Amino acid dipepetide frequency for Altererythrobacter sp. HN-Y73

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.654AlaAla: 14.654 ± 0.16	1.023AlaCys: 1.023 ± 0.031	6.891AlaAsp: 6.891 ± 0.101	7.628AlaGlu: 7.628 ± 0.101	4.014AlaPhe: 4.014 ± 0.067	10.004AlaGly: 10.004 ± 0.123	2.227AlaHis: 2.227 ± 0.048	6.466AlaIle: 6.466 ± 0.09	3.756AlaLys: 3.756 ± 0.069	12.627AlaLeu: 12.627 ± 0.144	3.609AlaMet: 3.609 ± 0.063	3.156AlaAsn: 3.156 ± 0.062	5.368AlaPro: 5.368 ± 0.091	4.556AlaGln: 4.556 ± 0.074	8.26AlaArg: 8.26 ± 0.119	6.6AlaSer: 6.6 ± 0.092	5.381AlaThr: 5.381 ± 0.086	7.384AlaVal: 7.384 ± 0.079	1.378AlaTrp: 1.378 ± 0.038	2.623AlaTyr: 2.623 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.996CysAla: 0.996 ± 0.033	0.131CysCys: 0.131 ± 0.012	0.597CysAsp: 0.597 ± 0.025	0.475CysGlu: 0.475 ± 0.018	0.324CysPhe: 0.324 ± 0.016	0.94CysGly: 0.94 ± 0.033	0.232CysHis: 0.232 ± 0.015	0.4CysIle: 0.4 ± 0.017	0.217CysLys: 0.217 ± 0.016	0.747CysLeu: 0.747 ± 0.027	0.166CysMet: 0.166 ± 0.012	0.25CysAsn: 0.25 ± 0.015	0.45CysPro: 0.45 ± 0.022	0.215CysGln: 0.215 ± 0.013	0.549CysArg: 0.549 ± 0.026	0.528CysSer: 0.528 ± 0.026	0.426CysThr: 0.426 ± 0.022	0.54CysVal: 0.54 ± 0.022	0.135CysTrp: 0.135 ± 0.012	0.192CysTyr: 0.192 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.711AspAla: 6.711 ± 0.112	0.546AspCys: 0.546 ± 0.026	3.683AspAsp: 3.683 ± 0.085	3.814AspGlu: 3.814 ± 0.071	2.402AspPhe: 2.402 ± 0.046	5.641AspGly: 5.641 ± 0.151	1.43AspHis: 1.43 ± 0.041	3.476AspIle: 3.476 ± 0.056	2.103AspLys: 2.103 ± 0.043	5.905AspLeu: 5.905 ± 0.088	1.657AspMet: 1.657 ± 0.037	1.838AspAsn: 1.838 ± 0.049	3.649AspPro: 3.649 ± 0.06	1.868AspGln: 1.868 ± 0.047	4.752AspArg: 4.752 ± 0.078	2.979AspSer: 2.979 ± 0.055	3.028AspThr: 3.028 ± 0.052	3.877AspVal: 3.877 ± 0.069	1.136AspTrp: 1.136 ± 0.033	1.911AspTyr: 1.911 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.636GluAla: 7.636 ± 0.1	0.408GluCys: 0.408 ± 0.02	3.507GluAsp: 3.507 ± 0.066	4.136GluGlu: 4.136 ± 0.09	1.763GluPhe: 1.763 ± 0.043	4.822GluGly: 4.822 ± 0.078	1.18GluHis: 1.18 ± 0.031	3.128GluIle: 3.128 ± 0.059	2.858GluLys: 2.858 ± 0.063	5.528GluLeu: 5.528 ± 0.078	1.588GluMet: 1.588 ± 0.042	2.04GluAsn: 2.04 ± 0.055	2.713GluPro: 2.713 ± 0.059	2.545GluGln: 2.545 ± 0.049	4.892GluArg: 4.892 ± 0.091	2.841GluSer: 2.841 ± 0.055	3.581GluThr: 3.581 ± 0.055	3.634GluVal: 3.634 ± 0.061	0.981GluTrp: 0.981 ± 0.034	