Amino acid dipepetide frequency for Sinobacterium caligoides

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.84AlaAla: 9.84 ± 0.134
1.137AlaCys: 1.137 ± 0.033
5.585AlaAsp: 5.585 ± 0.11
6.605AlaGlu: 6.605 ± 0.08
3.275AlaPhe: 3.275 ± 0.056
6.97AlaGly: 6.97 ± 0.111
1.655AlaHis: 1.655 ± 0.04
6.185AlaIle: 6.185 ± 0.076
4.576AlaLys: 4.576 ± 0.09
10.202AlaLeu: 10.202 ± 0.111
2.662AlaMet: 2.662 ± 0.054
3.417AlaAsn: 3.417 ± 0.064
3.144AlaPro: 3.144 ± 0.063
3.674AlaGln: 3.674 ± 0.063
4.072AlaArg: 4.072 ± 0.064
6.113AlaSer: 6.113 ± 0.081
4.82AlaThr: 4.82 ± 0.078
6.943AlaVal: 6.943 ± 0.098
1.021AlaTrp: 1.021 ± 0.027
2.502AlaTyr: 2.502 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.027CysAla: 1.027 ± 0.029
0.219CysCys: 0.219 ± 0.015
0.718CysAsp: 0.718 ± 0.026
0.643CysGlu: 0.643 ± 0.027
0.539CysPhe: 0.539 ± 0.022
0.989CysGly: 0.989 ± 0.031
0.351CysHis: 0.351 ± 0.019
0.622CysIle: 0.622 ± 0.024
0.435CysLys: 0.435 ± 0.02
1.228CysLeu: 1.228 ± 0.033
0.242CysMet: 0.242 ± 0.013
0.392CysAsn: 0.392 ± 0.017
0.467CysPro: 0.467 ± 0.021
0.528CysGln: 0.528 ± 0.019
0.655CysArg: 0.655 ± 0.023
0.886CysSer: 0.886 ± 0.025
0.512CysThr: 0.512 ± 0.019
0.72CysVal: 0.72 ± 0.026
0.197CysTrp: 0.197 ± 0.013
0.443CysTyr: 0.443 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.789AspAla: 4.789 ± 0.091
0.692AspCys: 0.692 ± 0.023
3.907AspAsp: 3.907 ± 0.079
4.066AspGlu: 4.066 ± 0.068
2.479AspPhe: 2.479 ± 0.059
4.718AspGly: 4.718 ± 0.15
1.279AspHis: 1.279 ± 0.037
4.059AspIle: 4.059 ± 0.064
2.737AspLys: 2.737 ± 0.051
4.941AspLeu: 4.941 ± 0.08
1.278AspMet: 1.278 ± 0.034
2.715AspAsn: 2.715 ± 0.066
2.108AspPro: 2.108 ± 0.087
2.185AspGln: 2.185 ± 0.048
2.693AspArg: 2.693 ± 0.047
4.027AspSer: 4.027 ± 0.101
2.81AspThr: 2.81 ± 0.091
3.898AspVal: 3.898 ± 0.078
0.802AspTrp: 0.802 ± 0.026
2.33AspTyr: 2.33 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.988GluAla: 5.988 ± 0.077
0.562GluCys: 0.562 ± 0.024
2.891GluAsp: 2.891 ± 0.079
3.632GluGlu: 3.632 ± 0.065
2.09GluPhe: 2.09 ± 0.045
4.201GluGly: 4.201 ± 0.074
1.514GluHis: 1.514 ± 0.043
3.286GluIle: 3.286 ± 0.062
2.937GluLys: 2.937 ± 0.056
6.971GluLeu: 6.971 ± 0.101
1.476GluMet: 1.476 ± 0.038
2.163GluAsn: 2.163 ± 0.043
1.971GluPro: 1.971 ± 0.044
4.211GluGln: 4.211 ± 0.084
3.64GluArg: 3.64 ± 0.059
3.589GluSer: 3.589 ± 0.053
2.812GluThr: 2.812 ± 0.051
4.426GluVal: 4.426 ± 0.07
0.684GluTrp: 0.684 ± 0.021
1.671GluTyr: 1.671 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.389PheAla: 3.389 ± 0.057
0.541PheCys: 0.541 ± 0.023
2.822PheAsp: 2.822 ± 0.06
2.162PheGlu: 2.162 ± 0.044
1.672PhePhe: 1.672 ± 0.044
2.904PheGly: 2.904 ± 0.06
0.768PheHis: 0.768 ± 0.024
2.532PheIle: 2.532 ± 0.054
1.69PheLys: 1.69 ± 0.042
3.162PheLeu: 3.162 ± 0.06
0.883PheMet: 0.883 ± 0.029
1.887PheAsn: 1.887 ± 0.039
1.229PhePro: 1.229 ± 0.033
1.119PheGln: 1.119 ± 0.031
1.457PheArg: 1.457 ± 0.037
3.389PheSer: 3.389 ± 0.07
2.244PheThr: 2.244 ± 0.056
2.581PheVal: 2.581 ± 0.052
0.466PheTrp: 0.466 ± 0.022
1.351PheTyr: 1.351 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
6.006GlyAla: 6.006 ± 0.094
1.077GlyCys: 1.077 ± 0.03
4.382GlyAsp: 4.382 ± 0.089
4.769GlyGlu: 4.769 ± 0.068
3.145GlyPhe: 3.145 ± 0.054
5.724GlyGly: 5.724 ± 0.115
1.563GlyHis: 1.563 ± 0.04
4.339GlyIle: 4.339 ± 0.074
3.391GlyLys: 3.391 ± 0.063
7.319GlyLeu: 7.319 ± 0.092
1.989GlyMet: 1.989 ± 0.046
2.582GlyAsn: 2.582 ± 0.063
1.79GlyPro: 1.79 ± 0.044
2.851GlyGln: 2.851 ± 0.06
3.725GlyArg: 3.725 ± 0.069
4.821GlySer: 4.821 ± 0.102
3.226GlyThr: 3.226 ± 0.066
5.643GlyVal: 5.643 ± 0.092
1.007GlyTrp: 1.007 ± 0.029
2.634GlyTyr: 2.634 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.67HisAla: 1.67 ± 0.041
0.41HisCys: 0.41 ± 0.022
1.238HisAsp: 1.238 ± 0.043
1.038HisGlu: 1.038 ± 0.031
0.947HisPhe: 0.947 ± 0.027
1.682HisGly: 1.682 ± 0.045
0.709HisHis: 0.709 ± 0.028
1.285HisIle: 1.285 ± 0.034
0.89HisLys: 0.89 ± 0.026
2.093HisLeu: 2.093 ± 0.046
0.479HisMet: 0.479 ± 0.02
0.868HisAsn: 0.868 ± 0.026
1.108HisPro: 1.108 ± 0.032
1.076HisGln: 1.076 ± 0.033
1.327HisArg: 1.327 ± 0.035
1.515HisSer: 1.515 ± 0.041
1.005HisThr: 1.005 ± 0.025
1.17HisVal: 1.17 ± 0.032
0.394HisTrp: 0.394 ± 0.02
1.045HisTyr: 1.045 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.631IleAla: 6.631 ± 0.086
0.71IleCys: 0.71 ± 0.022
4.707IleAsp: 4.707 ± 0.077
4.429IleGlu: 4.429 ± 0.061
1.998IlePhe: 1.998 ± 0.042
4.405IleGly: 4.405 ± 0.073
1.168IleHis: 1.168 ± 0.028
3.624IleIle: 3.624 ± 0.081
2.893IleLys: 2.893 ± 0.057
4.593IleLeu: 4.593 ± 0.071
1.175IleMet: 1.175 ± 0.035
2.97IleAsn: 2.97 ± 0.064
2.314IlePro: 2.314 ± 0.049
1.729IleGln: 1.729 ± 0.037
2.561IleArg: 2.561 ± 0.049
4.37IleSer: 4.37 ± 0.071
3.738IleThr: 3.738 ± 0.086
4.176IleVal: 4.176 ± 0.067
0.493IleTrp: 0.493 ± 0.024
1.739IleTyr: 1.739 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.125LysAla: 4.125 ± 0.076
0.308LysCys: 0.308 ± 0.02
2.265LysAsp: 2.265 ± 0.045
2.542LysGlu: 2.542 ± 0.062
1.23LysPhe: 1.23 ± 0.039
2.895LysGly: 2.895 ± 0.059
1.048LysHis: 1.048 ± 0.033
2.629LysIle: 2.629 ± 0.056
2.502LysLys: 2.502 ± 0.065
4.771LysLeu: 4.771 ± 0.082
1.199LysMet: 1.199 ± 0.034
1.834LysAsn: 1.834 ± 0.041
2.027LysPro: 2.027 ± 0.048
2.479LysGln: 2.479 ± 0.052
2.526LysArg: 2.526 ± 0.056
2.821LysSer: 2.821 ± 0.058
2.433LysThr: 2.433 ± 0.042
3.232LysVal: 3.232 ± 0.057
0.403LysTrp: 0.403 ± 0.018
1.107LysTyr: 1.107 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
10.77LeuAla: 10.77 ± 0.105
1.306LeuCys: 1.306 ± 0.036
5.655LeuAsp: 5.655 ± 0.077
5.812LeuGlu: 5.812 ± 0.085
4.006LeuPhe: 4.006 ± 0.083
6.847LeuGly: 6.847 ± 0.103
2.074LeuHis: 2.074 ± 0.047
5.904LeuIle: 5.904 ± 0.084
4.586LeuLys: 4.586 ± 0.084
12.01LeuLeu: 12.01 ± 0.18
2.625LeuMet: 2.625 ± 0.056
3.984LeuAsn: 3.984 ± 0.072
4.931LeuPro: 4.931 ± 0.076
4.524LeuGln: 4.524 ± 0.081
5.099LeuArg: 5.099 ± 0.084
8.529LeuSer: 8.529 ± 0.09
5.796LeuThr: 5.796 ± 0.158
6.654LeuVal: 6.654 ± 0.078
1.149LeuTrp: 1.149 ± 0.037
2.791LeuTyr: 2.791 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.575MetAla: 2.575 ± 0.052
0.196MetCys: 0.196 ± 0.011
1.113MetAsp: 1.113 ± 0.03
1.102MetGlu: 1.102 ± 0.035
0.817MetPhe: 0.817 ± 0.033
1.648MetGly: 1.648 ± 0.037
0.473MetHis: 0.473 ± 0.022
1.49MetIle: 1.49 ± 0.04
1.244MetLys: 1.244 ± 0.035
2.687MetLeu: 2.687 ± 0.059
0.699MetMet: 0.699 ± 0.029
0.938MetAsn: 0.938 ± 0.029
1.184MetPro: 1.184 ± 0.032
1.026MetGln: 1.026 ± 0.032
1.279MetArg: 1.279 ± 0.032
2.041MetSer: 2.041 ± 0.049
1.53MetThr: 1.53 ± 0.035
1.614MetVal: 1.614 ± 0.043
0.177MetTrp: 0.177 ± 0.011
0.494MetTyr: 0.494 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.198AsnAla: 3.198 ± 0.06
0.452AsnCys: 0.452 ± 0.022
2.413AsnAsp: 2.413 ± 0.062
2.046AsnGlu: 2.046 ± 0.043
1.436AsnPhe: 1.436 ± 0.036
2.737AsnGly: 2.737 ± 0.062
0.904AsnHis: 0.904 ± 0.028
2.789AsnIle: 2.789 ± 0.056
1.989AsnLys: 1.989 ± 0.048
3.392AsnLeu: 3.392 ± 0.055
0.844AsnMet: 0.844 ± 0.025
2.115AsnAsn: 2.115 ± 0.051
1.846AsnPro: 1.846 ± 0.041
1.537AsnGln: 1.537 ± 0.04
1.916AsnArg: 1.916 ± 0.04
2.719AsnSer: 2.719 ± 0.05
2.196AsnThr: 2.196 ± 0.052
2.301AsnVal: 2.301 ± 0.048
0.487AsnTrp: 0.487 ± 0.018
1.362AsnTyr: 1.362 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
3.667ProAla: 3.667 ± 0.065
0.393ProCys: 0.393 ± 0.02
2.219ProAsp: 2.219 ± 0.058
2.912ProGlu: 2.912 ± 0.053
1.543ProPhe: 1.543 ± 0.035
2.675ProGly: 2.675 ± 0.053
0.794ProHis: 0.794 ± 0.023
2.303ProIle: 2.303 ± 0.045
1.644ProLys: 1.644 ± 0.041
4.361ProLeu: 4.361 ± 0.066
1.004ProMet: 1.004 ± 0.032
1.377ProAsn: 1.377 ± 0.034
1.381ProPro: 1.381 ± 0.037
1.599ProGln: 1.599 ± 0.042
1.659ProArg: 1.659 ± 0.044
2.756ProSer: 2.756 ± 0.048
2.007ProThr: 2.007 ± 0.046
3.156ProVal: 3.156 ± 0.08
0.513ProTrp: 0.513 ± 0.02
1.181ProTyr: 1.181 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.493GlnAla: 4.493 ± 0.071
0.447GlnCys: 0.447 ± 0.022
1.712GlnAsp: 1.712 ± 0.044
1.995GlnGlu: 1.995 ± 0.045
1.45GlnPhe: 1.45 ± 0.031
3.023GlnGly: 3.023 ± 0.054
1.378GlnHis: 1.378 ± 0.037
2.075GlnIle: 2.075 ± 0.04
1.458GlnLys: 1.458 ± 0.034
6.041GlnLeu: 6.041 ± 0.113
1.061GlnMet: 1.061 ± 0.034
1.099GlnAsn: 1.099 ± 0.034
2.085GlnPro: 2.085 ± 0.042
4.231GlnGln: 4.231 ± 0.105
3.152GlnArg: 3.152 ± 0.075
2.792GlnSer: 2.792 ± 0.048
1.785GlnThr: 1.785 ± 0.036
2.871GlnVal: 2.871 ± 0.051
0.725GlnTrp: 0.725 ± 0.024
1.366GlnTyr: 1.366 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
4.127ArgAla: 4.127 ± 0.077
0.656ArgCys: 0.656 ± 0.023
2.705ArgAsp: 2.705 ± 0.055
3.225ArgGlu: 3.225 ± 0.063
2.309ArgPhe: 2.309 ± 0.045
3.179ArgGly: 3.179 ± 0.055
1.37ArgHis: 1.37 ± 0.039
2.852ArgIle: 2.852 ± 0.048
2.048ArgLys: 2.048 ± 0.051
5.782ArgLeu: 5.782 ± 0.087
1.236ArgMet: 1.236 ± 0.029
1.664ArgAsn: 1.664 ± 0.037
1.846ArgPro: 1.846 ± 0.042
2.916ArgGln: 2.916 ± 0.073
3.172ArgArg: 3.172 ± 0.07
3.156ArgSer: 3.156 ± 0.061
1.926ArgThr: 1.926 ± 0.039
3.42ArgVal: 3.42 ± 0.058
0.799ArgTrp: 0.799 ± 0.027
2.027ArgTyr: 2.027 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.425SerAla: 6.425 ± 0.093
0.859SerCys: 0.859 ± 0.027
4.021SerAsp: 4.021 ± 0.069
4.051SerGlu: 4.051 ± 0.065
2.932SerPhe: 2.932 ± 0.061
5.61SerGly: 5.61 ± 0.103
1.575SerHis: 1.575 ± 0.039
4.231SerIle: 4.231 ± 0.066
2.92SerLys: 2.92 ± 0.062
7.489SerLeu: 7.489 ± 0.088
1.659SerMet: 1.659 ± 0.04
2.772SerAsn: 2.772 ± 0.058
2.657SerPro: 2.657 ± 0.054
2.745SerGln: 2.745 ± 0.047
3.293SerArg: 3.293 ± 0.059
5.089SerSer: 5.089 ± 0.079
3.507SerThr: 3.507 ± 0.065
4.835SerVal: 4.835 ± 0.081
0.976SerTrp: 0.976 ± 0.027
2.49SerTyr: 2.49 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
5.332ThrAla: 5.332 ± 0.132
0.442ThrCys: 0.442 ± 0.021
2.918ThrAsp: 2.918 ± 0.081
3.053ThrGlu: 3.053 ± 0.057
1.752ThrPhe: 1.752 ± 0.038
4.0ThrGly: 4.0 ± 0.066
0.977ThrHis: 0.977 ± 0.032
3.4ThrIle: 3.4 ± 0.08
1.822ThrLys: 1.822 ± 0.042
6.122ThrLeu: 6.122 ± 0.139
1.145ThrMet: 1.145 ± 0.029
1.686ThrAsn: 1.686 ± 0.037
2.73ThrPro: 2.73 ± 0.061
1.882ThrGln: 1.882 ± 0.034
2.183ThrArg: 2.183 ± 0.042
3.144ThrSer: 3.144 ± 0.06
3.05ThrThr: 3.05 ± 0.065
4.013ThrVal: 4.013 ± 0.091
0.515ThrTrp: 0.515 ± 0.022
1.24ThrTyr: 1.24 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
7.053ValAla: 7.053 ± 0.089
0.773ValCys: 0.773 ± 0.026
4.879ValAsp: 4.879 ± 0.124
4.685ValGlu: 4.685 ± 0.075
2.695ValPhe: 2.695 ± 0.049
4.77ValGly: 4.77 ± 0.074
1.194ValHis: 1.194 ± 0.032
4.563ValIle: 4.563 ± 0.069
3.015ValLys: 3.015 ± 0.061
6.764ValLeu: 6.764 ± 0.082
1.747ValMet: 1.747 ± 0.041
2.69ValAsn: 2.69 ± 0.063
2.519ValPro: 2.519 ± 0.054
2.142ValGln: 2.142 ± 0.047
3.027ValArg: 3.027 ± 0.056
5.114ValSer: 5.114 ± 0.077
4.006ValThr: 4.006 ± 0.094
5.81ValVal: 5.81 ± 0.087
0.742ValTrp: 0.742 ± 0.022
1.808ValTyr: 1.808 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.89TrpAla: 0.89 ± 0.027
0.158TrpCys: 0.158 ± 0.011
0.585TrpAsp: 0.585 ± 0.023
0.469TrpGlu: 0.469 ± 0.02
0.51TrpPhe: 0.51 ± 0.022
0.802TrpGly: 0.802 ± 0.026
0.323TrpHis: 0.323 ± 0.016
0.527TrpIle: 0.527 ± 0.025
0.371TrpLys: 0.371 ± 0.018
1.85TrpLeu: 1.85 ± 0.045
0.305TrpMet: 0.305 ± 0.017
0.394TrpAsn: 0.394 ± 0.021
0.49TrpPro: 0.49 ± 0.02
0.97TrpGln: 0.97 ± 0.033
0.842TrpArg: 0.842 ± 0.027
0.879TrpSer: 0.879 ± 0.028
0.465TrpThr: 0.465 ± 0.022
0.832TrpVal: 0.832 ± 0.03
0.168TrpTrp: 0.168 ± 0.012
0.341TrpTyr: 0.341 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.402TyrAla: 2.402 ± 0.048
0.475TyrCys: 0.475 ± 0.02
1.777TyrAsp: 1.777 ± 0.044
1.483TyrGlu: 1.483 ± 0.035
1.424TyrPhe: 1.424 ± 0.039
2.206TyrGly: 2.206 ± 0.049
0.834TyrHis: 0.834 ± 0.027
1.727TyrIle: 1.727 ± 0.041
1.229TyrLys: 1.229 ± 0.037
3.275TyrLeu: 3.275 ± 0.054
0.618TyrMet: 0.618 ± 0.025
1.132TyrAsn: 1.132 ± 0.035
1.317TyrPro: 1.317 ± 0.034
1.813TyrGln: 1.813 ± 0.045
2.136TyrArg: 2.136 ± 0.04
2.384TyrSer: 2.384 ± 0.055
1.539TyrThr: 1.539 ± 0.029
1.698TyrVal: 1.698 ± 0.037
0.453TyrTrp: 0.453 ± 0.019
1.1TyrTyr: 1.1 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3807 proteins (1262493 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski