0.0 ± 0.0
Met
2.813MetAla: 2.813 ± 0.602
0.228MetCys: 0.228 ± 0.134
1.368MetAsp: 1.368 ± 0.353
1.064MetGlu: 1.064 ± 0.275
0.608MetPhe: 0.608 ± 0.178
2.281MetGly: 2.281 ± 0.454
0.304MetHis: 0.304 ± 0.148
1.368MetIle: 1.368 ± 0.334
1.672MetLys: 1.672 ± 0.355
2.813MetLeu: 2.813 ± 0.504
0.608MetMet: 0.608 ± 0.236
0.912MetAsn: 0.912 ± 0.246
1.824MetPro: 1.824 ± 0.277
1.368MetGln: 1.368 ± 0.327
1.596MetArg: 1.596 ± 0.322
3.193MetSer: 3.193 ± 0.492
1.52MetThr: 1.52 ± 0.335
1.292MetVal: 1.292 ± 0.257
0.228MetTrp: 0.228 ± 0.139
0.608MetTyr: 0.608 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
4.333AsnAla: 4.333 ± 0.507
0.304AsnCys: 0.304 ± 0.145
1.824AsnAsp: 1.824 ± 0.576
1.748AsnGlu: 1.748 ± 0.422
1.064AsnPhe: 1.064 ± 0.438
5.549AsnGly: 5.549 ± 0.921
0.76AsnHis: 0.76 ± 0.254
3.345AsnIle: 3.345 ± 0.527
2.509AsnLys: 2.509 ± 0.474
3.117AsnLeu: 3.117 ± 0.425
0.76AsnMet: 0.76 ± 0.242
1.14AsnAsn: 1.14 ± 0.267
2.281AsnPro: 2.281 ± 0.466
2.585AsnGln: 2.585 ± 0.476
1.748AsnArg: 1.748 ± 0.433
2.889AsnSer: 2.889 ± 0.482
2.281AsnThr: 2.281 ± 0.513
1.748AsnVal: 1.748 ± 0.46
0.456AsnTrp: 0.456 ± 0.169
1.748AsnTyr: 1.748 ± 0.399
0.0AsnXaa: 0.0 ± 0.0
Pro
4.637ProAla: 4.637 ± 0.744
0.38ProCys: 0.38 ± 0.159
2.737ProAsp: 2.737 ± 0.509
3.041ProGlu: 3.041 ± 0.556
1.14ProPhe: 1.14 ± 0.266
2.889ProGly: 2.889 ± 0.49
0.684ProHis: 0.684 ± 0.221
0.836ProIle: 0.836 ± 0.283
2.737ProLys: 2.737 ± 0.422
2.281ProLeu: 2.281 ± 0.298
1.216ProMet: 1.216 ± 0.422
1.444ProAsn: 1.444 ± 0.457
1.216ProPro: 1.216 ± 0.282
1.368ProGln: 1.368 ± 0.35
1.9ProArg: 1.9 ± 0.337
2.281ProSer: 2.281 ± 0.424
1.596ProThr: 1.596 ± 0.433
3.573ProVal: 3.573 ± 0.541
0.684ProTrp: 0.684 ± 0.213
1.216ProTyr: 1.216 ± 0.313
0.0ProXaa: 0.0 ± 0.0
Gln
5.017GlnAla: 5.017 ± 1.048
0.608GlnCys: 0.608 ± 0.185
1.976GlnAsp: 1.976 ± 0.356
3.117GlnGlu: 3.117 ± 0.459
1.976GlnPhe: 1.976 ± 0.387
2.661GlnGly: 2.661 ± 0.426
0.532GlnHis: 0.532 ± 0.194
2.813GlnIle: 2.813 ± 0.428
2.433GlnLys: 2.433 ± 0.575
4.637GlnLeu: 4.637 ± 1.1
1.064GlnMet: 1.064 ± 0.304
1.368GlnAsn: 1.368 ± 0.354
1.368GlnPro: 1.368 ± 0.285
4.029GlnGln: 4.029 ± 1.458
3.117GlnArg: 3.117 ± 0.492
2.889GlnSer: 2.889 ± 0.409
3.345GlnThr: 3.345 ± 0.707
3.269GlnVal: 3.269 ± 0.454
0.912GlnTrp: 0.912 ± 0.244
1.216GlnTyr: 1.216 ± 0.335
0.0GlnXaa: 0.0 ± 0.0
Arg
5.017ArgAla: 5.017 ± 0.572
0.988ArgCys: 0.988 ± 0.308
2.965ArgAsp: 2.965 ± 0.603
4.941ArgGlu: 4.941 ± 0.995
1.444ArgPhe: 1.444 ± 0.3
3.497ArgGly: 3.497 ± 0.489
1.292ArgHis: 1.292 ± 0.338
4.029ArgIle: 4.029 ± 0.559
4.637ArgLys: 4.637 ± 0.637
5.397ArgLeu: 5.397 ± 0.727
2.052ArgMet: 2.052 ± 0.427
1.976ArgAsn: 1.976 ± 0.427
1.976ArgPro: 1.976 ± 0.528
3.877ArgGln: 3.877 ± 0.636
4.485ArgArg: 4.485 ± 0.975
2.813ArgSer: 2.813 ± 0.614
2.737ArgThr: 2.737 ± 0.398
3.345ArgVal: 3.345 ± 0.429
1.292ArgTrp: 1.292 ± 0.356
1.748ArgTyr: 1.748 ± 0.478
0.0ArgXaa: 0.0 ± 0.0
Ser
7.146SerAla: 7.146 ± 0.87
0.38SerCys: 0.38 ± 0.174
5.017SerAsp: 5.017 ± 0.667
4.409SerGlu: 4.409 ± 0.853
2.357SerPhe: 2.357 ± 0.462
5.777SerGly: 5.777 ± 0.713
0.684SerHis: 0.684 ± 0.265
3.117SerIle: 3.117 ± 0.526
3.269SerLys: 3.269 ± 0.634
5.473SerLeu: 5.473 ± 0.646
1.596SerMet: 1.596 ± 0.344
2.889SerAsn: 2.889 ± 0.585
3.041SerPro: 3.041 ± 0.459
2.737SerGln: 2.737 ± 0.586
3.573SerArg: 3.573 ± 0.591
4.637SerSer: 4.637 ± 0.633
2.357SerThr: 2.357 ± 0.45
5.625SerVal: 5.625 ± 0.531
1.368SerTrp: 1.368 ± 0.37
1.672SerTyr: 1.672 ± 0.342
0.0SerXaa: 0.0 ± 0.0
Thr
6.842ThrAla: 6.842 ± 0.967
0.684ThrCys: 0.684 ± 0.276
4.181ThrAsp: 4.181 ± 0.487
3.345ThrGlu: 3.345 ± 0.348
2.204ThrPhe: 2.204 ± 0.421
4.637ThrGly: 4.637 ± 0.735
0.532ThrHis: 0.532 ± 0.223
3.345ThrIle: 3.345 ± 0.524
3.345ThrLys: 3.345 ± 0.667
3.725ThrLeu: 3.725 ± 0.672
0.456ThrMet: 0.456 ± 0.195
1.596ThrAsn: 1.596 ± 0.448
3.345ThrPro: 3.345 ± 0.549
1.9ThrGln: 1.9 ± 0.389
3.497ThrArg: 3.497 ± 0.524
3.117ThrSer: 3.117 ± 0.695
3.801ThrThr: 3.801 ± 0.56
4.561ThrVal: 4.561 ± 0.783
1.596ThrTrp: 1.596 ± 0.374
1.52ThrTyr: 1.52 ± 0.352
0.0ThrXaa: 0.0 ± 0.0
Val
6.005ValAla: 6.005 ± 0.723
0.532ValCys: 0.532 ± 0.216
3.041ValAsp: 3.041 ± 0.505
3.041ValGlu: 3.041 ± 0.457
2.889ValPhe: 2.889 ± 0.391
3.725ValGly: 3.725 ± 0.626
0.836ValHis: 0.836 ± 0.246
3.725ValIle: 3.725 ± 0.433
3.649ValLys: 3.649 ± 0.498
4.257ValLeu: 4.257 ± 0.561
1.292ValMet: 1.292 ± 0.293
3.649ValAsn: 3.649 ± 0.733
3.117ValPro: 3.117 ± 0.4
2.889ValGln: 2.889 ± 0.504
3.345ValArg: 3.345 ± 0.485
4.333ValSer: 4.333 ± 0.591
5.245ValThr: 5.245 ± 0.82
3.801ValVal: 3.801 ± 0.602
0.38ValTrp: 0.38 ± 0.178
1.596ValTyr: 1.596 ± 0.327
0.0ValXaa: 0.0 ± 0.0
Trp
1.292TrpAla: 1.292 ± 0.274
0.38TrpCys: 0.38 ± 0.163
0.988TrpAsp: 0.988 ± 0.23
0.988TrpGlu: 0.988 ± 0.294
0.608TrpPhe: 0.608 ± 0.212
1.292TrpGly: 1.292 ± 0.307
0.38TrpHis: 0.38 ± 0.16
1.064TrpIle: 1.064 ± 0.384
1.14TrpLys: 1.14 ± 0.33
2.052TrpLeu: 2.052 ± 0.532
0.76TrpMet: 0.76 ± 0.197
0.608TrpAsn: 0.608 ± 0.248
0.912TrpPro: 0.912 ± 0.349
0.912TrpGln: 0.912 ± 0.249
1.216TrpArg: 1.216 ± 0.324
1.444TrpSer: 1.444 ± 0.348
0.532TrpThr: 0.532 ± 0.2
0.912TrpVal: 0.912 ± 0.256
0.304TrpTrp: 0.304 ± 0.176
0.608TrpTyr: 0.608 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.281TyrAla: 2.281 ± 0.485
0.456TyrCys: 0.456 ± 0.177
2.737TyrAsp: 2.737 ± 0.527
1.292TyrGlu: 1.292 ± 0.368
0.532TyrPhe: 0.532 ± 0.183
2.128TyrGly: 2.128 ± 0.398
0.228TyrHis: 0.228 ± 0.15
1.596TyrIle: 1.596 ± 0.356
1.444TyrLys: 1.444 ± 0.288
2.889TyrLeu: 2.889 ± 0.385
0.532TyrMet: 0.532 ± 0.186
1.824TyrAsn: 1.824 ± 0.302
1.216TyrPro: 1.216 ± 0.27
1.596TyrGln: 1.596 ± 0.276
2.585TyrArg: 2.585 ± 0.414
1.976TyrSer: 1.976 ± 0.39
1.216TyrThr: 1.216 ± 0.304
1.216TyrVal: 1.216 ± 0.388
0.304TyrTrp: 0.304 ± 0.117
1.216TyrTyr: 1.216 ± 0.389
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (13156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski