Amino acid dipepetide frequency for Kitasatospora aureofaciens (Streptomyces aureofaciens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.57AlaAla: 23.57 ± 0.159	1.083AlaCys: 1.083 ± 0.024	8.554AlaAsp: 8.554 ± 0.067	9.466AlaGlu: 9.466 ± 0.108	3.595AlaPhe: 3.595 ± 0.041	13.903AlaGly: 13.903 ± 0.101	2.862AlaHis: 2.862 ± 0.038	3.3AlaIle: 3.3 ± 0.047	2.589AlaLys: 2.589 ± 0.046	15.282AlaLeu: 15.282 ± 0.114	2.385AlaMet: 2.385 ± 0.031	2.133AlaAsn: 2.133 ± 0.035	7.82AlaPro: 7.82 ± 0.083	3.901AlaGln: 3.901 ± 0.048	10.256AlaArg: 10.256 ± 0.087	5.488AlaSer: 5.488 ± 0.062	7.375AlaThr: 7.375 ± 0.065	13.272AlaVal: 13.272 ± 0.088	1.889AlaTrp: 1.889 ± 0.033	2.481AlaTyr: 2.481 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.085CysAla: 1.085 ± 0.024	0.103CysCys: 0.103 ± 0.008	0.45CysAsp: 0.45 ± 0.015	0.376CysGlu: 0.376 ± 0.015	0.22CysPhe: 0.22 ± 0.01	0.942CysGly: 0.942 ± 0.024	0.19CysHis: 0.19 ± 0.008	0.171CysIle: 0.171 ± 0.009	0.09CysLys: 0.09 ± 0.005	0.794CysLeu: 0.794 ± 0.022	0.119CysMet: 0.119 ± 0.007	0.145CysAsn: 0.145 ± 0.008	0.538CysPro: 0.538 ± 0.015	0.194CysGln: 0.194 ± 0.009	0.621CysArg: 0.621 ± 0.017	0.488CysSer: 0.488 ± 0.014	0.535CysThr: 0.535 ± 0.017	0.575CysVal: 0.575 ± 0.016	0.146CysTrp: 0.146 ± 0.008	0.159CysTyr: 0.159 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.224AspAla: 7.224 ± 0.068	0.451AspCys: 0.451 ± 0.014	3.054AspAsp: 3.054 ± 0.037	3.481AspGlu: 3.481 ± 0.038	1.636AspPhe: 1.636 ± 0.031	6.565AspGly: 6.565 ± 0.061	1.555AspHis: 1.555 ± 0.024	1.506AspIle: 1.506 ± 0.028	0.985AspLys: 0.985 ± 0.026	6.483AspLeu: 6.483 ± 0.064	0.618AspMet: 0.618 ± 0.018	0.933AspAsn: 0.933 ± 0.018	4.594AspPro: 4.594 ± 0.049	1.728AspGln: 1.728 ± 0.029	5.047AspArg: 5.047 ± 0.054	2.321AspSer: 2.321 ± 0.028	3.005AspThr: 3.005 ± 0.035	4.198AspVal: 4.198 ± 0.05	1.017AspTrp: 1.017 ± 0.025	1.136AspTyr: 1.136 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.33GluAla: 7.33 ± 0.088	0.354GluCys: 0.354 ± 0.011	2.652GluAsp: 2.652 ± 0.038	3.328GluGlu: 3.328 ± 0.05	1.476GluPhe: 1.476 ± 0.026	3.915GluGly: 3.915 ± 0.048	1.595GluHis: 1.595 ± 0.027	1.93GluIle: 1.93 ± 0.031	1.074GluLys: 1.074 ± 0.025	7.549GluLeu: 7.549 ± 0.083	0.725GluMet: 0.725 ± 0.02	0.918GluAsn: 0.918 ± 0.02	3.359GluPro: 3.359 ± 0.043	2.556GluGln: 2.556 ± 0.038	5.483GluArg: 5.483 ± 0.061	2.222GluSer: 2.222 ± 0.029	2.51GluThr: 2.51 ± 0.033	4.516GluVal: 4.516 ± 0.048	0.705GluTrp: 0.705 ± 0.018	1.07GluTyr: 1.07 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.703PheAla: 3.703 ± 0.048	0.268PheCys: 0.268 ± 0.012	1.983PheAsp: 1.983 ± 0.032	1.388PheGlu: 1.388 ± 0.024	0.826PhePhe: 0.826 ± 0.024	2.996PheGly: 2.996 ± 0.037	0.63PheHis: 0.63 ± 0.016	0.642PheIle: 0.642 ± 0.018	0.429PheLys: 0.429 ± 0.013	2.526PheLeu: 2.526 ± 0.039	0.34PheMet: 0.34 ± 0.012	0.539PheAsn: 0.539 ± 0.018	1.439PhePro: 1.439 ± 0.025	0.695PheGln: 0.695 ± 0.017	1.802PheArg: 1.802 ± 0.029	1.365PheSer: 1.365 ± 0.025	2.012PheThr: 2.012 ± 0.031	2.088PheVal: 2.088 ± 0.034	0.412PheTrp: 0.412 ± 0.012	0.555PheTyr: 0.555 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.525GlyAla: 11.525 ± 0.089	0.863GlyCys: 0.863 ± 0.018	4.839GlyAsp: 4.839 ± 0.051	5.035GlyGlu: 5.035 ± 0.056	2.818GlyPhe: 2.818 ± 0.037	9.06GlyGly: 9.06 ± 0.087	2.414GlyHis: 2.414 ± 0.033	3.258GlyIle: 3.258 ± 0.041	2.135GlyLys: 2.135 ± 0.041	10.164GlyLeu: 10.164 ± 0.075	1.882GlyMet: 1.882 ± 0.029	1.829GlyAsn: 1.829 ± 0.035	5.795GlyPro: 5.795 ± 0.057	2.836GlyGln: 2.836 ± 0.038	8.141GlyArg: 8.141 ± 0.065	5.446GlySer: 5.446 ± 0.057	6.475GlyThr: 6.475 ± 0.065	7.379GlyVal: 7.379 ± 0.068	1.763GlyTrp: 1.763 ± 0.034	2.383GlyTyr: 2.383 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.682HisAla: 2.682 ± 0.036	0.238HisCys: 0.238 ± 0.01	1.273HisAsp: 1.273 ± 0.022	1.128HisGlu: 1.128 ± 0.02	0.646HisPhe: 0.646 ± 0.02	2.455HisGly: 2.455 ± 0.033	0.745HisHis: 0.745 ± 0.02	0.584HisIle: 0.584 ± 0.017	0.311HisLys: 0.311 ± 0.011	2.652HisLeu: 2.652 ± 0.039	0.285HisMet: 0.285 ± 0.012	0.403HisAsn: 0.403 ± 0.012	1.96HisPro: 1.96 ± 0.033	0.745HisGln: 0.745 ± 0.018	2.277HisArg: 2.277 ± 0.035	1.056HisSer: 1.056 ± 0.024	1.292HisThr: 1.292 ± 0.027	1.602HisVal: 1.602 ± 0.03	0.44HisTrp: 0.44 ± 0.014	0.483HisTyr: 0.483 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.608IleAla: 4.608 ± 0.052	0.283IleCys: 0.283 ± 0.011	2.054IleAsp: 2.054 ± 0.035	1.841IleGlu: 1.841 ± 0.03	0.568IlePhe: 0.568 ± 0.016	3.557IleGly: 3.557 ± 0.044	0.588IleHis: 0.588 ± 0.016	0.743IleIle: 0.743 ± 0.024	0.615IleLys: 0.615 ± 0.019	2.119IleLeu: 2.119 ± 0.033	0.373IleMet: 0.373 ± 0.014	0.677IleAsn: 0.677 ± 0.021	1.649IlePro: 1.649 ± 0.029	0.678IleGln: 0.678 ± 0.017	2.137IleArg: 2.137 ± 0.035	1.572IleSer: 1.572 ± 0.031	2.139IleThr: 2.139 ± 0.032	2.347IleVal: 2.347 ± 0.037	0.371IleTrp: 0.371 ± 0.013	0.48IleTyr: 0.48 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.606LysAla: 2.606 ± 0.045	0.099LysCys: 0.099 ± 0.007	1.102LysAsp: 1.102 ± 0.029	0.908LysGlu: 0.908 ± 0.025	0.408LysPhe: 0.408 ± 0.014	1.535LysGly: 1.535 ± 0.029	0.4LysHis: 0.4 ± 0.013	0.698LysIle: 0.698 ± 0.022	0.578LysLys: 0.578 ± 0.023	1.88LysLeu: 1.88 ± 0.035	0.311LysMet: 0.311 ± 0.011	0.43LysAsn: 0.43 ± 0.015	1.223LysPro: 1.223 ± 0.026	0.648LysGln: 0.648 ± 0.019	1.19LysArg: 1.19 ± 0.024	0.959LysSer: 0.959 ± 0.025	1.032LysThr: 1.032 ± 0.029	1.71LysVal: 1.71 ± 0.03	0.215LysTrp: 0.215 ± 0.011	0.396LysTyr: 0.396 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.947LeuAla: 16.947 ± 0.121	0.835LeuCys: 0.835 ± 0.019	6.969LeuAsp: 6.969 ± 0.068	4.669LeuGlu: 4.669 ± 0.057	2.612LeuPhe: 2.612 ± 0.04	9.898LeuGly: 9.898 ± 0.07	2.455LeuHis: 2.455 ± 0.033	3.153LeuIle: 3.153 ± 0.045	1.739LeuLys: 1.739 ± 0.034	12.247LeuLeu: 12.247 ± 0.103	1.522LeuMet: 1.522 ± 0.026	1.741LeuAsn: 1.741 ± 0.029	7.115LeuPro: 7.115 ± 0.058	2.336LeuGln: 2.336 ± 0.031	8.938LeuArg: 8.938 ± 0.077	5.258LeuSer: 5.258 ± 0.047	7.151LeuThr: 7.151 ± 0.063	9.183LeuVal: 9.183 ± 0.075	1.355LeuTrp: 1.355 ± 0.029	1.815LeuTyr: 1.815 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.036	0.112MetCys: 0.112 ± 0.007	0.812MetAsp: 0.812 ± 0.018	0.594MetGlu: 0.594 ± 0.016	0.412MetPhe: 0.412 ± 0.014	1.154MetGly: 1.154 ± 0.02	0.332MetHis: 0.332 ± 0.011	0.582MetIle: 0.582 ± 0.017	0.349MetLys: 0.349 ± 0.014	1.59MetLeu: 1.59 ± 0.025	0.26MetMet: 0.26 ± 0.011	0.404MetAsn: 0.404 ± 0.013	1.063MetPro: 1.063 ± 0.022	0.403MetGln: 0.403 ± 0.014	1.244MetArg: 1.244 ± 0.025	1.139MetSer: 1.139 ± 0.021	1.436MetThr: 1.436 ± 0.023	1.246MetVal: 1.246 ± 0.026	0.174MetTrp: 0.174 ± 0.009	0.286MetTyr: 0.286 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.202AsnAla: 2.202 ± 0.038	0.159AsnCys: 0.159 ± 0.009	0.934AsnAsp: 0.934 ± 0.019	0.762AsnGlu: 0.762 ± 0.018	0.459AsnPhe: 0.459 ± 0.014	2.07AsnGly: 2.07 ± 0.038	0.399AsnHis: 0.399 ± 0.014	0.59AsnIle: 0.59 ± 0.015	0.357AsnLys: 0.357 ± 0.013	1.754AsnLeu: 1.754 ± 0.032	0.28AsnMet: 0.28 ± 0.013	0.423AsnAsn: 0.423 ± 0.017	1.461AsnPro: 1.461 ± 0.024	0.588AsnGln: 0.588 ± 0.017	1.307AsnArg: 1.307 ± 0.025	0.986AsnSer: 0.986 ± 0.025	1.171AsnThr: 1.171 ± 0.029	1.292AsnVal: 1.292 ± 0.026	0.292AsnTrp: 0.292 ± 0.012	0.417AsnTyr: 0.417 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.873ProAla: 9.873 ± 0.083	0.374ProCys: 0.374 ± 0.012	4.557ProAsp: 4.557 ± 0.046	4.383ProGlu: 4.383 ± 0.047	1.568ProPhe: 1.568 ± 0.029	7.263ProGly: 7.263 ± 0.066	1.316ProHis: 1.316 ± 0.03	1.365ProIle: 1.365 ± 0.026	1.098ProLys: 1.098 ± 0.024	5.581ProLeu: 5.581 ± 0.052	0.946ProMet: 0.946 ± 0.02	1.048ProAsn: 1.048 ± 0.025	3.532ProPro: 3.532 ± 0.054	1.935ProGln: 1.935 ± 0.036	3.796ProArg: 3.796 ± 0.041	3.287ProSer: 3.287 ± 0.047	3.725ProThr: 3.725 ± 0.052	5.941ProVal: 5.941 ± 0.056	0.94ProTrp: 0.94 ± 0.024	1.393ProTyr: 1.393 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.078GlnAla: 4.078 ± 0.049	0.191GlnCys: 0.191 ± 0.011	1.463GlnAsp: 1.463 ± 0.028	1.425GlnGlu: 1.425 ± 0.026	0.682GlnPhe: 0.682 ± 0.016	2.338GlnGly: 2.338 ± 0.036	0.735GlnHis: 0.735 ± 0.019	1.01GlnIle: 1.01 ± 0.023	0.542GlnLys: 0.542 ± 0.018	3.432GlnLeu: 3.432 ± 0.039	0.409GlnMet: 0.409 ± 0.014	0.53GlnAsn: 0.53 ± 0.016	1.965GlnPro: 1.965 ± 0.037	1.434GlnGln: 1.434 ± 0.035	2.488GlnArg: 2.488 ± 0.033	1.301GlnSer: 1.301 ± 0.025	1.329GlnThr: 1.329 ± 0.025	2.556GlnVal: 2.556 ± 0.041	0.481GlnTrp: 0.481 ± 0.015	0.642GlnTyr: 0.642 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.128ArgAla: 10.128 ± 0.087	0.595ArgCys: 0.595 ± 0.015	3.852ArgAsp: 3.852 ± 0.04	4.661ArgGlu: 4.661 ± 0.057	2.273ArgPhe: 2.273 ± 0.034	5.567ArgGly: 5.567 ± 0.05	2.127ArgHis: 2.127 ± 0.032	3.326ArgIle: 3.326 ± 0.036	1.353ArgLys: 1.353 ± 0.027	9.31ArgLeu: 9.31 ± 0.09	1.625ArgMet: 1.625 ± 0.026	1.311ArgAsn: 1.311 ± 0.026	5.442ArgPro: 5.442 ± 0.058	2.335ArgGln: 2.335 ± 0.031	7.85ArgArg: 7.85 ± 0.062	4.075ArgSer: 4.075 ± 0.043	5.511ArgThr: 5.511 ± 0.056	5.448ArgVal: 5.448 ± 0.051	1.417ArgTrp: 1.417 ± 0.024	1.794ArgTyr: 1.794 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.725SerAla: 6.725 ± 0.062	0.448SerCys: 0.448 ± 0.014	2.385SerAsp: 2.385 ± 0.035	2.157SerGlu: 2.157 ± 0.034	1.471SerPhe: 1.471 ± 0.027	5.782SerGly: 5.782 ± 0.061	0.997SerHis: 0.997 ± 0.02	1.387SerIle: 1.387 ± 0.026	0.883SerLys: 0.883 ± 0.023	4.671SerLeu: 4.671 ± 0.05	0.996SerMet: 0.996 ± 0.02	0.904SerAsn: 0.904 ± 0.02	3.242SerPro: 3.242 ± 0.045	1.203SerGln: 1.203 ± 0.025	3.41SerArg: 3.41 ± 0.036	2.731SerSer: 2.731 ± 0.044	3.126SerThr: 3.126 ± 0.04	4.045SerVal: 4.045 ± 0.048	0.948SerTrp: 0.948 ± 0.022	1.164SerTyr: 1.164 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.719ThrAla: 9.719 ± 0.075	0.423ThrCys: 0.423 ± 0.014	3.656ThrAsp: 3.656 ± 0.047	3.096ThrGlu: 3.096 ± 0.039	1.525ThrPhe: 1.525 ± 0.025	7.129ThrGly: 7.129 ± 0.07	1.107ThrHis: 1.107 ± 0.023	1.538ThrIle: 1.538 ± 0.033	0.959ThrLys: 0.959 ± 0.023	5.647ThrLeu: 5.647 ± 0.054	0.871ThrMet: 0.871 ± 0.021	1.029ThrAsn: 1.029 ± 0.026	4.343ThrPro: 4.343 ± 0.056	1.254ThrGln: 1.254 ± 0.025	3.746ThrArg: 3.746 ± 0.042	2.938ThrSer: 2.938 ± 0.047	4.032ThrThr: 4.032 ± 0.059	6.504ThrVal: 6.504 ± 0.061	0.874ThrTrp: 0.874 ± 0.02	1.156ThrTyr: 1.156 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.824ValAla: 10.824 ± 0.077	0.725ValCys: 0.725 ± 0.019	4.886ValAsp: 4.886 ± 0.051	4.844ValGlu: 4.844 ± 0.063	2.345ValPhe: 2.345 ± 0.035	6.667ValGly: 6.667 ± 0.057	1.99ValHis: 1.99 ± 0.03	2.688ValIle: 2.688 ± 0.039	1.593ValLys: 1.593 ± 0.031	10.208ValLeu: 10.208 ± 0.077	1.268ValMet: 1.268 ± 0.024	1.669ValAsn: 1.669 ± 0.029	5.453ValPro: 5.453 ± 0.052	2.17ValGln: 2.17 ± 0.032	6.989ValArg: 6.989 ± 0.057	4.145ValSer: 4.145 ± 0.047	5.405ValThr: 5.405 ± 0.053	7.865ValVal: 7.865 ± 0.085	1.072ValTrp: 1.072 ± 0.024	1.49ValTyr: 1.49 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.723TrpAla: 1.723 ± 0.031	0.167TrpCys: 0.167 ± 0.008	0.752TrpAsp: 0.752 ± 0.02	0.692TrpGlu: 0.692 ± 0.02	0.491TrpPhe: 0.491 ± 0.014	1.026TrpGly: 1.026 ± 0.024	0.395TrpHis: 0.395 ± 0.013	0.53TrpIle: 0.53 ± 0.016	0.333TrpLys: 0.333 ± 0.013	1.79TrpLeu: 1.79 ± 0.031	0.277TrpMet: 0.277 ± 0.01	0.414TrpAsn: 0.414 ± 0.015	0.825TrpPro: 0.825 ± 0.02	0.686TrpGln: 0.686 ± 0.019	1.324TrpArg: 1.324 ± 0.026	0.961TrpSer: 0.961 ± 0.021	1.126TrpThr: 1.126 ± 0.019	0.992TrpVal: 0.992 ± 0.021	0.364TrpTrp: 0.364 ± 0.015	0.377TrpTyr: 0.377 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.535TyrAla: 2.535 ± 0.035	0.17TyrCys: 0.17 ± 0.008	1.308TyrAsp: 1.308 ± 0.027	1.032TyrGlu: 1.032 ± 0.022	0.605TyrPhe: 0.605 ± 0.018	2.217TyrGly: 2.217 ± 0.032	0.424TyrHis: 0.424 ± 0.014	0.401TyrIle: 0.401 ± 0.013	0.317TyrLys: 0.317 ± 0.013	2.259TyrLeu: 2.259 ± 0.029	0.218TyrMet: 0.218 ± 0.01	0.423TyrAsn: 0.423 ± 0.014	1.105TyrPro: 1.105 ± 0.02	0.709TyrGln: 0.709 ± 0.018	1.952TyrArg: 1.952 ± 0.033	0.935TyrSer: 0.935 ± 0.02	1.16TyrThr: 1.16 ± 0.021	1.538TyrVal: 1.538 ± 0.027	0.369TyrTrp: 0.369 ± 0.013	0.451TyrTyr: 0.451 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7620 proteins (2446950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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