Amino acid dipepetide frequency for Gloeobacter kilaueensis JS1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.694AlaAla: 13.694 ± 0.145
1.056AlaCys: 1.056 ± 0.03
5.416AlaAsp: 5.416 ± 0.085
6.385AlaGlu: 6.385 ± 0.082
3.651AlaPhe: 3.651 ± 0.058
9.058AlaGly: 9.058 ± 0.099
2.045AlaHis: 2.045 ± 0.042
5.968AlaIle: 5.968 ± 0.067
2.586AlaLys: 2.586 ± 0.051
13.668AlaLeu: 13.668 ± 0.134
1.772AlaMet: 1.772 ± 0.039
2.873AlaAsn: 2.873 ± 0.054
5.11AlaPro: 5.11 ± 0.091
5.405AlaGln: 5.405 ± 0.075
7.388AlaArg: 7.388 ± 0.088
5.85AlaSer: 5.85 ± 0.061
5.367AlaThr: 5.367 ± 0.065
8.262AlaVal: 8.262 ± 0.088
1.261AlaTrp: 1.261 ± 0.038
2.515AlaTyr: 2.515 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.912CysAla: 0.912 ± 0.028
0.156CysCys: 0.156 ± 0.012
0.491CysAsp: 0.491 ± 0.018
0.575CysGlu: 0.575 ± 0.024
0.374CysPhe: 0.374 ± 0.016
0.855CysGly: 0.855 ± 0.025
0.242CysHis: 0.242 ± 0.014
0.414CysIle: 0.414 ± 0.016
0.188CysLys: 0.188 ± 0.01
1.214CysLeu: 1.214 ± 0.031
0.104CysMet: 0.104 ± 0.008
0.275CysAsn: 0.275 ± 0.015
0.623CysPro: 0.623 ± 0.025
0.359CysGln: 0.359 ± 0.015
0.815CysArg: 0.815 ± 0.027
0.578CysSer: 0.578 ± 0.021
0.47CysThr: 0.47 ± 0.019
0.559CysVal: 0.559 ± 0.021
0.171CysTrp: 0.171 ± 0.01
0.298CysTyr: 0.298 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.517AspAla: 4.517 ± 0.056
0.517AspCys: 0.517 ± 0.018
2.221AspAsp: 2.221 ± 0.048
3.031AspGlu: 3.031 ± 0.056
2.079AspPhe: 2.079 ± 0.039
4.457AspGly: 4.457 ± 0.07
0.85AspHis: 0.85 ± 0.025
2.387AspIle: 2.387 ± 0.049
1.286AspLys: 1.286 ± 0.03
6.342AspLeu: 6.342 ± 0.094
0.6AspMet: 0.6 ± 0.025
1.438AspAsn: 1.438 ± 0.035
3.509AspPro: 3.509 ± 0.056
1.967AspGln: 1.967 ± 0.036
3.909AspArg: 3.909 ± 0.052
2.798AspSer: 2.798 ± 0.047
2.275AspThr: 2.275 ± 0.048
2.799AspVal: 2.799 ± 0.044
1.062AspTrp: 1.062 ± 0.033
1.687AspTyr: 1.687 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.236GluAla: 7.236 ± 0.09
0.436GluCys: 0.436 ± 0.021
2.352GluAsp: 2.352 ± 0.043
3.492GluGlu: 3.492 ± 0.077
1.696GluPhe: 1.696 ± 0.036
3.785GluGly: 3.785 ± 0.058
1.169GluHis: 1.169 ± 0.031
2.728GluIle: 2.728 ± 0.048
2.169GluLys: 2.169 ± 0.047
6.489GluLeu: 6.489 ± 0.077
1.014GluMet: 1.014 ± 0.029
1.595GluAsn: 1.595 ± 0.043
3.02GluPro: 3.02 ± 0.075
3.993GluGln: 3.993 ± 0.069
5.924GluArg: 5.924 ± 0.086
2.829GluSer: 2.829 ± 0.053
2.575GluThr: 2.575 ± 0.05
4.187GluVal: 4.187 ± 0.059
0.769GluTrp: 0.769 ± 0.023
1.367GluTyr: 1.367 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.253PheAla: 4.253 ± 0.055
0.51PheCys: 0.51 ± 0.02
2.435PheAsp: 2.435 ± 0.045
2.416PheGlu: 2.416 ± 0.048
1.561PhePhe: 1.561 ± 0.035
3.19PheGly: 3.19 ± 0.048
0.607PheHis: 0.607 ± 0.021
1.628PheIle: 1.628 ± 0.037
1.112PheLys: 1.112 ± 0.032
3.656PheLeu: 3.656 ± 0.062
0.47PheMet: 0.47 ± 0.018
1.329PheAsn: 1.329 ± 0.039
1.46PhePro: 1.46 ± 0.036
1.374PheGln: 1.374 ± 0.026
2.048PheArg: 2.048 ± 0.041
2.534PheSer: 2.534 ± 0.049
1.93PheThr: 1.93 ± 0.04
2.798PheVal: 2.798 ± 0.048
0.715PheTrp: 0.715 ± 0.022
1.229PheTyr: 1.229 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
7.175GlyAla: 7.175 ± 0.104
0.873GlyCys: 0.873 ± 0.026
3.935GlyAsp: 3.935 ± 0.078
4.751GlyGlu: 4.751 ± 0.07
3.12GlyPhe: 3.12 ± 0.044
6.622GlyGly: 6.622 ± 0.111
1.522GlyHis: 1.522 ± 0.04
4.099GlyIle: 4.099 ± 0.057
2.847GlyLys: 2.847 ± 0.048
8.535GlyLeu: 8.535 ± 0.08
1.372GlyMet: 1.372 ± 0.032
2.572GlyAsn: 2.572 ± 0.058
3.103GlyPro: 3.103 ± 0.052
3.539GlyGln: 3.539 ± 0.062
5.564GlyArg: 5.564 ± 0.069
5.374GlySer: 5.374 ± 0.075
4.73GlyThr: 4.73 ± 0.085
5.216GlyVal: 5.216 ± 0.07
1.421GlyTrp: 1.421 ± 0.034
2.391GlyTyr: 2.391 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.363HisAla: 1.363 ± 0.033
0.291HisCys: 0.291 ± 0.013
0.822HisAsp: 0.822 ± 0.025
0.808HisGlu: 0.808 ± 0.027
0.95HisPhe: 0.95 ± 0.028
1.216HisGly: 1.216 ± 0.031
0.505HisHis: 0.505 ± 0.022
0.852HisIle: 0.852 ± 0.027
0.457HisLys: 0.457 ± 0.018
2.511HisLeu: 2.511 ± 0.054
0.227HisMet: 0.227 ± 0.013
0.54HisAsn: 0.54 ± 0.022
1.416HisPro: 1.416 ± 0.035
0.741HisGln: 0.741 ± 0.026
1.498HisArg: 1.498 ± 0.031
1.088HisSer: 1.088 ± 0.029
0.946HisThr: 0.946 ± 0.029
0.835HisVal: 0.835 ± 0.027
0.413HisTrp: 0.413 ± 0.019
0.701HisTyr: 0.701 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.285IleAla: 6.285 ± 0.081
0.528IleCys: 0.528 ± 0.021
3.557IleAsp: 3.557 ± 0.054
3.804IleGlu: 3.804 ± 0.054
1.718IlePhe: 1.718 ± 0.036
3.8IleGly: 3.8 ± 0.057
0.931IleHis: 0.931 ± 0.026
1.554IleIle: 1.554 ± 0.04
1.438IleLys: 1.438 ± 0.036
4.656IleLeu: 4.656 ± 0.055
0.376IleMet: 0.376 ± 0.015
1.416IleAsn: 1.416 ± 0.041
2.378IlePro: 2.378 ± 0.05
1.759IleGln: 1.759 ± 0.034
3.004IleArg: 3.004 ± 0.052
2.489IleSer: 2.489 ± 0.049
2.416IleThr: 2.416 ± 0.047
3.962IleVal: 3.962 ± 0.059
0.608IleTrp: 0.608 ± 0.022
1.335IleTyr: 1.335 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.086LysAla: 3.086 ± 0.052
0.166LysCys: 0.166 ± 0.011
1.497LysAsp: 1.497 ± 0.037
1.561LysGlu: 1.561 ± 0.036
0.908LysPhe: 0.908 ± 0.027
1.976LysGly: 1.976 ± 0.042
0.48LysHis: 0.48 ± 0.017
1.579LysIle: 1.579 ± 0.041
1.204LysLys: 1.204 ± 0.032
3.588LysLeu: 3.588 ± 0.056
0.539LysMet: 0.539 ± 0.019
1.009LysAsn: 1.009 ± 0.029
1.836LysPro: 1.836 ± 0.046
1.433LysGln: 1.433 ± 0.039
1.831LysArg: 1.831 ± 0.039
1.775LysSer: 1.775 ± 0.039
1.592LysThr: 1.592 ± 0.034
2.142LysVal: 2.142 ± 0.042
0.275LysTrp: 0.275 ± 0.014
0.693LysTyr: 0.693 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
14.197LeuAla: 14.197 ± 0.145
1.08LeuCys: 1.08 ± 0.036
5.878LeuAsp: 5.878 ± 0.079
7.023LeuGlu: 7.023 ± 0.088
4.031LeuPhe: 4.031 ± 0.062
9.018LeuGly: 9.018 ± 0.094
2.046LeuHis: 2.046 ± 0.047
5.286LeuIle: 5.286 ± 0.067
4.068LeuLys: 4.068 ± 0.055
13.357LeuLeu: 13.357 ± 0.136
1.738LeuMet: 1.738 ± 0.041
3.151LeuAsn: 3.151 ± 0.051
7.13LeuPro: 7.13 ± 0.091
5.218LeuGln: 5.218 ± 0.08
7.855LeuArg: 7.855 ± 0.095
7.523LeuSer: 7.523 ± 0.084
6.112LeuThr: 6.112 ± 0.081
8.999LeuVal: 8.999 ± 0.113
1.671LeuTrp: 1.671 ± 0.043
2.804LeuTyr: 2.804 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.79MetAla: 1.79 ± 0.034
0.085MetCys: 0.085 ± 0.009
0.666MetAsp: 0.666 ± 0.023
0.732MetGlu: 0.732 ± 0.024
0.449MetPhe: 0.449 ± 0.02
1.287MetGly: 1.287 ± 0.032
0.29MetHis: 0.29 ± 0.015
0.719MetIle: 0.719 ± 0.023
0.556MetLys: 0.556 ± 0.022
1.661MetLeu: 1.661 ± 0.033
0.222MetMet: 0.222 ± 0.012
0.562MetAsn: 0.562 ± 0.019
0.878MetPro: 0.878 ± 0.026
0.732MetGln: 0.732 ± 0.021
1.028MetArg: 1.028 ± 0.028
1.104MetSer: 1.104 ± 0.028
0.888MetThr: 0.888 ± 0.024
1.104MetVal: 1.104 ± 0.029
0.098MetTrp: 0.098 ± 0.009
0.259MetTyr: 0.259 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.554AsnAla: 2.554 ± 0.046
0.32AsnCys: 0.32 ± 0.016
1.214AsnAsp: 1.214 ± 0.033
1.105AsnGlu: 1.105 ± 0.027
1.31AsnPhe: 1.31 ± 0.037
2.443AsnGly: 2.443 ± 0.056
0.491AsnHis: 0.491 ± 0.021
1.409AsnIle: 1.409 ± 0.038
0.708AsnLys: 0.708 ± 0.025
3.858AsnLeu: 3.858 ± 0.062
0.347AsnMet: 0.347 ± 0.016
1.023AsnAsn: 1.023 ± 0.036
2.185AsnPro: 2.185 ± 0.044
1.242AsnGln: 1.242 ± 0.035
2.242AsnArg: 2.242 ± 0.042
1.682AsnSer: 1.682 ± 0.041
1.538AsnThr: 1.538 ± 0.038
1.794AsnVal: 1.794 ± 0.045
0.545AsnTrp: 0.545 ± 0.022
0.914AsnTyr: 0.914 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
6.602ProAla: 6.602 ± 0.091
0.366ProCys: 0.366 ± 0.018
3.46ProAsp: 3.46 ± 0.05
4.185ProGlu: 4.185 ± 0.073
2.017ProPhe: 2.017 ± 0.045
4.543ProGly: 4.543 ± 0.057
0.927ProHis: 0.927 ± 0.025
2.331ProIle: 2.331 ± 0.044
1.415ProLys: 1.415 ± 0.039
6.089ProLeu: 6.089 ± 0.078
0.902ProMet: 0.902 ± 0.023
1.514ProAsn: 1.514 ± 0.038
3.477ProPro: 3.477 ± 0.084
2.33ProGln: 2.33 ± 0.051
2.818ProArg: 2.818 ± 0.046
2.886ProSer: 2.886 ± 0.057
2.928ProThr: 2.928 ± 0.053
4.657ProVal: 4.657 ± 0.055
0.727ProTrp: 0.727 ± 0.025
1.402ProTyr: 1.402 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
5.235GlnAla: 5.235 ± 0.069
0.28GlnCys: 0.28 ± 0.015
1.623GlnAsp: 1.623 ± 0.04
2.23GlnGlu: 2.23 ± 0.048
1.615GlnPhe: 1.615 ± 0.036
2.988GlnGly: 2.988 ± 0.05
0.666GlnHis: 0.666 ± 0.024
2.833GlnIle: 2.833 ± 0.045
1.691GlnLys: 1.691 ± 0.04
6.037GlnLeu: 6.037 ± 0.091
0.986GlnMet: 0.986 ± 0.033
1.293GlnAsn: 1.293 ± 0.03
2.944GlnPro: 2.944 ± 0.062
2.952GlnGln: 2.952 ± 0.057
3.113GlnArg: 3.113 ± 0.052
2.551GlnSer: 2.551 ± 0.051
2.45GlnThr: 2.45 ± 0.04
3.654GlnVal: 3.654 ± 0.056
0.642GlnTrp: 0.642 ± 0.021
1.014GlnTyr: 1.014 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
6.613ArgAla: 6.613 ± 0.085
0.725ArgCys: 0.725 ± 0.023
2.932ArgAsp: 2.932 ± 0.052
3.976ArgGlu: 3.976 ± 0.054
3.049ArgPhe: 3.049 ± 0.053
4.214ArgGly: 4.214 ± 0.061
1.357ArgHis: 1.357 ± 0.032
3.633ArgIle: 3.633 ± 0.06
1.831ArgLys: 1.831 ± 0.04
9.344ArgLeu: 9.344 ± 0.129
1.303ArgMet: 1.303 ± 0.032
1.829ArgAsn: 1.829 ± 0.04
3.762ArgPro: 3.762 ± 0.052
3.709ArgGln: 3.709 ± 0.06
5.667ArgArg: 5.667 ± 0.086
4.566ArgSer: 4.566 ± 0.061
4.001ArgThr: 4.001 ± 0.057
4.476ArgVal: 4.476 ± 0.066
1.322ArgTrp: 1.322 ± 0.036
2.423ArgTyr: 2.423 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.029SerAla: 6.029 ± 0.076
0.588SerCys: 0.588 ± 0.02
3.241SerAsp: 3.241 ± 0.056
3.71SerGlu: 3.71 ± 0.064
2.392SerPhe: 2.392 ± 0.044
5.664SerGly: 5.664 ± 0.083
1.075SerHis: 1.075 ± 0.027
2.588SerIle: 2.588 ± 0.048
1.632SerLys: 1.632 ± 0.04
6.763SerLeu: 6.763 ± 0.076
0.908SerMet: 0.908 ± 0.026
1.755SerAsn: 1.755 ± 0.043
3.311SerPro: 3.311 ± 0.061
2.465SerGln: 2.465 ± 0.046
3.808SerArg: 3.808 ± 0.058
3.67SerSer: 3.67 ± 0.068
3.305SerThr: 3.305 ± 0.056
3.947SerVal: 3.947 ± 0.057
0.983SerTrp: 0.983 ± 0.029
1.782SerTyr: 1.782 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
6.101ThrAla: 6.101 ± 0.072
0.47ThrCys: 0.47 ± 0.018
