Amino acid dipepetide frequency for Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.543AlaAla: 6.543 ± 2.417
3.079AlaCys: 3.079 ± 0.351
4.234AlaAsp: 4.234 ± 1.902
3.079AlaGlu: 3.079 ± 1.145
3.079AlaPhe: 3.079 ± 2.484
3.079AlaGly: 3.079 ± 1.145
2.694AlaHis: 2.694 ± 2.493
3.079AlaIle: 3.079 ± 1.001
3.464AlaLys: 3.464 ± 1.002
11.932AlaLeu: 11.932 ± 2.479
0.77AlaMet: 0.77 ± 0.416
5.774AlaAsn: 5.774 ± 2.467
3.849AlaPro: 3.849 ± 1.537
3.464AlaGln: 3.464 ± 1.506
5.389AlaArg: 5.389 ± 1.659
4.234AlaSer: 4.234 ± 1.048
5.774AlaThr: 5.774 ± 2.611
3.079AlaVal: 3.079 ± 2.289
1.925AlaTrp: 1.925 ± 0.649
2.694AlaTyr: 2.694 ± 1.014
0.0AlaXaa: 0.0 ± 0.0
Cys
2.694CysAla: 2.694 ± 1.356
0.0CysCys: 0.0 ± 0.0
1.925CysAsp: 1.925 ± 1.295
1.155CysGlu: 1.155 ± 0.58
0.385CysPhe: 0.385 ± 0.21
0.77CysGly: 0.77 ± 0.644
0.385CysHis: 0.385 ± 0.21
0.385CysIle: 0.385 ± 0.848
0.77CysLys: 0.77 ± 0.42
1.925CysLeu: 1.925 ± 0.919
0.385CysMet: 0.385 ± 0.936
0.0CysAsn: 0.0 ± 0.0
3.079CysPro: 3.079 ± 0.986
1.54CysGln: 1.54 ± 0.603
1.155CysArg: 1.155 ± 1.276
1.925CysSer: 1.925 ± 0.666
1.925CysThr: 1.925 ± 0.871
0.77CysVal: 0.77 ± 0.42
0.0CysTrp: 0.0 ± 0.0
0.77CysTyr: 0.77 ± 0.644
0.0CysXaa: 0.0 ± 0.0
Asp
3.464AspAla: 3.464 ± 1.071
0.77AspCys: 0.77 ± 0.42
1.54AspAsp: 1.54 ± 0.84
3.079AspGlu: 3.079 ± 0.351
3.849AspPhe: 3.849 ± 1.251
1.54AspGly: 1.54 ± 1.159
1.925AspHis: 1.925 ± 1.159
3.464AspIle: 3.464 ± 0.406
1.925AspLys: 1.925 ± 1.049
5.774AspLeu: 5.774 ± 1.537
0.385AspMet: 0.385 ± 0.21
1.54AspAsn: 1.54 ± 0.84
3.849AspPro: 3.849 ± 1.684
3.079AspGln: 3.079 ± 0.624
2.309AspArg: 2.309 ± 0.553
3.079AspSer: 3.079 ± 1.209
3.464AspThr: 3.464 ± 1.105
3.079AspVal: 3.079 ± 1.679
0.77AspTrp: 0.77 ± 0.763
3.079AspTyr: 3.079 ± 1.056
0.0AspXaa: 0.0 ± 0.0
Glu
6.159GluAla: 6.159 ± 2.117
0.385GluCys: 0.385 ± 0.21
0.77GluAsp: 0.77 ± 0.416
3.079GluGlu: 3.079 ± 1.679
1.155GluPhe: 1.155 ± 0.443
2.309GluGly: 2.309 ± 0.81
2.309GluHis: 2.309 ± 1.259
1.54GluIle: 1.54 ± 0.603
1.925GluLys: 1.925 ± 0.649
6.543GluLeu: 6.543 ± 1.28
0.385GluMet: 0.385 ± 0.21
4.619GluAsn: 4.619 ± 0.903
5.004GluPro: 5.004 ± 1.591
1.54GluGln: 1.54 ± 0.567
4.234GluArg: 4.234 ± 1.23
1.155GluSer: 1.155 ± 0.443
3.464GluThr: 3.464 ± 1.506
1.155GluVal: 1.155 ± 0.63
0.77GluTrp: 0.77 ± 0.42
1.925GluTyr: 1.925 ± 0.818
0.0GluXaa: 0.0 ± 0.0
Phe
2.694PheAla: 2.694 ± 1.654
1.54PheCys: 1.54 ± 0.831
2.694PheAsp: 2.694 ± 1.204
1.54PheGlu: 1.54 ± 0.588
1.54PhePhe: 1.54 ± 0.5
2.694PheGly: 2.694 ± 0.786
1.54PheHis: 1.54 ± 1.129
1.925PheIle: 1.925 ± 1.049
1.54PheLys: 1.54 ± 0.799
3.464PheLeu: 3.464 ± 0.406
1.155PheMet: 1.155 ± 0.63
2.694PheAsn: 2.694 ± 0.89
1.925PhePro: 1.925 ± 0.96
2.309PheGln: 2.309 ± 0.793
2.309PheArg: 2.309 ± 0.441
1.925PheSer: 1.925 ± 1.049
2.309PheThr: 2.309 ± 1.644
0.77PheVal: 0.77 ± 0.42
0.385PheTrp: 0.385 ± 0.21
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
6.159GlyAla: 6.159 ± 1.605
1.54GlyCys: 1.54 ± 0.84
2.309GlyAsp: 2.309 ± 0.974
0.77GlyGlu: 0.77 ± 0.416
1.925GlyPhe: 1.925 ± 0.649
2.309GlyGly: 2.309 ± 0.974
3.464GlyHis: 3.464 ± 0.818
1.54GlyIle: 1.54 ± 1.061
3.464GlyLys: 3.464 ± 1.114
1.54GlyLeu: 1.54 ± 0.809
0.0GlyMet: 0.0 ± 0.0
2.694GlyAsn: 2.694 ± 0.789
3.849GlyPro: 3.849 ± 1.331
1.925GlyGln: 1.925 ± 0.731
1.155GlyArg: 1.155 ± 0.761
3.464GlySer: 3.464 ± 2.722
3.079GlyThr: 3.079 ± 1.176
1.925GlyVal: 1.925 ± 0.995
0.77GlyTrp: 0.77 ± 0.42
1.155GlyTyr: 1.155 ± 0.63
0.0GlyXaa: 0.0 ± 0.0
His
3.079HisAla: 3.079 ± 0.977
0.77HisCys: 0.77 ± 1.111
1.54HisAsp: 1.54 ± 1.466
2.309HisGlu: 2.309 ± 0.528
1.54HisPhe: 1.54 ± 0.588
1.925HisGly: 1.925 ± 0.561
1.54HisHis: 1.54 ± 0.84
2.309HisIle: 2.309 ± 0.974
1.155HisLys: 1.155 ± 0.443
3.464HisLeu: 3.464 ± 1.309
0.77HisMet: 0.77 ± 0.42
0.77HisAsn: 0.77 ± 0.42
1.925HisPro: 1.925 ± 1.295
1.925HisGln: 1.925 ± 0.484
1.925HisArg: 1.925 ± 0.717
3.849HisSer: 3.849 ± 2.286
5.004HisThr: 5.004 ± 1.367
1.54HisVal: 1.54 ± 0.852
0.385HisTrp: 0.385 ± 0.21
2.694HisTyr: 2.694 ± 2.088
0.0HisXaa: 0.0 ± 0.0
Ile
5.004IleAla: 5.004 ± 2.11
1.155IleCys: 1.155 ± 0.874
3.464IleAsp: 3.464 ± 1.233
3.464IleGlu: 3.464 ± 1.071
2.694IlePhe: 2.694 ± 0.786
3.464IleGly: 3.464 ± 0.881
2.309IleHis: 2.309 ± 1.645
2.694IleIle: 2.694 ± 2.707
1.925IleLys: 1.925 ± 0.649
3.464IleLeu: 3.464 ± 1.78
1.54IleMet: 1.54 ± 0.84
3.849IleAsn: 3.849 ± 0.542
2.309IlePro: 2.309 ± 1.259
2.309IleGln: 2.309 ± 0.528
3.079IleArg: 3.079 ± 1.781
3.464IleSer: 3.464 ± 1.017
4.234IleThr: 4.234 ± 0.775
2.309IleVal: 2.309 ± 1.275
0.385IleTrp: 0.385 ± 0.21
0.77IleTyr: 0.77 ± 0.919
0.0IleXaa: 0.0 ± 0.0
Lys
4.619LysAla: 4.619 ± 1.321
1.155LysCys: 1.155 ± 0.58
4.234LysAsp: 4.234 ± 1.642
2.309LysGlu: 2.309 ± 0.914
1.54LysPhe: 1.54 ± 0.5
2.309LysGly: 2.309 ± 0.818
2.309LysHis: 2.309 ± 1.259
2.694LysIle: 2.694 ± 1.014
1.155LysLys: 1.155 ± 0.63
4.234LysLeu: 4.234 ± 1.816
1.155LysMet: 1.155 ± 0.63
2.694LysAsn: 2.694 ± 1.469
5.774LysPro: 5.774 ± 3.403
1.54LysGln: 1.54 ± 0.831
2.309LysArg: 2.309 ± 0.441
3.464LysSer: 3.464 ± 1.14
4.619LysThr: 4.619 ± 1.42
1.155LysVal: 1.155 ± 0.8
0.0LysTrp: 0.0 ± 0.0
1.155LysTyr: 1.155 ± 0.409
0.0LysXaa: 0.0 ± 0.0
Leu
6.159LeuAla: 6.159 ± 1.705
1.54LeuCys: 1.54 ± 0.588
4.619LeuAsp: 4.619 ± 1.057
5.004LeuGlu: 5.004 ± 1.53
3.079LeuPhe: 3.079 ± 1.263
5.774LeuGly: 5.774 ± 1.43
3.079LeuHis: 3.079 ± 0.893
3.464LeuIle: 3.464 ± 1.677
6.928LeuLys: 6.928 ± 2.35
11.162LeuLeu: 11.162 ± 3.183
1.54LeuMet: 1.54 ± 0.831
5.389LeuAsn: 5.389 ± 1.665
7.313LeuPro: 7.313 ± 1.876
3.079LeuGln: 3.079 ± 0.854
4.234LeuArg: 4.234 ± 0.933
5.004LeuSer: 5.004 ± 0.983
8.853LeuThr: 8.853 ± 3.183
3.849LeuVal: 3.849 ± 1.63
0.77LeuTrp: 0.77 ± 0.42
4.234LeuTyr: 4.234 ± 0.806
0.0LeuXaa: 0.0 ± 0.0
Met
2.694MetAla: 2.694 ± 1.469
0.385MetCys: 0.385 ± 0.21
1.54MetAsp: 1.54 ± 0.572
0.385MetGlu: 0.385 ± 0.763
0.385MetPhe: 0.385 ± 0.516
1.155MetGly: 1.155 ± 0.63
0.385MetHis: 0.385 ± 0.848
1.155MetIle: 1.155 ± 0.409
1.155MetLys: 1.155 ± 0.409
1.925MetLeu: 1.925 ± 1.049
0.0MetMet: 0.0 ± 0.0
0.77MetAsn: 0.77 ± 0.416
1.155MetPro: 1.155 ± 1.77
0.385MetGln: 0.385 ± 0.21
0.77MetArg: 0.77 ± 0.42
1.155MetSer: 1.155 ± 0.913
0.0MetThr: 0.0 ± 0.0
0.385MetVal: 0.385 ± 0.21
0.0MetTrp: 0.0 ± 0.0
0.385MetTyr: 0.385 ± 0.21
0.0MetXaa: 0.0 ± 0.0
Asn
4.234AsnAla: 4.234 ± 0.937
1.54AsnCys: 1.54 ± 1.009
1.54AsnAsp: 1.54 ± 0.84
1.155AsnGlu: 1.155 ± 0.409
1.155AsnPhe: 1.155 ± 0.63
1.155AsnGly: 1.155 ± 0.913
1.54AsnHis: 1.54 ± 0.809
1.54AsnIle: 1.54 ± 0.572
3.079AsnLys: 3.079 ± 0.616
5.004AsnLeu: 5.004 ± 1.636
1.54AsnMet: 1.54 ± 0.5
1.155AsnAsn: 1.155 ± 0.409
5.389AsnPro: 5.389 ± 1.567
1.54AsnGln: 1.54 ± 0.5
2.309AsnArg: 2.309 ± 0.914
4.619AsnSer: 4.619 ± 1.556
2.309AsnThr: 2.309 ± 0.825
2.309AsnVal: 2.309 ± 0.825
0.77AsnTrp: 0.77 ± 0.416
2.694AsnTyr: 2.694 ± 0.413
0.0AsnXaa: 0.0 ± 0.0
Pro
5.389ProAla: 5.389 ± 1.647
1.155ProCys: 1.155 ± 1.043
4.619ProAsp: 4.619 ± 1.262
5.389ProGlu: 5.389 ± 1.529
3.464ProPhe: 3.464 ± 1.878
3.464ProGly: 3.464 ± 0.406
2.694ProHis: 2.694 ± 2.197
4.234ProIle: 4.234 ± 2.646
6.543ProLys: 6.543 ± 1.766
5.774ProLeu: 5.774 ± 2.108
0.0ProMet: 0.0 ± 0.0
1.925ProAsn: 1.925 ± 0.719
7.698ProPro: 7.698 ± 5.992
0.0ProGln: 0.0 ± 0.0
3.464ProArg: 3.464 ± 2.238
5.004ProSer: 5.004 ± 2.08
10.008ProThr: 10.008 ± 3.077
3.849ProVal: 3.849 ± 0.726
1.54ProTrp: 1.54 ± 0.588
1.155ProTyr: 1.155 ± 1.276
0.0ProXaa: 0.0 ± 0.0
Gln
2.694GlnAla: 2.694 ± 0.413
0.385GlnCys: 0.385 ± 0.21
3.079GlnAsp: 3.079 ± 1.679
1.155GlnGlu: 1.155 ± 0.63
0.385GlnPhe: 0.385 ± 0.21
1.155GlnGly: 1.155 ± 0.63
1.54GlnHis: 1.54 ± 0.602
3.079GlnIle: 3.079 ± 0.984
1.155GlnLys: 1.155 ± 0.63
4.619GlnLeu: 4.619 ± 1.464
0.77GlnMet: 0.77 ± 0.42
1.155GlnAsn: 1.155 ± 0.58
2.309GlnPro: 2.309 ± 1.455
3.464GlnGln: 3.464 ± 1.291
1.155GlnArg: 1.155 ± 0.58
3.464GlnSer: 3.464 ± 1.057
4.619GlnThr: 4.619 ± 1.172
1.925GlnVal: 1.925 ± 0.731
1.925GlnTrp: 1.925 ± 0.666
1.155GlnTyr: 1.155 ± 0.443
0.0GlnXaa: 0.0 ± 0.0
Arg
4.619ArgAla: 4.619 ± 2.351
2.309ArgCys: 2.309 ± 2.498
3.849ArgAsp: 3.849 ± 2.281
2.694ArgGlu: 2.694 ± 0.95
1.155ArgPhe: 1.155 ± 0.733
2.309ArgGly: 2.309 ± 1.159
2.309ArgHis: 2.309 ± 1.665
6.159ArgIle: 6.159 ± 1.548
1.54ArgLys: 1.54 ± 0.5
5.004ArgLeu: 5.004 ± 3.573
0.385ArgMet: 0.385 ± 0.627
2.309ArgAsn: 2.309 ± 0.818
3.464ArgPro: 3.464 ± 2.694
3.464ArgGln: 3.464 ± 1.238
2.309ArgArg: 2.309 ± 1.159
2.694ArgSer: 2.694 ± 2.372
3.849ArgThr: 3.849 ± 1.255
1.925ArgVal: 1.925 ± 0.649
0.385ArgTrp: 0.385 ± 0.21
2.694ArgTyr: 2.694 ± 0.95
0.0ArgXaa: 0.0 ± 0.0
Ser
3.464SerAla: 3.464 ± 1.716
0.77SerCys: 0.77 ± 0.644
2.309SerAsp: 2.309 ± 1.259
3.464SerGlu: 3.464 ± 0.623
2.309SerPhe: 2.309 ± 0.441
3.849SerGly: 3.849 ± 1.125
2.694SerHis: 2.694 ± 0.786
3.464SerIle: 3.464 ± 0.406
5.004SerLys: 5.004 ± 1.744
6.543SerLeu: 6.543 ± 1.54
0.385SerMet: 0.385 ± 0.447
2.309SerAsn: 2.309 ± 1.144
4.619SerPro: 4.619 ± 1.182
2.694SerGln: 2.694 ± 1.577
5.389SerArg: 5.389 ± 2.605
3.849SerSer: 3.849 ± 1.684
5.004SerThr: 5.004 ± 1.268
2.694SerVal: 2.694 ± 1.918
0.77SerTrp: 0.77 ± 0.42
1.155SerTyr: 1.155 ± 0.58
0.0SerXaa: 0.0 ± 0.0
Thr
3.849ThrAla: 3.849 ± 0.828
1.155ThrCys: 1.155 ± 0.58
4.619ThrAsp: 4.619 ± 1.515
4.619ThrGlu: 4.619 ± 0.921
4.619ThrPhe: 4.619 ± 1.289
2.694ThrGly: 2.694 ± 1.469
5.389ThrHis: 5.389 ± 0.776
5.774ThrIle: 5.774 ± 1.538
2.694ThrLys: 2.694 ± 0.883
4.619ThrLeu: 4.619 ± 1.828
2.694ThrMet: 2.694 ± 0.78
3.464ThrAsn: 3.464 ± 1.26
8.083ThrPro: 8.083 ± 1.493
3.079ThrGln: 3.079 ± 1.134
4.619ThrArg: 4.619 ± 1.462
5.004ThrSer: 5.004 ± 1.709
7.698ThrThr: 7.698 ± 2.162
3.849ThrVal: 3.849 ± 1.672
0.77ThrTrp: 0.77 ± 0.845
2.309ThrTyr: 2.309 ± 0.914
0.0ThrXaa: 0.0 ± 0.0
Val
2.694ValAla: 2.694 ± 0.745
0.77ValCys: 0.77 ± 1.275
1.155ValAsp: 1.155 ± 0.443
3.849ValGlu: 3.849 ± 1.255
0.385ValPhe: 0.385 ± 0.516
1.925ValGly: 1.925 ± 0.871
0.385ValHis: 0.385 ± 0.459
2.309ValIle: 2.309 ± 1.144
3.079ValLys: 3.079 ± 0.687
3.849ValLeu: 3.849 ± 0.542
1.155ValMet: 1.155 ± 0.621
1.925ValAsn: 1.925 ± 1.049
3.464ValPro: 3.464 ± 1.14
2.309ValGln: 2.309 ± 1.259
5.004ValArg: 5.004 ± 1.89
2.309ValSer: 2.309 ± 1.46
3.849ValThr: 3.849 ± 0.782
5.004ValVal: 5.004 ± 1.423
0.385ValTrp: 0.385 ± 0.516
0.77ValTyr: 0.77 ± 0.42
0.0ValXaa: 0.0 ± 0.0
Trp
0.77TrpAla: 0.77 ± 0.845
0.0TrpCys: 0.0 ± 0.0
0.77TrpAsp: 0.77 ± 0.42
1.54TrpGlu: 1.54 ± 0.84
0.77TrpPhe: 0.77 ± 0.644
0.0TrpGly: 0.0 ± 0.0
0.385TrpHis: 0.385 ± 0.21
0.0TrpIle: 0.0 ± 0.0
0.77TrpLys: 0.77 ± 0.42
1.54TrpLeu: 1.54 ± 0.84
0.385TrpMet: 0.385 ± 0.516
0.385TrpAsn: 0.385 ± 0.516
0.77TrpPro: 0.77 ± 0.42
0.385TrpGln: 0.385 ± 0.21
1.155TrpArg: 1.155 ± 0.58
0.0TrpSer: 0.0 ± 0.0
0.385TrpThr: 0.385 ± 0.21
2.694TrpVal: 2.694 ± 0.765
0.0TrpTrp: 0.0 ± 0.0
0.385TrpTyr: 0.385 ± 0.21
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.234TyrAla: 4.234 ± 1.259
1.54TyrCys: 1.54 ± 0.602
1.155TyrAsp: 1.155 ± 0.63
0.385TyrGlu: 0.385 ± 0.21
1.54TyrPhe: 1.54 ± 0.588
1.155TyrGly: 1.155 ± 0.63
1.54TyrHis: 1.54 ± 0.84
3.079TyrIle: 3.079 ± 1.26
1.155TyrLys: 1.155 ± 0.58
2.694TyrLeu: 2.694 ± 1.889
0.385TyrMet: 0.385 ± 0.21
1.155TyrAsn: 1.155 ± 0.8
1.54TyrPro: 1.54 ± 0.572
1.155TyrGln: 1.155 ± 0.63
1.155TyrArg: 1.155 ± 0.8
3.079TyrSer: 3.079 ± 1.204
1.54TyrThr: 1.54 ± 0.572
2.309TyrVal: 2.309 ± 0.553
0.385TyrTrp: 0.385 ± 0.21
0.77TyrTyr: 0.77 ± 0.416
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski