Amino acid dipepetide frequency for Pseudaminobacter salicylatoxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.434AlaAla: 16.434 ± 0.147	0.988AlaCys: 0.988 ± 0.03	6.813AlaAsp: 6.813 ± 0.074	7.707AlaGlu: 7.707 ± 0.092	4.583AlaPhe: 4.583 ± 0.061	10.835AlaGly: 10.835 ± 0.117	2.171AlaHis: 2.171 ± 0.038	6.685AlaIle: 6.685 ± 0.07	3.928AlaLys: 3.928 ± 0.065	12.663AlaLeu: 12.663 ± 0.108	3.666AlaMet: 3.666 ± 0.051	3.069AlaAsn: 3.069 ± 0.051	5.09AlaPro: 5.09 ± 0.074	3.686AlaGln: 3.686 ± 0.054	8.92AlaArg: 8.92 ± 0.089	6.372AlaSer: 6.372 ± 0.076	5.96AlaThr: 5.96 ± 0.067	8.731AlaVal: 8.731 ± 0.089	1.434AlaTrp: 1.434 ± 0.033	2.648AlaTyr: 2.648 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.887CysAla: 0.887 ± 0.025	0.105CysCys: 0.105 ± 0.01	0.513CysAsp: 0.513 ± 0.023	0.43CysGlu: 0.43 ± 0.019	0.342CysPhe: 0.342 ± 0.019	0.881CysGly: 0.881 ± 0.03	0.216CysHis: 0.216 ± 0.011	0.412CysIle: 0.412 ± 0.018	0.212CysLys: 0.212 ± 0.012	0.699CysLeu: 0.699 ± 0.025	0.156CysMet: 0.156 ± 0.008	0.203CysAsn: 0.203 ± 0.012	0.409CysPro: 0.409 ± 0.018	0.215CysGln: 0.215 ± 0.013	0.592CysArg: 0.592 ± 0.021	0.444CysSer: 0.444 ± 0.019	0.388CysThr: 0.388 ± 0.017	0.575CysVal: 0.575 ± 0.024	0.116CysTrp: 0.116 ± 0.008	0.196CysTyr: 0.196 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.657AspAla: 6.657 ± 0.076	0.497AspCys: 0.497 ± 0.019	3.035AspAsp: 3.035 ± 0.056	3.661AspGlu: 3.661 ± 0.059	2.298AspPhe: 2.298 ± 0.047	4.984AspGly: 4.984 ± 0.073	1.254AspHis: 1.254 ± 0.033	3.239AspIle: 3.239 ± 0.044	1.919AspLys: 1.919 ± 0.037	5.514AspLeu: 5.514 ± 0.067	1.499AspMet: 1.499 ± 0.037	1.404AspAsn: 1.404 ± 0.028	3.333AspPro: 3.333 ± 0.048	1.557AspGln: 1.557 ± 0.036	4.148AspArg: 4.148 ± 0.059	2.132AspSer: 2.132 ± 0.037	2.611AspThr: 2.611 ± 0.042	4.078AspVal: 4.078 ± 0.059	0.971AspTrp: 0.971 ± 0.026	1.467AspTyr: 1.467 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.933GluAla: 7.933 ± 0.092	0.352GluCys: 0.352 ± 0.016	2.845GluAsp: 2.845 ± 0.04	3.472GluGlu: 3.472 ± 0.067	1.946GluPhe: 1.946 ± 0.036	4.361GluGly: 4.361 ± 0.054	1.252GluHis: 1.252 ± 0.033	3.854GluIle: 3.854 ± 0.055	2.836GluLys: 2.836 ± 0.049	5.39GluLeu: 5.39 ± 0.067	1.621GluMet: 1.621 ± 0.036	1.828GluAsn: 1.828 ± 0.037	2.807GluPro: 2.807 ± 0.065	2.106GluGln: 2.106 ± 0.041	5.011GluArg: 5.011 ± 0.066	2.372GluSer: 2.372 ± 0.043	3.601GluThr: 3.601 ± 0.048	3.886GluVal: 3.886 ± 0.053	0.739GluTrp: 