Amino acid dipepetide frequency for Treponema berlinense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.076AlaAla: 6.076 ± 0.124
0.963AlaCys: 0.963 ± 0.035
4.326AlaAsp: 4.326 ± 0.09
5.663AlaGlu: 5.663 ± 0.1
3.468AlaPhe: 3.468 ± 0.073
5.64AlaGly: 5.64 ± 0.108
0.988AlaHis: 0.988 ± 0.04
4.702AlaIle: 4.702 ± 0.086
5.767AlaLys: 5.767 ± 0.101
6.901AlaLeu: 6.901 ± 0.102
1.716AlaMet: 1.716 ± 0.052
2.992AlaAsn: 2.992 ± 0.058
1.875AlaPro: 1.875 ± 0.058
2.66AlaGln: 2.66 ± 0.065
2.64AlaArg: 2.64 ± 0.064
4.519AlaSer: 4.519 ± 0.087
3.097AlaThr: 3.097 ± 0.07
5.743AlaVal: 5.743 ± 0.11
0.593AlaTrp: 0.593 ± 0.031
2.25AlaTyr: 2.25 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.166CysAla: 1.166 ± 0.043
0.262CysCys: 0.262 ± 0.019
0.725CysAsp: 0.725 ± 0.033
0.832CysGlu: 0.832 ± 0.04
0.698CysPhe: 0.698 ± 0.028
1.363CysGly: 1.363 ± 0.046
0.239CysHis: 0.239 ± 0.018
0.897CysIle: 0.897 ± 0.033
0.843CysLys: 0.843 ± 0.033
1.123CysLeu: 1.123 ± 0.047
0.226CysMet: 0.226 ± 0.018
0.517CysAsn: 0.517 ± 0.027
0.566CysPro: 0.566 ± 0.031
0.349CysGln: 0.349 ± 0.024
0.633CysArg: 0.633 ± 0.03
1.016CysSer: 1.016 ± 0.039
0.72CysThr: 0.72 ± 0.03
0.924CysVal: 0.924 ± 0.034
0.116CysTrp: 0.116 ± 0.013
0.466CysTyr: 0.466 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.629AspAla: 3.629 ± 0.077
0.827AspCys: 0.827 ± 0.033
3.012AspAsp: 3.012 ± 0.086
4.786AspGlu: 4.786 ± 0.103
3.938AspPhe: 3.938 ± 0.089
4.192AspGly: 4.192 ± 0.103
0.597AspHis: 0.597 ± 0.03
3.73AspIle: 3.73 ± 0.075
3.883AspLys: 3.883 ± 0.082
4.353AspLeu: 4.353 ± 0.092
1.163AspMet: 1.163 ± 0.041
2.197AspAsn: 2.197 ± 0.079
1.621AspPro: 1.621 ± 0.058
1.035AspGln: 1.035 ± 0.039
1.872AspArg: 1.872 ± 0.049
4.588AspSer: 4.588 ± 0.112
2.456AspThr: 2.456 ± 0.067
3.32AspVal: 3.32 ± 0.076
0.706AspTrp: 0.706 ± 0.032
2.233AspTyr: 2.233 ± 0.066
0.001AspXaa: 0.001 ± 0.001
Glu
4.365GluAla: 4.365 ± 0.096
0.766GluCys: 0.766 ± 0.036
3.552GluAsp: 3.552 ± 0.076
5.723GluGlu: 5.723 ± 0.115
3.071GluPhe: 3.071 ± 0.064
3.611GluGly: 3.611 ± 0.079
0.997GluHis: 0.997 ± 0.038
5.956GluIle: 5.956 ± 0.111
8.752GluLys: 8.752 ± 0.144
6.614GluLeu: 6.614 ± 0.098
1.628GluMet: 1.628 ± 0.054
5.958GluAsn: 5.958 ± 0.113
1.891GluPro: 1.891 ± 0.067
2.685GluGln: 2.685 ± 0.068
2.725GluArg: 2.725 ± 0.067
4.067GluSer: 4.067 ± 0.086
3.673GluThr: 3.673 ± 0.085
3.652GluVal: 3.652 ± 0.079
0.678GluTrp: 0.678 ± 0.027
2.651GluTyr: 2.651 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
4.181PheAla: 4.181 ± 0.088
1.059PheCys: 1.059 ± 0.041
3.169PheAsp: 3.169 ± 0.062
3.756PheGlu: 3.756 ± 0.079
3.239PhePhe: 3.239 ± 0.084
3.39PheGly: 3.39 ± 0.074
0.614PheHis: 0.614 ± 0.029
3.681PheIle: 3.681 ± 0.078
3.131PheLys: 3.131 ± 0.065
4.651PheLeu: 4.651 ± 0.096
1.191PheMet: 1.191 ± 0.04
2.552PheAsn: 2.552 ± 0.059
1.767PhePro: 1.767 ± 0.052
1.175PheGln: 1.175 ± 0.034
1.701PheArg: 1.701 ± 0.053
4.577PheSer: 4.577 ± 0.087
2.894PheThr: 2.894 ± 0.073
3.449PheVal: 3.449 ± 0.07
0.485PheTrp: 0.485 ± 0.029
2.129PheTyr: 2.129 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.234GlyAla: 4.234 ± 0.09
0.917GlyCys: 0.917 ± 0.039
3.057GlyAsp: 3.057 ± 0.081
4.168GlyGlu: 4.168 ± 0.082
3.684GlyPhe: 3.684 ± 0.075
4.121GlyGly: 4.121 ± 0.096
1.003GlyHis: 1.003 ± 0.036
5.592GlyIle: 5.592 ± 0.104
5.874GlyLys: 5.874 ± 0.093
5.432GlyLeu: 5.432 ± 0.099
1.625GlyMet: 1.625 ± 0.056
3.231GlyAsn: 3.231 ± 0.09
1.325GlyPro: 1.325 ± 0.042
1.912GlyGln: 1.912 ± 0.048
2.565GlyArg: 2.565 ± 0.054
4.425GlySer: 4.425 ± 0.111
4.121GlyThr: 4.121 ± 0.103
3.844GlyVal: 3.844 ± 0.08
0.7GlyTrp: 0.7 ± 0.032
2.318GlyTyr: 2.318 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
0.871HisAla: 0.871 ± 0.03
0.211HisCys: 0.211 ± 0.017
0.681HisAsp: 0.681 ± 0.034
0.889HisGlu: 0.889 ± 0.039
0.883HisPhe: 0.883 ± 0.039
0.999HisGly: 0.999 ± 0.042
0.27HisHis: 0.27 ± 0.022
1.095HisIle: 1.095 ± 0.039
0.928HisLys: 0.928 ± 0.04
1.275HisLeu: 1.275 ± 0.044
0.234HisMet: 0.234 ± 0.018
0.682HisAsn: 0.682 ± 0.034
0.664HisPro: 0.664 ± 0.033
0.394HisGln: 0.394 ± 0.026
0.545HisArg: 0.545 ± 0.028
1.03HisSer: 1.03 ± 0.037
0.756HisThr: 0.756 ± 0.03
0.815HisVal: 0.815 ± 0.034
0.138HisTrp: 0.138 ± 0.015
0.598HisTyr: 0.598 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.552IleAla: 5.552 ± 0.091
1.204IleCys: 1.204 ± 0.047
4.185IleAsp: 4.185 ± 0.079
5.337IleGlu: 5.337 ± 0.1
4.201IlePhe: 4.201 ± 0.094
4.145IleGly: 4.145 ± 0.079
1.112IleHis: 1.112 ± 0.049
4.747IleIle: 4.747 ± 0.097
5.3IleLys: 5.3 ± 0.087
7.057IleLeu: 7.057 ± 0.117
1.426IleMet: 1.426 ± 0.044
3.237IleAsn: 3.237 ± 0.073
3.154IlePro: 3.154 ± 0.072
2.345IleGln: 2.345 ± 0.06
2.848IleArg: 2.848 ± 0.061
5.626IleSer: 5.626 ± 0.111
4.069IleThr: 4.069 ± 0.083
4.396IleVal: 4.396 ± 0.077
0.518IleTrp: 0.518 ± 0.028
2.436IleTyr: 2.436 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
5.357LysAla: 5.357 ± 0.088
0.74LysCys: 0.74 ± 0.036
4.487LysAsp: 4.487 ± 0.078
5.928LysGlu: 5.928 ± 0.105
3.074LysPhe: 3.074 ± 0.064
4.03LysGly: 4.03 ± 0.079
0.901LysHis: 0.901 ± 0.036
7.902LysIle: 7.902 ± 0.101
8.521LysLys: 8.521 ± 0.138
6.332LysLeu: 6.332 ± 0.1
2.346LysMet: 2.346 ± 0.059
6.937LysAsn: 6.937 ± 0.113
2.281LysPro: 2.281 ± 0.059
2.315LysGln: 2.315 ± 0.06
2.656LysArg: 2.656 ± 0.066
5.032LysSer: 5.032 ± 0.081
5.626LysThr: 5.626 ± 0.097
4.421LysVal: 4.421 ± 0.08
0.665LysTrp: 0.665 ± 0.027
2.92LysTyr: 2.92 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
6.757LeuAla: 6.757 ± 0.112
1.465LeuCys: 1.465 ± 0.046
4.74LeuAsp: 4.74 ± 0.086
6.463LeuGlu: 6.463 ± 0.115
4.636LeuPhe: 4.636 ± 0.097
5.389LeuGly: 5.389 ± 0.104
1.347LeuHis: 1.347 ± 0.045
5.775LeuIle: 5.775 ± 0.103
7.762LeuLys: 7.762 ± 0.098
7.884LeuLeu: 7.884 ± 0.144
1.908LeuMet: 1.908 ± 0.058
4.623LeuAsn: 4.623 ± 0.079
3.698LeuPro: 3.698 ± 0.071
2.631LeuGln: 2.631 ± 0.065
3.528LeuArg: 3.528 ± 0.077
7.2LeuSer: 7.2 ± 0.109
4.791LeuThr: 4.791 ± 0.087
5.254LeuVal: 5.254 ± 0.081
0.781LeuTrp: 0.781 ± 0.035
2.928LeuTyr: 2.928 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
1.897MetAla: 1.897 ± 0.052
0.23MetCys: 0.23 ± 0.019
1.222MetAsp: 1.222 ± 0.043
1.513MetGlu: 1.513 ± 0.05
0.86MetPhe: 0.86 ± 0.037
1.326MetGly: 1.326 ± 0.045
0.353MetHis: 0.353 ± 0.021
1.524MetIle: 1.524 ± 0.051
1.903MetLys: 1.903 ± 0.058
2.047MetLeu: 2.047 ± 0.053
0.509MetMet: 0.509 ± 0.027
1.445MetAsn: 1.445 ± 0.047
0.843MetPro: 0.843 ± 0.038
0.867MetGln: 0.867 ± 0.036
0.852MetArg: 0.852 ± 0.031
1.402MetSer: 1.402 ± 0.043
1.269MetThr: 1.269 ± 0.045
1.277MetVal: 1.277 ± 0.041
0.15MetTrp: 0.15 ± 0.014
0.642MetTyr: 0.642 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.923AsnAla: 3.923 ± 0.08
0.861AsnCys: 0.861 ± 0.041
2.397AsnAsp: 2.397 ± 0.06
3.536AsnGlu: 3.536 ± 0.079
3.175AsnPhe: 3.175 ± 0.065
4.115AsnGly: 4.115 ± 0.082
0.725AsnHis: 0.725 ± 0.031
3.8AsnIle: 3.8 ± 0.08
3.282AsnLys: 3.282 ± 0.064
5.078AsnLeu: 5.078 ± 0.081
1.2AsnMet: 1.2 ± 0.048
2.219AsnAsn: 2.219 ± 0.069
2.649AsnPro: 2.649 ± 0.066
1.584AsnGln: 1.584 ± 0.044
2.034AsnArg: 2.034 ± 0.058
4.464AsnSer: 4.464 ± 0.093
2.278AsnThr: 2.278 ± 0.066
3.147AsnVal: 3.147 ± 0.066
0.522AsnTrp: 0.522 ± 0.032
2.114AsnTyr: 2.114 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.745ProAla: 2.745 ± 0.067
0.395ProCys: 0.395 ± 0.023
2.169ProAsp: 2.169 ± 0.058
3.512ProGlu: 3.512 ± 0.078
1.833ProPhe: 1.833 ± 0.057
2.129ProGly: 2.129 ± 0.06
0.546ProHis: 0.546 ± 0.028
1.672ProIle: 1.672 ± 0.055
2.278ProLys: 2.278 ± 0.065
3.109ProLeu: 3.109 ± 0.078
0.644ProMet: 0.644 ± 0.034
1.297ProAsn: 1.297 ± 0.046
0.884ProPro: 0.884 ± 0.038
1.287ProGln: 1.287 ± 0.041
1.035ProArg: 1.035 ± 0.042
2.15ProSer: 2.15 ± 0.053
1.351ProThr: 1.351 ± 0.046
3.147ProVal: 3.147 ± 0.078
0.295ProTrp: 0.295 ± 0.019
1.317ProTyr: 1.317 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.145GlnAla: 2.145 ± 0.061
0.263GlnCys: 0.263 ± 0.019
1.405GlnAsp: 1.405 ± 0.043
1.967GlnGlu: 1.967 ± 0.056
1.373GlnPhe: 1.373 ± 0.044
1.429GlnGly: 1.429 ± 0.045
0.391GlnHis: 0.391 ± 0.021
2.883GlnIle: 2.883 ± 0.063
3.826GlnLys: 3.826 ± 0.08
2.624GlnLeu: 2.624 ± 0.07
0.853GlnMet: 0.853 ± 0.038
2.573GlnAsn: 2.573 ± 0.068
0.762GlnPro: 0.762 ± 0.035
1.02GlnGln: 1.02 ± 0.046
1.17GlnArg: 1.17 ± 0.035
1.865GlnSer: 1.865 ± 0.052
1.875GlnThr: 1.875 ± 0.061
1.64GlnVal: 1.64 ± 0.045
0.262GlnTrp: 0.262 ± 0.021
0.948GlnTyr: 0.948 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.368ArgAla: 2.368 ± 0.059
0.434ArgCys: 0.434 ± 0.028
1.775ArgAsp: 1.775 ± 0.054
2.501ArgGlu: 2.501 ± 0.066
1.869ArgPhe: 1.869 ± 0.057
2.131ArgGly: 2.131 ± 0.05
0.632ArgHis: 0.632 ± 0.029
3.046ArgIle: 3.046 ± 0.067
3.099ArgLys: 3.099 ± 0.068
3.541ArgLeu: 3.541 ± 0.077
1.007ArgMet: 1.007 ± 0.035
1.972ArgAsn: 1.972 ± 0.055
1.212ArgPro: 1.212 ± 0.045
1.401ArgGln: 1.401 ± 0.05
1.743ArgArg: 1.743 ± 0.058
2.261ArgSer: 2.261 ± 0.056
2.079ArgThr: 2.079 ± 0.06
2.158ArgVal: 2.158 ± 0.051
0.374ArgTrp: 0.374 ± 0.023
1.401ArgTyr: 1.401 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.377SerAla: 5.377 ± 0.102
0.855SerCys: 0.855 ± 0.032
4.093SerAsp: 4.093 ± 0.085
5.341SerGlu: 5.341 ± 0.098
3.967SerPhe: 3.967 ± 0.092
5.607SerGly: 5.607 ± 0.135
0.913SerHis: 0.913 ± 0.033
4.72SerIle: 4.72 ± 0.083
5.236SerLys: 5.236 ± 0.083
6.484SerLeu: 6.484 ± 0.092
1.218SerMet: 1.218 ± 0.045
2.908SerAsn: 2.908 ± 0.069
2.42SerPro: 2.42 ± 0.064
2.454SerGln: 2.454 ± 0.068
2.488SerArg: 2.488 ± 0.064
5.656SerSer: 5.656 ± 0.176
3.468SerThr: 3.468 ± 0.099
5.224SerVal: 5.224 ± 0.115
0.66SerTrp: 0.66 ± 0.033
2.474SerTyr: 2.474 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.421ThrAla: 4.421 ± 0.103
0.546ThrCys: 0.546 ± 0.027
3.201ThrAsp: 3.201 ± 0.072
3.89ThrGlu: 3.89 ± 0.086
2.518ThrPhe: 2.518 ± 0.068
4.413ThrGly: 4.413 ± 0.093
0.778ThrHis: 0.778 ± 0.027
3.581ThrIle: 3.581 ± 0.081
3.671ThrLys: 3.671 ± 0.076
4.748ThrLeu: 4.748 ± 0.088
1.056ThrMet: 1.056 ± 0.038
2.147ThrAsn: 2.147 ± 0.064
2.056ThrPro: 2.056 ± 0.06
1.7ThrGln: 1.7 ± 0.045
1.657ThrArg: 1.657 ± 0.051
3.35ThrSer: 3.35 ± 0.092
2.667ThrThr: 2.667 ± 0.067
4.742ThrVal: 4.742 ± 0.104
0.463ThrTrp: 0.463 ± 0.024
1.676ThrTyr: 1.676 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.525ValAla: 4.525 ± 0.082
1.051ValCys: 1.051 ± 0.037
3.317ValAsp: 3.317 ± 0.086
4.261ValGlu: 4.261 ± 0.092
3.723ValPhe: 3.723 ± 0.08
3.219ValGly: 3.219 ± 0.073
0.867ValHis: 0.867 ± 0.035
4.563ValIle: 4.563 ± 0.09
4.871ValLys: 4.871 ± 0.087
6.341ValLeu: 6.341 ± 0.108
1.291ValMet: 1.291 ± 0.05
3.038ValAsn: 3.038 ± 0.065
2.659ValPro: 2.659 ± 0.059
2.138ValGln: 2.138 ± 0.054
2.457ValArg: 2.457 ± 0.064
4.827ValSer: 4.827 ± 0.098
3.561ValThr: 3.561 ± 0.082
4.127ValVal: 4.127 ± 0.096
0.605ValTrp: 0.605 ± 0.031
2.319ValTyr: 2.319 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.586TrpAla: 0.586 ± 0.032
0.131TrpCys: 0.131 ± 0.013
0.494TrpAsp: 0.494 ± 0.03
0.554TrpGlu: 0.554 ± 0.027
0.515TrpPhe: 0.515 ± 0.027
0.531TrpGly: 0.531 ± 0.027
0.171TrpHis: 0.171 ± 0.014
0.678TrpIle: 0.678 ± 0.032
0.831TrpLys: 0.831 ± 0.036
0.804TrpLeu: 0.804 ± 0.033
0.198TrpMet: 0.198 ± 0.017
0.712TrpAsn: 0.712 ± 0.033
0.239TrpPro: 0.239 ± 0.019
0.409TrpGln: 0.409 ± 0.025
0.365TrpArg: 0.365 ± 0.024
0.537TrpSer: 0.537 ± 0.03
0.561TrpThr: 0.561 ± 0.029
0.413TrpVal: 0.413 ± 0.023
0.112TrpTrp: 0.112 ± 0.013
0.366TrpTyr: 0.366 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.402TyrAla: 2.402 ± 0.056
0.501TyrCys: 0.501 ± 0.024
2.133TyrAsp: 2.133 ± 0.061
2.397TyrGlu: 2.397 ± 0.062
2.064TyrPhe: 2.064 ± 0.055
2.368TyrGly: 2.368 ± 0.055
0.51TyrHis: 0.51 ± 0.027
2.35TyrIle: 2.35 ± 0.068
2.715TyrLys: 2.715 ± 0.059
3.162TyrLeu: 3.162 ± 0.079
0.688TyrMet: 0.688 ± 0.026
1.867TyrAsn: 1.867 ± 0.066
1.23TyrPro: 1.23 ± 0.045
0.913TyrGln: 0.913 ± 0.039
1.49TyrArg: 1.49 ± 0.052
2.971TyrSer: 2.971 ± 0.079
1.974TyrThr: 1.974 ± 0.055
2.068TyrVal: 2.068 ± 0.05
0.383TyrTrp: 0.383 ± 0.023
1.451TyrTyr: 1.451 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.001
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.004
Statistics based on 2163 proteins (748883 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski