Amino acid dipepetide frequency for Arenitalea lutea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.843AlaAla: 3.843 ± 0.09	0.59AlaCys: 0.59 ± 0.028	3.274AlaAsp: 3.274 ± 0.068	3.96AlaGlu: 3.96 ± 0.067	3.408AlaPhe: 3.408 ± 0.061	4.052AlaGly: 4.052 ± 0.076	1.112AlaHis: 1.112 ± 0.032	5.592AlaIle: 5.592 ± 0.093	4.766AlaLys: 4.766 ± 0.083	6.3AlaLeu: 6.3 ± 0.101	1.423AlaMet: 1.423 ± 0.045	3.656AlaAsn: 3.656 ± 0.06	1.872AlaPro: 1.872 ± 0.042	2.355AlaGln: 2.355 ± 0.047	1.928AlaArg: 1.928 ± 0.056	4.307AlaSer: 4.307 ± 0.065	3.624AlaThr: 3.624 ± 0.074	3.949AlaVal: 3.949 ± 0.074	0.606AlaTrp: 0.606 ± 0.024	2.48AlaTyr: 2.48 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.446CysAla: 0.446 ± 0.019	0.104CysCys: 0.104 ± 0.011	0.565CysAsp: 0.565 ± 0.029	0.522CysGlu: 0.522 ± 0.024	0.439CysPhe: 0.439 ± 0.024	0.634CysGly: 0.634 ± 0.029	0.194CysHis: 0.194 ± 0.017	0.61CysIle: 0.61 ± 0.024	0.524CysLys: 0.524 ± 0.023	0.641CysLeu: 0.641 ± 0.027	0.165CysMet: 0.165 ± 0.014	0.467CysAsn: 0.467 ± 0.023	0.363CysPro: 0.363 ± 0.026	0.209CysGln: 0.209 ± 0.013	0.181CysArg: 0.181 ± 0.013	0.597CysSer: 0.597 ± 0.029	0.422CysThr: 0.422 ± 0.022	0.433CysVal: 0.433 ± 0.023	0.062CysTrp: 0.062 ± 0.008	0.327CysTyr: 0.327 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.039AspAla: 4.039 ± 0.063	0.501AspCys: 0.501 ± 0.03	3.395AspAsp: 3.395 ± 0.07	3.803AspGlu: 3.803 ± 0.071	3.66AspPhe: 3.66 ± 0.065	4.05AspGly: 4.05 ± 0.103	0.831AspHis: 0.831 ± 0.03	4.846AspIle: 4.846 ± 0.076	4.236AspLys: 4.236 ± 0.078	5.409AspLeu: 5.409 ± 0.074	1.169AspMet: 1.169 ± 0.038	3.475AspAsn: 3.475 ± 0.077	1.534AspPro: 1.534 ± 0.052	1.303AspGln: 1.303 ± 0.039	1.752AspArg: 1.752 ± 0.036	3.345AspSer: 3.345 ± 0.071	2.915AspThr: 2.915 ± 0.065	3.968AspVal: 3.968 ± 0.064	0.767AspTrp: 0.767 ± 0.026	2.981AspTyr: 2.981 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.675GluAla: 4.675 ± 0.082	0.35GluCys: 0.35 ± 0.02	3.938GluAsp: 3.938 ± 0.064	4.455GluGlu: 4.455 ± 0.072	3.131GluPhe: 3.131 ± 0.058	3.673GluGly: 3.673 ± 0.057	1.223GluHis: 1.223 ± 0.033	5.311GluIle: 5.311 ± 0.076	5.26GluLys: 5.26 ± 0.096	6.093GluLeu: 6.093 ± 0.088	1.397GluMet: 1.397 ± 0.039	4.671GluAsn: 4.671 ± 0.082	1.577GluPro: 1.577 ± 0.038	2.201GluGln: 2.201 ± 0.045	2.359GluArg: 2.359 ± 0.054	3.64GluSer: 3.64 ± 0.06	3.96GluThr: 3.96 ± 0.073	4.269GluVal: 4.269 ± 0.063	0.562GluTrp: 0.562 ± 0.022	2.261GluTyr: 2.261 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.936PheAla: 2.936 ± 0.057	0.464PheCys: 0.464 ± 0.026	3.376PheAsp: 3.376 ± 0.055	3.511PheGlu: 3.511 ± 0.056	2.616PhePhe: 2.616 ± 0.058	3.623PheGly: 3.623 ± 0.068	0.834PheHis: 0.834 ± 0.027	4.112PheIle: 4.112 ± 0.071	4.233PheLys: 4.233 ± 0.07	4.56PheLeu: 4.56 ± 0.076	1.105PheMet: 1.105 ± 0.039	3.731PheAsn: 3.731 ± 0.072	1.652PhePro: 1.652 ± 0.044	1.547PheGln: 1.547 ± 0.043	1.492PheArg: 1.492 ± 0.036	3.961PheSer: 3.961 ± 0.076	3.013PheThr: 3.013 ± 0.062	3.137PheVal: 3.137 ± 0.052	0.564PheTrp: 0.564 ± 0.024	2.122PheTyr: 2.122 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.123GlyAla: 4.123 ± 0.082	0.612GlyCys: 0.612 ± 0.029	3.652GlyAsp: 3.652 ± 0.081	3.588GlyGlu: 3.588 ± 0.059	3.62GlyPhe: 3.62 ± 0.066	4.477GlyGly: 4.477 ± 0.096	1.13GlyHis: 1.13 ± 0.038	5.407GlyIle: 5.407 ± 0.079	4.788GlyLys: 4.788 ± 0.075	5.756GlyLeu: 5.756 ± 0.082	1.497GlyMet: 1.497 ± 0.039	3.666GlyAsn: 3.666 ± 0.074	1.375GlyPro: 1.375 ± 0.043	1.732GlyGln: 1.732 ± 0.047	1.99GlyArg: 1.99 ± 0.054	4.004GlySer: 4.004 ± 0.082	3.967GlyThr: 3.967 ± 0.089	4.495GlyVal: 4.495 ± 0.071	0.756GlyTrp: 0.756 ± 0.03	2.758GlyTyr: 2.758 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.051HisAla: 1.051 ± 0.031	0.2HisCys: 0.2 ± 0.014	0.919HisAsp: 0.919 ± 0.03	1.0HisGlu: 1.0 ± 0.028	1.177HisPhe: 1.177 ± 0.036	1.113HisGly: 1.113 ± 0.034	0.476HisHis: 0.476 ± 0.022	1.543HisIle: 1.543 ± 0.037	1.306HisLys: 1.306 ± 0.04	1.717HisLeu: 1.717 ± 0.043	0.345HisMet: 0.345 ± 0.018	1.034HisAsn: 1.034 ± 0.036	0.871HisPro: 0.871 ± 0.034	0.675HisGln: 0.675 ± 0.03	0.592HisArg: 0.592 ± 0.025	1.012HisSer: 1.012 ± 0.031	0.944HisThr: 0.944 ± 0.031	1.041HisVal: 1.041 ± 0.031	0.249HisTrp: 0.249 ± 0.015	0.832HisTyr: 0.832 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.553IleAla: 5.553 ± 0.081	0.662IleCys: 0.662 ± 0.025	5.306IleAsp: 5.306 ± 0.069	5.932IleGlu: 5.932 ± 0.085	3.518IlePhe: 3.518 ± 0.063	5.16IleGly: 5.16 ± 0.082	1.375IleHis: 1.375 ± 0.04	6.558IleIle: 6.558 ± 0.105	6.335IleLys: 6.335 ± 0.092	7.097IleLeu: 7.097 ± 0.108	1.434IleMet: 1.434 ± 0.037	5.341IleAsn: 5.341 ± 0.078	3.322IlePro: 3.322 ± 0.065	2.459IleGln: 2.459 ± 0.051	2.268IleArg: 2.268 ± 0.05	5.677IleSer: 5.677 ± 0.071	4.965IleThr: 4.965 ± 0.087	4.994IleVal: 4.994 ± 0.073	0.74IleTrp: 0.74 ± 0.031	2.887IleTyr: 2.887 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	5.18LysAla: 5.18 ± 0.086	0.336LysCys: 0.336 ± 0.017	4.54LysAsp: 4.54 ± 0.067	5.588LysGlu: 5.588 ± 0.081	3.175LysPhe: 3.175 ± 0.066	4.423LysGly: 4.423 ± 0.066	1.665LysHis: 1.665 ± 0.037	6.242LysIle: 6.242 ± 0.086	6.615LysLys: 6.615 ± 0.098	7.015LysLeu: 7.015 ± 0.093	1.822LysMet: 1.822 ± 0.041	5.335LysAsn: 5.335 ± 0.077	2.603LysPro: 2.603 ± 0.052	2.889LysGln: 2.889 ± 0.063	2.957LysArg: 2.957 ± 0.057	4.761LysSer: 4.761 ± 0.077	4.935LysThr: 4.935 ± 0.075	4.66LysVal: 4.66 ± 0.079	0.791LysTrp: 0.791 ± 0.03	3.11LysTyr: 3.11 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	5.554LeuAla: 5.554 ± 0.09	0.696LeuCys: 0.696 ± 0.029	5.147LeuAsp: 5.147 ± 0.072	6.146LeuGlu: 6.146 ± 0.08	4.785LeuPhe: 4.785 ± 0.082	5.792LeuGly: 5.792 ± 0.093	1.513LeuHis: 1.513 ± 0.037	7.228LeuIle: 7.228 ± 0.106	8.246LeuLys: 8.246 ± 0.097	8.305LeuLeu: 8.305 ± 0.109	1.971LeuMet: 1.971 ± 0.044	6.266LeuAsn: 6.266 ± 0.086	3.418LeuPro: 3.418 ± 0.052	3.008LeuGln: 3.008 ± 0.054	2.982LeuArg: 2.982 ± 0.062	6.482LeuSer: 6.482 ± 0.07	4.919LeuThr: 4.919 ± 0.066	5.466LeuVal: 5.466 ± 0.076	0.79LeuTrp: 0.79 ± 0.029	3.123LeuTyr: 3.123 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.567MetAla: 1.567 ± 0.039	0.155MetCys: 0.155 ± 0.013	1.024MetAsp: 1.024 ± 0.031	1.151MetGlu: 1.151 ± 0.035	0.897MetPhe: 0.897 ± 0.032	1.221MetGly: 1.221 ± 0.037	0.44MetHis: 0.44 ± 0.021	1.466MetIle: 1.466 ± 0.042	2.054MetLys: 2.054 ± 0.042	2.011MetLeu: 2.011 ± 0.042	0.55MetMet: 0.55 ± 0.027	1.273MetAsn: 1.273 ± 0.038	0.838MetPro: 0.838 ± 0.028	0.83MetGln: 0.83 ± 0.031	0.806MetArg: 0.806 ± 0.031	1.43MetSer: 1.43 ± 0.042	1.091MetThr: 1.091 ± 0.034	1.299MetVal: 1.299 ± 0.038	0.168MetTrp: 0.168 ± 0.014	0.724MetTyr: 0.724 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	4.078AsnAla: 4.078 ± 0.07	0.557AsnCys: 0.557 ± 0.029	3.673AsnAsp: 3.673 ± 0.075	3.944AsnGlu: 3.944 ± 0.066	3.152AsnPhe: 3.152 ± 0.062	4.098AsnGly: 4.098 ± 0.086	1.189AsnHis: 1.189 ± 0.037	5.323AsnIle: 5.323 ± 0.093	4.694AsnLys: 4.694 ± 0.085	5.699AsnLeu: 5.699 ± 0.07	1.329AsnMet: 1.329 ± 0.036	4.539AsnAsn: 4.539 ± 0.092	2.849AsnPro: 2.849 ± 0.06	2.31AsnGln: 2.31 ± 0.058	2.201AsnArg: 2.201 ± 0.055	4.062AsnSer: 4.062 ± 0.08	4.032AsnThr: 4.032 ± 0.081	3.698AsnVal: 3.698 ± 0.068	0.806AsnTrp: 0.806 ± 0.029	2.965AsnTyr: 2.965 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.753ProAla: 1.753 ± 0.054	0.236ProCys: 0.236 ± 0.017	2.143ProAsp: 2.143 ± 0.049	2.903ProGlu: 2.903 ± 0.06	1.919ProPhe: 1.919 ± 0.045	1.833ProGly: 1.833 ± 0.045	0.613ProHis: 0.613 ± 0.028	2.778ProIle: 2.778 ± 0.047	2.533ProLys: 2.533 ± 0.054	2.859ProLeu: 2.859 ± 0.054	0.68ProMet: 0.68 ± 0.027	2.37ProAsn: 2.37 ± 0.056	0.782ProPro: 0.782 ± 0.028	1.048ProGln: 1.048 ± 0.033	0.907ProArg: 0.907 ± 0.028	2.095ProSer: 2.095 ± 0.05	1.869ProThr: 1.869 ± 0.049	2.187ProVal: 2.187 ± 0.042	0.347ProTrp: 0.347 ± 0.019	1.348ProTyr: 1.348 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.913GlnAla: 1.913 ± 0.049	0.196GlnCys: 0.196 ± 0.014	1.768GlnAsp: 1.768 ± 0.041	2.2GlnGlu: 2.2 ± 0.052	1.708GlnPhe: 1.708 ± 0.049	1.77GlnGly: 1.77 ± 0.042	0.637GlnHis: 0.637 ± 0.025	2.683GlnIle: 2.683 ± 0.055	2.511GlnLys: 2.511 ± 0.062	3.293GlnLeu: 3.293 ± 0.058	0.757GlnMet: 0.757 ± 0.025	2.175GlnAsn: 2.175 ± 0.05	1.058GlnPro: 1.058 ± 0.031	1.274GlnGln: 1.274 ± 0.042	1.136GlnArg: 1.136 ± 0.037	1.823GlnSer: 1.823 ± 0.042	1.845GlnThr: 1.845 ± 0.046	2.002GlnVal: 2.002 ± 0.044	0.331GlnTrp: 0.331 ± 0.019	1.236GlnTyr: 1.236 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.056ArgAla: 2.056 ± 0.045	0.208ArgCys: 0.208 ± 0.015	1.714ArgAsp: 1.714 ± 0.048	1.946ArgGlu: 1.946 ± 0.048	1.797ArgPhe: 1.797 ± 0.047	1.946ArgGly: 1.946 ± 0.046	0.622ArgHis: 0.622 ± 0.022	2.8ArgIle: 2.8 ± 0.057	2.563ArgLys: 2.563 ± 0.062	3.111ArgLeu: 3.111 ± 0.074	0.786ArgMet: 0.786 ± 0.03	1.97ArgAsn: 1.97 ± 0.044	1.043ArgPro: 1.043 ± 0.037	1.056ArgGln: 1.056 ± 0.034	1.262ArgArg: 1.262 ± 0.039	1.745ArgSer: 1.745 ± 0.045	1.774ArgThr: 1.774 ± 0.041	1.992ArgVal: 1.992 ± 0.047	0.371ArgTrp: 0.371 ± 0.021	1.455ArgTyr: 1.455 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.719SerAla: 3.719 ± 0.07	0.653SerCys: 0.653 ± 0.027	3.6SerAsp: 3.6 ± 0.067	4.125SerGlu: 4.125 ± 0.062	3.819SerPhe: 3.819 ± 0.055	4.62SerGly: 4.62 ± 0.078	1.128SerHis: 1.128 ± 0.035	5.435SerIle: 5.435 ± 0.075	5.181SerLys: 5.181 ± 0.068	5.744SerLeu: 5.744 ± 0.079	1.292SerMet: 1.292 ± 0.037	4.267SerAsn: 4.267 ± 0.086	1.997SerPro: 1.997 ± 0.043	2.072SerGln: 2.072 ± 0.043	1.992SerArg: 1.992 ± 0.042	4.206SerSer: 4.206 ± 0.089	3.526SerThr: 3.526 ± 0.069	4.028SerVal: 4.028 ± 0.064	0.718SerTrp: 0.718 ± 0.03	2.591SerTyr: 2.591 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	3.551ThrAla: 3.551 ± 0.073	0.413ThrCys: 0.413 ± 0.022	3.305ThrAsp: 3.305 ± 0.076	3.396ThrGlu: 3.396 ± 0.056	3.157ThrPhe: 3.157 ± 0.061	3.909ThrGly: 3.909 ± 0.073	1.075ThrHis: 1.075 ± 0.032	5.025ThrIle: 5.025 ± 0.071	4.072ThrLys: 4.072 ± 0.063	5.32ThrLeu: 5.32 ± 0.077	0.984ThrMet: 0.984 ± 0.028	3.535ThrAsn: 3.535 ± 0.081	2.385ThrPro: 2.385 ± 0.052	1.813ThrGln: 1.813 ± 0.044	1.605ThrArg: 1.605 ± 0.043	3.923ThrSer: 3.923 ± 0.085	3.522ThrThr: 3.522 ± 0.096	3.81ThrVal: 3.81 ± 0.079	0.634ThrTrp: 0.634 ± 0.028	2.46ThrTyr: 2.46 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.075ValAla: 4.075 ± 0.074	0.528ValCys: 0.528 ± 0.025	3.695ValAsp: 3.695 ± 0.071	3.989ValGlu: 3.989 ± 0.06	3.567ValPhe: 3.567 ± 0.064	3.792ValGly: 3.792 ± 0.069	0.969ValHis: 0.969 ± 0.029	5.066ValIle: 5.066 ± 0.08	4.71ValLys: 4.71 ± 0.063	6.136ValLeu: 6.136 ± 0.071	1.28ValMet: 1.28 ± 0.04	3.808ValAsn: 3.808 ± 0.075	2.047ValPro: 2.047 ± 0.045	1.634ValGln: 1.634 ± 0.04	1.875ValArg: 1.875 ± 0.057	4.483ValSer: 4.483 ± 0.063	3.607ValThr: 3.607 ± 0.071	4.306ValVal: 4.306 ± 0.073	0.598ValTrp: 0.598 ± 0.023	2.409ValTyr: 2.409 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.585TrpAla: 0.585 ± 0.023	0.112TrpCys: 0.112 ± 0.009	0.643TrpAsp: 0.643 ± 0.029	0.647TrpGlu: 0.647 ± 0.029	0.578TrpPhe: 0.578 ± 0.024	0.658TrpGly: 0.658 ± 0.028	0.229TrpHis: 0.229 ± 0.016	0.698TrpIle: 0.698 ± 0.026	0.775TrpLys: 0.775 ± 0.027	1.003TrpLeu: 1.003 ± 0.03	0.292TrpMet: 0.292 ± 0.02	0.75TrpAsn: 0.75 ± 0.031	0.221TrpPro: 0.221 ± 0.015	0.407TrpGln: 0.407 ± 0.02	0.395TrpArg: 0.395 ± 0.02	0.644TrpSer: 0.644 ± 0.027	0.63TrpThr: 0.63 ± 0.029	0.642TrpVal: 0.642 ± 0.03	0.156TrpTrp: 0.156 ± 0.015	0.446TrpTyr: 0.446 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.4TyrAla: 2.4 ± 0.047	0.332TyrCys: 0.332 ± 0.021	2.302TyrAsp: 2.302 ± 0.052	2.199TyrGlu: 2.199 ± 0.048	2.464TyrPhe: 2.464 ± 0.056	2.551TyrGly: 2.551 ± 0.059	0.841TyrHis: 0.841 ± 0.031	2.859TyrIle: 2.859 ± 0.06	3.243TyrLys: 3.243 ± 0.068	3.768TyrLeu: 3.768 ± 0.059	0.716TyrMet: 0.716 ± 0.027	2.87TyrAsn: 2.87 ± 0.058	1.399TyrPro: 1.399 ± 0.039	1.492TyrGln: 1.492 ± 0.041	1.537TyrArg: 1.537 ± 0.038	2.516TyrSer: 2.516 ± 0.056	2.334TyrThr: 2.334 ± 0.056	2.197TyrVal: 2.197 ± 0.043	0.495TyrTrp: 0.495 ± 0.021	1.731TyrTyr: 1.731 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2965 proteins (1027488 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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