Amino acid dipepetide frequency for Neisseria elongata subsp. glycolytica ATCC 29315

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.275AlaAla: 16.275 ± 0.288
1.322AlaCys: 1.322 ± 0.055
6.992AlaAsp: 6.992 ± 0.131
8.288AlaGlu: 8.288 ± 0.145
3.953AlaPhe: 3.953 ± 0.089
8.004AlaGly: 8.004 ± 0.146
1.919AlaHis: 1.919 ± 0.064
4.147AlaIle: 4.147 ± 0.085
5.089AlaLys: 5.089 ± 0.112
10.895AlaLeu: 10.895 ± 0.183
2.587AlaMet: 2.587 ± 0.069
3.034AlaAsn: 3.034 ± 0.092
3.733AlaPro: 3.733 ± 0.095
4.593AlaGln: 4.593 ± 0.109
5.446AlaArg: 5.446 ± 0.097
4.475AlaSer: 4.475 ± 0.088
3.801AlaThr: 3.801 ± 0.091
9.178AlaVal: 9.178 ± 0.145
1.26AlaTrp: 1.26 ± 0.05
2.926AlaTyr: 2.926 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.114CysAla: 1.114 ± 0.047
0.16CysCys: 0.16 ± 0.016
0.509CysAsp: 0.509 ± 0.03
0.587CysGlu: 0.587 ± 0.038
0.439CysPhe: 0.439 ± 0.028
1.25CysGly: 1.25 ± 0.047
0.277CysHis: 0.277 ± 0.025
0.561CysIle: 0.561 ± 0.033
0.352CysLys: 0.352 ± 0.025
1.028CysLeu: 1.028 ± 0.041
0.191CysMet: 0.191 ± 0.018
0.368CysAsn: 0.368 ± 0.029
0.578CysPro: 0.578 ± 0.036
0.345CysGln: 0.345 ± 0.026
0.805CysArg: 0.805 ± 0.042
0.55CysSer: 0.55 ± 0.028
0.529CysThr: 0.529 ± 0.032
0.591CysVal: 0.591 ± 0.033
0.108CysTrp: 0.108 ± 0.013
0.309CysTyr: 0.309 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.935AspAla: 4.935 ± 0.097
0.579AspCys: 0.579 ± 0.033
2.916AspAsp: 2.916 ± 0.083
3.683AspGlu: 3.683 ± 0.09
2.507AspPhe: 2.507 ± 0.068
4.836AspGly: 4.836 ± 0.099
0.928AspHis: 0.928 ± 0.044
3.683AspIle: 3.683 ± 0.08
3.104AspLys: 3.104 ± 0.067
5.151AspLeu: 5.151 ± 0.093
1.28AspMet: 1.28 ± 0.049
2.106AspAsn: 2.106 ± 0.058
1.978AspPro: 1.978 ± 0.059
1.304AspGln: 1.304 ± 0.05
2.441AspArg: 2.441 ± 0.058
2.751AspSer: 2.751 ± 0.078
2.962AspThr: 2.962 ± 0.072
3.384AspVal: 3.384 ± 0.074
0.957AspTrp: 0.957 ± 0.041
2.099AspTyr: 2.099 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
6.593GluAla: 6.593 ± 0.113
0.571GluCys: 0.571 ± 0.031
2.641GluAsp: 2.641 ± 0.073
3.89GluGlu: 3.89 ± 0.102
2.131GluPhe: 2.131 ± 0.054
3.893GluGly: 3.893 ± 0.087
1.54GluHis: 1.54 ± 0.053
3.971GluIle: 3.971 ± 0.091
3.811GluLys: 3.811 ± 0.086
6.099GluLeu: 6.099 ± 0.123
1.735GluMet: 1.735 ± 0.062
3.085GluAsn: 3.085 ± 0.071
2.117GluPro: 2.117 ± 0.064
3.319GluGln: 3.319 ± 0.085
3.814GluArg: 3.814 ± 0.096
2.754GluSer: 2.754 ± 0.065
3.59GluThr: 3.59 ± 0.09
3.428GluVal: 3.428 ± 0.095
0.903GluTrp: 0.903 ± 0.044
1.718GluTyr: 1.718 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
4.58PheAla: 4.58 ± 0.087
0.543PheCys: 0.543 ± 0.028
2.739PheAsp: 2.739 ± 0.067
2.155PheGlu: 2.155 ± 0.063
1.674PhePhe: 1.674 ± 0.052
3.598PheGly: 3.598 ± 0.089
0.812PheHis: 0.812 ± 0.042
2.121PheIle: 2.121 ± 0.067
1.751PheLys: 1.751 ± 0.058
3.517PheLeu: 3.517 ± 0.079
0.928PheMet: 0.928 ± 0.042
1.582PheAsn: 1.582 ± 0.045
1.509PhePro: 1.509 ± 0.053
1.352PheGln: 1.352 ± 0.046
1.913PheArg: 1.913 ± 0.061
2.672PheSer: 2.672 ± 0.073
2.083PheThr: 2.083 ± 0.062
2.656PheVal: 2.656 ± 0.064
0.55PheTrp: 0.55 ± 0.037
1.294PheTyr: 1.294 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
6.276GlyAla: 6.276 ± 0.117
0.962GlyCys: 0.962 ± 0.042
3.571GlyAsp: 3.571 ± 0.085
4.631GlyGlu: 4.631 ± 0.082
3.384GlyPhe: 3.384 ± 0.088
6.686GlyGly: 6.686 ± 0.114
1.641GlyHis: 1.641 ± 0.058
4.919GlyIle: 4.919 ± 0.094
5.179GlyLys: 5.179 ± 0.096
7.982GlyLeu: 7.982 ± 0.136
2.207GlyMet: 2.207 ± 0.07
2.945GlyAsn: 2.945 ± 0.1
1.239GlyPro: 1.239 ± 0.052
2.891GlyGln: 2.891 ± 0.075
5.125GlyArg: 5.125 ± 0.089
4.539GlySer: 4.539 ± 0.101
3.633GlyThr: 3.633 ± 0.077
4.937GlyVal: 4.937 ± 0.102
1.253GlyTrp: 1.253 ± 0.051
2.435GlyTyr: 2.435 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.926HisAla: 1.926 ± 0.06
0.286HisCys: 0.286 ± 0.023
1.141HisAsp: 1.141 ± 0.042
1.18HisGlu: 1.18 ± 0.044
0.905HisPhe: 0.905 ± 0.035
1.908HisGly: 1.908 ± 0.063
0.602HisHis: 0.602 ± 0.035
1.55HisIle: 1.55 ± 0.051
0.97HisLys: 0.97 ± 0.045
2.144HisLeu: 2.144 ± 0.069
0.439HisMet: 0.439 ± 0.025
0.851HisAsn: 0.851 ± 0.039
1.386HisPro: 1.386 ± 0.051
0.802HisGln: 0.802 ± 0.036
1.245HisArg: 1.245 ± 0.045
1.163HisSer: 1.163 ± 0.042
1.379HisThr: 1.379 ± 0.053
1.103HisVal: 1.103 ± 0.045
0.335HisTrp: 0.335 ± 0.023
0.787HisTyr: 0.787 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.943IleAla: 5.943 ± 0.094
0.592IleCys: 0.592 ± 0.035
3.305IleAsp: 3.305 ± 0.078
3.585IleGlu: 3.585 ± 0.08
1.828IlePhe: 1.828 ± 0.061
4.896IleGly: 4.896 ± 0.093
1.159IleHis: 1.159 ± 0.043
3.026IleIle: 3.026 ± 0.084
2.566IleLys: 2.566 ± 0.067
5.241IleLeu: 5.241 ± 0.099
1.208IleMet: 1.208 ± 0.046
2.229IleAsn: 2.229 ± 0.067
2.559IlePro: 2.559 ± 0.064
1.713IleGln: 1.713 ± 0.059
3.377IleArg: 3.377 ± 0.076
3.055IleSer: 3.055 ± 0.084
3.086IleThr: 3.086 ± 0.082
3.734IleVal: 3.734 ± 0.078
0.614IleTrp: 0.614 ± 0.031
1.401IleTyr: 1.401 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.893LysAla: 4.893 ± 0.108
0.262LysCys: 0.262 ± 0.021
2.399LysAsp: 2.399 ± 0.069
2.941LysGlu: 2.941 ± 0.084
1.564LysPhe: 1.564 ± 0.054
3.31LysGly: 3.31 ± 0.088
1.221LysHis: 1.221 ± 0.046
3.314LysIle: 3.314 ± 0.079
2.859LysLys: 2.859 ± 0.083
5.04LysLeu: 5.04 ± 0.097
1.484LysMet: 1.484 ± 0.051
2.373LysAsn: 2.373 ± 0.075
2.666LysPro: 2.666 ± 0.069
2.671LysGln: 2.671 ± 0.077
2.872LysArg: 2.872 ± 0.084
2.423LysSer: 2.423 ± 0.066
3.211LysThr: 3.211 ± 0.075
2.955LysVal: 2.955 ± 0.08
0.579LysTrp: 0.579 ± 0.032
1.327LysTyr: 1.327 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
11.53LeuAla: 11.53 ± 0.192
1.059LeuCys: 1.059 ± 0.038
5.503LeuAsp: 5.503 ± 0.092
5.394LeuGlu: 5.394 ± 0.11
4.273LeuPhe: 4.273 ± 0.102
6.837LeuGly: 6.837 ± 0.11
2.458LeuHis: 2.458 ± 0.076
5.258LeuIle: 5.258 ± 0.096
5.541LeuLys: 5.541 ± 0.1
11.461LeuLeu: 11.461 ± 0.231
2.541LeuMet: 2.541 ± 0.073
4.207LeuAsn: 4.207 ± 0.105
6.397LeuPro: 6.397 ± 0.129
4.183LeuGln: 4.183 ± 0.091
5.415LeuArg: 5.415 ± 0.101
6.634LeuSer: 6.634 ± 0.102
5.354LeuThr: 5.354 ± 0.094
5.659LeuVal: 5.659 ± 0.102
1.231LeuTrp: 1.231 ± 0.05
2.716LeuTyr: 2.716 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.423MetAla: 2.423 ± 0.073
0.231MetCys: 0.231 ± 0.018
1.106MetAsp: 1.106 ± 0.046
1.177MetGlu: 1.177 ± 0.048
0.848MetPhe: 0.848 ± 0.041
1.731MetGly: 1.731 ± 0.064
0.484MetHis: 0.484 ± 0.031
1.155MetIle: 1.155 ± 0.05
1.559MetLys: 1.559 ± 0.047
2.656MetLeu: 2.656 ± 0.075
0.81MetMet: 0.81 ± 0.044
1.18MetAsn: 1.18 ± 0.043
1.419MetPro: 1.419 ± 0.046
1.219MetGln: 1.219 ± 0.045
1.463MetArg: 1.463 ± 0.052
1.474MetSer: 1.474 ± 0.051
1.386MetThr: 1.386 ± 0.046
1.473MetVal: 1.473 ± 0.054
0.231MetTrp: 0.231 ± 0.019
0.511MetTyr: 0.511 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.664AsnAla: 3.664 ± 0.091
0.421AsnCys: 0.421 ± 0.028
1.89AsnAsp: 1.89 ± 0.065
2.117AsnGlu: 2.117 ± 0.058
1.281AsnPhe: 1.281 ± 0.052
3.679AsnGly: 3.679 ± 0.093
0.875AsnHis: 0.875 ± 0.036
2.657AsnIle: 2.657 ± 0.071
1.787AsnLys: 1.787 ± 0.057
3.551AsnLeu: 3.551 ± 0.083
0.836AsnMet: 0.836 ± 0.038
1.456AsnAsn: 1.456 ± 0.056
2.451AsnPro: 2.451 ± 0.073
1.483AsnGln: 1.483 ± 0.06
2.509AsnArg: 2.509 ± 0.065
1.753AsnSer: 1.753 ± 0.061
2.027AsnThr: 2.027 ± 0.065
2.32AsnVal: 2.32 ± 0.075
0.499AsnTrp: 0.499 ± 0.03
1.083AsnTyr: 1.083 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
5.06ProAla: 5.06 ± 0.116
0.409ProCys: 0.409 ± 0.028
3.004ProAsp: 3.004 ± 0.077
3.693ProGlu: 3.693 ± 0.086
2.039ProPhe: 2.039 ± 0.062
2.14ProGly: 2.14 ± 0.064
1.078ProHis: 1.078 ± 0.046
1.882ProIle: 1.882 ± 0.055
2.18ProLys: 2.18 ± 0.068
4.543ProLeu: 4.543 ± 0.087
1.005ProMet: 1.005 ± 0.044
1.802ProAsn: 1.802 ± 0.062
2.078ProPro: 2.078 ± 0.08
2.378ProGln: 2.378 ± 0.067
1.856ProArg: 1.856 ± 0.058
2.423ProSer: 2.423 ± 0.067
1.944ProThr: 1.944 ± 0.058
3.557ProVal: 3.557 ± 0.078
0.463ProTrp: 0.463 ± 0.027
1.271ProTyr: 1.271 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
4.984GlnAla: 4.984 ± 0.099
0.34GlnCys: 0.34 ± 0.024
1.803GlnAsp: 1.803 ± 0.05
2.248GlnGlu: 2.248 ± 0.075
1.296GlnPhe: 1.296 ± 0.051
2.895GlnGly: 2.895 ± 0.069
0.993GlnHis: 0.993 ± 0.042
2.535GlnIle: 2.535 ± 0.072
2.126GlnLys: 2.126 ± 0.063
3.492GlnLeu: 3.492 ± 0.083
0.993GlnMet: 0.993 ± 0.04
2.091GlnAsn: 2.091 ± 0.069
1.915GlnPro: 1.915 ± 0.055
2.24GlnGln: 2.24 ± 0.094
2.257GlnArg: 2.257 ± 0.064
2.366GlnSer: 2.366 ± 0.065
3.135GlnThr: 3.135 ± 0.085
2.302GlnVal: 2.302 ± 0.058
0.586GlnTrp: 0.586 ± 0.033
1.363GlnTyr: 1.363 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
4.929ArgAla: 4.929 ± 0.103
0.489ArgCys: 0.489 ± 0.027
2.829ArgAsp: 2.829 ± 0.072
3.85ArgGlu: 3.85 ± 0.096
2.937ArgPhe: 2.937 ± 0.068
3.4ArgGly: 3.4 ± 0.086
1.613ArgHis: 1.613 ± 0.051
3.381ArgIle: 3.381 ± 0.08
2.567ArgLys: 2.567 ± 0.069
6.932ArgLeu: 6.932 ± 0.117
1.471ArgMet: 1.471 ± 0.049
2.191ArgAsn: 2.191 ± 0.067
2.734ArgPro: 2.734 ± 0.074
3.16ArgGln: 3.16 ± 0.095
4.189ArgArg: 4.189 ± 0.107
2.687ArgSer: 2.687 ± 0.066
2.43ArgThr: 2.43 ± 0.069
3.181ArgVal: 3.181 ± 0.075
0.699ArgTrp: 0.699 ± 0.036
2.077ArgTyr: 2.077 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
5.48SerAla: 5.48 ± 0.099
0.571SerCys: 0.571 ± 0.03
3.165SerAsp: 3.165 ± 0.073
3.309SerGlu: 3.309 ± 0.091
2.171SerPhe: 2.171 ± 0.057
5.366SerGly: 5.366 ± 0.11
1.152SerHis: 1.152 ± 0.047
2.711SerIle: 2.711 ± 0.071
2.27SerLys: 2.27 ± 0.064
5.454SerLeu: 5.454 ± 0.091
1.199SerMet: 1.199 ± 0.05
1.69SerAsn: 1.69 ± 0.047
2.353SerPro: 2.353 ± 0.062
1.815SerGln: 1.815 ± 0.055
3.176SerArg: 3.176 ± 0.073
2.896SerSer: 2.896 ± 0.082
2.327SerThr: 2.327 ± 0.067
3.793SerVal: 3.793 ± 0.078
0.676SerTrp: 0.676 ± 0.038
1.523SerTyr: 1.523 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
6.732ThrAla: 6.732 ± 0.119
0.425ThrCys: 0.425 ± 0.027
2.968ThrAsp: 2.968 ± 0.077
2.962ThrGlu: 2.962 ± 0.071
1.929ThrPhe: 1.929 ± 0.055
4.097ThrGly: 4.097 ± 0.088
1.013ThrHis: 1.013 ± 0.042
2.428ThrIle: 2.428 ± 0.058
1.604ThrLys: 1.604 ± 0.051
5.809ThrLeu: 5.809 ± 0.095
0.921ThrMet: 0.921 ± 0.041
1.463ThrAsn: 1.463 ± 0.062
2.934ThrPro: 2.934 ± 0.071
1.738ThrGln: 1.738 ± 0.059
2.599ThrArg: 2.599 ± 0.062
2.049ThrSer: 2.049 ± 0.064
2.198ThrThr: 2.198 ± 0.069
4.531ThrVal: 4.531 ± 0.102
0.481ThrTrp: 0.481 ± 0.027
1.221ThrTyr: 1.221 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
6.447ValAla: 6.447 ± 0.119
0.92ValCys: 0.92 ± 0.043
2.929ValAsp: 2.929 ± 0.08
3.844ValGlu: 3.844 ± 0.095
2.891ValPhe: 2.891 ± 0.073
4.685ValGly: 4.685 ± 0.1
1.278ValHis: 1.278 ± 0.043
3.683ValIle: 3.683 ± 0.083
3.42ValLys: 3.42 ± 0.089
7.38ValLeu: 7.38 ± 0.129
1.897ValMet: 1.897 ± 0.056
2.291ValAsn: 2.291 ± 0.072
2.896ValPro: 2.896 ± 0.069
2.353ValGln: 2.353 ± 0.065
3.926ValArg: 3.926 ± 0.075
4.354ValSer: 4.354 ± 0.074
2.852ValThr: 2.852 ± 0.09
4.566ValVal: 4.566 ± 0.12
0.979ValTrp: 0.979 ± 0.042
1.973ValTyr: 1.973 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
1.152TrpAla: 1.152 ± 0.05
0.139TrpCys: 0.139 ± 0.015
0.563TrpAsp: 0.563 ± 0.03
0.522TrpGlu: 0.522 ± 0.029
0.602TrpPhe: 0.602 ± 0.03
0.774TrpGly: 0.774 ± 0.038
0.44TrpHis: 0.44 ± 0.026
0.62TrpIle: 0.62 ± 0.035
0.535TrpLys: 0.535 ± 0.029
2.095TrpLeu: 2.095 ± 0.069
0.304TrpMet: 0.304 ± 0.022
0.367TrpAsn: 0.367 ± 0.025
0.447TrpPro: 0.447 ± 0.027
1.126TrpGln: 1.126 ± 0.051
1.003TrpArg: 1.003 ± 0.045
0.54TrpSer: 0.54 ± 0.029
0.548TrpThr: 0.548 ± 0.029
0.704TrpVal: 0.704 ± 0.033
0.198TrpTrp: 0.198 ± 0.019
0.385TrpTyr: 0.385 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.981TyrAla: 2.981 ± 0.074
0.368TyrCys: 0.368 ± 0.023
1.612TyrAsp: 1.612 ± 0.055
1.546TyrGlu: 1.546 ± 0.056
1.376TyrPhe: 1.376 ± 0.052
2.451TyrGly: 2.451 ± 0.072
0.619TyrHis: 0.619 ± 0.031
1.515TyrIle: 1.515 ± 0.044
1.093TyrLys: 1.093 ± 0.043
3.179TyrLeu: 3.179 ± 0.071
0.497TyrMet: 0.497 ± 0.029
1.029TyrAsn: 1.029 ± 0.042
1.417TyrPro: 1.417 ± 0.048
1.278TyrGln: 1.278 ± 0.048
2.319TyrArg: 2.319 ± 0.065
1.538TyrSer: 1.538 ± 0.053
1.627TyrThr: 1.627 ± 0.056
1.512TyrVal: 1.512 ± 0.048
0.461TyrTrp: 0.461 ± 0.026
0.9TyrTyr: 0.9 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2073 proteins (611106 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski