Amino acid dipepetide frequency for Halobacteriovorax sp. DA5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.523AlaAla: 4.523 ± 0.097	0.812AlaCys: 0.812 ± 0.03	3.214AlaAsp: 3.214 ± 0.065	3.175AlaGlu: 3.175 ± 0.063	2.97AlaPhe: 2.97 ± 0.059	4.207AlaGly: 4.207 ± 0.096	1.246AlaHis: 1.246 ± 0.039	4.928AlaIle: 4.928 ± 0.072	5.54AlaLys: 5.54 ± 0.105	6.457AlaLeu: 6.457 ± 0.078	1.751AlaMet: 1.751 ± 0.041	3.396AlaAsn: 3.396 ± 0.067	2.217AlaPro: 2.217 ± 0.064	2.65AlaGln: 2.65 ± 0.056	2.496AlaArg: 2.496 ± 0.059	4.479AlaSer: 4.479 ± 0.07	3.596AlaThr: 3.596 ± 0.078	3.603AlaVal: 3.603 ± 0.064	0.503AlaTrp: 0.503 ± 0.024	2.152AlaTyr: 2.152 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.641CysAla: 0.641 ± 0.027	0.117CysCys: 0.117 ± 0.011	0.685CysAsp: 0.685 ± 0.025	0.728CysGlu: 0.728 ± 0.029	0.585CysPhe: 0.585 ± 0.024	0.799CysGly: 0.799 ± 0.031	0.325CysHis: 0.325 ± 0.021	0.626CysIle: 0.626 ± 0.026	0.585CysLys: 0.585 ± 0.028	1.087CysLeu: 1.087 ± 0.037	0.229CysMet: 0.229 ± 0.016	0.485CysAsn: 0.485 ± 0.023	0.476CysPro: 0.476 ± 0.022	0.382CysGln: 0.382 ± 0.02	0.444CysArg: 0.444 ± 0.023	0.814CysSer: 0.814 ± 0.028	0.537CysThr: 0.537 ± 0.03	0.607CysVal: 0.607 ± 0.023	0.107CysTrp: 0.107 ± 0.015	0.401CysTyr: 0.401 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.338AspAla: 3.338 ± 0.066	0.598AspCys: 0.598 ± 0.028	3.162AspAsp: 3.162 ± 0.067	4.484AspGlu: 4.484 ± 0.084	3.61AspPhe: 3.61 ± 0.06	3.718AspGly: 3.718 ± 0.065	1.14AspHis: 1.14 ± 0.035	4.958AspIle: 4.958 ± 0.07	4.121AspLys: 4.121 ± 0.078	5.969AspLeu: 5.969 ± 0.09	1.287AspMet: 1.287 ± 0.039	2.835AspAsn: 2.835 ± 0.049	1.761AspPro: 1.761 ± 0.042	1.836AspGln: 1.836 ± 0.041	2.269AspArg: 2.269 ± 0.052	3.757AspSer: 3.757 ± 0.072	2.619AspThr: 2.619 ± 0.059	3.354AspVal: 3.354 ± 0.058	0.554AspTrp: 0.554 ± 0.026	2.762AspTyr: 2.762 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.323GluAla: 4.323 ± 0.072	0.678GluCys: 0.678 ± 0.032	3.991GluAsp: 3.991 ± 0.063	5.677GluGlu: 5.677 ± 0.089	3.481GluPhe: 3.481 ± 0.063	3.747GluGly: 3.747 ± 0.069	1.195GluHis: 1.195 ± 0.038	5.857GluIle: 5.857 ± 0.089	5.89GluLys: 5.89 ± 0.097	7.31GluLeu: 7.31 ± 0.091	1.72GluMet: 1.72 ± 0.041	4.027GluAsn: 4.027 ± 0.065	1.268GluPro: 1.268 ± 0.041	2.28GluGln: 2.28 ± 0.046	2.963GluArg: 2.963 ± 0.064	4.284GluSer: 4.284 ± 0.074	3.31GluThr: 3.31 ± 0.053	5.096GluVal: 5.096 ± 0.073	0.525GluTrp: 0.525 ± 0.024	2.633GluTyr: 2.633 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.02PheAla: 3.02 ± 0.053	0.582PheCys: 0.582 ± 0.025	3.383PheAsp: 3.383 ± 0.054	3.471PheGlu: 3.471 ± 0.066	2.839PhePhe: 2.839 ± 0.06	3.187PheGly: 3.187 ± 0.068	0.987PheHis: 0.987 ± 0.029	3.806PheIle: 3.806 ± 0.073	4.076PheLys: 4.076 ± 0.071	4.604PheLeu: 4.604 ± 0.076	1.127PheMet: 1.127 ± 0.033	3.107PheAsn: 3.107 ± 0.06	1.516PhePro: 1.516 ± 0.044	1.406PheGln: 1.406 ± 0.035	1.715PheArg: 1.715 ± 0.045	4.121PheSer: 4.121 ± 0.07	2.65PheThr: 2.65 ± 0.05	2.97PheVal: 2.97 ± 0.058	0.482PheTrp: 0.482 ± 0.024	2.226PheTyr: 2.226 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.269GlyAla: 4.269 ± 0.094	0.654GlyCys: 0.654 ± 0.029	3.468GlyAsp: 3.468 ± 0.07	4.12GlyGlu: 4.12 ± 0.08	2.964GlyPhe: 2.964 ± 0.059	4.339GlyGly: 4.339 ± 0.14	1.549GlyHis: 1.549 ± 0.046	4.811GlyIle: 4.811 ± 0.087	4.562GlyLys: 4.562 ± 0.068	5.934GlyLeu: 5.934 ± 0.087	1.468GlyMet: 1.468 ± 0.042	2.904GlyAsn: 2.904 ± 0.07	1.728GlyPro: 1.728 ± 0.042	2.264GlyGln: 2.264 ± 0.055	2.609GlyArg: 2.609 ± 0.06	4.06GlySer: 4.06 ± 0.104	3.378GlyThr: 3.378 ± 0.081	4.468GlyVal: 4.468 ± 0.066	0.517GlyTrp: 0.517 ± 0.025	2.178GlyTyr: 2.178 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.161HisAla: 1.161 ± 0.036	0.239HisCys: 0.239 ± 0.016	1.003HisAsp: 1.003 ± 0.034	1.304HisGlu: 1.304 ± 0.037	1.14HisPhe: 1.14 ± 0.038	1.269HisGly: 1.269 ± 0.038	0.475HisHis: 0.475 ± 0.021	1.408HisIle: 1.408 ± 0.039	1.223HisLys: 1.223 ± 0.035	1.959HisLeu: 1.959 ± 0.048	0.447HisMet: 0.447 ± 0.023	0.892HisAsn: 0.892 ± 0.029	0.819HisPro: 0.819 ± 0.028	0.634HisGln: 0.634 ± 0.026	0.777HisArg: 0.777 ± 0.027	1.227HisSer: 1.227 ± 0.035	0.874HisThr: 0.874 ± 0.032	0.991HisVal: 0.991 ± 0.028	0.197HisTrp: 0.197 ± 0.015	0.798HisTyr: 0.798 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.114IleAla: 5.114 ± 0.069	0.862IleCys: 0.862 ± 0.034	4.88IleAsp: 4.88 ± 0.067	5.826IleGlu: 5.826 ± 0.085	3.766IlePhe: 3.766 ± 0.073	4.625IleGly: 4.625 ± 0.085	1.435IleHis: 1.435 ± 0.043	5.415IleIle: 5.415 ± 0.09	5.842IleLys: 5.842 ± 0.087	6.677IleLeu: 6.677 ± 0.098	1.336IleMet: 1.336 ± 0.039	4.489IleAsn: 4.489 ± 0.07	2.728IlePro: 2.728 ± 0.052	2.297IleGln: 2.297 ± 0.05	2.845IleArg: 2.845 ± 0.062	6.007IleSer: 6.007 ± 0.088	4.155IleThr: 4.155 ± 0.067	4.53IleVal: 4.53 ± 0.079	0.529IleTrp: 0.529 ± 0.025	2.789IleTyr: 2.789 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.947LysAla: 4.947 ± 0.085	0.622LysCys: 0.622 ± 0.027	5.057LysAsp: 5.057 ± 0.079	6.714LysGlu: 6.714 ± 0.103	3.374LysPhe: 3.374 ± 0.064	4.296LysGly: 4.296 ± 0.069	1.317LysHis: 1.317 ± 0.035	5.947LysIle: 5.947 ± 0.072	7.636LysLys: 7.636 ± 0.146	7.481LysLeu: 7.481 ± 0.108	1.984LysMet: 1.984 ± 0.05	4.7LysAsn: 4.7 ± 0.086	1.876LysPro: 1.876 ± 0.047	2.317LysGln: 2.317 ± 0.055	3.376LysArg: 3.376 ± 0.071	5.266LysSer: 5.266 ± 0.08	4.012LysThr: 4.012 ± 0.065	5.316LysVal: 5.316 ± 0.084	0.643LysTrp: 0.643 ± 0.027	3.09LysTyr: 3.09 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	6.569LeuAla: 6.569 ± 0.079	0.971LeuCys: 0.971 ± 0.032	5.517LeuAsp: 5.517 ± 0.084	6.903LeuGlu: 6.903 ± 0.098	4.679LeuPhe: 4.679 ± 0.086	6.046LeuGly: 6.046 ± 0.083	1.518LeuHis: 1.518 ± 0.039	6.896LeuIle: 6.896 ± 0.099	8.371LeuLys: 8.371 ± 0.103	8.236LeuLeu: 8.236 ± 0.13	2.302LeuMet: 2.302 ± 0.052	5.538LeuAsn: 5.538 ± 0.085	3.14LeuPro: 3.14 ± 0.056	2.478LeuGln: 2.478 ± 0.055	3.75LeuArg: 3.75 ± 0.06	7.683LeuSer: 7.683 ± 0.096	5.285LeuThr: 5.285 ± 0.083	5.633LeuVal: 5.633 ± 0.084	0.68LeuTrp: 0.68 ± 0.027	3.048LeuTyr: 3.048 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.976MetAla: 1.976 ± 0.054	0.204MetCys: 0.204 ± 0.014	1.264MetAsp: 1.264 ± 0.04	1.308MetGlu: 1.308 ± 0.034	0.861MetPhe: 0.861 ± 0.033	1.524MetGly: 1.524 ± 0.044	0.355MetHis: 0.355 ± 0.017	1.649MetIle: 1.649 ± 0.041	2.337MetLys: 2.337 ± 0.045	1.87MetLeu: 1.87 ± 0.044	0.637MetMet: 0.637 ± 0.027	1.375MetAsn: 1.375 ± 0.036	0.841MetPro: 0.841 ± 0.032	0.723MetGln: 0.723 ± 0.027	1.014MetArg: 1.014 ± 0.032	1.744MetSer: 1.744 ± 0.048	1.347MetThr: 1.347 ± 0.038	1.253MetVal: 1.253 ± 0.038	0.168MetTrp: 0.168 ± 0.013	0.622MetTyr: 0.622 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.975AsnAla: 2.975 ± 0.063	0.615AsnCys: 0.615 ± 0.025	3.163AsnAsp: 3.163 ± 0.069	4.06AsnGlu: 4.06 ± 0.069	3.123AsnPhe: 3.123 ± 0.062	3.312AsnGly: 3.312 ± 0.085	0.979AsnHis: 0.979 ± 0.031	4.504AsnIle: 4.504 ± 0.085	3.88AsnLys: 3.88 ± 0.076	5.461AsnLeu: 5.461 ± 0.077	1.184AsnMet: 1.184 ± 0.033	2.864AsnAsn: 2.864 ± 0.061	2.054AsnPro: 2.054 ± 0.048	1.831AsnGln: 1.831 ± 0.046	2.162AsnArg: 2.162 ± 0.047	3.788AsnSer: 3.788 ± 0.06	2.732AsnThr: 2.732 ± 0.06	3.001AsnVal: 3.001 ± 0.065	0.554AsnTrp: 0.554 ± 0.024	2.433AsnTyr: 2.433 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.919ProAla: 1.919 ± 0.054	0.294ProCys: 0.294 ± 0.017	1.555ProAsp: 1.555 ± 0.041	2.354ProGlu: 2.354 ± 0.049	1.655ProPhe: 1.655 ± 0.038	1.901ProGly: 1.901 ± 0.048	0.641ProHis: 0.641 ± 0.026	2.409ProIle: 2.409 ± 0.048	2.386ProLys: 2.386 ± 0.058	2.877ProLeu: 2.877 ± 0.055	0.732ProMet: 0.732 ± 0.026	1.626ProAsn: 1.626 ± 0.043	0.758ProPro: 0.758 ± 0.027	1.048ProGln: 1.048 ± 0.03	1.12ProArg: 1.12 ± 0.037	2.267ProSer: 2.267 ± 0.051	1.779ProThr: 1.779 ± 0.047	2.144ProVal: 2.144 ± 0.053	0.319ProTrp: 0.319 ± 0.02	1.217ProTyr: 1.217 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.3GlnAla: 2.3 ± 0.052	0.259GlnCys: 0.259 ± 0.017	1.898GlnAsp: 1.898 ± 0.042	2.482GlnGlu: 2.482 ± 0.058	1.54GlnPhe: 1.54 ± 0.041	1.928GlnGly: 1.928 ± 0.043	0.463GlnHis: 0.463 ± 0.019	2.56GlnIle: 2.56 ± 0.058	2.789GlnLys: 2.789 ± 0.061	3.004GlnLeu: 3.004 ± 0.058	0.88GlnMet: 0.88 ± 0.029	1.827GlnAsn: 1.827 ± 0.047	0.575GlnPro: 0.575 ± 0.027	1.064GlnGln: 1.064 ± 0.043	1.431GlnArg: 1.431 ± 0.035	2.126GlnSer: 2.126 ± 0.05	1.733GlnThr: 1.733 ± 0.039	2.172GlnVal: 2.172 ± 0.045	0.271GlnTrp: 0.271 ± 0.016	1.221GlnTyr: 1.221 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.443ArgAla: 2.443 ± 0.049	0.339ArgCys: 0.339 ± 0.018	2.449ArgAsp: 2.449 ± 0.047	2.883ArgGlu: 2.883 ± 0.06	2.046ArgPhe: 2.046 ± 0.047	2.394ArgGly: 2.394 ± 0.058	0.736ArgHis: 0.736 ± 0.029	3.04ArgIle: 3.04 ± 0.056	3.088ArgLys: 3.088 ± 0.059	3.802ArgLeu: 3.802 ± 0.064	0.983ArgMet: 0.983 ± 0.035	2.095ArgAsn: 2.095 ± 0.055	1.387ArgPro: 1.387 ± 0.038	1.236ArgGln: 1.236 ± 0.034	1.726ArgArg: 1.726 ± 0.045	2.595ArgSer: 2.595 ± 0.05	1.915ArgThr: 1.915 ± 0.04	2.594ArgVal: 2.594 ± 0.046	0.317ArgTrp: 0.317 ± 0.016	1.704ArgTyr: 1.704 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.218SerAla: 4.218 ± 0.072	1.028SerCys: 1.028 ± 0.04	3.843SerAsp: 3.843 ± 0.059	4.485SerGlu: 4.485 ± 0.066	4.227SerPhe: 4.227 ± 0.072	4.632SerGly: 4.632 ± 0.114	1.354SerHis: 1.354 ± 0.039	5.349SerIle: 5.349 ± 0.082	5.442SerLys: 5.442 ± 0.083	7.147SerLeu: 7.147 ± 0.095	1.584SerMet: 1.584 ± 0.04	3.866SerAsn: 3.866 ± 0.072	2.127SerPro: 2.127 ± 0.041	2.493SerGln: 2.493 ± 0.042	2.655SerArg: 2.655 ± 0.056	5.403SerSer: 5.403 ± 0.09	3.767SerThr: 3.767 ± 0.09	4.256SerVal: 4.256 ± 0.07	0.678SerTrp: 0.678 ± 0.03	2.87SerTyr: 2.87 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.203ThrAla: 3.203 ± 0.079	0.579ThrCys: 0.579 ± 0.027	2.747ThrAsp: 2.747 ± 0.072	2.746ThrGlu: 2.746 ± 0.061	2.708ThrPhe: 2.708 ± 0.054	3.553ThrGly: 3.553 ± 0.085	1.033ThrHis: 1.033 ± 0.031	4.09ThrIle: 4.09 ± 0.061	4.109ThrLys: 4.109 ± 0.076	5.275ThrLeu: 5.275 ± 0.086	1.042ThrMet: 1.042 ± 0.03	2.86ThrAsn: 2.86 ± 0.064	2.254ThrPro: 2.254 ± 0.052	1.934ThrGln: 1.934 ± 0.047	1.865ThrArg: 1.865 ± 0.042	3.872ThrSer: 3.872 ± 0.081	3.218ThrThr: 3.218 ± 0.082	3.101ThrVal: 3.101 ± 0.076	0.434ThrTrp: 0.434 ± 0.02	2.125ThrTyr: 2.125 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.344ValAla: 4.344 ± 0.078	0.653ValCys: 0.653 ± 0.027	4.086ValAsp: 4.086 ± 0.065	4.516ValGlu: 4.516 ± 0.069	2.98ValPhe: 2.98 ± 0.05	3.877ValGly: 3.877 ± 0.073	1.071ValHis: 1.071 ± 0.036	4.639ValIle: 4.639 ± 0.072	4.743ValLys: 4.743 ± 0.074	5.427ValLeu: 5.427 ± 0.08	1.278ValMet: 1.278 ± 0.036	3.342ValAsn: 3.342 ± 0.067	1.87ValPro: 1.87 ± 0.047	1.761ValGln: 1.761 ± 0.041	2.335ValArg: 2.335 ± 0.048	4.599ValSer: 4.599 ± 0.07	3.383ValThr: 3.383 ± 0.071	4.073ValVal: 4.073 ± 0.069	0.474ValTrp: 0.474 ± 0.021	2.055ValTyr: 2.055 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.575TrpAla: 0.575 ± 0.024	0.095TrpCys: 0.095 ± 0.011	0.525TrpAsp: 0.525 ± 0.025	0.47TrpGlu: 0.47 ± 0.022	0.423TrpPhe: 0.423 ± 0.021	0.666TrpGly: 0.666 ± 0.035	0.213TrpHis: 0.213 ± 0.015	0.541TrpIle: 0.541 ± 0.023	0.551TrpLys: 0.551 ± 0.024	0.796TrpLeu: 0.796 ± 0.03	0.247TrpMet: 0.247 ± 0.016	0.447TrpAsn: 0.447 ± 0.022	0.299TrpPro: 0.299 ± 0.017	0.352TrpGln: 0.352 ± 0.019	0.369TrpArg: 0.369 ± 0.02	0.577TrpSer: 0.577 ± 0.024	0.438TrpThr: 0.438 ± 0.024	0.461TrpVal: 0.461 ± 0.024	0.11TrpTrp: 0.11 ± 0.011	0.277TrpTyr: 0.277 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.058TyrAla: 2.058 ± 0.05	0.458TyrCys: 0.458 ± 0.026	2.245TyrAsp: 2.245 ± 0.047	2.547TyrGlu: 2.547 ± 0.056	2.306TyrPhe: 2.306 ± 0.045	2.224TyrGly: 2.224 ± 0.047	0.805TyrHis: 0.805 ± 0.029	2.712TyrIle: 2.712 ± 0.053	2.801TyrLys: 2.801 ± 0.057	3.866TyrLeu: 3.866 ± 0.067	0.855TyrMet: 0.855 ± 0.03	2.0TyrAsn: 2.0 ± 0.046	1.307TyrPro: 1.307 ± 0.033	1.538TyrGln: 1.538 ± 0.044	1.848TyrArg: 1.848 ± 0.044	2.756TyrSer: 2.756 ± 0.062	2.022TyrThr: 2.022 ± 0.049	1.883TyrVal: 1.883 ± 0.047	0.369TyrTrp: 0.369 ± 0.02	1.558TyrTyr: 1.558 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3125 proteins (1005824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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