Amino acid dipepetide frequency for Schistosoma mattheei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.506AlaAla: 3.506 ± 0.045	1.013AlaCys: 1.013 ± 0.013	2.246AlaAsp: 2.246 ± 0.021	2.539AlaGlu: 2.539 ± 0.027	1.895AlaPhe: 1.895 ± 0.022	2.09AlaGly: 2.09 ± 0.026	1.025AlaHis: 1.025 ± 0.016	2.765AlaIle: 2.765 ± 0.028	2.341AlaLys: 2.341 ± 0.024	4.448AlaLeu: 4.448 ± 0.04	0.954AlaMet: 0.954 ± 0.013	2.441AlaAsn: 2.441 ± 0.021	1.766AlaPro: 1.766 ± 0.02	1.663AlaGln: 1.663 ± 0.019	2.326AlaArg: 2.326 ± 0.025	4.138AlaSer: 4.138 ± 0.033	2.776AlaThr: 2.776 ± 0.03	2.908AlaVal: 2.908 ± 0.026	0.44AlaTrp: 0.44 ± 0.01	1.504AlaTyr: 1.504 ± 0.018	0.006AlaXaa: 0.006 ± 0.001
Cys	0.868CysAla: 0.868 ± 0.013	0.538CysCys: 0.538 ± 0.011	1.094CysAsp: 1.094 ± 0.017	1.082CysGlu: 1.082 ± 0.014	0.935CysPhe: 0.935 ± 0.012	1.03CysGly: 1.03 ± 0.017	0.638CysHis: 0.638 ± 0.011	1.509CysIle: 1.509 ± 0.02	1.092CysLys: 1.092 ± 0.016	2.386CysLeu: 2.386 ± 0.026	0.444CysMet: 0.444 ± 0.01	1.219CysAsn: 1.219 ± 0.018	1.003CysPro: 1.003 ± 0.016	0.928CysGln: 0.928 ± 0.015	1.111CysArg: 1.111 ± 0.015	2.143CysSer: 2.143 ± 0.021	1.291CysThr: 1.291 ± 0.015	1.084CysVal: 1.084 ± 0.014	0.225CysTrp: 0.225 ± 0.007	0.667CysTyr: 0.667 ± 0.012	0.003CysXaa: 0.003 ± 0.001
Asp	2.165AspAla: 2.165 ± 0.023	1.016AspCys: 1.016 ± 0.015	4.114AspAsp: 4.114 ± 0.061	3.571AspGlu: 3.571 ± 0.03	2.021AspPhe: 2.021 ± 0.021	2.49AspGly: 2.49 ± 0.024	1.529AspHis: 1.529 ± 0.02	3.502AspIle: 3.502 ± 0.031	2.788AspLys: 2.788 ± 0.03	4.98AspLeu: 4.98 ± 0.031	1.011AspMet: 1.011 ± 0.015	3.662AspAsn: 3.662 ± 0.034	2.282AspPro: 2.282 ± 0.021	2.047AspGln: 2.047 ± 0.02	2.382AspArg: 2.382 ± 0.024	4.628AspSer: 4.628 ± 0.035	2.608AspThr: 2.608 ± 0.021	3.1AspVal: 3.1 ± 0.026	0.594AspTrp: 0.594 ± 0.011	1.857AspTyr: 1.857 ± 0.021	0.005AspXaa: 0.005 ± 0.001
Glu	2.904GluAla: 2.904 ± 0.027	1.056GluCys: 1.056 ± 0.015	2.924GluAsp: 2.924 ± 0.027	4.136GluGlu: 4.136 ± 0.044	2.096GluPhe: 2.096 ± 0.019	1.891GluGly: 1.891 ± 0.024	1.431GluHis: 1.431 ± 0.016	3.627GluIle: 3.627 ± 0.028	3.654GluLys: 3.654 ± 0.036	5.724GluLeu: 5.724 ± 0.044	1.296GluMet: 1.296 ± 0.015	3.795GluAsn: 3.795 ± 0.032	1.72GluPro: 1.72 ± 0.023	2.532GluGln: 2.532 ± 0.025	2.751GluArg: 2.751 ± 0.029	4.519GluSer: 4.519 ± 0.032	3.224GluThr: 3.224 ± 0.025	2.885GluVal: 2.885 ± 0.025	0.565GluTrp: 0.565 ± 0.01	1.753GluTyr: 1.753 ± 0.019	0.005GluXaa: 0.005 ± 0.001
Phe	1.629PheAla: 1.629 ± 0.019	0.881PheCys: 0.881 ± 0.013	2.151PheAsp: 2.151 ± 0.02	1.848PheGlu: 1.848 ± 0.016	1.452PhePhe: 1.452 ± 0.018	1.836PheGly: 1.836 ± 0.021	1.216PheHis: 1.216 ± 0.015	2.972PheIle: 2.972 ± 0.029	1.977PheLys: 1.977 ± 0.021	3.573PheLeu: 3.573 ± 0.027	0.89PheMet: 0.89 ± 0.013	2.639PheAsn: 2.639 ± 0.022	1.708PhePro: 1.708 ± 0.021	1.525PheGln: 1.525 ± 0.019	1.849PheArg: 1.849 ± 0.023	3.665PheSer: 3.665 ± 0.027	2.598PheThr: 2.598 ± 0.022	2.213PheVal: 2.213 ± 0.022	0.385PheTrp: 0.385 ± 0.008	1.423PheTyr: 1.423 ± 0.017	0.003PheXaa: 0.003 ± 0.001
Gly	1.871GlyAla: 1.871 ± 0.023	0.929GlyCys: 0.929 ± 0.015	2.18GlyAsp: 2.18 ± 0.034	2.234GlyGlu: 2.234 ± 0.035	1.982GlyPhe: 1.982 ± 0.022	2.763GlyGly: 2.763 ± 0.042	1.21GlyHis: 1.21 ± 0.016	2.873GlyIle: 2.873 ± 0.026	2.621GlyLys: 2.621 ± 0.024	4.295GlyLeu: 4.295 ± 0.033	0.912GlyMet: 0.912 ± 0.014	2.382GlyAsn: 2.382 ± 0.022	1.856GlyPro: 1.856 ± 0.044	1.727GlyGln: 1.727 ± 0.018	2.464GlyArg: 2.464 ± 0.024	4.199GlySer: 4.199 ± 0.033	2.456GlyThr: 2.456 ± 0.026	2.553GlyVal: 2.553 ± 0.027	0.568GlyTrp: 0.568 ± 0.012	1.507GlyTyr: 1.507 ± 0.022	0.005GlyXaa: 0.005 ± 0.001
His	0.957HisAla: 0.957 ± 0.014	0.672HisCys: 0.672 ± 0.011	1.315HisAsp: 1.315 ± 0.018	1.463HisGlu: 1.463 ± 0.017	1.188HisPhe: 1.188 ± 0.015	1.263HisGly: 1.263 ± 0.018	1.687HisHis: 1.687 ± 0.028	1.844HisIle: 1.844 ± 0.019	1.564HisLys: 1.564 ± 0.018	3.103HisLeu: 3.103 ± 0.027	0.565HisMet: 0.565 ± 0.01	1.87HisAsn: 1.87 ± 0.021	1.347HisPro: 1.347 ± 0.016	1.504HisGln: 1.504 ± 0.016	1.554HisArg: 1.554 ± 0.016	2.989HisSer: 2.989 ± 0.03	1.603HisThr: 1.603 ± 0.019	1.428HisVal: 1.428 ± 0.015	0.341HisTrp: 0.341 ± 0.009	1.035HisTyr: 1.035 ± 0.016	0.005HisXaa: 0.005 ± 0.001
Ile	2.7IleAla: 2.7 ± 0.022	1.459IleCys: 1.459 ± 0.019	3.794IleAsp: 3.794 ± 0.032	3.517IleGlu: 3.517 ± 0.03	2.449IlePhe: 2.449 ± 0.022	2.883IleGly: 2.883 ± 0.024	2.214IleHis: 2.214 ± 0.022	4.719IleIle: 4.719 ± 0.046	3.813IleLys: 3.813 ± 0.033	5.973IleLeu: 5.973 ± 0.04	1.372IleMet: 1.372 ± 0.016	4.975IleAsn: 4.975 ± 0.04	3.375IlePro: 3.375 ± 0.028	3.098IleGln: 3.098 ± 0.025	3.166IleArg: 3.166 ± 0.028	6.398IleSer: 6.398 ± 0.037	4.365IleThr: 4.365 ± 0.048	3.228IleVal: 3.228 ± 0.029	0.721IleTrp: 0.721 ± 0.012	2.153IleTyr: 2.153 ± 0.023	0.007IleXaa: 0.007 ± 0.001
Lys	2.73LysAla: 2.73 ± 0.026	1.307LysCys: 1.307 ± 0.018	2.474LysAsp: 2.474 ± 0.025	3.447LysGlu: 3.447 ± 0.03	2.049LysPhe: 2.049 ± 0.021	1.836LysGly: 1.836 ± 0.032	1.747LysHis: 1.747 ± 0.022	3.519LysIle: 3.519 ± 0.031	3.573LysLys: 3.573 ± 0.037	5.86LysLeu: 5.86 ± 0.039	1.34LysMet: 1.34 ± 0.017	3.345LysAsn: 3.345 ± 0.027	2.538LysPro: 2.538 ± 0.024	3.004LysGln: 3.004 ± 0.03	3.299LysArg: 3.299 ± 0.029	5.714LysSer: 5.714 ± 0.042	3.505LysThr: 3.505 ± 0.029	2.769LysVal: 2.769 ± 0.025	0.57LysTrp: 0.57 ± 0.011	2.01LysTyr: 2.01 ± 0.025	0.005LysXaa: 0.005 ± 0.001
Leu	4.647LeuAla: 4.647 ± 0.038	2.144LeuCys: 2.144 ± 0.022	4.891LeuAsp: 4.891 ± 0.034	4.817LeuGlu: 4.817 ± 0.037	4.014LeuPhe: 4.014 ± 0.031	3.844LeuGly: 3.844 ± 0.033	2.719LeuHis: 2.719 ± 0.023	6.356LeuIle: 6.356 ± 0.051	5.716LeuLys: 5.716 ± 0.042	10.233LeuLeu: 10.233 ± 0.105	2.044LeuMet: 2.044 ± 0.019	6.702LeuAsn: 6.702 ± 0.042	5.008LeuPro: 5.008 ± 0.034	4.048LeuGln: 4.048 ± 0.031	5.069LeuArg: 5.069 ± 0.044	9.767LeuSer: 9.767 ± 0.046	5.828LeuThr: 5.828 ± 0.037	4.859LeuVal: 4.859 ± 0.034	0.955LeuTrp: 0.955 ± 0.016	2.896LeuTyr: 2.896 ± 0.025	0.016LeuXaa: 0.016 ± 0.002
Met	1.027MetAla: 1.027 ± 0.015	0.39MetCys: 0.39 ± 0.009	1.194MetAsp: 1.194 ± 0.014	1.335MetGlu: 1.335 ± 0.016	0.84MetPhe: 0.84 ± 0.012	0.852MetGly: 0.852 ± 0.012	0.518MetHis: 0.518 ± 0.009	1.364MetIle: 1.364 ± 0.016	1.66MetLys: 1.66 ± 0.018	2.037MetLeu: 2.037 ± 0.022	0.698MetMet: 0.698 ± 0.024	1.966MetAsn: 1.966 ± 0.019	0.844MetPro: 0.844 ± 0.013	0.831MetGln: 0.831 ± 0.014	0.95MetArg: 0.95 ± 0.013	1.795MetSer: 1.795 ± 0.017	1.233MetThr: 1.233 ± 0.014	1.13MetVal: 1.13 ± 0.02	0.189MetTrp: 0.189 ± 0.006	0.658MetTyr: 0.658 ± 0.012	0.002MetXaa: 0.002 ± 0.001
Asn	2.486AsnAla: 2.486 ± 0.025	1.346AsnCys: 1.346 ± 0.019	4.182AsnAsp: 4.182 ± 0.036	4.133AsnGlu: 4.133 ± 0.034	2.256AsnPhe: 2.256 ± 0.022	2.74AsnGly: 2.74 ± 0.026	2.272AsnHis: 2.272 ± 0.023	4.781AsnIle: 4.781 ± 0.034	4.009AsnLys: 4.009 ± 0.035	5.851AsnLeu: 5.851 ± 0.035	1.344AsnMet: 1.344 ± 0.015	8.583AsnAsn: 8.583 ± 0.108	2.902AsnPro: 2.902 ± 0.023	3.275AsnGln: 3.275 ± 0.031	2.91AsnArg: 2.91 ± 0.023	7.322AsnSer: 7.322 ± 0.055	4.503AsnThr: 4.503 ± 0.059	3.374AsnVal: 3.374 ± 0.026	0.657AsnTrp: 0.657 ± 0.013	2.351AsnTyr: 2.351 ± 0.028	0.014AsnXaa: 0.014 ± 0.002
Pro	1.797ProAla: 1.797 ± 0.022	0.877ProCys: 0.877 ± 0.015	2.329ProAsp: 2.329 ± 0.022	2.322ProGlu: 2.322 ± 0.023	1.661ProPhe: 1.661 ± 0.018	2.285ProGly: 2.285 ± 0.052	1.169ProHis: 1.169 ± 0.014	3.222ProIle: 3.222 ± 0.026	2.278ProLys: 2.278 ± 0.022	3.909ProLeu: 3.909 ± 0.03	0.879ProMet: 0.879 ± 0.012	2.939ProAsn: 2.939 ± 0.024	2.95ProPro: 2.95 ± 0.043	1.578ProGln: 1.578 ± 0.02	1.968ProArg: 1.968 ± 0.02	4.871ProSer: 4.871 ± 0.039	3.289ProThr: 3.289 ± 0.032	3.013ProVal: 3.013 ± 0.025	0.38ProTrp: 0.38 ± 0.008	1.419ProTyr: 1.419 ± 0.017	0.005ProXaa: 0.005 ± 0.001
Gln	1.877GlnAla: 1.877 ± 0.02	0.93GlnCys: 0.93 ± 0.015	1.528GlnAsp: 1.528 ± 0.017	2.073GlnGlu: 2.073 ± 0.023	1.674GlnPhe: 1.674 ± 0.019	1.353GlnGly: 1.353 ± 0.019	1.374GlnHis: 1.374 ± 0.014	2.86GlnIle: 2.86 ± 0.027	2.266GlnLys: 2.266 ± 0.025	5.126GlnLeu: 5.126 ± 0.034	1.076GlnMet: 1.076 ± 0.013	2.733GlnAsn: 2.733 ± 0.024	1.911GlnPro: 1.911 ± 0.02	3.246GlnGln: 3.246 ± 0.044	2.144GlnArg: 2.144 ± 0.022	4.372GlnSer: 4.372 ± 0.032	2.632GlnThr: 2.632 ± 0.023	2.016GlnVal: 2.016 ± 0.021	0.486GlnTrp: 0.486 ± 0.011	1.452GlnTyr: 1.452 ± 0.019	0.006GlnXaa: 0.006 ± 0.001
Arg	2.17ArgAla: 2.17 ± 0.025	1.048ArgCys: 1.048 ± 0.016	2.14ArgAsp: 2.14 ± 0.021	2.499ArgGlu: 2.499 ± 0.026	2.04ArgPhe: 2.04 ± 0.021	2.033ArgGly: 2.033 ± 0.028	1.506ArgHis: 1.506 ± 0.02	3.405ArgIle: 3.405 ± 0.025	3.272ArgLys: 3.272 ± 0.028	5.486ArgLeu: 5.486 ± 0.039	1.172ArgMet: 1.172 ± 0.014	2.893ArgAsn: 2.893 ± 0.024	2.171ArgPro: 2.171 ± 0.024	2.382ArgGln: 2.382 ± 0.023	3.658ArgArg: 3.658 ± 0.039	4.3ArgSer: 4.3 ± 0.039	2.767ArgThr: 2.767 ± 0.021	2.419ArgVal: 2.419 ± 0.021	0.58ArgTrp: 0.58 ± 0.012	1.647ArgTyr: 1.647 ± 0.018	0.005ArgXaa: 0.005 ± 0.001
Ser	4.023SerAla: 4.023 ± 0.03	2.074SerCys: 2.074 ± 0.021	5.136SerAsp: 5.136 ± 0.034	4.895SerGlu: 4.895 ± 0.038	3.701SerPhe: 3.701 ± 0.029	4.723SerGly: 4.723 ± 0.039	2.64SerHis: 2.64 ± 0.024	6.48SerIle: 6.48 ± 0.042	5.306SerLys: 5.306 ± 0.035	8.92SerLeu: 8.92 ± 0.044	2.103SerMet: 2.103 ± 0.022	7.652SerAsn: 7.652 ± 0.054	4.522SerPro: 4.522 ± 0.042	3.835SerGln: 3.835 ± 0.032	4.453SerArg: 4.453 ± 0.036	14.162SerSer: 14.162 ± 0.109	7.25SerThr: 7.25 ± 0.049	5.819SerVal: 5.819 ± 0.038	0.841SerTrp: 0.841 ± 0.014	2.783SerTyr: 2.783 ± 0.027	0.011SerXaa: 0.011 ± 0.001
Thr	2.988ThrAla: 2.988 ± 0.028	1.303ThrCys: 1.303 ± 0.015	3.35ThrAsp: 3.35 ± 0.025	3.357ThrGlu: 3.357 ± 0.025	2.166ThrPhe: 2.166 ± 0.022	2.963ThrGly: 2.963 ± 0.03	1.48ThrHis: 1.48 ± 0.018	4.247ThrIle: 4.247 ± 0.05	3.253ThrLys: 3.253 ± 0.024	5.29ThrLeu: 5.29 ± 0.034	1.343ThrMet: 1.343 ± 0.017	5.106ThrAsn: 5.106 ± 0.057	2.898ThrPro: 2.898 ± 0.031	2.154ThrGln: 2.154 ± 0.021	2.642ThrArg: 2.642 ± 0.023	7.106ThrSer: 7.106 ± 0.05	7.359ThrThr: 7.359 ± 0.4	3.66ThrVal: 3.66 ± 0.029	0.585ThrTrp: 0.585 ± 0.012	1.816ThrTyr: 1.816 ± 0.017	0.012ThrXaa: 0.012 ± 0.001
Val	2.652ValAla: 2.652 ± 0.025	1.293ValCys: 1.293 ± 0.018	3.062ValAsp: 3.062 ± 0.029	2.895ValGlu: 2.895 ± 0.025	2.052ValPhe: 2.052 ± 0.02	2.772ValGly: 2.772 ± 0.026	1.523ValHis: 1.523 ± 0.016	3.447ValIle: 3.447 ± 0.024	3.124ValLys: 3.124 ± 0.026	4.826ValLeu: 4.826 ± 0.037	1.094ValMet: 1.094 ± 0.018	3.643ValAsn: 3.643 ± 0.025	2.369ValPro: 2.369 ± 0.022	2.032ValGln: 2.032 ± 0.021	2.622ValArg: 2.622 ± 0.023	5.341ValSer: 5.341 ± 0.033	3.357ValThr: 3.357 ± 0.027	3.223ValVal: 3.223 ± 0.032	0.544ValTrp: 0.544 ± 0.012	1.806ValTyr: 1.806 ± 0.02	0.008ValXaa: 0.008 ± 0.001
Trp	0.386TrpAla: 0.386 ± 0.009	0.244TrpCys: 0.244 ± 0.008	0.526TrpAsp: 0.526 ± 0.01	0.506TrpGlu: 0.506 ± 0.011	0.453TrpPhe: 0.453 ± 0.01	0.367TrpGly: 0.367 ± 0.008	0.259TrpHis: 0.259 ± 0.008	0.85TrpIle: 0.85 ± 0.012	0.742TrpLys: 0.742 ± 0.013	1.092TrpLeu: 1.092 ± 0.017	0.27TrpMet: 0.27 ± 0.007	0.703TrpAsn: 0.703 ± 0.011	0.471TrpPro: 0.471 ± 0.009	0.321TrpGln: 0.321 ± 0.009	0.603TrpArg: 0.603 ± 0.011	0.897TrpSer: 0.897 ± 0.014	0.589TrpThr: 0.589 ± 0.01	0.417TrpVal: 0.417 ± 0.009	0.13TrpTrp: 0.13 ± 0.005	0.309TrpTyr: 0.309 ± 0.008	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.405TyrAla: 1.405 ± 0.02	0.767TyrCys: 0.767 ± 0.013	1.72TyrAsp: 1.72 ± 0.02	1.817TyrGlu: 1.817 ± 0.022	1.503TyrPhe: 1.503 ± 0.018	1.57TyrGly: 1.57 ± 0.021	1.135TyrHis: 1.135 ± 0.014	2.025TyrIle: 2.025 ± 0.022	1.587TyrLys: 1.587 ± 0.022	3.448TyrLeu: 3.448 ± 0.027	0.697TyrMet: 0.697 ± 0.012	2.029TyrAsn: 2.029 ± 0.02	1.494TyrPro: 1.494 ± 0.019	1.398TyrGln: 1.398 ± 0.017	1.665TyrArg: 1.665 ± 0.018	2.989TyrSer: 2.989 ± 0.028	1.834TyrThr: 1.834 ± 0.018	1.581TyrVal: 1.581 ± 0.017	0.379TyrTrp: 0.379 ± 0.008	1.295TyrTyr: 1.295 ± 0.018	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.003XaaCys: 0.003 ± 0.001	0.005XaaAsp: 0.005 ± 0.001	0.006XaaGlu: 0.006 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.004XaaGly: 0.004 ± 0.001	0.003XaaHis: 0.003 ± 0.001	0.012XaaIle: 0.012 ± 0.002	0.008XaaLys: 0.008 ± 0.001	0.011XaaLeu: 0.011 ± 0.001	0.007XaaMet: 0.007 ± 0.001	0.014XaaAsn: 0.014 ± 0.002	0.005XaaPro: 0.005 ± 0.001	0.007XaaGln: 0.007 ± 0.001	0.004XaaArg: 0.004 ± 0.001	0.012XaaSer: 0.012 ± 0.001	0.01XaaThr: 0.01 ± 0.001	0.006XaaVal: 0.006 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.003XaaTyr: 0.003 ± 0.001	2.801XaaXaa: 2.801 ± 0.133

Statistics based on 22244 proteins (5383249 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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