Amino acid dipepetide frequency for Planktothrix agardhii NIVA-CYA 126/8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.021AlaAla: 5.021 ± 0.082	0.709AlaCys: 0.709 ± 0.023	3.439AlaAsp: 3.439 ± 0.057	4.667AlaGlu: 4.667 ± 0.066	2.558AlaPhe: 2.558 ± 0.044	4.669AlaGly: 4.669 ± 0.078	1.07AlaHis: 1.07 ± 0.022	6.254AlaIle: 6.254 ± 0.07	3.883AlaLys: 3.883 ± 0.053	7.493AlaLeu: 7.493 ± 0.088	1.392AlaMet: 1.392 ± 0.035	3.139AlaAsn: 3.139 ± 0.067	2.356AlaPro: 2.356 ± 0.045	3.583AlaGln: 3.583 ± 0.057	2.75AlaArg: 2.75 ± 0.053	4.076AlaSer: 4.076 ± 0.064	4.152AlaThr: 4.152 ± 0.058	4.567AlaVal: 4.567 ± 0.066	0.804AlaTrp: 0.804 ± 0.024	2.119AlaTyr: 2.119 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.499CysAla: 0.499 ± 0.02	0.157CysCys: 0.157 ± 0.012	0.564CysAsp: 0.564 ± 0.021	0.5CysGlu: 0.5 ± 0.02	0.447CysPhe: 0.447 ± 0.014	0.728CysGly: 0.728 ± 0.028	0.293CysHis: 0.293 ± 0.014	0.588CysIle: 0.588 ± 0.022	0.34CysLys: 0.34 ± 0.016	1.189CysLeu: 1.189 ± 0.034	0.133CysMet: 0.133 ± 0.01	0.364CysAsn: 0.364 ± 0.017	0.55CysPro: 0.55 ± 0.02	0.663CysGln: 0.663 ± 0.025	0.498CysArg: 0.498 ± 0.019	0.627CysSer: 0.627 ± 0.022	0.427CysThr: 0.427 ± 0.017	0.536CysVal: 0.536 ± 0.022	0.143CysTrp: 0.143 ± 0.01	0.431CysTyr: 0.431 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.096AspAla: 3.096 ± 0.046	0.543AspCys: 0.543 ± 0.021	2.275AspAsp: 2.275 ± 0.056	2.94AspGlu: 2.94 ± 0.061	2.537AspPhe: 2.537 ± 0.05	3.136AspGly: 3.136 ± 0.065	0.96AspHis: 0.96 ± 0.03	3.824AspIle: 3.824 ± 0.06	2.217AspLys: 2.217 ± 0.048	6.142AspLeu: 6.142 ± 0.074	0.772AspMet: 0.772 ± 0.023	2.102AspAsn: 2.102 ± 0.05	2.626AspPro: 2.626 ± 0.05	2.855AspGln: 2.855 ± 0.05	2.725AspArg: 2.725 ± 0.044	3.064AspSer: 3.064 ± 0.053	2.363AspThr: 2.363 ± 0.05	2.715AspVal: 2.715 ± 0.046	0.901AspTrp: 0.901 ± 0.023	2.06AspTyr: 2.06 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.798GluAla: 4.798 ± 0.056	0.454GluCys: 0.454 ± 0.019	3.057GluAsp: 3.057 ± 0.055	4.003GluGlu: 4.003 ± 0.096	2.56GluPhe: 2.56 ± 0.044	3.199GluGly: 3.199 ± 0.053	1.002GluHis: 1.002 ± 0.03	5.647GluIle: 5.647 ± 0.068	4.003GluLys: 4.003 ± 0.061	7.362GluLeu: 7.362 ± 0.094	1.414GluMet: 1.414 ± 0.034	3.166GluAsn: 3.166 ± 0.049	2.513GluPro: 2.513 ± 0.059	3.91GluGln: 3.91 ± 0.064	3.145GluArg: 3.145 ± 0.053	3.703GluSer: 3.703 ± 0.06	4.207GluThr: 4.207 ± 0.065	4.042GluVal: 4.042 ± 0.058	0.777GluTrp: 0.777 ± 0.027	2.02GluTyr: 2.02 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.682PheAla: 2.682 ± 0.049	0.567PheCys: 0.567 ± 0.021	2.267PheAsp: 2.267 ± 0.045	2.407PheGlu: 2.407 ± 0.043	1.709PhePhe: 1.709 ± 0.042	2.689PheGly: 2.689 ± 0.053	0.686PheHis: 0.686 ± 0.023	2.775PheIle: 2.775 ± 0.044	1.988PheLys: 1.988 ± 0.041	4.298PheLeu: 4.298 ± 0.063	0.775PheMet: 0.775 ± 0.024	2.16PheAsn: 2.16 ± 0.043	2.066PhePro: 2.066 ± 0.038	1.907PheGln: 1.907 ± 0.039	1.701PheArg: 1.701 ± 0.034	3.128PheSer: 3.128 ± 0.05	2.122PheThr: 2.122 ± 0.038	2.36PheVal: 2.36 ± 0.046	0.747PheTrp: 0.747 ± 0.025	1.469PheTyr: 1.469 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.134GlyAla: 4.134 ± 0.084	0.765GlyCys: 0.765 ± 0.024	3.323GlyAsp: 3.323 ± 0.061	4.269GlyGlu: 4.269 ± 0.061	3.001GlyPhe: 3.001 ± 0.053	4.8GlyGly: 4.8 ± 0.106	1.167GlyHis: 1.167 ± 0.035	5.398GlyIle: 5.398 ± 0.076	4.03GlyLys: 4.03 ± 0.063	7.161GlyLeu: 7.161 ± 0.088	1.423GlyMet: 1.423 ± 0.035	3.322GlyAsn: 3.322 ± 0.092	1.249GlyPro: 1.249 ± 0.031	3.059GlyGln: 3.059 ± 0.053	2.93GlyArg: 2.93 ± 0.05	3.91GlySer: 3.91 ± 0.076	3.62GlyThr: 3.62 ± 0.066	4.448GlyVal: 4.448 ± 0.066	1.076GlyTrp: 1.076 ± 0.03	2.39GlyTyr: 2.39 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.898HisAla: 0.898 ± 0.026	0.26HisCys: 0.26 ± 0.013	0.774HisAsp: 0.774 ± 0.029	0.857HisGlu: 0.857 ± 0.023	0.787HisPhe: 0.787 ± 0.021	1.012HisGly: 1.012 ± 0.027	0.607HisHis: 0.607 ± 0.028	1.09HisIle: 1.09 ± 0.03	0.674HisLys: 0.674 ± 0.023	2.297HisLeu: 2.297 ± 0.049	0.135HisMet: 0.135 ± 0.011	0.713HisAsn: 0.713 ± 0.024	1.401HisPro: 1.401 ± 0.029	1.359HisGln: 1.359 ± 0.031	1.04HisArg: 1.04 ± 0.029	1.162HisSer: 1.162 ± 0.026	0.782HisThr: 0.782 ± 0.026	0.653HisVal: 0.653 ± 0.022	0.334HisTrp: 0.334 ± 0.013	0.673HisTyr: 0.673 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.289IleAla: 6.289 ± 0.073	0.783IleCys: 0.783 ± 0.024	3.968IleAsp: 3.968 ± 0.062	4.99IleGlu: 4.99 ± 0.064	2.892IlePhe: 2.892 ± 0.047	4.559IleGly: 4.559 ± 0.075	1.281IleHis: 1.281 ± 0.032	5.249IleIle: 5.249 ± 0.08	3.852IleLys: 3.852 ± 0.055	8.155IleLeu: 8.155 ± 0.091	1.043IleMet: 1.043 ± 0.03	3.881IleAsn: 3.881 ± 0.062	4.287IlePro: 4.287 ± 0.06	3.773IleGln: 3.773 ± 0.059	3.161IleArg: 3.161 ± 0.05	5.082IleSer: 5.082 ± 0.06	4.192IleThr: 4.192 ± 0.067	4.332IleVal: 4.332 ± 0.064	0.944IleTrp: 0.944 ± 0.029	2.279IleTyr: 2.279 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	3.66LysAla: 3.66 ± 0.05	0.31LysCys: 0.31 ± 0.017	2.347LysAsp: 2.347 ± 0.046	2.81LysGlu: 2.81 ± 0.048	1.895LysPhe: 1.895 ± 0.043	2.769LysGly: 2.769 ± 0.053	0.769LysHis: 0.769 ± 0.024	4.351LysIle: 4.351 ± 0.069	2.701LysLys: 2.701 ± 0.057	5.755LysLeu: 5.755 ± 0.068	1.022LysMet: 1.022 ± 0.023	2.745LysAsn: 2.745 ± 0.053	2.793LysPro: 2.793 ± 0.048	2.985LysGln: 2.985 ± 0.056	2.347LysArg: 2.347 ± 0.048	3.231LysSer: 3.231 ± 0.051	3.702LysThr: 3.702 ± 0.058	3.083LysVal: 3.083 ± 0.045	0.554LysTrp: 0.554 ± 0.019	1.481LysTyr: 1.481 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	8.308LeuAla: 8.308 ± 0.086	0.913LeuCys: 0.913 ± 0.026	5.625LeuAsp: 5.625 ± 0.079	8.385LeuGlu: 8.385 ± 0.099	4.141LeuPhe: 4.141 ± 0.07	7.944LeuGly: 7.944 ± 0.091	1.666LeuHis: 1.666 ± 0.039	8.096LeuIle: 8.096 ± 0.09	6.686LeuLys: 6.686 ± 0.075	10.808LeuLeu: 10.808 ± 0.127	2.132LeuMet: 2.132 ± 0.043	5.445LeuAsn: 5.445 ± 0.074	5.5LeuPro: 5.5 ± 0.072	5.332LeuGln: 5.332 ± 0.08	4.92LeuArg: 4.92 ± 0.07	7.661LeuSer: 7.661 ± 0.085	7.002LeuThr: 7.002 ± 0.084	6.612LeuVal: 6.612 ± 0.074	1.511LeuTrp: 1.511 ± 0.045	2.828LeuTyr: 2.828 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.67MetAla: 1.67 ± 0.037	0.124MetCys: 0.124 ± 0.01	0.744MetAsp: 0.744 ± 0.024	1.065MetGlu: 1.065 ± 0.028	0.55MetPhe: 0.55 ± 0.018	1.549MetGly: 1.549 ± 0.036	0.209MetHis: 0.209 ± 0.01	1.485MetIle: 1.485 ± 0.033	0.945MetLys: 0.945 ± 0.026	1.675MetLeu: 1.675 ± 0.033	0.449MetMet: 0.449 ± 0.018	0.951MetAsn: 0.951 ± 0.028	0.79MetPro: 0.79 ± 0.025	0.813MetGln: 0.813 ± 0.025	0.843MetArg: 0.843 ± 0.026	1.249MetSer: 1.249 ± 0.028	1.24MetThr: 1.24 ± 0.026	1.327MetVal: 1.327 ± 0.034	0.141MetTrp: 0.141 ± 0.011	0.338MetTyr: 0.338 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.667AsnAla: 2.667 ± 0.055	0.56AsnCys: 0.56 ± 0.021	1.974AsnAsp: 1.974 ± 0.065	1.778AsnGlu: 1.778 ± 0.041	2.175AsnPhe: 2.175 ± 0.043	2.606AsnGly: 2.606 ± 0.058	1.027AsnHis: 1.027 ± 0.028	3.483AsnIle: 3.483 ± 0.061	1.833AsnLys: 1.833 ± 0.042	6.347AsnLeu: 6.347 ± 0.098	0.657AsnMet: 0.657 ± 0.023	2.406AsnAsn: 2.406 ± 0.055	3.533AsnPro: 3.533 ± 0.056	3.581AsnGln: 3.581 ± 0.059	2.456AsnArg: 2.456 ± 0.044	3.615AsnSer: 3.615 ± 0.067	2.426AsnThr: 2.426 ± 0.047	1.97AsnVal: 1.97 ± 0.041	0.892AsnTrp: 0.892 ± 0.025	1.844AsnTyr: 1.844 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.795ProAla: 2.795 ± 0.05	0.379ProCys: 0.379 ± 0.019	3.265ProAsp: 3.265 ± 0.056	4.472ProGlu: 4.472 ± 0.067	1.8ProPhe: 1.8 ± 0.038	2.947ProGly: 2.947 ± 0.05	0.87ProHis: 0.87 ± 0.024	3.511ProIle: 3.511 ± 0.057	2.466ProLys: 2.466 ± 0.045	4.93ProLeu: 4.93 ± 0.073	0.855ProMet: 0.855 ± 0.025	2.746ProAsn: 2.746 ± 0.05	2.538ProPro: 2.538 ± 0.06	2.792ProGln: 2.792 ± 0.06	1.736ProArg: 1.736 ± 0.034	3.004ProSer: 3.004 ± 0.057	2.953ProThr: 2.953 ± 0.076	3.127ProVal: 3.127 ± 0.058	0.61ProTrp: 0.61 ± 0.022	1.414ProTyr: 1.414 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.271GlnAla: 4.271 ± 0.063	0.371GlnCys: 0.371 ± 0.018	2.481GlnAsp: 2.481 ± 0.045	3.924GlnGlu: 3.924 ± 0.063	2.2GlnPhe: 2.2 ± 0.045	3.769GlnGly: 3.769 ± 0.055	0.814GlnHis: 0.814 ± 0.028	4.055GlnIle: 4.055 ± 0.056	3.169GlnLys: 3.169 ± 0.056	6.355GlnLeu: 6.355 ± 0.085	1.04GlnMet: 1.04 ± 0.028	2.56GlnAsn: 2.56 ± 0.052	2.791GlnPro: 2.791 ± 0.051	3.905GlnGln: 3.905 ± 0.072	2.712GlnArg: 2.712 ± 0.052	3.054GlnSer: 3.054 ± 0.057	3.355GlnThr: 3.355 ± 0.062	3.766GlnVal: 3.766 ± 0.056	0.74GlnTrp: 0.74 ± 0.028	1.446GlnTyr: 1.446 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.593ArgAla: 2.593 ± 0.051	0.457ArgCys: 0.457 ± 0.019	2.284ArgAsp: 2.284 ± 0.044	3.096ArgGlu: 3.096 ± 0.053	2.083ArgPhe: 2.083 ± 0.044	2.789ArgGly: 2.789 ± 0.05	0.922ArgHis: 0.922 ± 0.027	3.316ArgIle: 3.316 ± 0.039	2.068ArgLys: 2.068 ± 0.039	5.429ArgLeu: 5.429 ± 0.076	0.913ArgMet: 0.913 ± 0.029	1.988ArgAsn: 1.988 ± 0.038	2.0ArgPro: 2.0 ± 0.035	2.857ArgGln: 2.857 ± 0.058	2.55ArgArg: 2.55 ± 0.052	2.912ArgSer: 2.912 ± 0.049	2.269ArgThr: 2.269 ± 0.044	2.911ArgVal: 2.911 ± 0.049	0.7ArgTrp: 0.7 ± 0.025	1.806ArgTyr: 1.806 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.822SerAla: 3.822 ± 0.059	0.621SerCys: 0.621 ± 0.022	3.31SerAsp: 3.31 ± 0.054	4.175SerGlu: 4.175 ± 0.061	2.46SerPhe: 2.46 ± 0.047	4.638SerGly: 4.638 ± 0.081	1.254SerHis: 1.254 ± 0.028	4.25SerIle: 4.25 ± 0.068	2.735SerLys: 2.735 ± 0.045	7.514SerLeu: 7.514 ± 0.09	1.15SerMet: 1.15 ± 0.031	2.817SerAsn: 2.817 ± 0.048	3.868SerPro: 3.868 ± 0.075	3.958SerGln: 3.958 ± 0.059	2.85SerArg: 2.85 ± 0.044	4.453SerSer: 4.453 ± 0.072	3.227SerThr: 3.227 ± 0.065	4.015SerVal: 4.015 ± 0.053	0.931SerTrp: 0.931 ± 0.028	2.028SerTyr: 2.028 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.301ThrAla: 4.301 ± 0.056	0.497ThrCys: 0.497 ± 0.016	2.815ThrAsp: 2.815 ± 0.054	3.786ThrGlu: 3.786 ± 0.059	2.031ThrPhe: 2.031 ± 0.041	4.362ThrGly: 4.362 ± 0.074	1.002ThrHis: 1.002 ± 0.03	4.098ThrIle: 4.098 ± 0.06	2.221ThrLys: 2.221 ± 0.051	6.731ThrLeu: 6.731 ± 0.074	0.8ThrMet: 0.8 ± 0.024	2.317ThrAsn: 2.317 ± 0.045	3.677ThrPro: 3.677 ± 0.075	3.112ThrGln: 3.112 ± 0.053	2.23ThrArg: 2.23 ± 0.038	3.254ThrSer: 3.254 ± 0.057	3.323ThrThr: 3.323 ± 0.068	4.025ThrVal: 4.025 ± 0.057	0.692ThrTrp: 0.692 ± 0.024	1.593ThrTyr: 1.593 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	4.721ValAla: 4.721 ± 0.072	0.656ValCys: 0.656 ± 0.021	3.099ValAsp: 3.099 ± 0.049	4.223ValGlu: 4.223 ± 0.061	2.556ValPhe: 2.556 ± 0.04	4.24ValGly: 4.24 ± 0.072	0.898ValHis: 0.898 ± 0.026	4.663ValIle: 4.663 ± 0.071	3.413ValLys: 3.413 ± 0.047	6.227ValLeu: 6.227 ± 0.074	1.293ValMet: 1.293 ± 0.03	2.968ValAsn: 2.968 ± 0.049	2.515ValPro: 2.515 ± 0.047	2.679ValGln: 2.679 ± 0.045	2.721ValArg: 2.721 ± 0.05	3.984ValSer: 3.984 ± 0.061	3.391ValThr: 3.391 ± 0.059	3.972ValVal: 3.972 ± 0.061	0.797ValTrp: 0.797 ± 0.023	1.847ValTyr: 1.847 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.718TrpAla: 0.718 ± 0.025	0.147TrpCys: 0.147 ± 0.01	0.683TrpAsp: 0.683 ± 0.027	0.962TrpGlu: 0.962 ± 0.029	0.637TrpPhe: 0.637 ± 0.022	0.996TrpGly: 0.996 ± 0.032	0.267TrpHis: 0.267 ± 0.014	0.96TrpIle: 0.96 ± 0.029	0.804TrpLys: 0.804 ± 0.022	1.796TrpLeu: 1.796 ± 0.04	0.318TrpMet: 0.318 ± 0.015	0.652TrpAsn: 0.652 ± 0.025	0.353TrpPro: 0.353 ± 0.015	1.096TrpGln: 1.096 ± 0.034	0.725TrpArg: 0.725 ± 0.023	0.842TrpSer: 0.842 ± 0.028	0.584TrpThr: 0.584 ± 0.024	0.929TrpVal: 0.929 ± 0.026	0.211TrpTrp: 0.211 ± 0.014	0.393TrpTyr: 0.393 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.758TyrAla: 1.758 ± 0.037	0.404TyrCys: 0.404 ± 0.018	1.561TyrAsp: 1.561 ± 0.034	1.672TyrGlu: 1.672 ± 0.038	1.483TyrPhe: 1.483 ± 0.044	2.076TyrGly: 2.076 ± 0.038	0.744TyrHis: 0.744 ± 0.025	1.901TyrIle: 1.901 ± 0.032	1.283TyrLys: 1.283 ± 0.034	3.85TyrLeu: 3.85 ± 0.063	0.438TyrMet: 0.438 ± 0.018	1.387TyrAsn: 1.387 ± 0.033	1.806TyrPro: 1.806 ± 0.033	2.558TyrGln: 2.558 ± 0.048	1.903TyrArg: 1.903 ± 0.042	2.065TyrSer: 2.065 ± 0.05	1.524TyrThr: 1.524 ± 0.032	1.475TyrVal: 1.475 ± 0.035	0.569TyrTrp: 0.569 ± 0.022	1.233TyrTyr: 1.233 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4186 proteins (1394687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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