Amino acid dipepetide frequency for Altererythrobacter atlanticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.366AlaAla: 16.366 ± 0.191	1.094AlaCys: 1.094 ± 0.034	7.135AlaAsp: 7.135 ± 0.091	8.612AlaGlu: 8.612 ± 0.111	4.142AlaPhe: 4.142 ± 0.07	10.929AlaGly: 10.929 ± 0.126	2.185AlaHis: 2.185 ± 0.048	6.758AlaIle: 6.758 ± 0.083	3.528AlaLys: 3.528 ± 0.072	12.854AlaLeu: 12.854 ± 0.155	3.807AlaMet: 3.807 ± 0.067	3.185AlaAsn: 3.185 ± 0.058	5.662AlaPro: 5.662 ± 0.087	4.503AlaGln: 4.503 ± 0.076	9.073AlaArg: 9.073 ± 0.108	6.455AlaSer: 6.455 ± 0.088	5.549AlaThr: 5.549 ± 0.086	7.636AlaVal: 7.636 ± 0.105	1.541AlaTrp: 1.541 ± 0.041	2.478AlaTyr: 2.478 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.036	0.113CysCys: 0.113 ± 0.01	0.586CysAsp: 0.586 ± 0.023	0.527CysGlu: 0.527 ± 0.025	0.312CysPhe: 0.312 ± 0.019	0.916CysGly: 0.916 ± 0.03	0.248CysHis: 0.248 ± 0.016	0.356CysIle: 0.356 ± 0.021	0.159CysLys: 0.159 ± 0.013	0.678CysLeu: 0.678 ± 0.027	0.162CysMet: 0.162 ± 0.013	0.232CysAsn: 0.232 ± 0.017	0.431CysPro: 0.431 ± 0.02	0.203CysGln: 0.203 ± 0.014	0.559CysArg: 0.559 ± 0.022	0.548CysSer: 0.548 ± 0.023	0.43CysThr: 0.43 ± 0.023	0.515CysVal: 0.515 ± 0.021	0.101CysTrp: 0.101 ± 0.009	0.183CysTyr: 0.183 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.099AspAla: 7.099 ± 0.088	0.531AspCys: 0.531 ± 0.027	3.332AspAsp: 3.332 ± 0.067	3.959AspGlu: 3.959 ± 0.071	2.386AspPhe: 2.386 ± 0.041	5.717AspGly: 5.717 ± 0.087	1.314AspHis: 1.314 ± 0.041	3.092AspIle: 3.092 ± 0.061	1.731AspLys: 1.731 ± 0.043	5.845AspLeu: 5.845 ± 0.083	1.524AspMet: 1.524 ± 0.039	1.604AspAsn: 1.604 ± 0.042	4.025AspPro: 4.025 ± 0.063	1.85AspGln: 1.85 ± 0.046	4.685AspArg: 4.685 ± 0.07	2.566AspSer: 2.566 ± 0.05	2.558AspThr: 2.558 ± 0.056	3.745AspVal: 3.745 ± 0.065	1.235AspTrp: 1.235 ± 0.037	1.682AspTyr: 1.682 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.973GluAla: 7.973 ± 0.098	0.376GluCys: 0.376 ± 0.019	3.73GluAsp: 3.73 ± 0.063	4.601GluGlu: 4.601 ± 0.07	2.003GluPhe: 2.003 ± 0.046	5.239GluGly: 5.239 ± 0.07	1.213GluHis: 1.213 ± 0.035	3.542GluIle: 3.542 ± 0.058	2.517GluLys: 2.517 ± 0.055	6.12GluLeu: 6.12 ± 0.085	1.792GluMet: 1.792 ± 0.038	1.866GluAsn: 1.866 ± 0.045	2.992GluPro: 2.992 ± 0.052	2.486GluGln: 2.486 ± 0.054	5.162GluArg: 5.162 ± 0.089	2.82GluSer: 2.82 ± 0.06	3.462GluThr: 3.462 ± 0.064	4.016GluVal: 4.016 ± 0.08	0.949GluTrp: 0.949 ± 0.033	1.322GluTyr: 1.322 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.764PheAla: 4.764 ± 0.063	0.323PheCys: 0.323 ± 0.018	2.842PheAsp: 2.842 ± 0.059	2.269PheGlu: 2.269 ± 0.047	1.372PhePhe: 1.372 ± 0.04	3.721PheGly: 3.721 ± 0.069	0.722PheHis: 0.722 ± 0.028	1.585PheIle: 1.585 ± 0.041	0.814PheLys: 0.814 ± 0.029	3.262PheLeu: 3.262 ± 0.056	0.804PheMet: 0.804 ± 0.03	1.06PheAsn: 1.06 ± 0.034	1.581PhePro: 1.581 ± 0.037	0.97PheGln: 0.97 ± 0.029	2.282PheArg: 2.282 ± 0.042	2.202PheSer: 2.202 ± 0.049	2.097PheThr: 2.097 ± 0.052	2.604PheVal: 2.604 ± 0.049	0.562PheTrp: 0.562 ± 0.024	0.954PheTyr: 0.954 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	9.467GlyAla: 9.467 ± 0.125	0.842GlyCys: 0.842 ± 0.027	5.014GlyAsp: 5.014 ± 0.071	5.807GlyGlu: 5.807 ± 0.081	3.6GlyPhe: 3.6 ± 0.064	8.049GlyGly: 8.049 ± 0.141	1.805GlyHis: 1.805 ± 0.046	4.607GlyIle: 4.607 ± 0.073	3.475GlyLys: 3.475 ± 0.07	8.49GlyLeu: 8.49 ± 0.097	2.602GlyMet: 2.602 ± 0.05	2.568GlyAsn: 2.568 ± 0.063	3.925GlyPro: 3.925 ± 0.067	3.027GlyGln: 3.027 ± 0.052	6.185GlyArg: 6.185 ± 0.079	5.162GlySer: 5.162 ± 0.096	4.87GlyThr: 4.87 ± 0.091	5.839GlyVal: 5.839 ± 0.074	1.613GlyTrp: 1.613 ± 0.043	2.166GlyTyr: 2.166 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.114HisAla: 2.114 ± 0.053	0.279HisCys: 0.279 ± 0.015	1.231HisAsp: 1.231 ± 0.032	1.064HisGlu: 1.064 ± 0.034	0.823HisPhe: 0.823 ± 0.03	1.949HisGly: 1.949 ± 0.051	0.511HisHis: 0.511 ± 0.022	0.937HisIle: 0.937 ± 0.031	0.459HisLys: 0.459 ± 0.021	1.815HisLeu: 1.815 ± 0.045	0.486HisMet: 0.486 ± 0.023	0.443HisAsn: 0.443 ± 0.025	1.297HisPro: 1.297 ± 0.042	0.515HisGln: 0.515 ± 0.018	1.38HisArg: 1.38 ± 0.037	1.027HisSer: 1.027 ± 0.035	0.738HisThr: 0.738 ± 0.029	1.405HisVal: 1.405 ± 0.042	0.378HisTrp: 0.378 ± 0.021	0.539HisTyr: 0.539 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.492IleAla: 7.492 ± 0.095	0.485IleCys: 0.485 ± 0.02	3.628IleAsp: 3.628 ± 0.068	3.815IleGlu: 3.815 ± 0.067	1.779IlePhe: 1.779 ± 0.048	5.308IleGly: 5.308 ± 0.075	0.911IleHis: 0.911 ± 0.029	2.035IleIle: 2.035 ± 0.041	1.107IleLys: 1.107 ± 0.034	4.132IleLeu: 4.132 ± 0.068	1.062IleMet: 1.062 ± 0.035	1.361IleAsn: 1.361 ± 0.039	2.449IlePro: 2.449 ± 0.046	1.143IleGln: 1.143 ± 0.035	3.479IleArg: 3.479 ± 0.059	3.039IleSer: 3.039 ± 0.048	2.57IleThr: 2.57 ± 0.053	3.989IleVal: 3.989 ± 0.065	0.664IleTrp: 0.664 ± 0.024	1.114IleTyr: 1.114 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.632LysAla: 3.632 ± 0.068	0.164LysCys: 0.164 ± 0.013	1.56LysAsp: 1.56 ± 0.037	1.503LysGlu: 1.503 ± 0.041	0.79LysPhe: 0.79 ± 0.03	2.519LysGly: 2.519 ± 0.054	0.564LysHis: 0.564 ± 0.021	1.568LysIle: 1.568 ± 0.046	1.162LysLys: 1.162 ± 0.046	3.213LysLeu: 3.213 ± 0.061	0.69LysMet: 0.69 ± 0.025	0.792LysAsn: 0.792 ± 0.032	1.907LysPro: 1.907 ± 0.045	0.978LysGln: 0.978 ± 0.029	2.266LysArg: 2.266 ± 0.048	1.567LysSer: 1.567 ± 0.043	1.587LysThr: 1.587 ± 0.041	2.06LysVal: 2.06 ± 0.043	0.42LysTrp: 0.42 ± 0.02	0.591LysTyr: 0.591 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.02LeuAla: 14.02 ± 0.158	0.782LeuCys: 0.782 ± 0.031	6.087LeuAsp: 6.087 ± 0.088	5.687LeuGlu: 5.687 ± 0.086	3.712LeuPhe: 3.712 ± 0.065	8.29LeuGly: 8.29 ± 0.094	1.733LeuHis: 1.733 ± 0.047	4.596LeuIle: 4.596 ± 0.073	2.81LeuLys: 2.81 ± 0.056	9.746LeuLeu: 9.746 ± 0.124	2.15LeuMet: 2.15 ± 0.056	2.268LeuAsn: 2.268 ± 0.051	5.635LeuPro: 5.635 ± 0.081	2.873LeuGln: 2.873 ± 0.054	6.864LeuArg: 6.864 ± 0.088	6.135LeuSer: 6.135 ± 0.079	5.274LeuThr: 5.274 ± 0.079	7.127LeuVal: 7.127 ± 0.095	1.215LeuTrp: 1.215 ± 0.039	1.869LeuTyr: 1.869 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.402MetAla: 3.402 ± 0.059	0.135MetCys: 0.135 ± 0.012	1.274MetAsp: 1.274 ± 0.037	1.359MetGlu: 1.359 ± 0.035	0.705MetPhe: 0.705 ± 0.028	1.968MetGly: 1.968 ± 0.05	0.481MetHis: 0.481 ± 0.022	1.383MetIle: 1.383 ± 0.039	0.995MetLys: 0.995 ± 0.03	2.715MetLeu: 2.715 ± 0.056	0.661MetMet: 0.661 ± 0.025	0.766MetAsn: 0.766 ± 0.028	1.595MetPro: 1.595 ± 0.04	0.872MetGln: 0.872 ± 0.029	1.98MetArg: 1.98 ± 0.044	1.476MetSer: 1.476 ± 0.037	1.558MetThr: 1.558 ± 0.039	1.654MetVal: 1.654 ± 0.043	0.24MetTrp: 0.24 ± 0.016	0.296MetTyr: 0.296 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.15AsnAla: 3.15 ± 0.061	0.281AsnCys: 0.281 ± 0.017	1.447AsnAsp: 1.447 ± 0.039	1.339AsnGlu: 1.339 ± 0.039	1.07AsnPhe: 1.07 ± 0.036	2.637AsnGly: 2.637 ± 0.06	0.513AsnHis: 0.513 ± 0.022	1.393AsnIle: 1.393 ± 0.039	0.644AsnLys: 0.644 ± 0.026	2.567AsnLeu: 2.567 ± 0.062	0.65AsnMet: 0.65 ± 0.024	0.706AsnAsn: 0.706 ± 0.029	1.861AsnPro: 1.861 ± 0.047	0.82AsnGln: 0.82 ± 0.026	1.994AsnArg: 1.994 ± 0.05	1.485AsnSer: 1.485 ± 0.036	1.117AsnThr: 1.117 ± 0.034	1.932AsnVal: 1.932 ± 0.048	0.453AsnTrp: 0.453 ± 0.02	0.74AsnTyr: 0.74 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.579ProAla: 6.579 ± 0.086	0.35ProCys: 0.35 ± 0.022	4.005ProAsp: 4.005 ± 0.073	4.382ProGlu: 4.382 ± 0.071	1.986ProPhe: 1.986 ± 0.047	4.9ProGly: 4.9 ± 0.077	1.054ProHis: 1.054 ± 0.032	2.46ProIle: 2.46 ± 0.051	1.338ProLys: 1.338 ± 0.039	4.901ProLeu: 4.901 ± 0.084	1.205ProMet: 1.205 ± 0.038	1.276ProAsn: 1.276 ± 0.042	2.85ProPro: 2.85 ± 0.081	1.864ProGln: 1.864 ± 0.045	3.018ProArg: 3.018 ± 0.052	2.667ProSer: 2.667 ± 0.049	2.265ProThr: 2.265 ± 0.049	4.192ProVal: 4.192 ± 0.073	0.688ProTrp: 0.688 ± 0.026	1.136ProTyr: 1.136 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.21GlnAla: 4.21 ± 0.072	0.248GlnCys: 0.248 ± 0.014	1.781GlnAsp: 1.781 ± 0.041	1.858GlnGlu: 1.858 ± 0.049	1.191GlnPhe: 1.191 ± 0.033	2.591GlnGly: 2.591 ± 0.043	0.601GlnHis: 0.601 ± 0.026	1.87GlnIle: 1.87 ± 0.042	0.878GlnLys: 0.878 ± 0.035	3.446GlnLeu: 3.446 ± 0.062	0.929GlnMet: 0.929 ± 0.032	0.825GlnAsn: 0.825 ± 0.029	1.857GlnPro: 1.857 ± 0.048	1.336GlnGln: 1.336 ± 0.039	2.441GlnArg: 2.441 ± 0.051	1.696GlnSer: 1.696 ± 0.04	1.541GlnThr: 1.541 ± 0.044	2.222GlnVal: 2.222 ± 0.051	0.451GlnTrp: 0.451 ± 0.023	0.691GlnTyr: 0.691 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.843ArgAla: 7.843 ± 0.104	0.512ArgCys: 0.512 ± 0.025	4.177ArgAsp: 4.177 ± 0.061	4.8ArgGlu: 4.8 ± 0.082	2.999ArgPhe: 2.999 ± 0.053	5.066ArgGly: 5.066 ± 0.083	1.574ArgHis: 1.574 ± 0.044	4.317ArgIle: 4.317 ± 0.065	2.469ArgLys: 2.469 ± 0.06	7.737ArgLeu: 7.737 ± 0.117	2.016ArgMet: 2.016 ± 0.041	2.106ArgAsn: 2.106 ± 0.045	3.467ArgPro: 3.467 ± 0.058	2.709ArgGln: 2.709 ± 0.057	5.602ArgArg: 5.602 ± 0.081	3.755ArgSer: 3.755 ± 0.059	3.12ArgThr: 3.12 ± 0.06	4.414ArgVal: 4.414 ± 0.063	1.11ArgTrp: 1.11 ± 0.029	1.78ArgTyr: 1.78 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.551SerAla: 6.551 ± 0.087	0.445SerCys: 0.445 ± 0.023	3.243SerAsp: 3.243 ± 0.057	3.063SerGlu: 3.063 ± 0.052	2.348SerPhe: 2.348 ± 0.047	5.714SerGly: 5.714 ± 0.088	1.027SerHis: 1.027 ± 0.031	2.774SerIle: 2.774 ± 0.051	1.34SerLys: 1.34 ± 0.04	5.485SerLeu: 5.485 ± 0.077	1.316SerMet: 1.316 ± 0.037	1.415SerAsn: 1.415 ± 0.046	2.796SerPro: 2.796 ± 0.061	1.647SerGln: 1.647 ± 0.04	3.725SerArg: 3.725 ± 0.071	2.947SerSer: 2.947 ± 0.064	2.528SerThr: 2.528 ± 0.06	3.789SerVal: 3.789 ± 0.062	0.845SerTrp: 0.845 ± 0.034	1.398SerTyr: 1.398 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.711ThrAla: 5.711 ± 0.09	0.39ThrCys: 0.39 ± 0.023	2.824ThrAsp: 2.824 ± 0.06	2.679ThrGlu: 2.679 ± 0.055	1.723ThrPhe: 1.723 ± 0.041	5.302ThrGly: 5.302 ± 0.087	0.884ThrHis: 0.884 ± 0.03	2.868ThrIle: 2.868 ± 0.057	1.126ThrLys: 1.126 ± 0.034	5.187ThrLeu: 5.187 ± 0.08	1.219ThrMet: 1.219 ± 0.035	1.261ThrAsn: 1.261 ± 0.045	3.136ThrPro: 3.136 ± 0.053	1.488ThrGln: 1.488 ± 0.036	3.278ThrArg: 3.278 ± 0.059	2.576ThrSer: 2.576 ± 0.047	2.298ThrThr: 2.298 ± 0.051	3.743ThrVal: 3.743 ± 0.063	0.541ThrTrp: 0.541 ± 0.024	1.174ThrTyr: 1.174 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	8.169ValAla: 8.169 ± 0.095	0.567ValCys: 0.567 ± 0.024	4.267ValAsp: 4.267 ± 0.056	4.813ValGlu: 4.813 ± 0.073	2.325ValPhe: 2.325 ± 0.055	5.212ValGly: 5.212 ± 0.083	1.235ValHis: 1.235 ± 0.036	3.777ValIle: 3.777 ± 0.059	1.96ValLys: 1.96 ± 0.048	6.721ValLeu: 6.721 ± 0.096	1.659ValMet: 1.659 ± 0.048	1.955ValAsn: 1.955 ± 0.043	3.88ValPro: 3.88 ± 0.062	2.016ValGln: 2.016 ± 0.035	4.407ValArg: 4.407 ± 0.073	4.035ValSer: 4.035 ± 0.067	4.101ValThr: 4.101 ± 0.07	4.863ValVal: 4.863 ± 0.074	0.826ValTrp: 0.826 ± 0.027	1.267ValTyr: 1.267 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.417TrpAla: 1.417 ± 0.039	0.122TrpCys: 0.122 ± 0.011	0.765TrpAsp: 0.765 ± 0.026	0.726TrpGlu: 0.726 ± 0.025	0.59TrpPhe: 0.59 ± 0.023	1.008TrpGly: 1.008 ± 0.027	0.35TrpHis: 0.35 ± 0.021	0.707TrpIle: 0.707 ± 0.028	0.459TrpLys: 0.459 ± 0.02	1.831TrpLeu: 1.831 ± 0.054	0.344TrpMet: 0.344 ± 0.017	0.488TrpAsn: 0.488 ± 0.021	0.693TrpPro: 0.693 ± 0.026	0.689TrpGln: 0.689 ± 0.03	1.308TrpArg: 1.308 ± 0.04	0.903TrpSer: 0.903 ± 0.031	0.705TrpThr: 0.705 ± 0.028	0.8TrpVal: 0.8 ± 0.033	0.256TrpTrp: 0.256 ± 0.017	0.284TrpTyr: 0.284 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.499TyrAla: 2.499 ± 0.046	0.252TyrCys: 0.252 ± 0.016	1.555TyrAsp: 1.555 ± 0.041	1.316TyrGlu: 1.316 ± 0.04	0.935TyrPhe: 0.935 ± 0.032	2.079TyrGly: 2.079 ± 0.049	0.467TyrHis: 0.467 ± 0.022	0.936TyrIle: 0.936 ± 0.032	0.56TyrLys: 0.56 ± 0.025	2.13TyrLeu: 2.13 ± 0.048	0.433TyrMet: 0.433 ± 0.021	0.622TyrAsn: 0.622 ± 0.023	1.079TyrPro: 1.079 ± 0.032	0.674TyrGln: 0.674 ± 0.029	1.882TyrArg: 1.882 ± 0.044	1.335TyrSer: 1.335 ± 0.041	1.042TyrThr: 1.042 ± 0.043	1.512TyrVal: 1.512 ± 0.039	0.354TyrTrp: 0.354 ± 0.021	0.657TyrTyr: 0.657 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3254 proteins (1052863 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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