Amino acid dipepetide frequency for Eubacterium aggregans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.433AlaAla: 8.433 ± 0.148	1.255AlaCys: 1.255 ± 0.04	4.837AlaAsp: 4.837 ± 0.089	5.501AlaGlu: 5.501 ± 0.088	3.698AlaPhe: 3.698 ± 0.066	6.727AlaGly: 6.727 ± 0.1	1.497AlaHis: 1.497 ± 0.047	6.749AlaIle: 6.749 ± 0.105	4.781AlaLys: 4.781 ± 0.082	9.305AlaLeu: 9.305 ± 0.129	2.979AlaMet: 2.979 ± 0.06	2.568AlaAsn: 2.568 ± 0.062	2.752AlaPro: 2.752 ± 0.063	3.149AlaGln: 3.149 ± 0.07	3.527AlaArg: 3.527 ± 0.081	4.085AlaSer: 4.085 ± 0.065	4.295AlaThr: 4.295 ± 0.072	6.737AlaVal: 6.737 ± 0.097	0.689AlaTrp: 0.689 ± 0.03	2.784AlaTyr: 2.784 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.108CysAla: 1.108 ± 0.034	0.302CysCys: 0.302 ± 0.021	0.865CysAsp: 0.865 ± 0.037	0.827CysGlu: 0.827 ± 0.031	0.615CysPhe: 0.615 ± 0.025	1.598CysGly: 1.598 ± 0.052	0.411CysHis: 0.411 ± 0.025	1.039CysIle: 1.039 ± 0.03	0.607CysLys: 0.607 ± 0.029	1.251CysLeu: 1.251 ± 0.038	0.357CysMet: 0.357 ± 0.02	0.456CysAsn: 0.456 ± 0.024	0.814CysPro: 0.814 ± 0.03	0.591CysGln: 0.591 ± 0.025	0.726CysArg: 0.726 ± 0.028	0.746CysSer: 0.746 ± 0.034	0.813CysThr: 0.813 ± 0.029	1.042CysVal: 1.042 ± 0.036	0.094CysTrp: 0.094 ± 0.01	0.516CysTyr: 0.516 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	5.446AspAla: 5.446 ± 0.101	0.916AspCys: 0.916 ± 0.033	3.108AspAsp: 3.108 ± 0.091	3.959AspGlu: 3.959 ± 0.071	2.807AspPhe: 2.807 ± 0.072	4.839AspGly: 4.839 ± 0.078	1.099AspHis: 1.099 ± 0.039	4.649AspIle: 4.649 ± 0.082	2.826AspLys: 2.826 ± 0.057	5.398AspLeu: 5.398 ± 0.084	1.702AspMet: 1.702 ± 0.05	2.027AspAsn: 2.027 ± 0.052	2.255AspPro: 2.255 ± 0.052	1.743AspGln: 1.743 ± 0.046	2.374AspArg: 2.374 ± 0.061	2.716AspSer: 2.716 ± 0.066	3.475AspThr: 3.475 ± 0.059	4.08AspVal: 4.08 ± 0.063	0.575AspTrp: 0.575 ± 0.029	2.825AspTyr: 2.825 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	6.613GluAla: 6.613 ± 0.094	0.727GluCys: 0.727 ± 0.032	4.203GluAsp: 4.203 ± 0.071	5.391GluGlu: 5.391 ± 0.111	1.943GluPhe: 1.943 ± 0.047	4.833GluGly: 4.833 ± 0.079	1.091GluHis: 1.091 ± 0.034	5.191GluIle: 5.191 ± 0.092	5.13GluLys: 5.13 ± 0.087	5.38GluLeu: 5.38 ± 0.095	2.561GluMet: 2.561 ± 0.057	3.112GluAsn: 3.112 ± 0.059	1.877GluPro: 1.877 ± 0.049	2.138GluGln: 2.138 ± 0.057	3.102GluArg: 3.102 ± 0.073	3.403GluSer: 3.403 ± 0.071	3.523GluThr: 3.523 ± 0.065	4.323GluVal: 4.323 ± 0.088	0.508GluTrp: 0.508 ± 0.022	2.166GluTyr: 2.166 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.826PheAla: 2.826 ± 0.058	0.643PheCys: 0.643 ± 0.027	2.461PheAsp: 2.461 ± 0.055	2.506PheGlu: 2.506 ± 0.06	1.782PhePhe: 1.782 ± 0.052	3.209PheGly: 3.209 ± 0.071	0.681PheHis: 0.681 ± 0.03	2.994PheIle: 2.994 ± 0.064	2.256PheLys: 2.256 ± 0.053	3.491PheLeu: 3.491 ± 0.081	1.122PheMet: 1.122 ± 0.039	1.661PheAsn: 1.661 ± 0.049	1.42PhePro: 1.42 ± 0.039	1.06PheGln: 1.06 ± 0.038	1.315PheArg: 1.315 ± 0.039	2.655PheSer: 2.655 ± 0.056	2.423PheThr: 2.423 ± 0.052	2.681PheVal: 2.681 ± 0.059	0.379PheTrp: 0.379 ± 0.02	1.468PheTyr: 1.468 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	6.372GlyAla: 6.372 ± 0.093	1.401GlyCys: 1.401 ± 0.042	4.484GlyAsp: 4.484 ± 0.08	4.958GlyGlu: 4.958 ± 0.094	3.269GlyPhe: 3.269 ± 0.07	6.222GlyGly: 6.222 ± 0.108	1.498GlyHis: 1.498 ± 0.05	6.677GlyIle: 6.677 ± 0.087	4.689GlyLys: 4.689 ± 0.078	7.139GlyLeu: 7.139 ± 0.107	2.715GlyMet: 2.715 ± 0.056	2.906GlyAsn: 2.906 ± 0.076	1.95GlyPro: 1.95 ± 0.057	2.665GlyGln: 2.665 ± 0.054	3.418GlyArg: 3.418 ± 0.074	4.478GlySer: 4.478 ± 0.079	4.835GlyThr: 4.835 ± 0.088	5.989GlyVal: 5.989 ± 0.087	0.746GlyTrp: 0.746 ± 0.031	3.091GlyTyr: 3.091 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.182HisAla: 1.182 ± 0.035	0.412HisCys: 0.412 ± 0.023	0.889HisAsp: 0.889 ± 0.033	0.848HisGlu: 0.848 ± 0.034	0.892HisPhe: 0.892 ± 0.032	1.404HisGly: 1.404 ± 0.04	0.6HisHis: 0.6 ± 0.035	1.301HisIle: 1.301 ± 0.044	0.782HisLys: 0.782 ± 0.034	1.934HisLeu: 1.934 ± 0.047	0.45HisMet: 0.45 ± 0.024	0.668HisAsn: 0.668 ± 0.028	1.082HisPro: 1.082 ± 0.037	0.768HisGln: 0.768 ± 0.03	0.988HisArg: 0.988 ± 0.038	1.043HisSer: 1.043 ± 0.037	1.043HisThr: 1.043 ± 0.031	1.05HisVal: 1.05 ± 0.036	0.188HisTrp: 0.188 ± 0.016	0.868HisTyr: 0.868 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.524IleAla: 6.524 ± 0.098	1.097IleCys: 1.097 ± 0.038	4.375IleAsp: 4.375 ± 0.077	4.56IleGlu: 4.56 ± 0.081	2.869IlePhe: 2.869 ± 0.064	5.694IleGly: 5.694 ± 0.092	1.499IleHis: 1.499 ± 0.041	5.625IleIle: 5.625 ± 0.095	3.807IleLys: 3.807 ± 0.067	7.081IleLeu: 7.081 ± 0.108	1.903IleMet: 1.903 ± 0.046	2.954IleAsn: 2.954 ± 0.057	3.719IlePro: 3.719 ± 0.064	2.609IleGln: 2.609 ± 0.066	3.384IleArg: 3.384 ± 0.07	4.272IleSer: 4.272 ± 0.079	4.763IleThr: 4.763 ± 0.079	4.899IleVal: 4.899 ± 0.091	0.502IleTrp: 0.502 ± 0.026	2.254IleTyr: 2.254 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.394LysAla: 5.394 ± 0.093	0.598LysCys: 0.598 ± 0.027	3.419LysAsp: 3.419 ± 0.066	4.587LysGlu: 4.587 ± 0.086	1.356LysPhe: 1.356 ± 0.043	4.201LysGly: 4.201 ± 0.076	0.981LysHis: 0.981 ± 0.032	4.109LysIle: 4.109 ± 0.075	4.759LysLys: 4.759 ± 0.094	4.199LysLeu: 4.199 ± 0.078	1.977LysMet: 1.977 ± 0.053	2.809LysAsn: 2.809 ± 0.058	2.011LysPro: 2.011 ± 0.047	1.836LysGln: 1.836 ± 0.05	2.857LysArg: 2.857 ± 0.062	3.033LysSer: 3.033 ± 0.063	3.503LysThr: 3.503 ± 0.071	3.83LysVal: 3.83 ± 0.07	0.506LysTrp: 0.506 ± 0.024	1.937LysTyr: 1.937 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.854LeuAla: 7.854 ± 0.11	1.556LeuCys: 1.556 ± 0.051	5.416LeuAsp: 5.416 ± 0.084	6.111LeuGlu: 6.111 ± 0.088	3.646LeuPhe: 3.646 ± 0.079	7.389LeuGly: 7.389 ± 0.11	1.44LeuHis: 1.44 ± 0.042	5.885LeuIle: 5.885 ± 0.093	6.026LeuLys: 6.026 ± 0.089	8.292LeuLeu: 8.292 ± 0.127	2.807LeuMet: 2.807 ± 0.065	3.517LeuAsn: 3.517 ± 0.062	3.903LeuPro: 3.903 ± 0.068	2.291LeuGln: 2.291 ± 0.052	3.924LeuArg: 3.924 ± 0.072	6.545LeuSer: 6.545 ± 0.097	5.442LeuThr: 5.442 ± 0.081	6.025LeuVal: 6.025 ± 0.086	0.816LeuTrp: 0.816 ± 0.034	2.978LeuTyr: 2.978 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	3.448MetAla: 3.448 ± 0.068	0.317MetCys: 0.317 ± 0.02	2.353MetAsp: 2.353 ± 0.052	2.398MetGlu: 2.398 ± 0.049	0.749MetPhe: 0.749 ± 0.027	2.632MetGly: 2.632 ± 0.059	0.375MetHis: 0.375 ± 0.022	1.929MetIle: 1.929 ± 0.056	1.972MetLys: 1.972 ± 0.047	2.415MetLeu: 2.415 ± 0.053	0.958MetMet: 0.958 ± 0.034	1.378MetAsn: 1.378 ± 0.041	1.185MetPro: 1.185 ± 0.039	0.788MetGln: 0.788 ± 0.03	1.149MetArg: 1.149 ± 0.038	1.58MetSer: 1.58 ± 0.041	1.927MetThr: 1.927 ± 0.049	2.401MetVal: 2.401 ± 0.059	0.164MetTrp: 0.164 ± 0.013	0.695MetTyr: 0.695 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.282AsnAla: 3.282 ± 0.057	0.568AsnCys: 0.568 ± 0.027	1.876AsnAsp: 1.876 ± 0.047	2.077AsnGlu: 2.077 ± 0.059	1.289AsnPhe: 1.289 ± 0.035	3.048AsnGly: 3.048 ± 0.071	0.832AsnHis: 0.832 ± 0.027	3.119AsnIle: 3.119 ± 0.054	1.97AsnLys: 1.97 ± 0.057	3.58AsnLeu: 3.58 ± 0.062	1.043AsnMet: 1.043 ± 0.038	1.531AsnAsn: 1.531 ± 0.053	2.254AsnPro: 2.254 ± 0.051	1.47AsnGln: 1.47 ± 0.042	1.912AsnArg: 1.912 ± 0.05	1.821AsnSer: 1.821 ± 0.055	2.408AsnThr: 2.408 ± 0.053	2.444AsnVal: 2.444 ± 0.052	0.346AsnTrp: 0.346 ± 0.023	1.395AsnTyr: 1.395 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.811ProAla: 2.811 ± 0.057	0.502ProCys: 0.502 ± 0.026	2.384ProAsp: 2.384 ± 0.053	3.642ProGlu: 3.642 ± 0.065	1.641ProPhe: 1.641 ± 0.044	3.296ProGly: 3.296 ± 0.063	0.699ProHis: 0.699 ± 0.029	2.67ProIle: 2.67 ± 0.06	1.947ProLys: 1.947 ± 0.049	3.379ProLeu: 3.379 ± 0.072	1.143ProMet: 1.143 ± 0.036	1.269ProAsn: 1.269 ± 0.04	1.048ProPro: 1.048 ± 0.042	1.379ProGln: 1.379 ± 0.043	1.399ProArg: 1.399 ± 0.046	1.932ProSer: 1.932 ± 0.05	2.103ProThr: 2.103 ± 0.054	3.275ProVal: 3.275 ± 0.066	0.392ProTrp: 0.392 ± 0.026	1.374ProTyr: 1.374 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.02GlnAla: 3.02 ± 0.058	0.506GlnCys: 0.506 ± 0.024	1.747GlnAsp: 1.747 ± 0.045	2.325GlnGlu: 2.325 ± 0.057	1.113GlnPhe: 1.113 ± 0.036	2.675GlnGly: 2.675 ± 0.058	0.516GlnHis: 0.516 ± 0.024	2.394GlnIle: 2.394 ± 0.054	2.157GlnLys: 2.157 ± 0.049	2.854GlnLeu: 2.854 ± 0.061	1.187GlnMet: 1.187 ± 0.035	1.49GlnAsn: 1.49 ± 0.036	0.951GlnPro: 0.951 ± 0.034	1.108GlnGln: 1.108 ± 0.036	1.544GlnArg: 1.544 ± 0.039	1.868GlnSer: 1.868 ± 0.049	1.813GlnThr: 1.813 ± 0.05	2.387GlnVal: 2.387 ± 0.049	0.382GlnTrp: 0.382 ± 0.021	1.199GlnTyr: 1.199 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.046ArgAla: 3.046 ± 0.063	0.733ArgCys: 0.733 ± 0.033	2.444ArgAsp: 2.444 ± 0.054	3.243ArgGlu: 3.243 ± 0.059	1.868ArgPhe: 1.868 ± 0.046	2.952ArgGly: 2.952 ± 0.059	0.915ArgHis: 0.915 ± 0.034	3.526ArgIle: 3.526 ± 0.06	2.654ArgLys: 2.654 ± 0.058	4.109ArgLeu: 4.109 ± 0.084	1.544ArgMet: 1.544 ± 0.042	1.586ArgAsn: 1.586 ± 0.045	1.494ArgPro: 1.494 ± 0.042	1.815ArgGln: 1.815 ± 0.05	2.43ArgArg: 2.43 ± 0.061	2.139ArgSer: 2.139 ± 0.052	2.136ArgThr: 2.136 ± 0.057	2.967ArgVal: 2.967 ± 0.068	0.366ArgTrp: 0.366 ± 0.019	1.787ArgTyr: 1.787 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.33SerAla: 4.33 ± 0.092	0.727SerCys: 0.727 ± 0.029	3.206SerAsp: 3.206 ± 0.073	3.361SerGlu: 3.361 ± 0.064	2.296SerPhe: 2.296 ± 0.049	5.063SerGly: 5.063 ± 0.085	1.139SerHis: 1.139 ± 0.041	4.006SerIle: 4.006 ± 0.08	2.766SerLys: 2.766 ± 0.06	4.96SerLeu: 4.96 ± 0.078	1.626SerMet: 1.626 ± 0.047	1.899SerAsn: 1.899 ± 0.055	2.088SerPro: 2.088 ± 0.052	2.006SerGln: 2.006 ± 0.045	2.435SerArg: 2.435 ± 0.064	2.938SerSer: 2.938 ± 0.072	3.302SerThr: 3.302 ± 0.078	3.898SerVal: 3.898 ± 0.069	0.504SerTrp: 0.504 ± 0.026	1.871SerTyr: 1.871 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.149ThrAla: 5.149 ± 0.088	0.738ThrCys: 0.738 ± 0.028	3.194ThrAsp: 3.194 ± 0.064	3.394ThrGlu: 3.394 ± 0.063	2.31ThrPhe: 2.31 ± 0.055	5.154ThrGly: 5.154 ± 0.086	1.092ThrHis: 1.092 ± 0.036	4.556ThrIle: 4.556 ± 0.08	2.696ThrLys: 2.696 ± 0.059	6.125ThrLeu: 6.125 ± 0.086	1.522ThrMet: 1.522 ± 0.041	1.949ThrAsn: 1.949 ± 0.048	2.909ThrPro: 2.909 ± 0.062	2.088ThrGln: 2.088 ± 0.052	2.251ThrArg: 2.251 ± 0.054	2.676ThrSer: 2.676 ± 0.06	3.654ThrThr: 3.654 ± 0.083	4.43ThrVal: 4.43 ± 0.079	0.509ThrTrp: 0.509 ± 0.027	1.987ThrTyr: 1.987 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	6.112ValAla: 6.112 ± 0.094	1.13ValCys: 1.13 ± 0.041	4.674ValAsp: 4.674 ± 0.074	4.771ValGlu: 4.771 ± 0.083	2.931ValPhe: 2.931 ± 0.061	5.104ValGly: 5.104 ± 0.085	1.081ValHis: 1.081 ± 0.032	5.091ValIle: 5.091 ± 0.087	3.85ValLys: 3.85 ± 0.072	6.964ValLeu: 6.964 ± 0.112	2.138ValMet: 2.138 ± 0.048	2.563ValAsn: 2.563 ± 0.056	2.737ValPro: 2.737 ± 0.064	2.015ValGln: 2.015 ± 0.052	2.798ValArg: 2.798 ± 0.053	4.077ValSer: 4.077 ± 0.071	4.137ValThr: 4.137 ± 0.075	5.613ValVal: 5.613 ± 0.094	0.494ValTrp: 0.494 ± 0.021	2.391ValTyr: 2.391 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.642TrpAla: 0.642 ± 0.028	0.119TrpCys: 0.119 ± 0.012	0.526TrpAsp: 0.526 ± 0.025	0.621TrpGlu: 0.621 ± 0.031	0.372TrpPhe: 0.372 ± 0.025	0.687TrpGly: 0.687 ± 0.03	0.181TrpHis: 0.181 ± 0.015	0.577TrpIle: 0.577 ± 0.024	0.439TrpLys: 0.439 ± 0.02	0.789TrpLeu: 0.789 ± 0.032	0.303TrpMet: 0.303 ± 0.02	0.358TrpAsn: 0.358 ± 0.022	0.298TrpPro: 0.298 ± 0.016	0.418TrpGln: 0.418 ± 0.022	0.394TrpArg: 0.394 ± 0.02	0.433TrpSer: 0.433 ± 0.025	0.411TrpThr: 0.411 ± 0.024	0.618TrpVal: 0.618 ± 0.026	0.11TrpTrp: 0.11 ± 0.012	0.298TrpTyr: 0.298 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.759TyrAla: 2.759 ± 0.06	0.529TyrCys: 0.529 ± 0.025	2.353TyrAsp: 2.353 ± 0.05	2.134TyrGlu: 2.134 ± 0.053	1.587TyrPhe: 1.587 ± 0.044	2.778TyrGly: 2.778 ± 0.055	0.766TyrHis: 0.766 ± 0.03	2.306TyrIle: 2.306 ± 0.048	1.788TyrLys: 1.788 ± 0.053	3.216TyrLeu: 3.216 ± 0.067	0.775TyrMet: 0.775 ± 0.032	1.565TyrAsn: 1.565 ± 0.045	1.539TyrPro: 1.539 ± 0.044	1.299TyrGln: 1.299 ± 0.04	1.827TyrArg: 1.827 ± 0.046	1.98TyrSer: 1.98 ± 0.056	2.378TyrThr: 2.378 ± 0.058	1.979TyrVal: 1.979 ± 0.045	0.323TyrTrp: 0.323 ± 0.02	1.457TyrTyr: 1.457 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2753 proteins (855004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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