2.556ThrAsp: 2.556 ± 0.044
2.298ThrGlu: 2.298 ± 0.04
2.002ThrPhe: 2.002 ± 0.039
4.999ThrGly: 4.999 ± 0.072
0.867ThrHis: 0.867 ± 0.021
2.807ThrIle: 2.807 ± 0.052
1.119ThrLys: 1.119 ± 0.03
5.967ThrLeu: 5.967 ± 0.07
0.694ThrMet: 0.694 ± 0.022
1.454ThrAsn: 1.454 ± 0.037
3.276ThrPro: 3.276 ± 0.059
1.785ThrGln: 1.785 ± 0.037
3.131ThrArg: 3.131 ± 0.048
3.373ThrSer: 3.373 ± 0.057
3.005ThrThr: 3.005 ± 0.066
4.257ThrVal: 4.257 ± 0.064
0.559ThrTrp: 0.559 ± 0.022
1.441ThrTyr: 1.441 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
8.163ValAla: 8.163 ± 0.089
0.73ValCys: 0.73 ± 0.026
3.421ValAsp: 3.421 ± 0.055
4.545ValGlu: 4.545 ± 0.061
2.625ValPhe: 2.625 ± 0.053
5.451ValGly: 5.451 ± 0.072
1.304ValHis: 1.304 ± 0.029
3.327ValIle: 3.327 ± 0.057
1.732ValLys: 1.732 ± 0.042
8.803ValLeu: 8.803 ± 0.11
0.956ValMet: 0.956 ± 0.031
1.974ValAsn: 1.974 ± 0.041
4.004ValPro: 4.004 ± 0.056
3.141ValGln: 3.141 ± 0.046
5.391ValArg: 5.391 ± 0.071
4.386ValSer: 4.386 ± 0.057
3.493ValThr: 3.493 ± 0.053
5.59ValVal: 5.59 ± 0.072
0.906ValTrp: 0.906 ± 0.028
1.725ValTyr: 1.725 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.195TrpAla: 1.195 ± 0.033
0.152TrpCys: 0.152 ± 0.01
0.606TrpAsp: 0.606 ± 0.021
0.755TrpGlu: 0.755 ± 0.028
0.546TrpPhe: 0.546 ± 0.019
0.978TrpGly: 0.978 ± 0.031
0.31TrpHis: 0.31 ± 0.015
0.723TrpIle: 0.723 ± 0.024
0.437TrpLys: 0.437 ± 0.017
2.212TrpLeu: 2.212 ± 0.046
0.259TrpMet: 0.259 ± 0.014
0.467TrpAsn: 0.467 ± 0.019
0.648TrpPro: 0.648 ± 0.031
1.329TrpGln: 1.329 ± 0.041
1.185TrpArg: 1.185 ± 0.033
0.906TrpSer: 0.906 ± 0.03
0.662TrpThr: 0.662 ± 0.024
0.878TrpVal: 0.878 ± 0.025
0.303TrpTrp: 0.303 ± 0.017
0.381TrpTyr: 0.381 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.332TyrAla: 2.332 ± 0.043
0.343TyrCys: 0.343 ± 0.017
1.409TyrAsp: 1.409 ± 0.036
1.441TyrGlu: 1.441 ± 0.032
1.162TyrPhe: 1.162 ± 0.03
2.217TyrGly: 2.217 ± 0.054
0.497TyrHis: 0.497 ± 0.019
1.147TyrIle: 1.147 ± 0.031
0.697TyrLys: 0.697 ± 0.023
3.438TyrLeu: 3.438 ± 0.052
0.321TyrMet: 0.321 ± 0.014
0.854TyrAsn: 0.854 ± 0.029
1.505TyrPro: 1.505 ± 0.034
1.326TyrGln: 1.326 ± 0.033
2.514TyrArg: 2.514 ± 0.049
1.654TyrSer: 1.654 ± 0.036
1.478TyrThr: 1.478 ± 0.036
1.549TyrVal: 1.549 ± 0.039
0.482TyrTrp: 0.482 ± 0.02
0.996TyrTyr: 0.996 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4462 proteins (1407085 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski