Amino acid dipepetide frequency for Ammoniphilus sp. CFH 90114

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.815AlaAla: 5.815 ± 0.081
0.631AlaCys: 0.631 ± 0.02
3.24AlaAsp: 3.24 ± 0.056
4.874AlaGlu: 4.874 ± 0.06
3.02AlaPhe: 3.02 ± 0.053
5.315AlaGly: 5.315 ± 0.065
1.373AlaHis: 1.373 ± 0.034
5.615AlaIle: 5.615 ± 0.072
4.4AlaLys: 4.4 ± 0.06
7.289AlaLeu: 7.289 ± 0.07
2.215AlaMet: 2.215 ± 0.04
2.511AlaAsn: 2.511 ± 0.051
2.285AlaPro: 2.285 ± 0.044
2.632AlaGln: 2.632 ± 0.046
3.045AlaArg: 3.045 ± 0.046
4.187AlaSer: 4.187 ± 0.056
3.592AlaThr: 3.592 ± 0.053
5.544AlaVal: 5.544 ± 0.067
0.69AlaTrp: 0.69 ± 0.024
2.29AlaTyr: 2.29 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.449CysAla: 0.449 ± 0.017
0.115CysCys: 0.115 ± 0.009
0.402CysAsp: 0.402 ± 0.015
0.439CysGlu: 0.439 ± 0.02
0.354CysPhe: 0.354 ± 0.016
0.742CysGly: 0.742 ± 0.025
0.208CysHis: 0.208 ± 0.012
0.52CysIle: 0.52 ± 0.018
0.401CysLys: 0.401 ± 0.016
0.775CysLeu: 0.775 ± 0.022
0.208CysMet: 0.208 ± 0.013
0.264CysAsn: 0.264 ± 0.012
0.422CysPro: 0.422 ± 0.019
0.276CysGln: 0.276 ± 0.014
0.41CysArg: 0.41 ± 0.02
0.581CysSer: 0.581 ± 0.018
0.416CysThr: 0.416 ± 0.018
0.421CysVal: 0.421 ± 0.017
0.076CysTrp: 0.076 ± 0.007
0.267CysTyr: 0.267 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.07AspAla: 3.07 ± 0.053
0.374AspCys: 0.374 ± 0.017
2.077AspAsp: 2.077 ± 0.045
3.595AspGlu: 3.595 ± 0.056
2.099AspPhe: 2.099 ± 0.037
3.308AspGly: 3.308 ± 0.062
1.274AspHis: 1.274 ± 0.036
3.812AspIle: 3.812 ± 0.05
2.706AspLys: 2.706 ± 0.052
5.171AspLeu: 5.171 ± 0.066
1.347AspMet: 1.347 ± 0.032
1.498AspAsn: 1.498 ± 0.039
2.288AspPro: 2.288 ± 0.046
2.445AspGln: 2.445 ± 0.042
2.63AspArg: 2.63 ± 0.038
2.537AspSer: 2.537 ± 0.045
2.217AspThr: 2.217 ± 0.039
3.564AspVal: 3.564 ± 0.048
0.677AspTrp: 0.677 ± 0.024
1.927AspTyr: 1.927 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
5.475GluAla: 5.475 ± 0.065
0.424GluCys: 0.424 ± 0.02
3.508GluAsp: 3.508 ± 0.055
6.777GluGlu: 6.777 ± 0.096
2.448GluPhe: 2.448 ± 0.043
4.743GluGly: 4.743 ± 0.062
1.48GluHis: 1.48 ± 0.032
5.268GluIle: 5.268 ± 0.06
5.495GluLys: 5.495 ± 0.072
7.259GluLeu: 7.259 ± 0.076
2.219GluMet: 2.219 ± 0.043
2.79GluAsn: 2.79 ± 0.045
2.058GluPro: 2.058 ± 0.04
3.709GluGln: 3.709 ± 0.055
3.758GluArg: 3.758 ± 0.055
3.55GluSer: 3.55 ± 0.051
3.357GluThr: 3.357 ± 0.049
5.466GluVal: 5.466 ± 0.069
0.979GluTrp: 0.979 ± 0.028
2.122GluTyr: 2.122 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
2.888PheAla: 2.888 ± 0.043
0.36PheCys: 0.36 ± 0.015
2.085PheAsp: 2.085 ± 0.036
2.519PheGlu: 2.519 ± 0.043
2.058PhePhe: 2.058 ± 0.047
3.175PheGly: 3.175 ± 0.046
1.024PheHis: 1.024 ± 0.029
3.479PheIle: 3.479 ± 0.058
1.959PheLys: 1.959 ± 0.039
4.576PheLeu: 4.576 ± 0.074
1.139PheMet: 1.139 ± 0.026
1.623PheAsn: 1.623 ± 0.034
1.721PhePro: 1.721 ± 0.033
1.582PheGln: 1.582 ± 0.033
1.694PheArg: 1.694 ± 0.036
3.099PheSer: 3.099 ± 0.052
2.456PheThr: 2.456 ± 0.044
2.853PheVal: 2.853 ± 0.043
0.468PheTrp: 0.468 ± 0.019
1.549PheTyr: 1.549 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
4.983GlyAla: 4.983 ± 0.081
0.708GlyCys: 0.708 ± 0.023
3.236GlyAsp: 3.236 ± 0.057
4.557GlyGlu: 4.557 ± 0.063
3.32GlyPhe: 3.32 ± 0.049
5.028GlyGly: 5.028 ± 0.088
1.469GlyHis: 1.469 ± 0.036
5.818GlyIle: 5.818 ± 0.064
4.952GlyLys: 4.952 ± 0.058
7.143GlyLeu: 7.143 ± 0.082
2.315GlyMet: 2.315 ± 0.041
2.654GlyAsn: 2.654 ± 0.041
1.88GlyPro: 1.88 ± 0.039
2.628GlyGln: 2.628 ± 0.042
3.143GlyArg: 3.143 ± 0.052
4.123GlySer: 4.123 ± 0.066
4.213GlyThr: 4.213 ± 0.058
5.529GlyVal: 5.529 ± 0.062
0.93GlyTrp: 0.93 ± 0.026
2.849GlyTyr: 2.849 ± 0.047
0.001GlyXaa: 0.001 ± 0.001
His
1.343HisAla: 1.343 ± 0.027
0.196HisCys: 0.196 ± 0.011
1.033HisAsp: 1.033 ± 0.025
1.341HisGlu: 1.341 ± 0.03
1.067HisPhe: 1.067 ± 0.029
1.497HisGly: 1.497 ± 0.035
0.767HisHis: 0.767 ± 0.025
1.552HisIle: 1.552 ± 0.032
0.903HisLys: 0.903 ± 0.024
2.413HisLeu: 2.413 ± 0.049
0.593HisMet: 0.593 ± 0.018
0.707HisAsn: 0.707 ± 0.022
1.392HisPro: 1.392 ± 0.033
1.052HisGln: 1.052 ± 0.028
1.095HisArg: 1.095 ± 0.03
1.282HisSer: 1.282 ± 0.03
1.085HisThr: 1.085 ± 0.028
1.5HisVal: 1.5 ± 0.03
0.287HisTrp: 0.287 ± 0.015
0.907HisTyr: 0.907 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.558IleAla: 5.558 ± 0.065
0.645IleCys: 0.645 ± 0.019
3.768IleAsp: 3.768 ± 0.048
5.304IleGlu: 5.304 ± 0.065
2.82IlePhe: 2.82 ± 0.052
5.67IleGly: 5.67 ± 0.076
1.842IleHis: 1.842 ± 0.033
4.926IleIle: 4.926 ± 0.07
3.834IleLys: 3.834 ± 0.057
7.336IleLeu: 7.336 ± 0.095
1.867IleMet: 1.867 ± 0.038
2.736IleAsn: 2.736 ± 0.048
3.678IlePro: 3.678 ± 0.05
3.27IleGln: 3.27 ± 0.054
3.588IleArg: 3.588 ± 0.049
4.843IleSer: 4.843 ± 0.061
4.134IleThr: 4.134 ± 0.061
5.21IleVal: 5.21 ± 0.059
0.672IleTrp: 0.672 ± 0.023
2.243IleTyr: 2.243 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.18LysAla: 4.18 ± 0.06
0.313LysCys: 0.313 ± 0.017
3.272LysAsp: 3.272 ± 0.047
5.941LysGlu: 5.941 ± 0.066
1.733LysPhe: 1.733 ± 0.042
4.364LysGly: 4.364 ± 0.058
1.18LysHis: 1.18 ± 0.032
3.982LysIle: 3.982 ± 0.056
4.797LysLys: 4.797 ± 0.065
5.493LysLeu: 5.493 ± 0.076
2.032LysMet: 2.032 ± 0.037
2.549LysAsn: 2.549 ± 0.039
2.279LysPro: 2.279 ± 0.041
2.797LysGln: 2.797 ± 0.05
3.207LysArg: 3.207 ± 0.05
3.114LysSer: 3.114 ± 0.042
3.04LysThr: 3.04 ± 0.047
4.543LysVal: 4.543 ± 0.059
0.803LysTrp: 0.803 ± 0.024
1.848LysTyr: 1.848 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
7.772LeuAla: 7.772 ± 0.076
0.774LeuCys: 0.774 ± 0.024
5.17LeuAsp: 5.17 ± 0.065
7.121LeuGlu: 7.121 ± 0.075
4.709LeuPhe: 4.709 ± 0.079
7.167LeuGly: 7.167 ± 0.079
2.126LeuHis: 2.126 ± 0.041
7.001LeuIle: 7.001 ± 0.099
6.133LeuLys: 6.133 ± 0.07
10.379LeuLeu: 10.379 ± 0.132
2.6LeuMet: 2.6 ± 0.042
3.965LeuAsn: 3.965 ± 0.053
4.27LeuPro: 4.27 ± 0.051
3.988LeuGln: 3.988 ± 0.058
4.469LeuArg: 4.469 ± 0.062
7.154LeuSer: 7.154 ± 0.081
5.591LeuThr: 5.591 ± 0.057
6.954LeuVal: 6.954 ± 0.073
0.966LeuTrp: 0.966 ± 0.027
3.154LeuTyr: 3.154 ± 0.053
0.001LeuXaa: 0.001 ± 0.001
Met
2.263MetAla: 2.263 ± 0.048
0.154MetCys: 0.154 ± 0.011
1.602MetAsp: 1.602 ± 0.037
2.279MetGlu: 2.279 ± 0.044
1.028MetPhe: 1.028 ± 0.025
2.217MetGly: 2.217 ± 0.043
0.418MetHis: 0.418 ± 0.019
2.209MetIle: 2.209 ± 0.042
2.378MetLys: 2.378 ± 0.042
2.549MetLeu: 2.549 ± 0.038
0.996MetMet: 0.996 ± 0.027
1.519MetAsn: 1.519 ± 0.033
1.067MetPro: 1.067 ± 0.03
0.958MetGln: 0.958 ± 0.027
1.238MetArg: 1.238 ± 0.03
1.747MetSer: 1.747 ± 0.035
1.577MetThr: 1.577 ± 0.029
2.082MetVal: 2.082 ± 0.039
0.225MetTrp: 0.225 ± 0.013
0.725MetTyr: 0.725 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.314AsnAla: 2.314 ± 0.046
0.281AsnCys: 0.281 ± 0.014
1.683AsnAsp: 1.683 ± 0.037
2.622AsnGlu: 2.622 ± 0.046
1.361AsnPhe: 1.361 ± 0.031
2.851AsnGly: 2.851 ± 0.053
0.985AsnHis: 0.985 ± 0.024
2.623AsnIle: 2.623 ± 0.048
2.298AsnLys: 2.298 ± 0.043
3.849AsnLeu: 3.849 ± 0.052
1.155AsnMet: 1.155 ± 0.032
1.514AsnAsn: 1.514 ± 0.04
2.138AsnPro: 2.138 ± 0.035
2.134AsnGln: 2.134 ± 0.044
2.179AsnArg: 2.179 ± 0.039
1.975AsnSer: 1.975 ± 0.039
1.923AsnThr: 1.923 ± 0.039
2.612AsnVal: 2.612 ± 0.042
0.466AsnTrp: 0.466 ± 0.018
1.343AsnTyr: 1.343 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
2.559ProAla: 2.559 ± 0.047
0.255ProCys: 0.255 ± 0.013
2.109ProAsp: 2.109 ± 0.043
3.079ProGlu: 3.079 ± 0.052
1.987ProPhe: 1.987 ± 0.037
2.745ProGly: 2.745 ± 0.052
0.978ProHis: 0.978 ± 0.024
3.012ProIle: 3.012 ± 0.05
2.085ProLys: 2.085 ± 0.039
3.991ProLeu: 3.991 ± 0.059
1.059ProMet: 1.059 ± 0.028
1.596ProAsn: 1.596 ± 0.037
1.338ProPro: 1.338 ± 0.033
1.41ProGln: 1.41 ± 0.036
1.417ProArg: 1.417 ± 0.032
2.648ProSer: 2.648 ± 0.037
2.308ProThr: 2.308 ± 0.05
3.084ProVal: 3.084 ± 0.047
0.448ProTrp: 0.448 ± 0.019
1.608ProTyr: 1.608 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.371GlnAla: 3.371 ± 0.045
0.283GlnCys: 0.283 ± 0.014
1.929GlnAsp: 1.929 ± 0.045
3.369GlnGlu: 3.369 ± 0.054
1.654GlnPhe: 1.654 ± 0.032
2.807GlnGly: 2.807 ± 0.045
0.858GlnHis: 0.858 ± 0.022
2.811GlnIle: 2.811 ± 0.04
2.444GlnLys: 2.444 ± 0.037
4.336GlnLeu: 4.336 ± 0.061
1.244GlnMet: 1.244 ± 0.033
1.43GlnAsn: 1.43 ± 0.032
1.525GlnPro: 1.525 ± 0.036
2.044GlnGln: 2.044 ± 0.051
1.875GlnArg: 1.875 ± 0.041
2.342GlnSer: 2.342 ± 0.047
2.123GlnThr: 2.123 ± 0.036
3.247GlnVal: 3.247 ± 0.049
0.564GlnTrp: 0.564 ± 0.022
1.347GlnTyr: 1.347 ± 0.033
0.001GlnXaa: 0.001 ± 0.001
Arg
2.813ArgAla: 2.813 ± 0.048
0.348ArgCys: 0.348 ± 0.015
2.331ArgAsp: 2.331 ± 0.045
3.739ArgGlu: 3.739 ± 0.05
2.07ArgPhe: 2.07 ± 0.041
2.84ArgGly: 2.84 ± 0.051
0.909ArgHis: 0.909 ± 0.026
3.599ArgIle: 3.599 ± 0.054
3.333ArgLys: 3.333 ± 0.047
4.765ArgLeu: 4.765 ± 0.066
1.524ArgMet: 1.524 ± 0.032
1.932ArgAsn: 1.932 ± 0.035
1.572ArgPro: 1.572 ± 0.036
1.777ArgGln: 1.777 ± 0.043
2.341ArgArg: 2.341 ± 0.045
2.593ArgSer: 2.593 ± 0.042
2.317ArgThr: 2.317 ± 0.04
3.371ArgVal: 3.371 ± 0.054
0.61ArgTrp: 0.61 ± 0.022
1.724ArgTyr: 1.724 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
3.758SerAla: 3.758 ± 0.058
0.453SerCys: 0.453 ± 0.017
2.581SerAsp: 2.581 ± 0.048
3.697SerGlu: 3.697 ± 0.056
3.115SerPhe: 3.115 ± 0.045
4.366SerGly: 4.366 ± 0.055
1.366SerHis: 1.366 ± 0.031
4.93SerIle: 4.93 ± 0.065
3.485SerLys: 3.485 ± 0.045
6.695SerLeu: 6.695 ± 0.082
1.888SerMet: 1.888 ± 0.039
2.259SerAsn: 2.259 ± 0.046
2.531SerPro: 2.531 ± 0.042
2.305SerGln: 2.305 ± 0.048
2.703SerArg: 2.703 ± 0.04
4.105SerSer: 4.105 ± 0.063
3.184SerThr: 3.184 ± 0.054
4.231SerVal: 4.231 ± 0.078
0.756SerTrp: 0.756 ± 0.025
2.197SerTyr: 2.197 ± 0.045
0.001SerXaa: 0.001 ± 0.001
Thr
3.813ThrAla: 3.813 ± 0.062
0.399ThrCys: 0.399 ± 0.017
2.543ThrAsp: 2.543 ± 0.044
3.329ThrGlu: 3.329 ± 0.051
2.34ThrPhe: 2.34 ± 0.04
4.326ThrGly: 4.326 ± 0.05
1.147ThrHis: 1.147 ± 0.026
4.128ThrIle: 4.128 ± 0.058
2.827ThrLys: 2.827 ± 0.053
5.477ThrLeu: 5.477 ± 0.067
1.427ThrMet: 1.427 ± 0.028
2.035ThrAsn: 2.035 ± 0.044
2.543ThrPro: 2.543 ± 0.045
1.777ThrGln: 1.777 ± 0.035
2.244ThrArg: 2.244 ± 0.042
3.204ThrSer: 3.204 ± 0.053
2.999ThrThr: 2.999 ± 0.049
4.201ThrVal: 4.201 ± 0.059
0.562ThrTrp: 0.562 ± 0.021
1.85ThrTyr: 1.85 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
5.319ValAla: 5.319 ± 0.067
0.633ValCys: 0.633 ± 0.021
3.762ValAsp: 3.762 ± 0.053
5.353ValGlu: 5.353 ± 0.069
2.955ValPhe: 2.955 ± 0.044
5.048ValGly: 5.048 ± 0.065
1.513ValHis: 1.513 ± 0.033
5.391ValIle: 5.391 ± 0.069
4.443ValLys: 4.443 ± 0.059
7.054ValLeu: 7.054 ± 0.066
2.134ValMet: 2.134 ± 0.038
2.895ValAsn: 2.895 ± 0.044
2.893ValPro: 2.893 ± 0.05
2.766ValGln: 2.766 ± 0.05
3.172ValArg: 3.172 ± 0.046
4.722ValSer: 4.722 ± 0.058
4.355ValThr: 4.355 ± 0.069
5.481ValVal: 5.481 ± 0.076
0.722ValTrp: 0.722 ± 0.025
2.293ValTyr: 2.293 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.73TrpAla: 0.73 ± 0.024
0.094TrpCys: 0.094 ± 0.008
0.561TrpAsp: 0.561 ± 0.021
0.745TrpGlu: 0.745 ± 0.024
0.548TrpPhe: 0.548 ± 0.018
0.783TrpGly: 0.783 ± 0.026
0.208TrpHis: 0.208 ± 0.013
0.92TrpIle: 0.92 ± 0.032
0.821TrpLys: 0.821 ± 0.023
1.274TrpLeu: 1.274 ± 0.034
0.42TrpMet: 0.42 ± 0.016
0.6TrpAsn: 0.6 ± 0.022
0.292TrpPro: 0.292 ± 0.015
0.392TrpGln: 0.392 ± 0.016
0.478TrpArg: 0.478 ± 0.018
0.714TrpSer: 0.714 ± 0.019
0.575TrpThr: 0.575 ± 0.019
0.806TrpVal: 0.806 ± 0.021
0.161TrpTrp: 0.161 ± 0.011
0.351TrpTyr: 0.351 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.09TyrAla: 2.09 ± 0.036
0.307TyrCys: 0.307 ± 0.014
1.727TyrAsp: 1.727 ± 0.035
2.203TyrGlu: 2.203 ± 0.042
1.623TyrPhe: 1.623 ± 0.037
2.481TyrGly: 2.481 ± 0.042
0.89TyrHis: 0.89 ± 0.023
2.349TyrIle: 2.349 ± 0.044
1.774TyrLys: 1.774 ± 0.039
3.637TyrLeu: 3.637 ± 0.051
0.845TyrMet: 0.845 ± 0.023
1.228TyrAsn: 1.228 ± 0.029
1.543TyrPro: 1.543 ± 0.032
1.663TyrGln: 1.663 ± 0.038
1.822TyrArg: 1.822 ± 0.035
2.086TyrSer: 2.086 ± 0.034
1.709TyrThr: 1.709 ± 0.036
2.205TyrVal: 2.205 ± 0.043
0.41TyrTrp: 0.41 ± 0.015
1.401TyrTyr: 1.401 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.001
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.001XaaMet: 0.001 ± 0.001
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5120 proteins (1503553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski