Amino acid dipepetide frequency for Donghicola tyrosinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.621AlaAla: 15.621 ± 0.149	1.101AlaCys: 1.101 ± 0.036	6.818AlaAsp: 6.818 ± 0.092	7.921AlaGlu: 7.921 ± 0.103	4.193AlaPhe: 4.193 ± 0.064	9.99AlaGly: 9.99 ± 0.139	2.196AlaHis: 2.196 ± 0.054	6.034AlaIle: 6.034 ± 0.057	4.291AlaLys: 4.291 ± 0.064	13.31AlaLeu: 13.31 ± 0.12	3.73AlaMet: 3.73 ± 0.063	3.132AlaAsn: 3.132 ± 0.066	5.601AlaPro: 5.601 ± 0.095	4.638AlaGln: 4.638 ± 0.059	7.479AlaArg: 7.479 ± 0.11	5.82AlaSer: 5.82 ± 0.085	5.952AlaThr: 5.952 ± 0.12	7.936AlaVal: 7.936 ± 0.093	1.316AlaTrp: 1.316 ± 0.038	2.555AlaTyr: 2.555 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.087CysAla: 1.087 ± 0.037	0.121CysCys: 0.121 ± 0.01	0.646CysAsp: 0.646 ± 0.023	0.482CysGlu: 0.482 ± 0.019	0.349CysPhe: 0.349 ± 0.015	0.922CysGly: 0.922 ± 0.034	0.295CysHis: 0.295 ± 0.019	0.435CysIle: 0.435 ± 0.019	0.241CysLys: 0.241 ± 0.014	0.886CysLeu: 0.886 ± 0.028	0.213CysMet: 0.213 ± 0.013	0.23CysAsn: 0.23 ± 0.015	0.531CysPro: 0.531 ± 0.022	0.286CysGln: 0.286 ± 0.016	0.514CysArg: 0.514 ± 0.022	0.474CysSer: 0.474 ± 0.021	0.492CysThr: 0.492 ± 0.023	0.656CysVal: 0.656 ± 0.026	0.121CysTrp: 0.121 ± 0.009	0.208CysTyr: 0.208 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.187AspAla: 7.187 ± 0.102	0.567AspCys: 0.567 ± 0.023	3.492AspAsp: 3.492 ± 0.074	3.526AspGlu: 3.526 ± 0.068	2.304AspPhe: 2.304 ± 0.043	5.67AspGly: 5.67 ± 0.132	1.373AspHis: 1.373 ± 0.035	3.156AspIle: 3.156 ± 0.082	1.81AspLys: 1.81 ± 0.046	6.834AspLeu: 6.834 ± 0.09	1.738AspMet: 1.738 ± 0.035	1.479AspAsn: 1.479 ± 0.041	3.351AspPro: 3.351 ± 0.054	2.183AspGln: 2.183 ± 0.043	3.853AspArg: 3.853 ± 0.068	2.423AspSer: 2.423 ± 0.055	3.091AspThr: 3.091 ± 0.064	4.382AspVal: 4.382 ± 0.093	1.149AspTrp: 1.149 ± 0.028	1.606AspTyr: 1.606 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.986GluAla: 7.986 ± 0.11	0.396GluCys: 0.396 ± 0.018	3.485GluAsp: 3.485 ± 0.055	3.654GluGlu: 3.654 ± 0.087	1.799GluPhe: 1.799 ± 0.04	5.058GluGly: 5.058 ± 0.066	1.109GluHis: 1.109 ± 0.035	3.622GluIle: 3.622 ± 0.059	2.355GluLys: 2.355 ± 0.052	5.103GluLeu: 5.103 ± 0.069	1.964GluMet: 1.964 ± 0.042	1.912GluAsn: 1.912 ± 0.039	2.18GluPro: 2.18 ± 0.049	2.05GluGln: 2.05 ± 0.039	3.822GluArg: 3.822 ± 0.063	2.112GluSer: 2.112 ± 0.038	3.752GluThr: 3.752 ± 0.054	4.441GluVal: 4.441 ± 0.067	0.744GluTrp: 0.744 ± 0.024	1.126GluTyr: 1.126 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.388PheAla: 4.388 ± 0.067	0.408PheCys: 0.408 ± 0.018	2.89PheAsp: 2.89 ± 0.047	2.185PheGlu: 2.185 ± 0.04	1.469PhePhe: 1.469 ± 0.041	3.734PheGly: 3.734 ± 0.055	0.766PheHis: 0.766 ± 0.026	1.685PheIle: 1.685 ± 0.037	1.102PheLys: 1.102 ± 0.03	3.263PheLeu: 3.263 ± 0.061	0.93PheMet: 0.93 ± 0.029	1.078PheAsn: 1.078 ± 0.03	1.46PhePro: 1.46 ± 0.037	1.069PheGln: 1.069 ± 0.031	2.074PheArg: 2.074 ± 0.046	2.206PheSer: 2.206 ± 0.04	2.134PheThr: 2.134 ± 0.045	2.648PheVal: 2.648 ± 0.046	0.498PheTrp: 0.498 ± 0.02	1.001PheTyr: 1.001 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.684GlyAla: 9.684 ± 0.141	0.854GlyCys: 0.854 ± 0.027	4.843GlyAsp: 4.843 ± 0.127	4.367GlyGlu: 4.367 ± 0.063	3.573GlyPhe: 3.573 ± 0.05	7.268GlyGly: 7.268 ± 0.124	1.922GlyHis: 1.922 ± 0.045	4.727GlyIle: 4.727 ± 0.062	3.273GlyLys: 3.273 ± 0.058	8.889GlyLeu: 8.889 ± 0.09	2.599GlyMet: 2.599 ± 0.046	2.48GlyAsn: 2.48 ± 0.096	3.289GlyPro: 3.289 ± 0.057	3.379GlyGln: 3.379 ± 0.054	5.198GlyArg: 5.198 ± 0.067	4.283GlySer: 4.283 ± 0.098	4.835GlyThr: 4.835 ± 0.146	6.409GlyVal: 6.409 ± 0.095	1.324GlyTrp: 1.324 ± 0.037	2.475GlyTyr: 2.475 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.149HisAla: 2.149 ± 0.049	0.232HisCys: 0.232 ± 0.013	1.244HisAsp: 1.244 ± 0.035	1.09HisGlu: 1.09 ± 0.03	0.82HisPhe: 0.82 ± 0.026	1.906HisGly: 1.906 ± 0.048	0.545HisHis: 0.545 ± 0.022	1.014HisIle: 1.014 ± 0.027	0.608HisLys: 0.608 ± 0.023	2.151HisLeu: 2.151 ± 0.049	0.611HisMet: 0.611 ± 0.024	0.486HisAsn: 0.486 ± 0.017	1.325HisPro: 1.325 ± 0.043	0.666HisGln: 0.666 ± 0.026	1.222HisArg: 1.222 ± 0.036	1.009HisSer: 1.009 ± 0.032	0.92HisThr: 0.92 ± 0.027	1.476HisVal: 1.476 ± 0.033	0.352HisTrp: 0.352 ± 0.018	0.577HisTyr: 0.577 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.035IleAla: 7.035 ± 0.08	0.657IleCys: 0.657 ± 0.023	3.507IleAsp: 3.507 ± 0.074	3.558IleGlu: 3.558 ± 0.051	1.882IlePhe: 1.882 ± 0.041	4.88IleGly: 4.88 ± 0.069	1.011IleHis: 1.011 ± 0.028	2.542IleIle: 2.542 ± 0.051	1.715IleLys: 1.715 ± 0.039	4.805IleLeu: 4.805 ± 0.062	1.173IleMet: 1.173 ± 0.029	1.564IleAsn: 1.564 ± 0.052	2.375IlePro: 2.375 ± 0.047	1.41IleGln: 1.41 ± 0.031	3.091IleArg: 3.091 ± 0.05	3.36IleSer: 3.36 ± 0.051	3.289IleThr: 3.289 ± 0.098	3.722IleVal: 3.722 ± 0.053	0.702IleTrp: 0.702 ± 0.024	1.247IleTyr: 1.247 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.405LysAla: 4.405 ± 0.073	0.224LysCys: 0.224 ± 0.013	2.004LysAsp: 2.004 ± 0.041	1.85LysGlu: 1.85 ± 0.042	1.0LysPhe: 1.0 ± 0.028	3.065LysGly: 3.065 ± 0.049	0.634LysHis: 0.634 ± 0.024	1.882LysIle: 1.882 ± 0.041	1.315LysLys: 1.315 ± 0.039	3.127LysLeu: 3.127 ± 0.057	1.041LysMet: 1.041 ± 0.027	0.927LysAsn: 0.927 ± 0.024	1.818LysPro: 1.818 ± 0.046	1.058LysGln: 1.058 ± 0.031	2.245LysArg: 2.245 ± 0.054	1.897LysSer: 1.897 ± 0.039	2.191LysThr: 2.191 ± 0.042	2.498LysVal: 2.498 ± 0.05	0.421LysTrp: 0.421 ± 0.018	0.71LysTyr: 0.71 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.118LeuAla: 12.118 ± 0.124	0.983LeuCys: 0.983 ± 0.033	5.959LeuAsp: 5.959 ± 0.082	5.57LeuGlu: 5.57 ± 0.074	3.537LeuPhe: 3.537 ± 0.067	8.155LeuGly: 8.155 ± 0.08	1.937LeuHis: 1.937 ± 0.047	5.265LeuIle: 5.265 ± 0.069	3.438LeuLys: 3.438 ± 0.063	8.844LeuLeu: 8.844 ± 0.133	2.838LeuMet: 2.838 ± 0.055	2.939LeuAsn: 2.939 ± 0.058	5.401LeuPro: 5.401 ± 0.078	2.987LeuGln: 2.987 ± 0.047	6.759LeuArg: 6.759 ± 0.081	6.827LeuSer: 6.827 ± 0.093	6.275LeuThr: 6.275 ± 0.133	6.689LeuVal: 6.689 ± 0.083	1.283LeuTrp: 1.283 ± 0.034	2.028LeuTyr: 2.028 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.534MetAla: 3.534 ± 0.059	0.217MetCys: 0.217 ± 0.013	1.564MetAsp: 1.564 ± 0.032	1.315MetGlu: 1.315 ± 0.037	0.845MetPhe: 0.845 ± 0.025	2.38MetGly: 2.38 ± 0.048	0.515MetHis: 0.515 ± 0.021	1.648MetIle: 1.648 ± 0.037	1.17MetLys: 1.17 ± 0.03	2.711MetLeu: 2.711 ± 0.053	0.842MetMet: 0.842 ± 0.024	0.975MetAsn: 0.975 ± 0.031	1.547MetPro: 1.547 ± 0.038	1.092MetGln: 1.092 ± 0.026	1.797MetArg: 1.797 ± 0.036	1.878MetSer: 1.878 ± 0.04	2.292MetThr: 2.292 ± 0.042	1.992MetVal: 1.992 ± 0.036	0.257MetTrp: 0.257 ± 0.013	0.39MetTyr: 0.39 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.424AsnAla: 3.424 ± 0.06	0.278AsnCys: 0.278 ± 0.013	1.806AsnAsp: 1.806 ± 0.068	1.34AsnGlu: 1.34 ± 0.031	1.033AsnPhe: 1.033 ± 0.029	2.855AsnGly: 2.855 ± 0.081	0.546AsnHis: 0.546 ± 0.017	1.558AsnIle: 1.558 ± 0.05	0.834AsnLys: 0.834 ± 0.022	2.775AsnLeu: 2.775 ± 0.056	0.796AsnMet: 0.796 ± 0.023	0.798AsnAsn: 0.798 ± 0.028	1.855AsnPro: 1.855 ± 0.032	0.852AsnGln: 0.852 ± 0.026	1.787AsnArg: 1.787 ± 0.039	1.355AsnSer: 1.355 ± 0.04	1.508AsnThr: 1.508 ± 0.04	2.023AsnVal: 2.023 ± 0.067	0.45AsnTrp: 0.45 ± 0.018	0.7AsnTyr: 0.7 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.444ProAla: 5.444 ± 0.079	0.369ProCys: 0.369 ± 0.019	3.692ProAsp: 3.692 ± 0.061	4.242ProGlu: 4.242 ± 0.079	1.911ProPhe: 1.911 ± 0.046	3.191ProGly: 3.191 ± 0.048	1.014ProHis: 1.014 ± 0.032	2.247ProIle: 2.247 ± 0.041	1.831ProLys: 1.831 ± 0.044	4.511ProLeu: 4.511 ± 0.076	1.334ProMet: 1.334 ± 0.034	1.374ProAsn: 1.374 ± 0.032	1.768ProPro: 1.768 ± 0.049	1.724ProGln: 1.724 ± 0.045	2.448ProArg: 2.448 ± 0.061	2.516ProSer: 2.516 ± 0.053	2.44ProThr: 2.44 ± 0.043	4.024ProVal: 4.024 ± 0.065	0.636ProTrp: 0.636 ± 0.023	1.132ProTyr: 1.132 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.101GlnAla: 4.101 ± 0.065	0.232GlnCys: 0.232 ± 0.015	1.879GlnAsp: 1.879 ± 0.033	1.75GlnGlu: 1.75 ± 0.04	1.136GlnPhe: 1.136 ± 0.03	2.751GlnGly: 2.751 ± 0.042	0.676GlnHis: 0.676 ± 0.024	2.383GlnIle: 2.383 ± 0.041	1.227GlnLys: 1.227 ± 0.032	3.048GlnLeu: 3.048 ± 0.054	1.286GlnMet: 1.286 ± 0.027	1.095GlnAsn: 1.095 ± 0.029	1.643GlnPro: 1.643 ± 0.04	1.277GlnGln: 1.277 ± 0.033	2.314GlnArg: 2.314 ± 0.049	1.972GlnSer: 1.972 ± 0.036	2.114GlnThr: 2.114 ± 0.053	2.494GlnVal: 2.494 ± 0.041	0.392GlnTrp: 0.392 ± 0.018	0.605GlnTyr: 0.605 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.03ArgAla: 7.03 ± 0.091	0.486ArgCys: 0.486 ± 0.02	3.939ArgAsp: 3.939 ± 0.061	3.422ArgGlu: 3.422 ± 0.061	2.51ArgPhe: 2.51 ± 0.052	4.188ArgGly: 4.188 ± 0.064	1.408ArgHis: 1.408 ± 0.039	3.679ArgIle: 3.679 ± 0.051	2.36ArgLys: 2.36 ± 0.05	6.747ArgLeu: 6.747 ± 0.101	1.945ArgMet: 1.945 ± 0.048	1.801ArgAsn: 1.801 ± 0.036	2.918ArgPro: 2.918 ± 0.066	2.343ArgGln: 2.343 ± 0.047	4.468ArgArg: 4.468 ± 0.093	3.108ArgSer: 3.108 ± 0.044	3.032ArgThr: 3.032 ± 0.053	4.32ArgVal: 4.32 ± 0.067	0.874ArgTrp: 0.874 ± 0.024	1.54ArgTyr: 1.54 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.043SerAla: 6.043 ± 0.097	0.469SerCys: 0.469 ± 0.021	3.456SerAsp: 3.456 ± 0.059	3.034SerGlu: 3.034 ± 0.049	2.302SerPhe: 2.302 ± 0.043	5.564SerGly: 5.564 ± 0.145	1.12SerHis: 1.12 ± 0.035	2.617SerIle: 2.617 ± 0.051	1.688SerLys: 1.688 ± 0.038	5.195SerLeu: 5.195 ± 0.072	1.433SerMet: 1.433 ± 0.031	1.54SerAsn: 1.54 ± 0.037	2.336SerPro: 2.336 ± 0.044	1.75SerGln: 1.75 ± 0.036	3.151SerArg: 3.151 ± 0.057	2.737SerSer: 2.737 ± 0.059	2.666SerThr: 2.666 ± 0.064	4.017SerVal: 4.017 ± 0.091	0.65SerTrp: 0.65 ± 0.021	1.377SerTyr: 1.377 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.298ThrAla: 6.298 ± 0.138	0.528ThrCys: 0.528 ± 0.025	3.322ThrAsp: 3.322 ± 0.066	3.169ThrGlu: 3.169 ± 0.051	2.095ThrPhe: 2.095 ± 0.047	5.524ThrGly: 5.524 ± 0.162	1.148ThrHis: 1.148 ± 0.03	2.934ThrIle: 2.934 ± 0.073	1.65ThrLys: 1.65 ± 0.036	6.279ThrLeu: 6.279 ± 0.138	1.369ThrMet: 1.369 ± 0.03	1.493ThrAsn: 1.493 ± 0.043	3.372ThrPro: 3.372 ± 0.043	1.79ThrGln: 1.79 ± 0.043	3.357ThrArg: 3.357 ± 0.054	2.907ThrSer: 2.907 ± 0.083	3.027ThrThr: 3.027 ± 0.127	4.462ThrVal: 4.462 ± 0.125	0.651ThrTrp: 0.651 ± 0.022	1.412ThrTyr: 1.412 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.382ValAla: 8.382 ± 0.09	0.68ValCys: 0.68 ± 0.025	4.166ValAsp: 4.166 ± 0.082	4.21ValGlu: 4.21 ± 0.07	2.779ValPhe: 2.779 ± 0.046	5.355ValGly: 5.355 ± 0.069	1.337ValHis: 1.337 ± 0.032	4.365ValIle: 4.365 ± 0.061	2.302ValLys: 2.302 ± 0.045	7.45ValLeu: 7.45 ± 0.084	2.189ValMet: 2.189 ± 0.044	2.146ValAsn: 2.146 ± 0.05	3.349ValPro: 3.349 ± 0.066	2.372ValGln: 2.372 ± 0.05	4.078ValArg: 4.078 ± 0.059	4.241ValSer: 4.241 ± 0.081	4.783ValThr: 4.783 ± 0.147	5.622ValVal: 5.622 ± 0.064	0.93ValTrp: 0.93 ± 0.026	1.573ValTyr: 1.573 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.219TrpAla: 1.219 ± 0.033	0.139TrpCys: 0.139 ± 0.011	0.739TrpAsp: 0.739 ± 0.023	0.605TrpGlu: 0.605 ± 0.021	0.496TrpPhe: 0.496 ± 0.019	1.013TrpGly: 1.013 ± 0.028	0.34TrpHis: 0.34 ± 0.015	0.685TrpIle: 0.685 ± 0.023	0.477TrpLys: 0.477 ± 0.019	1.565TrpLeu: 1.565 ± 0.039	0.416TrpMet: 0.416 ± 0.017	0.443TrpAsn: 0.443 ± 0.019	0.636TrpPro: 0.636 ± 0.022	0.646TrpGln: 0.646 ± 0.022	0.982TrpArg: 0.982 ± 0.033	0.774TrpSer: 0.774 ± 0.023	0.766TrpThr: 0.766 ± 0.025	0.901TrpVal: 0.901 ± 0.026	0.192TrpTrp: 0.192 ± 0.012	0.277TrpTyr: 0.277 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.04	0.25TyrCys: 0.25 ± 0.013	1.723TyrAsp: 1.723 ± 0.036	1.385TyrGlu: 1.385 ± 0.036	0.952TyrPhe: 0.952 ± 0.026	2.198TyrGly: 2.198 ± 0.048	0.51TyrHis: 0.51 ± 0.021	1.048TyrIle: 1.048 ± 0.029	0.623TyrLys: 0.623 ± 0.02	2.338TyrLeu: 2.338 ± 0.042	0.516TyrMet: 0.516 ± 0.018	0.683TyrAsn: 0.683 ± 0.026	1.092TyrPro: 1.092 ± 0.031	0.803TyrGln: 0.803 ± 0.023	1.479TyrArg: 1.479 ± 0.033	1.245TyrSer: 1.245 ± 0.03	1.225TyrThr: 1.225 ± 0.034	1.599TyrVal: 1.599 ± 0.033	0.368TyrTrp: 0.368 ± 0.017	0.642TyrTyr: 0.642 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4472 proteins (1407917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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