0.739 ± 0.021	1.058GluTyr: 1.058 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.58PheAla: 4.58 ± 0.06	0.37PheCys: 0.37 ± 0.014	2.651PheAsp: 2.651 ± 0.049	2.293PheGlu: 2.293 ± 0.044	1.546PhePhe: 1.546 ± 0.045	3.895PheGly: 3.895 ± 0.047	0.795PheHis: 0.795 ± 0.022	1.912PheIle: 1.912 ± 0.035	1.032PheLys: 1.032 ± 0.028	3.592PheLeu: 3.592 ± 0.059	0.916PheMet: 0.916 ± 0.026	1.053PheAsn: 1.053 ± 0.029	1.662PhePro: 1.662 ± 0.037	1.096PheGln: 1.096 ± 0.025	2.328PheArg: 2.328 ± 0.036	2.442PheSer: 2.442 ± 0.037	1.932PheThr: 1.932 ± 0.039	3.004PheVal: 3.004 ± 0.05	0.586PheTrp: 0.586 ± 0.023	0.933PheTyr: 0.933 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.033GlyAla: 9.033 ± 0.105	0.783GlyCys: 0.783 ± 0.024	4.343GlyAsp: 4.343 ± 0.059	5.002GlyGlu: 5.002 ± 0.057	3.791GlyPhe: 3.791 ± 0.058	7.346GlyGly: 7.346 ± 0.134	1.895GlyHis: 1.895 ± 0.038	4.961GlyIle: 4.961 ± 0.074	3.745GlyLys: 3.745 ± 0.052	8.691GlyLeu: 8.691 ± 0.094	2.59GlyMet: 2.59 ± 0.041	2.475GlyAsn: 2.475 ± 0.074	3.251GlyPro: 3.251 ± 0.05	2.791GlyGln: 2.791 ± 0.051	6.033GlyArg: 6.033 ± 0.065	4.671GlySer: 4.671 ± 0.08	4.641GlyThr: 4.641 ± 0.107	6.128GlyVal: 6.128 ± 0.063	1.327GlyTrp: 1.327 ± 0.034	2.331GlyTyr: 2.331 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.295HisAla: 2.295 ± 0.043	0.221HisCys: 0.221 ± 0.012	1.242HisAsp: 1.242 ± 0.03	1.173HisGlu: 1.173 ± 0.026	0.881HisPhe: 0.881 ± 0.024	1.992HisGly: 1.992 ± 0.036	0.559HisHis: 0.559 ± 0.024	0.997HisIle: 0.997 ± 0.029	0.533HisLys: 0.533 ± 0.018	1.92HisLeu: 1.92 ± 0.038	0.538HisMet: 0.538 ± 0.019	0.469HisAsn: 0.469 ± 0.018	1.291HisPro: 1.291 ± 0.03	0.551HisGln: 0.551 ± 0.019	1.381HisArg: 1.381 ± 0.033	0.957HisSer: 0.957 ± 0.025	0.872HisThr: 0.872 ± 0.023	1.522HisVal: 1.522 ± 0.034	0.332HisTrp: 0.332 ± 0.015	0.561HisTyr: 0.561 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.523IleAla: 7.523 ± 0.083	0.537IleCys: 0.537 ± 0.02	3.71IleAsp: 3.71 ± 0.056	3.784IleGlu: 3.784 ± 0.048	1.918IlePhe: 1.918 ± 0.036	5.264IleGly: 5.264 ± 0.077	0.927IleHis: 0.927 ± 0.026	2.575IleIle: 2.575 ± 0.051	1.437IleLys: 1.437 ± 0.031	4.561IleLeu: 4.561 ± 0.065	1.166IleMet: 1.166 ± 0.032	1.486IleAsn: 1.486 ± 0.032	2.331IlePro: 2.331 ± 0.041	1.238IleGln: 1.238 ± 0.03	3.608IleArg: 3.608 ± 0.057	3.125IleSer: 3.125 ± 0.052	2.752IleThr: 2.752 ± 0.046	4.667IleVal: 4.667 ± 0.057	0.618IleTrp: 0.618 ± 0.022	1.242IleTyr: 1.242 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.543LysAla: 4.543 ± 0.065	0.151LysCys: 0.151 ± 0.011	1.825LysAsp: 1.825 ± 0.035	1.814LysGlu: 1.814 ± 0.043	0.989LysPhe: 0.989 ± 0.027	2.769LysGly: 2.769 ± 0.051	0.64LysHis: 0.64 ± 0.019	1.888LysIle: 1.888 ± 0.036	1.476LysLys: 1.476 ± 0.04	3.616LysLeu: 3.616 ± 0.049	0.893LysMet: 0.893 ± 0.026	0.957LysAsn: 0.957 ± 0.027	2.29LysPro: 2.29 ± 0.041	1.06LysGln: 1.06 ± 0.028	2.509LysArg: 2.509 ± 0.043	2.021LysSer: 2.021 ± 0.04	2.039LysThr: 2.039 ± 0.04	2.632LysVal: 2.632 ± 0.049	0.432LysTrp: 0.432 ± 0.018	0.682LysTyr: 0.682 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.046LeuAla: 13.046 ± 0.118	0.86LeuCys: 0.86 ± 0.025	5.918LeuAsp: 5.918 ± 0.069	5.328LeuGlu: 5.328 ± 0.067	3.676LeuPhe: 3.676 ± 0.054	8.074LeuGly: 8.074 ± 0.082	1.8LeuHis: 1.8 ± 0.037	4.999LeuIle: 4.999 ± 0.065	3.824LeuLys: 3.824 ± 0.053	9.167LeuLeu: 9.167 ± 0.115	2.337LeuMet: 2.337 ± 0.037	2.525LeuAsn: 2.525 ± 0.043	5.31LeuPro: 5.31 ± 0.066	2.64LeuGln: 2.64 ± 0.042	6.371LeuArg: 6.371 ± 0.078	6.396LeuSer: 6.396 ± 0.067	5.324LeuThr: 5.324 ± 0.062	7.498LeuVal: 7.498 ± 0.092	1.069LeuTrp: 1.069 ± 0.028	2.133LeuTyr: 2.133 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.245MetAla: 3.245 ± 0.046	0.153MetCys: 0.153 ± 0.01	1.138MetAsp: 1.138 ± 0.027	1.282MetGlu: 1.282 ± 0.032	0.783MetPhe: 0.783 ± 0.025	1.892MetGly: 1.892 ± 0.039	0.48MetHis: 0.48 ± 0.018	1.458MetIle: 1.458 ± 0.036	1.159MetLys: 1.159 ± 0.025	2.721MetLeu: 2.721 ± 0.041	0.7MetMet: 0.7 ± 0.025	0.904MetAsn: 0.904 ± 0.028	1.56MetPro: 1.56 ± 0.032	0.876MetGln: 0.876 ± 0.027	1.939MetArg: 1.939 ± 0.036	1.73MetSer: 1.73 ± 0.038	1.99MetThr: 1.99 ± 0.04	1.884MetVal: 1.884 ± 0.038	0.236MetTrp: 0.236 ± 0.014	0.32MetTyr: 0.32 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.264AsnAla: 3.264 ± 0.054	0.221AsnCys: 0.221 ± 0.011	1.481AsnAsp: 1.481 ± 0.031	1.389AsnGlu: 1.389 ± 0.031	0.992AsnPhe: 0.992 ± 0.029	2.723AsnGly: 2.723 ± 0.077	0.543AsnHis: 0.543 ± 0.019	1.49AsnIle: 1.49 ± 0.034	0.745AsnLys: 0.745 ± 0.021	2.554AsnLeu: 2.554 ± 0.042	0.691AsnMet: 0.691 ± 0.02	0.726AsnAsn: 0.726 ± 0.026	1.908AsnPro: 1.908 ± 0.032	0.757AsnGln: 0.757 ± 0.025	1.828AsnArg: 1.828 ± 0.037	1.338AsnSer: 1.338 ± 0.032	1.309AsnThr: 1.309 ± 0.034	2.094AsnVal: 2.094 ± 0.04	0.444AsnTrp: 0.444 ± 0.018	0.724AsnTyr: 0.724 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.019ProAla: 6.019 ± 0.077	0.309ProCys: 0.309 ± 0.017	3.496ProAsp: 3.496 ± 0.054	3.743ProGlu: 3.743 ± 0.053	2.029ProPhe: 2.029 ± 0.037	4.323ProGly: 4.323 ± 0.055	1.089ProHis: 1.089 ± 0.027	2.332ProIle: 2.332 ± 0.041	1.681ProLys: 1.681 ± 0.032	4.609ProLeu: 4.609 ± 0.061	1.195ProMet: 1.195 ± 0.025	1.358ProAsn: 1.358 ± 0.036	2.027ProPro: 2.027 ± 0.045	1.684ProGln: 1.684 ± 0.038	2.868ProArg: 2.868 ± 0.048	2.673ProSer: 2.673 ± 0.044	2.32ProThr: 2.32 ± 0.042	4.159ProVal: 4.159 ± 0.053	0.705ProTrp: 0.705 ± 0.022	1.221ProTyr: 1.221 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.965GlnAla: 3.965 ± 0.06	0.186GlnCys: 0.186 ± 0.011	1.41GlnAsp: 1.41 ± 0.034	1.629GlnGlu: 1.629 ± 0.036	1.051GlnPhe: 1.051 ± 0.028	2.23GlnGly: 2.23 ± 0.04	0.644GlnHis: 0.644 ± 0.018	1.784GlnIle: 1.784 ± 0.035	1.208GlnLys: 1.208 ± 0.03	2.686GlnLeu: 2.686 ± 0.042	0.91GlnMet: 0.91 ± 0.023	0.888GlnAsn: 0.888 ± 0.024	1.737GlnPro: 1.737 ± 0.037	1.194GlnGln: 1.194 ± 0.036	2.352GlnArg: 2.352 ± 0.049	1.7GlnSer: 1.7 ± 0.031	1.67GlnThr: 1.67 ± 0.038	2.137GlnVal: 2.137 ± 0.04	0.38GlnTrp: 0.38 ± 0.016	0.59GlnTyr: 0.59 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.762ArgAla: 7.762 ± 0.086	0.466ArgCys: 0.466 ± 0.02	4.024ArgAsp: 4.024 ± 0.058	4.33ArgGlu: 4.33 ± 0.066	2.925ArgPhe: 2.925 ± 0.051	4.667ArgGly: 4.667 ± 0.061	1.777ArgHis: 1.777 ± 0.038	4.191ArgIle: 4.191 ± 0.059	2.722ArgLys: 2.722 ± 0.05	7.626ArgLeu: 7.626 ± 0.082	1.963ArgMet: 1.963 ± 0.034	2.056ArgAsn: 2.056 ± 0.042	3.384ArgPro: 3.384 ± 0.049	2.615ArgGln: 2.615 ± 0.048	5.454ArgArg: 5.454 ± 0.077	3.652ArgSer: 3.652 ± 0.062	3.321ArgThr: 3.321 ± 0.042	4.56ArgVal: 4.56 ± 0.05	0.909ArgTrp: 0.909 ± 0.028	1.682ArgTyr: 1.682 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.13SerAla: 6.13 ± 0.077	0.404SerCys: 0.404 ± 0.019	2.93SerAsp: 2.93 ± 0.048	2.855SerGlu: 2.855 ± 0.051	2.402SerPhe: 2.402 ± 0.041	5.791SerGly: 5.791 ± 0.088	1.119SerHis: 1.119 ± 0.027	2.905SerIle: 2.905 ± 0.044	1.581SerLys: 1.581 ± 0.032	5.426SerLeu: 5.426 ± 0.065	1.45SerMet: 1.45 ± 0.033	1.414SerAsn: 1.414 ± 0.031	2.748SerPro: 2.748 ± 0.049	1.617SerGln: 1.617 ± 0.037	3.761SerArg: 3.761 ± 0.057	3.037SerSer: 3.037 ± 0.049	2.762SerThr: 2.762 ± 0.046	3.947SerVal: 3.947 ± 0.054	0.748SerTrp: 0.748 ± 0.023	1.356SerTyr: 1.356 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.213ThrAla: 6.213 ± 0.071	0.386ThrCys: 0.386 ± 0.016	2.726ThrAsp: 2.726 ± 0.045	2.665ThrGlu: 2.665 ± 0.045	2.078ThrPhe: 2.078 ± 0.038	5.131ThrGly: 5.131 ± 0.104	0.978ThrHis: 0.978 ± 0.031	3.034ThrIle: 3.034 ± 0.057	1.474ThrLys: 1.474 ± 0.033	5.641ThrLeu: 5.641 ± 0.087	1.328ThrMet: 1.328 ± 0.029	1.309ThrAsn: 1.309 ± 0.034	3.15ThrPro: 3.15 ± 0.052	1.407ThrGln: 1.407 ± 0.033	3.331ThrArg: 3.331 ± 0.052	2.766ThrSer: 2.766 ± 0.048	2.905ThrThr: 2.905 ± 0.063	4.465ThrVal: 4.465 ± 0.07	0.624ThrTrp: 0.624 ± 0.019	1.177ThrTyr: 1.177 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.205ValAla: 9.205 ± 0.084	0.619ValCys: 0.619 ± 0.02	4.062ValAsp: 4.062 ± 0.059	4.821ValGlu: 4.821 ± 0.053	2.879ValPhe: 2.879 ± 0.051	5.639ValGly: 5.639 ± 0.074	1.309ValHis: 1.309 ± 0.032	4.13ValIle: 4.13 ± 0.056	2.505ValLys: 2.505 ± 0.049	7.385ValLeu: 7.385 ± 0.071	1.937ValMet: 1.937 ± 0.036	1.993ValAsn: 1.993 ± 0.042	3.722ValPro: 3.722 ± 0.052	1.985ValGln: 1.985 ± 0.035	4.831ValArg: 4.831 ± 0.057	4.517ValSer: 4.517 ± 0.053	4.489ValThr: 4.489 ± 0.06	6.023ValVal: 6.023 ± 0.066	0.893ValTrp: 0.893 ± 0.026	1.49ValTyr: 1.49 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.205TrpAla: 1.205 ± 0.036	0.147TrpCys: 0.147 ± 0.01	0.595TrpAsp: 0.595 ± 0.022	0.585TrpGlu: 0.585 ± 0.02	0.551TrpPhe: 0.551 ± 0.02	0.862TrpGly: 0.862 ± 0.027	0.338TrpHis: 0.338 ± 0.016	0.643TrpIle: 0.643 ± 0.026	0.529TrpLys: 0.529 ± 0.022	1.592TrpLeu: 1.592 ± 0.044	0.411TrpMet: 0.411 ± 0.016	0.506TrpAsn: 0.506 ± 0.02	0.689TrpPro: 0.689 ± 0.025	0.587TrpGln: 0.587 ± 0.021	1.034TrpArg: 1.034 ± 0.029	0.808TrpSer: 0.808 ± 0.025	0.737TrpThr: 0.737 ± 0.026	0.786TrpVal: 0.786 ± 0.024	0.216TrpTrp: 0.216 ± 0.012	0.305TrpTyr: 0.305 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.442TyrAla: 2.442 ± 0.042	0.237TyrCys: 0.237 ± 0.013	1.501TyrAsp: 1.501 ± 0.03	1.306TyrGlu: 1.306 ± 0.029	0.96TyrPhe: 0.96 ± 0.023	2.168TyrGly: 2.168 ± 0.041	0.5TyrHis: 0.5 ± 0.018	0.981TyrIle: 0.981 ± 0.032	0.681TyrLys: 0.681 ± 0.024	2.242TyrLeu: 2.242 ± 0.041	0.485TyrMet: 0.485 ± 0.018	0.598TyrAsn: 0.598 ± 0.024	1.139TyrPro: 1.139 ± 0.03	0.686TyrGln: 0.686 ± 0.022	1.793TyrArg: 1.793 ± 0.041	1.23TyrSer: 1.23 ± 0.03	1.163TyrThr: 1.163 ± 0.031	1.66TyrVal: 1.66 ± 0.036	0.346TyrTrp: 0.346 ± 0.016	0.584TyrTyr: 0.584 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4695 proteins (1431895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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