Amino acid dipepetide frequency for Rhodobacteraceae bacterium 63075

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.119AlaAla: 16.119 ± 0.172	1.068AlaCys: 1.068 ± 0.037	6.444AlaAsp: 6.444 ± 0.081	9.227AlaGlu: 9.227 ± 0.134	4.389AlaPhe: 4.389 ± 0.075	10.646AlaGly: 10.646 ± 0.108	2.516AlaHis: 2.516 ± 0.059	5.399AlaIle: 5.399 ± 0.083	3.902AlaLys: 3.902 ± 0.066	14.562AlaLeu: 14.562 ± 0.156	3.68AlaMet: 3.68 ± 0.062	2.483AlaAsn: 2.483 ± 0.052	5.883AlaPro: 5.883 ± 0.089	4.575AlaGln: 4.575 ± 0.075	9.667AlaArg: 9.667 ± 0.112	5.729AlaSer: 5.729 ± 0.069	5.175AlaThr: 5.175 ± 0.078	7.81AlaVal: 7.81 ± 0.091	1.414AlaTrp: 1.414 ± 0.034	2.61AlaTyr: 2.61 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.126CysAla: 1.126 ± 0.037	0.112CysCys: 0.112 ± 0.012	0.615CysAsp: 0.615 ± 0.025	0.559CysGlu: 0.559 ± 0.022	0.356CysPhe: 0.356 ± 0.018	0.939CysGly: 0.939 ± 0.03	0.27CysHis: 0.27 ± 0.016	0.389CysIle: 0.389 ± 0.021	0.228CysLys: 0.228 ± 0.016	0.843CysLeu: 0.843 ± 0.032	0.174CysMet: 0.174 ± 0.014	0.22CysAsn: 0.22 ± 0.015	0.488CysPro: 0.488 ± 0.022	0.202CysGln: 0.202 ± 0.014	0.537CysArg: 0.537 ± 0.023	0.455CysSer: 0.455 ± 0.02	0.477CysThr: 0.477 ± 0.023	0.61CysVal: 0.61 ± 0.028	0.084CysTrp: 0.084 ± 0.008	0.202CysTyr: 0.202 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.143AspAla: 7.143 ± 0.104	0.537AspCys: 0.537 ± 0.026	3.398AspAsp: 3.398 ± 0.098	4.033AspGlu: 4.033 ± 0.061	2.324AspPhe: 2.324 ± 0.048	5.374AspGly: 5.374 ± 0.09	1.296AspHis: 1.296 ± 0.035	3.176AspIle: 3.176 ± 0.05	1.874AspLys: 1.874 ± 0.047	5.638AspLeu: 5.638 ± 0.081	1.804AspMet: 1.804 ± 0.044	1.188AspAsn: 1.188 ± 0.029	3.182AspPro: 3.182 ± 0.055	1.478AspGln: 1.478 ± 0.039	3.594AspArg: 3.594 ± 0.063	2.25AspSer: 2.25 ± 0.055	2.803AspThr: 2.803 ± 0.066	4.415AspVal: 4.415 ± 0.077	1.153AspTrp: 1.153 ± 0.033	1.575AspTyr: 1.575 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	9.752GluAla: 9.752 ± 0.117	0.439GluCys: 0.439 ± 0.022	3.965GluAsp: 3.965 ± 0.071	4.877GluGlu: 4.877 ± 0.087	1.978GluPhe: 1.978 ± 0.044	5.749GluGly: 5.749 ± 0.091	1.352GluHis: 1.352 ± 0.04	4.031GluIle: 4.031 ± 0.058	2.705GluLys: 2.705 ± 0.052	6.208GluLeu: 6.208 ± 0.079	2.166GluMet: 2.166 ± 0.041	1.993GluAsn: 1.993 ± 0.041	2.812GluPro: 2.812 ± 0.055	2.168GluGln: 2.168 ± 0.051	5.082GluArg: 5.082 ± 0.078	2.846GluSer: 2.846 ± 0.057	4.369GluThr: 4.369 ± 0.071	4.514GluVal: 4.514 ± 0.071	0.736GluTrp: 0.736 ± 0.028	1.144GluTyr: 1.144 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.401PheAla: 4.401 ± 0.073	0.434PheCys: 0.434 ± 0.022	2.806PheAsp: 2.806 ± 0.05	2.846PheGlu: 2.846 ± 0.053	1.479PhePhe: 1.479 ± 0.038	3.671PheGly: 3.671 ± 0.064	0.754PheHis: 0.754 ± 0.026	1.759PheIle: 1.759 ± 0.043	1.038PheLys: 1.038 ± 0.032	3.388PheLeu: 3.388 ± 0.068	0.912PheMet: 0.912 ± 0.028	1.002PheAsn: 1.002 ± 0.031	1.513PhePro: 1.513 ± 0.039	0.965PheGln: 0.965 ± 0.029	2.121PheArg: 2.121 ± 0.055	2.232PheSer: 2.232 ± 0.048	2.068PheThr: 2.068 ± 0.048	2.604PheVal: 2.604 ± 0.058	0.616PheTrp: 0.616 ± 0.025	0.918PheTyr: 0.918 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.507GlyAla: 10.507 ± 0.123	0.84GlyCys: 0.84 ± 0.029	4.714GlyAsp: 4.714 ± 0.096	5.814GlyGlu: 5.814 ± 0.081	3.837GlyPhe: 3.837 ± 0.071	7.711GlyGly: 7.711 ± 0.136	2.005GlyHis: 2.005 ± 0.045	4.195GlyIle: 4.195 ± 0.081	3.557GlyLys: 3.557 ± 0.07	9.35GlyLeu: 9.35 ± 0.105	2.627GlyMet: 2.627 ± 0.048	2.082GlyAsn: 2.082 ± 0.061	3.741GlyPro: 3.741 ± 0.057	3.046GlyGln: 3.046 ± 0.055	5.827GlyArg: 5.827 ± 0.073	4.167GlySer: 4.167 ± 0.075	4.459GlyThr: 4.459 ± 0.076	6.044GlyVal: 6.044 ± 0.074	1.515GlyTrp: 1.515 ± 0.046	2.399GlyTyr: 2.399 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.422HisAla: 2.422 ± 0.053	0.226HisCys: 0.226 ± 0.015	1.291HisAsp: 1.291 ± 0.041	1.326HisGlu: 1.326 ± 0.038	0.882HisPhe: 0.882 ± 0.031	2.048HisGly: 2.048 ± 0.052	0.538HisHis: 0.538 ± 0.022	1.023HisIle: 1.023 ± 0.032	0.563HisLys: 0.563 ± 0.022	2.046HisLeu: 2.046 ± 0.047	0.576HisMet: 0.576 ± 0.024	0.449HisAsn: 0.449 ± 0.021	1.337HisPro: 1.337 ± 0.037	0.54HisGln: 0.54 ± 0.023	1.314HisArg: 1.314 ± 0.038	0.885HisSer: 0.885 ± 0.032	0.836HisThr: 0.836 ± 0.032	1.671HisVal: 1.671 ± 0.045	0.369HisTrp: 0.369 ± 0.02	0.603HisTyr: 0.603 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.743IleAla: 6.743 ± 0.079	0.637IleCys: 0.637 ± 0.023	3.379IleAsp: 3.379 ± 0.065	3.788IleGlu: 3.788 ± 0.06	1.755IlePhe: 1.755 ± 0.044	4.877IleGly: 4.877 ± 0.072	0.879IleHis: 0.879 ± 0.029	2.359IleIle: 2.359 ± 0.057	1.531IleLys: 1.531 ± 0.038	4.322IleLeu: 4.322 ± 0.07	1.168IleMet: 1.168 ± 0.032	1.296IleAsn: 1.296 ± 0.039	2.14IlePro: 2.14 ± 0.038	1.012IleGln: 1.012 ± 0.034	3.136IleArg: 3.136 ± 0.051	2.935IleSer: 2.935 ± 0.054	2.967IleThr: 2.967 ± 0.054	3.595IleVal: 3.595 ± 0.061	0.699IleTrp: 0.699 ± 0.028	1.143IleTyr: 1.143 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.491LysAla: 4.491 ± 0.062	0.202LysCys: 0.202 ± 0.013	1.855LysAsp: 1.855 ± 0.044	1.841LysGlu: 1.841 ± 0.049	0.937LysPhe: 0.937 ± 0.031	2.949LysGly: 2.949 ± 0.054	0.675LysHis: 0.675 ± 0.025	1.65LysIle: 1.65 ± 0.044	1.305LysLys: 1.305 ± 0.047	3.506LysLeu: 3.506 ± 0.058	0.937LysMet: 0.937 ± 0.029	0.846LysAsn: 0.846 ± 0.031	1.998LysPro: 1.998 ± 0.056	1.018LysGln: 1.018 ± 0.032	2.611LysArg: 2.611 ± 0.054	1.887LysSer: 1.887 ± 0.045	2.017LysThr: 2.017 ± 0.05	2.202LysVal: 2.202 ± 0.05	0.395LysTrp: 0.395 ± 0.02	0.655LysTyr: 0.655 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.989LeuAla: 12.989 ± 0.131	0.947LeuCys: 0.947 ± 0.028	5.785LeuAsp: 5.785 ± 0.076	6.664LeuGlu: 6.664 ± 0.079	3.663LeuPhe: 3.663 ± 0.071	8.905LeuGly: 8.905 ± 0.115	1.912LeuHis: 1.912 ± 0.042	4.835LeuIle: 4.835 ± 0.081	3.547LeuLys: 3.547 ± 0.061	8.84LeuLeu: 8.84 ± 0.129	2.71LeuMet: 2.71 ± 0.058	2.382LeuAsn: 2.382 ± 0.05	5.231LeuPro: 5.231 ± 0.085	2.544LeuGln: 2.544 ± 0.049	7.023LeuArg: 7.023 ± 0.082	6.738LeuSer: 6.738 ± 0.087	5.549LeuThr: 5.549 ± 0.08	6.69LeuVal: 6.69 ± 0.093	1.316LeuTrp: 1.316 ± 0.038	2.035LeuTyr: 2.035 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.407MetAla: 3.407 ± 0.059	0.17MetCys: 0.17 ± 0.013	1.431MetAsp: 1.431 ± 0.038	1.606MetGlu: 1.606 ± 0.038	0.807MetPhe: 0.807 ± 0.031	2.382MetGly: 2.382 ± 0.055	0.502MetHis: 0.502 ± 0.021	1.576MetIle: 1.576 ± 0.046	1.138MetLys: 1.138 ± 0.031	2.641MetLeu: 2.641 ± 0.056	0.804MetMet: 0.804 ± 0.031	0.865MetAsn: 0.865 ± 0.031	1.49MetPro: 1.49 ± 0.038	1.044MetGln: 1.044 ± 0.036	2.121MetArg: 2.121 ± 0.044	2.011MetSer: 2.011 ± 0.049	1.928MetThr: 1.928 ± 0.043	1.733MetVal: 1.733 ± 0.043	0.238MetTrp: 0.238 ± 0.017	0.334MetTyr: 0.334 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.187AsnAla: 3.187 ± 0.062	0.233AsnCys: 0.233 ± 0.016	1.377AsnAsp: 1.377 ± 0.047	1.271AsnGlu: 1.271 ± 0.039	0.927AsnPhe: 0.927 ± 0.027	2.138AsnGly: 2.138 ± 0.048	0.53AsnHis: 0.53 ± 0.023	1.36AsnIle: 1.36 ± 0.036	0.68AsnLys: 0.68 ± 0.029	2.334AsnLeu: 2.334 ± 0.052	0.687AsnMet: 0.687 ± 0.027	0.609AsnAsn: 0.609 ± 0.025	1.666AsnPro: 1.666 ± 0.042	0.621AsnGln: 0.621 ± 0.023	1.598AsnArg: 1.598 ± 0.039	1.12AsnSer: 1.12 ± 0.034	1.289AsnThr: 1.289 ± 0.037	1.712AsnVal: 1.712 ± 0.042	0.414AsnTrp: 0.414 ± 0.02	0.592AsnTyr: 0.592 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.263ProAla: 5.263 ± 0.072	0.385ProCys: 0.385 ± 0.019	3.514ProAsp: 3.514 ± 0.053	4.867ProGlu: 4.867 ± 0.069	1.908ProPhe: 1.908 ± 0.046	4.257ProGly: 4.257 ± 0.064	1.098ProHis: 1.098 ± 0.037	2.036ProIle: 2.036 ± 0.041	1.692ProLys: 1.692 ± 0.046	4.546ProLeu: 4.546 ± 0.072	1.304ProMet: 1.304 ± 0.034	1.131ProAsn: 1.131 ± 0.035	2.106ProPro: 2.106 ± 0.052	1.58ProGln: 1.58 ± 0.039	2.996ProArg: 2.996 ± 0.056	2.451ProSer: 2.451 ± 0.048	2.023ProThr: 2.023 ± 0.047	3.896ProVal: 3.896 ± 0.061	0.638ProTrp: 0.638 ± 0.025	1.165ProTyr: 1.165 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.815GlnAla: 3.815 ± 0.059	0.176GlnCys: 0.176 ± 0.012	1.641GlnAsp: 1.641 ± 0.043	1.749GlnGlu: 1.749 ± 0.043	1.028GlnPhe: 1.028 ± 0.033	2.631GlnGly: 2.631 ± 0.052	0.589GlnHis: 0.589 ± 0.027	1.913GlnIle: 1.913 ± 0.047	1.095GlnLys: 1.095 ± 0.032	2.774GlnLeu: 2.774 ± 0.059	1.037GlnMet: 1.037 ± 0.032	0.829GlnAsn: 0.829 ± 0.031	1.459GlnPro: 1.459 ± 0.039	0.966GlnGln: 0.966 ± 0.035	2.085GlnArg: 2.085 ± 0.044	1.755GlnSer: 1.755 ± 0.043	1.682GlnThr: 1.682 ± 0.043	2.173GlnVal: 2.173 ± 0.05	0.343GlnTrp: 0.343 ± 0.017	0.587GlnTyr: 0.587 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.582ArgAla: 8.582 ± 0.097	0.501ArgCys: 0.501 ± 0.023	3.966ArgAsp: 3.966 ± 0.064	4.778ArgGlu: 4.778 ± 0.07	2.761ArgPhe: 2.761 ± 0.052	4.856ArgGly: 4.856 ± 0.072	1.547ArgHis: 1.547 ± 0.04	3.837ArgIle: 3.837 ± 0.062	2.701ArgLys: 2.701 ± 0.054	7.576ArgLeu: 7.576 ± 0.087	1.972ArgMet: 1.972 ± 0.045	1.648ArgAsn: 1.648 ± 0.04	3.208ArgPro: 3.208 ± 0.061	2.247ArgGln: 2.247 ± 0.055	5.114ArgArg: 5.114 ± 0.081	3.482ArgSer: 3.482 ± 0.061	2.66ArgThr: 2.66 ± 0.048	4.545ArgVal: 4.545 ± 0.064	0.944ArgTrp: 0.944 ± 0.033	1.625ArgTyr: 1.625 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.037SerAla: 6.037 ± 0.078	0.491SerCys: 0.491 ± 0.022	3.268SerAsp: 3.268 ± 0.059	3.631SerGlu: 3.631 ± 0.06	2.314SerPhe: 2.314 ± 0.046	5.722SerGly: 5.722 ± 0.085	1.121SerHis: 1.121 ± 0.031	2.312SerIle: 2.312 ± 0.05	1.589SerLys: 1.589 ± 0.035	5.001SerLeu: 5.001 ± 0.075	1.391SerMet: 1.391 ± 0.04	1.305SerAsn: 1.305 ± 0.043	2.457SerPro: 2.457 ± 0.046	1.654SerGln: 1.654 ± 0.04	3.395SerArg: 3.395 ± 0.063	2.576SerSer: 2.576 ± 0.063	2.421SerThr: 2.421 ± 0.053	3.612SerVal: 3.612 ± 0.052	0.738SerTrp: 0.738 ± 0.03	1.387SerTyr: 1.387 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.689ThrAla: 5.689 ± 0.083	0.485ThrCys: 0.485 ± 0.021	2.855ThrAsp: 2.855 ± 0.059	3.156ThrGlu: 3.156 ± 0.058	1.827ThrPhe: 1.827 ± 0.041	5.352ThrGly: 5.352 ± 0.08	1.087ThrHis: 1.087 ± 0.033	2.56ThrIle: 2.56 ± 0.05	1.366ThrLys: 1.366 ± 0.034	5.562ThrLeu: 5.562 ± 0.067	1.246ThrMet: 1.246 ± 0.038	1.2ThrAsn: 1.2 ± 0.037	3.101ThrPro: 3.101 ± 0.052	1.447ThrGln: 1.447 ± 0.035	3.58ThrArg: 3.58 ± 0.06	2.622ThrSer: 2.622 ± 0.059	2.398ThrThr: 2.398 ± 0.05	3.849ThrVal: 3.849 ± 0.06	0.669ThrTrp: 0.669 ± 0.025	1.216ThrTyr: 1.216 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.697ValAla: 7.697 ± 0.099	0.609ValCys: 0.609 ± 0.023	3.693ValAsp: 3.693 ± 0.064	4.615ValGlu: 4.615 ± 0.081	2.906ValPhe: 2.906 ± 0.057	5.03ValGly: 5.03 ± 0.071	1.349ValHis: 1.349 ± 0.039	4.232ValIle: 4.232 ± 0.072	2.356ValLys: 2.356 ± 0.053	7.156ValLeu: 7.156 ± 0.103	2.099ValMet: 2.099 ± 0.05	1.89ValAsn: 1.89 ± 0.044	3.329ValPro: 3.329 ± 0.052	1.971ValGln: 1.971 ± 0.042	4.048ValArg: 4.048 ± 0.059	4.354ValSer: 4.354 ± 0.064	4.313ValThr: 4.313 ± 0.076	4.953ValVal: 4.953 ± 0.075	0.855ValTrp: 0.855 ± 0.03	1.477ValTyr: 1.477 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.362TrpAla: 1.362 ± 0.038	0.137TrpCys: 0.137 ± 0.012	0.712TrpAsp: 0.712 ± 0.026	0.743TrpGlu: 0.743 ± 0.028	0.539TrpPhe: 0.539 ± 0.024	1.045TrpGly: 1.045 ± 0.034	0.351TrpHis: 0.351 ± 0.02	0.69TrpIle: 0.69 ± 0.026	0.444TrpLys: 0.444 ± 0.02	1.677TrpLeu: 1.677 ± 0.048	0.41TrpMet: 0.41 ± 0.022	0.379TrpAsn: 0.379 ± 0.02	0.682TrpPro: 0.682 ± 0.028	0.613TrpGln: 0.613 ± 0.025	1.12TrpArg: 1.12 ± 0.039	0.764TrpSer: 0.764 ± 0.027	0.704TrpThr: 0.704 ± 0.025	0.874TrpVal: 0.874 ± 0.027	0.2TrpTrp: 0.2 ± 0.016	0.248TrpTyr: 0.248 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.563TyrAla: 2.563 ± 0.05	0.259TyrCys: 0.259 ± 0.015	1.526TyrAsp: 1.526 ± 0.039	1.497TyrGlu: 1.497 ± 0.037	0.909TyrPhe: 0.909 ± 0.028	2.155TyrGly: 2.155 ± 0.047	0.574TyrHis: 0.574 ± 0.026	1.026TyrIle: 1.026 ± 0.034	0.671TyrLys: 0.671 ± 0.025	2.336TyrLeu: 2.336 ± 0.047	0.521TyrMet: 0.521 ± 0.021	0.546TyrAsn: 0.546 ± 0.025	1.035TyrPro: 1.035 ± 0.031	0.636TyrGln: 0.636 ± 0.025	1.583TyrArg: 1.583 ± 0.042	1.165TyrSer: 1.165 ± 0.044	1.126TyrThr: 1.126 ± 0.035	1.429TyrVal: 1.429 ± 0.037	0.36TyrTrp: 0.36 ± 0.02	0.595TyrTyr: 0.595 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3352 proteins (1034919 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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