1.22GluTyr: 1.22 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.577PheAla: 4.577 ± 0.069	0.364PheCys: 0.364 ± 0.02	2.763PheAsp: 2.763 ± 0.05	2.156PheGlu: 2.156 ± 0.046	1.392PhePhe: 1.392 ± 0.04	3.666PheGly: 3.666 ± 0.076	0.747PheHis: 0.747 ± 0.028	1.681PheIle: 1.681 ± 0.042	0.919PheLys: 0.919 ± 0.035	3.248PheLeu: 3.248 ± 0.07	0.821PheMet: 0.821 ± 0.029	1.162PheAsn: 1.162 ± 0.034	1.621PhePro: 1.621 ± 0.041	0.978PheGln: 0.978 ± 0.03	2.239PheArg: 2.239 ± 0.049	2.238PheSer: 2.238 ± 0.044	2.258PheThr: 2.258 ± 0.051	2.451PheVal: 2.451 ± 0.053	0.567PheTrp: 0.567 ± 0.024	0.999PheTyr: 0.999 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.519GlyAla: 8.519 ± 0.119	0.812GlyCys: 0.812 ± 0.032	5.071GlyAsp: 5.071 ± 0.144	5.18GlyGlu: 5.18 ± 0.068	3.627GlyPhe: 3.627 ± 0.069	7.338GlyGly: 7.338 ± 0.129	1.894GlyHis: 1.894 ± 0.049	4.433GlyIle: 4.433 ± 0.067	3.565GlyLys: 3.565 ± 0.057	8.357GlyLeu: 8.357 ± 0.116	2.394GlyMet: 2.394 ± 0.05	2.472GlyAsn: 2.472 ± 0.055	3.529GlyPro: 3.529 ± 0.062	3.137GlyGln: 3.137 ± 0.056	5.635GlyArg: 5.635 ± 0.081	5.064GlySer: 5.064 ± 0.091	4.867GlyThr: 4.867 ± 0.104	5.533GlyVal: 5.533 ± 0.083	1.472GlyTrp: 1.472 ± 0.04	2.341GlyTyr: 2.341 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.097HisAla: 2.097 ± 0.05	0.279HisCys: 0.279 ± 0.017	1.207HisAsp: 1.207 ± 0.033	1.139HisGlu: 1.139 ± 0.039	0.897HisPhe: 0.897 ± 0.027	1.903HisGly: 1.903 ± 0.046	0.581HisHis: 0.581 ± 0.026	1.199HisIle: 1.199 ± 0.037	0.596HisLys: 0.596 ± 0.023	1.905HisLeu: 1.905 ± 0.049	0.497HisMet: 0.497 ± 0.024	0.551HisAsn: 0.551 ± 0.022	1.326HisPro: 1.326 ± 0.034	0.584HisGln: 0.584 ± 0.022	1.502HisArg: 1.502 ± 0.042	1.137HisSer: 1.137 ± 0.036	0.831HisThr: 0.831 ± 0.031	1.333HisVal: 1.333 ± 0.039	0.432HisTrp: 0.432 ± 0.022	0.64HisTyr: 0.64 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.359IleAla: 7.359 ± 0.093	0.514IleCys: 0.514 ± 0.023	3.926IleAsp: 3.926 ± 0.057	3.726IleGlu: 3.726 ± 0.06	1.846IlePhe: 1.846 ± 0.044	5.053IleGly: 5.053 ± 0.077	0.957IleHis: 0.957 ± 0.034	2.403IleIle: 2.403 ± 0.059	1.309IleLys: 1.309 ± 0.04	4.33IleLeu: 4.33 ± 0.065	1.032IleMet: 1.032 ± 0.033	1.453IleAsn: 1.453 ± 0.039	2.405IlePro: 2.405 ± 0.052	1.248IleGln: 1.248 ± 0.034	3.38IleArg: 3.38 ± 0.058	3.167IleSer: 3.167 ± 0.058	2.797IleThr: 2.797 ± 0.062	3.902IleVal: 3.902 ± 0.067	0.706IleTrp: 0.706 ± 0.025	1.16IleTyr: 1.16 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.233LysAla: 4.233 ± 0.071	0.188LysCys: 0.188 ± 0.013	1.902LysAsp: 1.902 ± 0.04	1.718LysGlu: 1.718 ± 0.042	0.849LysPhe: 0.849 ± 0.029	2.909LysGly: 2.909 ± 0.058	0.605LysHis: 0.605 ± 0.022	1.664LysIle: 1.664 ± 0.042	1.355LysLys: 1.355 ± 0.049	3.373LysLeu: 3.373 ± 0.062	0.847LysMet: 0.847 ± 0.029	0.943LysAsn: 0.943 ± 0.029	2.069LysPro: 2.069 ± 0.046	1.204LysGln: 1.204 ± 0.037	2.518LysArg: 2.518 ± 0.048	1.778LysSer: 1.778 ± 0.046	1.822LysThr: 1.822 ± 0.041	2.208LysVal: 2.208 ± 0.045	0.436LysTrp: 0.436 ± 0.02	0.619LysTyr: 0.619 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.649LeuAla: 12.649 ± 0.145	0.876LeuCys: 0.876 ± 0.031	6.241LeuAsp: 6.241 ± 0.084	5.432LeuGlu: 5.432 ± 0.083	3.761LeuPhe: 3.761 ± 0.071	7.794LeuGly: 7.794 ± 0.099	1.96LeuHis: 1.96 ± 0.036	5.078LeuIle: 5.078 ± 0.071	3.028LeuLys: 3.028 ± 0.057	9.272LeuLeu: 9.272 ± 0.135	2.229LeuMet: 2.229 ± 0.055	2.689LeuAsn: 2.689 ± 0.051	5.45LeuPro: 5.45 ± 0.076	2.885LeuGln: 2.885 ± 0.058	6.643LeuArg: 6.643 ± 0.088	6.651LeuSer: 6.651 ± 0.078	5.804LeuThr: 5.804 ± 0.087	6.532LeuVal: 6.532 ± 0.091	1.22LeuTrp: 1.22 ± 0.04	2.13LeuTyr: 2.13 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.296MetAla: 3.296 ± 0.054	0.157MetCys: 0.157 ± 0.013	1.274MetAsp: 1.274 ± 0.035	1.36MetGlu: 1.36 ± 0.043	0.661MetPhe: 0.661 ± 0.025	1.978MetGly: 1.978 ± 0.05	0.478MetHis: 0.478 ± 0.02	1.387MetIle: 1.387 ± 0.038	1.037MetLys: 1.037 ± 0.032	2.604MetLeu: 2.604 ± 0.056	0.717MetMet: 0.717 ± 0.025	0.769MetAsn: 0.769 ± 0.025	1.478MetPro: 1.478 ± 0.037	0.929MetGln: 0.929 ± 0.029	1.832MetArg: 1.832 ± 0.04	1.6MetSer: 1.6 ± 0.038	1.602MetThr: 1.602 ± 0.037	1.633MetVal: 1.633 ± 0.043	0.21MetTrp: 0.21 ± 0.014	0.3MetTyr: 0.3 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.371AsnAla: 3.371 ± 0.058	0.268AsnCys: 0.268 ± 0.014	1.689AsnAsp: 1.689 ± 0.052	1.368AsnGlu: 1.368 ± 0.04	1.094AsnPhe: 1.094 ± 0.03	2.702AsnGly: 2.702 ± 0.062	0.511AsnHis: 0.511 ± 0.022	1.587AsnIle: 1.587 ± 0.047	0.747AsnLys: 0.747 ± 0.021	2.772AsnLeu: 2.772 ± 0.058	0.72AsnMet: 0.72 ± 0.03	0.803AsnAsn: 0.803 ± 0.029	1.877AsnPro: 1.877 ± 0.05	0.853AsnGln: 0.853 ± 0.029	2.146AsnArg: 2.146 ± 0.048	1.612AsnSer: 1.612 ± 0.053	1.337AsnThr: 1.337 ± 0.04	1.991AsnVal: 1.991 ± 0.057	0.516AsnTrp: 0.516 ± 0.021	0.8AsnTyr: 0.8 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.009ProAla: 6.009 ± 0.092	0.351ProCys: 0.351 ± 0.02	4.115ProAsp: 4.115 ± 0.073	4.109ProGlu: 4.109 ± 0.071	1.99ProPhe: 1.99 ± 0.041	4.277ProGly: 4.277 ± 0.065	1.055ProHis: 1.055 ± 0.035	2.258ProIle: 2.258 ± 0.044	1.515ProLys: 1.515 ± 0.04	4.799ProLeu: 4.799 ± 0.069	1.119ProMet: 1.119 ± 0.03	1.275ProAsn: 1.275 ± 0.03	2.49ProPro: 2.49 ± 0.074	1.852ProGln: 1.852 ± 0.043	2.761ProArg: 2.761 ± 0.059	2.843ProSer: 2.843 ± 0.056	2.232ProThr: 2.232 ± 0.044	4.126ProVal: 4.126 ± 0.066	0.665ProTrp: 0.665 ± 0.025	1.143ProTyr: 1.143 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.188GlnAla: 4.188 ± 0.073	0.269GlnCys: 0.269 ± 0.017	1.906GlnAsp: 1.906 ± 0.045	1.803GlnGlu: 1.803 ± 0.045	1.177GlnPhe: 1.177 ± 0.037	2.615GlnGly: 2.615 ± 0.051	0.697GlnHis: 0.697 ± 0.024	1.893GlnIle: 1.893 ± 0.043	1.127GlnLys: 1.127 ± 0.038	3.334GlnLeu: 3.334 ± 0.067	0.904GlnMet: 0.904 ± 0.03	0.973GlnAsn: 0.973 ± 0.031	1.747GlnPro: 1.747 ± 0.041	1.433GlnGln: 1.433 ± 0.047	2.543GlnArg: 2.543 ± 0.057	2.126GlnSer: 2.126 ± 0.046	1.846GlnThr: 1.846 ± 0.043	2.27GlnVal: 2.27 ± 0.051	0.499GlnTrp: 0.499 ± 0.023	0.71GlnTyr: 0.71 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.177ArgAla: 7.177 ± 0.097	0.5ArgCys: 0.5 ± 0.024	4.204ArgAsp: 4.204 ± 0.076	4.448ArgGlu: 4.448 ± 0.086	3.122ArgPhe: 3.122 ± 0.051	4.492ArgGly: 4.492 ± 0.074	1.752ArgHis: 1.752 ± 0.045	4.032ArgIle: 4.032 ± 0.059	2.691ArgLys: 2.691 ± 0.052	7.686ArgLeu: 7.686 ± 0.114	1.872ArgMet: 1.872 ± 0.04	2.183ArgAsn: 2.183 ± 0.048	3.273ArgPro: 3.273 ± 0.066	2.632ArgGln: 2.632 ± 0.058	5.162ArgArg: 5.162 ± 0.094	3.912ArgSer: 3.912 ± 0.068	3.101ArgThr: 3.101 ± 0.048	4.119ArgVal: 4.119 ± 0.067	1.146ArgTrp: 1.146 ± 0.035	1.873ArgTyr: 1.873 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.615SerAla: 6.615 ± 0.1	0.468SerCys: 0.468 ± 0.019	3.896SerAsp: 3.896 ± 0.078	3.373SerGlu: 3.373 ± 0.058	2.409SerPhe: 2.409 ± 0.047	5.841SerGly: 5.841 ± 0.092	1.168SerHis: 1.168 ± 0.032	2.886SerIle: 2.886 ± 0.055	1.639SerLys: 1.639 ± 0.043	5.772SerLeu: 5.772 ± 0.083	1.382SerMet: 1.382 ± 0.037	1.526SerAsn: 1.526 ± 0.043	2.978SerPro: 2.978 ± 0.049	1.861SerGln: 1.861 ± 0.047	3.794SerArg: 3.794 ± 0.064	3.51SerSer: 3.51 ± 0.081	2.773SerThr: 2.773 ± 0.048	3.834SerVal: 3.834 ± 0.073	0.887SerTrp: 0.887 ± 0.027	1.599SerTyr: 1.599 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.925ThrAla: 5.925 ± 0.083	0.412ThrCys: 0.412 ± 0.021	3.033ThrAsp: 3.033 ± 0.058	2.719ThrGlu: 2.719 ± 0.05	1.834ThrPhe: 1.834 ± 0.047	5.337ThrGly: 5.337 ± 0.079	1.04ThrHis: 1.04 ± 0.032	3.136ThrIle: 3.136 ± 0.069	1.399ThrLys: 1.399 ± 0.036	5.619ThrLeu: 5.619 ± 0.085	1.174ThrMet: 1.174 ± 0.03	1.397ThrAsn: 1.397 ± 0.039	3.221ThrPro: 3.221 ± 0.059	1.662ThrGln: 1.662 ± 0.043	3.37ThrArg: 3.37 ± 0.051	2.923ThrSer: 2.923 ± 0.06	2.507ThrThr: 2.507 ± 0.053	3.881ThrVal: 3.881 ± 0.078	0.558ThrTrp: 0.558 ± 0.023	1.338ThrTyr: 1.338 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.649ValAla: 7.649 ± 0.101	0.53ValCys: 0.53 ± 0.021	4.109ValAsp: 4.109 ± 0.066	4.335ValGlu: 4.335 ± 0.065	2.173ValPhe: 2.173 ± 0.046	4.747ValGly: 4.747 ± 0.073	1.226ValHis: 1.226 ± 0.032	3.744ValIle: 3.744 ± 0.074	2.213ValLys: 2.213 ± 0.049	6.491ValLeu: 6.491 ± 0.083	1.714ValMet: 1.714 ± 0.042	2.012ValAsn: 2.012 ± 0.053	3.52ValPro: 3.52 ± 0.065	2.129ValGln: 2.129 ± 0.042	4.131ValArg: 4.131 ± 0.078	4.323ValSer: 4.323 ± 0.081	4.323ValThr: 4.323 ± 0.102	4.376ValVal: 4.376 ± 0.066	0.819ValTrp: 0.819 ± 0.025	1.377ValTyr: 1.377 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.34TrpAla: 1.34 ± 0.039	0.142TrpCys: 0.142 ± 0.011	0.712TrpAsp: 0.712 ± 0.031	0.685TrpGlu: 0.685 ± 0.027	0.56TrpPhe: 0.56 ± 0.025	0.937TrpGly: 0.937 ± 0.032	0.37TrpHis: 0.37 ± 0.021	0.762TrpIle: 0.762 ± 0.029	0.499TrpLys: 0.499 ± 0.022	1.812TrpLeu: 1.812 ± 0.045	0.377TrpMet: 0.377 ± 0.019	0.497TrpAsn: 0.497 ± 0.021	0.7TrpPro: 0.7 ± 0.03	0.719TrpGln: 0.719 ± 0.03	1.239TrpArg: 1.239 ± 0.043	0.915TrpSer: 0.915 ± 0.028	0.771TrpThr: 0.771 ± 0.028	0.789TrpVal: 0.789 ± 0.027	0.245TrpTrp: 0.245 ± 0.016	0.293TrpTyr: 0.293 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.605TyrAla: 2.605 ± 0.045	0.272TyrCys: 0.272 ± 0.016	1.677TyrAsp: 1.677 ± 0.048	1.394TyrGlu: 1.394 ± 0.043	0.95TyrPhe: 0.95 ± 0.035	2.245TyrGly: 2.245 ± 0.05	0.525TyrHis: 0.525 ± 0.022	1.06TyrIle: 1.06 ± 0.036	0.667TyrLys: 0.667 ± 0.025	2.144TyrLeu: 2.144 ± 0.054	0.483TyrMet: 0.483 ± 0.018	0.778TyrAsn: 0.778 ± 0.033	1.121TyrPro: 1.121 ± 0.034	0.771TyrGln: 0.771 ± 0.029	2.029TyrArg: 2.029 ± 0.044	1.465TyrSer: 1.465 ± 0.043	1.196TyrThr: 1.196 ± 0.041	1.525TyrVal: 1.525 ± 0.046	0.359TyrTrp: 0.359 ± 0.018	0.763TyrTyr: 0.763 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3349 proteins (1079632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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