Amino acid dipepetide frequency for Fructilactobacillus fructivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.174AlaAla: 5.174 ± 0.143
0.342AlaCys: 0.342 ± 0.033
4.236AlaAsp: 4.236 ± 0.114
3.283AlaGlu: 3.283 ± 0.093
2.879AlaPhe: 2.879 ± 0.101
4.91AlaGly: 4.91 ± 0.126
1.199AlaHis: 1.199 ± 0.057
5.519AlaIle: 5.519 ± 0.154
5.436AlaLys: 5.436 ± 0.152
6.326AlaLeu: 6.326 ± 0.15
2.004AlaMet: 2.004 ± 0.068
3.6AlaAsn: 3.6 ± 0.088
2.069AlaPro: 2.069 ± 0.079
2.748AlaGln: 2.748 ± 0.102
2.273AlaArg: 2.273 ± 0.076
4.691AlaSer: 4.691 ± 0.407
3.824AlaThr: 3.824 ± 0.102
4.769AlaVal: 4.769 ± 0.135
0.546AlaTrp: 0.546 ± 0.036
2.303AlaTyr: 2.303 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.304CysAla: 0.304 ± 0.028
0.035CysCys: 0.035 ± 0.009
0.287CysAsp: 0.287 ± 0.025
0.254CysGlu: 0.254 ± 0.026
0.221CysPhe: 0.221 ± 0.027
0.515CysGly: 0.515 ± 0.038
0.121CysHis: 0.121 ± 0.018
0.307CysIle: 0.307 ± 0.03
0.196CysLys: 0.196 ± 0.024
0.395CysLeu: 0.395 ± 0.033
0.091CysMet: 0.091 ± 0.015
0.189CysAsn: 0.189 ± 0.022
0.221CysPro: 0.221 ± 0.027
0.148CysGln: 0.148 ± 0.019
0.161CysArg: 0.161 ± 0.019
0.294CysSer: 0.294 ± 0.027
0.206CysThr: 0.206 ± 0.025
0.307CysVal: 0.307 ± 0.032
0.045CysTrp: 0.045 ± 0.01
0.148CysTyr: 0.148 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.246AspAla: 4.246 ± 0.108
0.224AspCys: 0.224 ± 0.021
4.752AspAsp: 4.752 ± 0.126
4.47AspGlu: 4.47 ± 0.134
2.891AspPhe: 2.891 ± 0.094
4.138AspGly: 4.138 ± 0.128
1.825AspHis: 1.825 ± 0.074
4.166AspIle: 4.166 ± 0.117
4.593AspLys: 4.593 ± 0.122
5.775AspLeu: 5.775 ± 0.144
1.516AspMet: 1.516 ± 0.063
3.497AspAsn: 3.497 ± 0.125
2.901AspPro: 2.901 ± 0.096
3.505AspGln: 3.505 ± 0.121
2.439AspArg: 2.439 ± 0.074
4.055AspSer: 4.055 ± 0.409
2.899AspThr: 2.899 ± 0.104
4.666AspVal: 4.666 ± 0.122
0.706AspTrp: 0.706 ± 0.044
2.655AspTyr: 2.655 ± 0.085
0.0AspXaa: 0.0 ± 0.0
Glu
3.505GluAla: 3.505 ± 0.104
0.211GluCys: 0.211 ± 0.024
3.108GluAsp: 3.108 ± 0.099
2.788GluGlu: 2.788 ± 0.113
2.155GluPhe: 2.155 ± 0.077
2.431GluGly: 2.431 ± 0.109
1.182GluHis: 1.182 ± 0.054
4.166GluIle: 4.166 ± 0.12
4.244GluLys: 4.244 ± 0.121
5.091GluLeu: 5.091 ± 0.131
1.86GluMet: 1.86 ± 0.075
3.195GluAsn: 3.195 ± 0.098
1.566GluPro: 1.566 ± 0.062
2.22GluGln: 2.22 ± 0.094
2.28GluArg: 2.28 ± 0.088
2.962GluSer: 2.962 ± 0.104
2.652GluThr: 2.652 ± 0.094
3.701GluVal: 3.701 ± 0.121
0.417GluTrp: 0.417 ± 0.034
1.835GluTyr: 1.835 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
2.891PheAla: 2.891 ± 0.111
0.256PheCys: 0.256 ± 0.027
3.037PheAsp: 3.037 ± 0.105
1.946PheGlu: 1.946 ± 0.068
2.052PhePhe: 2.052 ± 0.087
3.457PheGly: 3.457 ± 0.108
0.837PheHis: 0.837 ± 0.048
3.095PheIle: 3.095 ± 0.117
3.145PheLys: 3.145 ± 0.086
3.756PheLeu: 3.756 ± 0.128
1.199PheMet: 1.199 ± 0.058
2.537PheAsn: 2.537 ± 0.074
1.519PhePro: 1.519 ± 0.061
1.373PheGln: 1.373 ± 0.062
1.29PheArg: 1.29 ± 0.058
2.793PheSer: 2.793 ± 0.091
2.416PheThr: 2.416 ± 0.08
3.145PheVal: 3.145 ± 0.103
0.518PheTrp: 0.518 ± 0.036
1.644PheTyr: 1.644 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
4.51GlyAla: 4.51 ± 0.123
0.329GlyCys: 0.329 ± 0.027
3.766GlyAsp: 3.766 ± 0.117
3.108GlyGlu: 3.108 ± 0.101
3.004GlyPhe: 3.004 ± 0.098
4.292GlyGly: 4.292 ± 0.14
1.481GlyHis: 1.481 ± 0.059
6.059GlyIle: 6.059 ± 0.156
5.554GlyLys: 5.554 ± 0.134
6.132GlyLeu: 6.132 ± 0.137
2.14GlyMet: 2.14 ± 0.076
3.301GlyAsn: 3.301 ± 0.105
1.659GlyPro: 1.659 ± 0.063
2.562GlyGln: 2.562 ± 0.084
2.459GlyArg: 2.459 ± 0.091
4.327GlySer: 4.327 ± 0.166
4.01GlyThr: 4.01 ± 0.123
4.877GlyVal: 4.877 ± 0.145
0.684GlyTrp: 0.684 ± 0.047
2.705GlyTyr: 2.705 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
1.292HisAla: 1.292 ± 0.06
0.091HisCys: 0.091 ± 0.016
1.393HisAsp: 1.393 ± 0.061
1.227HisGlu: 1.227 ± 0.06
1.114HisPhe: 1.114 ± 0.059
1.599HisGly: 1.599 ± 0.073
0.779HisHis: 0.779 ± 0.044
1.358HisIle: 1.358 ± 0.065
1.172HisLys: 1.172 ± 0.055
2.059HisLeu: 2.059 ± 0.084
0.52HisMet: 0.52 ± 0.039
1.026HisAsn: 1.026 ± 0.058
1.224HisPro: 1.224 ± 0.066
1.026HisGln: 1.026 ± 0.056
0.882HisArg: 0.882 ± 0.052
1.159HisSer: 1.159 ± 0.054
0.993HisThr: 0.993 ± 0.053
1.491HisVal: 1.491 ± 0.055
0.209HisTrp: 0.209 ± 0.022
0.88HisTyr: 0.88 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
5.793IleAla: 5.793 ± 0.156
0.475IleCys: 0.475 ± 0.038
5.031IleAsp: 5.031 ± 0.126
3.646IleGlu: 3.646 ± 0.105
3.175IlePhe: 3.175 ± 0.112
5.561IleGly: 5.561 ± 0.154
1.363IleHis: 1.363 ± 0.055
6.087IleIle: 6.087 ± 0.178
5.511IleLys: 5.511 ± 0.136
6.776IleLeu: 6.776 ± 0.191
2.004IleMet: 2.004 ± 0.084
4.505IleAsn: 4.505 ± 0.122
3.183IlePro: 3.183 ± 0.094
2.564IleGln: 2.564 ± 0.078
2.534IleArg: 2.534 ± 0.085
5.232IleSer: 5.232 ± 0.129
4.131IleThr: 4.131 ± 0.105
5.679IleVal: 5.679 ± 0.139
0.573IleTrp: 0.573 ± 0.045
2.409IleTyr: 2.409 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.563LysAla: 4.563 ± 0.132
0.234LysCys: 0.234 ± 0.025
4.93LysAsp: 4.93 ± 0.134
4.352LysGlu: 4.352 ± 0.116
2.547LysPhe: 2.547 ± 0.078
3.731LysGly: 3.731 ± 0.099
1.667LysHis: 1.667 ± 0.076
5.403LysIle: 5.403 ± 0.122
6.884LysLys: 6.884 ± 0.147
6.19LysLeu: 6.19 ± 0.123
2.984LysMet: 2.984 ± 0.07
5.001LysAsn: 5.001 ± 0.126
2.7LysPro: 2.7 ± 0.098
3.892LysGln: 3.892 ± 0.122
3.59LysArg: 3.59 ± 0.11
4.365LysSer: 4.365 ± 0.128
4.211LysThr: 4.211 ± 0.105
5.003LysVal: 5.003 ± 0.133
0.669LysTrp: 0.669 ± 0.043
3.004LysTyr: 3.004 ± 0.095
0.0LysXaa: 0.0 ± 0.0
Leu
6.268LeuAla: 6.268 ± 0.158
0.44LeuCys: 0.44 ± 0.042
5.546LeuAsp: 5.546 ± 0.118
3.91LeuGlu: 3.91 ± 0.118
3.922LeuPhe: 3.922 ± 0.131
6.097LeuGly: 6.097 ± 0.15
1.642LeuHis: 1.642 ± 0.066
7.231LeuIle: 7.231 ± 0.197
7.125LeuLys: 7.125 ± 0.144
7.736LeuLeu: 7.736 ± 0.206
2.401LeuMet: 2.401 ± 0.079
5.275LeuAsn: 5.275 ± 0.104
3.588LeuPro: 3.588 ± 0.099
2.881LeuGln: 2.881 ± 0.075
3.06LeuArg: 3.06 ± 0.095
6.617LeuSer: 6.617 ± 0.17
5.104LeuThr: 5.104 ± 0.127
6.484LeuVal: 6.484 ± 0.153
0.686LeuTrp: 0.686 ± 0.042
2.66LeuTyr: 2.66 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
2.336MetAla: 2.336 ± 0.085
0.133MetCys: 0.133 ± 0.019
1.798MetAsp: 1.798 ± 0.071
1.28MetGlu: 1.28 ± 0.058
1.041MetPhe: 1.041 ± 0.055
1.876MetGly: 1.876 ± 0.077
0.49MetHis: 0.49 ± 0.036
2.28MetIle: 2.28 ± 0.078
2.544MetLys: 2.544 ± 0.077
2.147MetLeu: 2.147 ± 0.072
0.867MetMet: 0.867 ± 0.046
1.908MetAsn: 1.908 ± 0.08
1.101MetPro: 1.101 ± 0.053
1.021MetGln: 1.021 ± 0.046
0.975MetArg: 0.975 ± 0.049
2.147MetSer: 2.147 ± 0.196
1.72MetThr: 1.72 ± 0.07
2.044MetVal: 2.044 ± 0.076
0.244MetTrp: 0.244 ± 0.027
0.717MetTyr: 0.717 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.741AsnAla: 3.741 ± 0.107
0.246AsnCys: 0.246 ± 0.024
4.206AsnAsp: 4.206 ± 0.128
3.374AsnGlu: 3.374 ± 0.103
2.313AsnPhe: 2.313 ± 0.083
4.41AsnGly: 4.41 ± 0.109
1.536AsnHis: 1.536 ± 0.066
3.547AsnIle: 3.547 ± 0.088
3.764AsnLys: 3.764 ± 0.116
4.742AsnLeu: 4.742 ± 0.102
1.549AsnMet: 1.549 ± 0.057
3.676AsnAsn: 3.676 ± 0.169
2.484AsnPro: 2.484 ± 0.082
3.113AsnGln: 3.113 ± 0.117
2.112AsnArg: 2.112 ± 0.078
3.487AsnSer: 3.487 ± 0.213
2.68AsnThr: 2.68 ± 0.092
4.166AsnVal: 4.166 ± 0.124
0.588AsnTrp: 0.588 ± 0.044
2.147AsnTyr: 2.147 ± 0.076
0.0AsnXaa: 0.0 ± 0.0
Pro
2.308ProAla: 2.308 ± 0.074
0.103ProCys: 0.103 ± 0.015
2.713ProAsp: 2.713 ± 0.095
2.552ProGlu: 2.552 ± 0.092
1.705ProPhe: 1.705 ± 0.072
2.429ProGly: 2.429 ± 0.092
0.719ProHis: 0.719 ± 0.044
2.942ProIle: 2.942 ± 0.092
3.032ProLys: 3.032 ± 0.083
2.914ProLeu: 2.914 ± 0.091
0.895ProMet: 0.895 ± 0.046
2.27ProAsn: 2.27 ± 0.084
0.586ProPro: 0.586 ± 0.036
1.39ProGln: 1.39 ± 0.06
1.134ProArg: 1.134 ± 0.058
2.263ProSer: 2.263 ± 0.09
2.238ProThr: 2.238 ± 0.069
2.851ProVal: 2.851 ± 0.089
0.277ProTrp: 0.277 ± 0.031
1.438ProTyr: 1.438 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
2.871GlnAla: 2.871 ± 0.103
0.101GlnCys: 0.101 ± 0.018
2.167GlnAsp: 2.167 ± 0.083
1.808GlnGlu: 1.808 ± 0.074
1.77GlnPhe: 1.77 ± 0.058
1.984GlnGly: 1.984 ± 0.075
0.817GlnHis: 0.817 ± 0.046
3.289GlnIle: 3.289 ± 0.096
3.547GlnLys: 3.547 ± 0.114
4.03GlnLeu: 4.03 ± 0.125
1.373GlnMet: 1.373 ± 0.07
2.454GlnAsn: 2.454 ± 0.091
1.622GlnPro: 1.622 ± 0.075
1.866GlnGln: 1.866 ± 0.09
1.551GlnArg: 1.551 ± 0.072
2.63GlnSer: 2.63 ± 0.138
2.366GlnThr: 2.366 ± 0.086
3.027GlnVal: 3.027 ± 0.092
0.357GlnTrp: 0.357 ± 0.031
1.441GlnTyr: 1.441 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
2.366ArgAla: 2.366 ± 0.072
0.138ArgCys: 0.138 ± 0.02
2.449ArgAsp: 2.449 ± 0.086
1.969ArgGlu: 1.969 ± 0.09
1.619ArgPhe: 1.619 ± 0.061
2.348ArgGly: 2.348 ± 0.085
0.84ArgHis: 0.84 ± 0.051
2.866ArgIle: 2.866 ± 0.092
2.647ArgLys: 2.647 ± 0.083
3.404ArgLeu: 3.404 ± 0.113
1.089ArgMet: 1.089 ± 0.053
2.089ArgAsn: 2.089 ± 0.078
1.302ArgPro: 1.302 ± 0.065
1.466ArgGln: 1.466 ± 0.057
1.843ArgArg: 1.843 ± 0.091
2.084ArgSer: 2.084 ± 0.081
1.838ArgThr: 1.838 ± 0.074
2.668ArgVal: 2.668 ± 0.107
0.292ArgTrp: 0.292 ± 0.027
1.491ArgTyr: 1.491 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
4.473SerAla: 4.473 ± 0.381
0.214SerCys: 0.214 ± 0.022
5.066SerAsp: 5.066 ± 0.402
3.615SerGlu: 3.615 ± 0.12
2.856SerPhe: 2.856 ± 0.091
4.739SerGly: 4.739 ± 0.184
1.297SerHis: 1.297 ± 0.059
4.463SerIle: 4.463 ± 0.109
4.928SerLys: 4.928 ± 0.137
5.486SerLeu: 5.486 ± 0.186
1.888SerMet: 1.888 ± 0.191
3.766SerAsn: 3.766 ± 0.203
2.026SerPro: 2.026 ± 0.077
2.771SerGln: 2.771 ± 0.16
2.2SerArg: 2.2 ± 0.081
4.146SerSer: 4.146 ± 0.164
4.086SerThr: 4.086 ± 0.638
4.435SerVal: 4.435 ± 0.128
0.561SerTrp: 0.561 ± 0.04
2.135SerTyr: 2.135 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
3.741ThrAla: 3.741 ± 0.106
0.226ThrCys: 0.226 ± 0.027
3.502ThrAsp: 3.502 ± 0.099
2.358ThrGlu: 2.358 ± 0.084
2.336ThrPhe: 2.336 ± 0.071
4.189ThrGly: 4.189 ± 0.107
1.106ThrHis: 1.106 ± 0.045
4.518ThrIle: 4.518 ± 0.113
3.912ThrLys: 3.912 ± 0.101
4.752ThrLeu: 4.752 ± 0.125
1.292ThrMet: 1.292 ± 0.055
3.195ThrAsn: 3.195 ± 0.096
2.459ThrPro: 2.459 ± 0.085
1.863ThrGln: 1.863 ± 0.064
1.72ThrArg: 1.72 ± 0.072
4.274ThrSer: 4.274 ± 0.611
3.145ThrThr: 3.145 ± 0.11
3.947ThrVal: 3.947 ± 0.099
0.528ThrTrp: 0.528 ± 0.043
1.848ThrTyr: 1.848 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
5.152ValAla: 5.152 ± 0.135
0.395ValCys: 0.395 ± 0.032
4.918ValAsp: 4.918 ± 0.134
3.583ValGlu: 3.583 ± 0.121
2.838ValPhe: 2.838 ± 0.095
5.204ValGly: 5.204 ± 0.134
1.325ValHis: 1.325 ± 0.059
5.883ValIle: 5.883 ± 0.141
5.136ValLys: 5.136 ± 0.119
6.187ValLeu: 6.187 ± 0.157
1.901ValMet: 1.901 ± 0.077
4.091ValAsn: 4.091 ± 0.095
2.796ValPro: 2.796 ± 0.071
2.476ValGln: 2.476 ± 0.08
2.414ValArg: 2.414 ± 0.095
4.908ValSer: 4.908 ± 0.151
4.309ValThr: 4.309 ± 0.119
5.649ValVal: 5.649 ± 0.137
0.563ValTrp: 0.563 ± 0.042
2.308ValTyr: 2.308 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.465TrpAla: 0.465 ± 0.033
0.048TrpCys: 0.048 ± 0.012
0.52TrpAsp: 0.52 ± 0.037
0.354TrpGlu: 0.354 ± 0.033
0.498TrpPhe: 0.498 ± 0.038
0.621TrpGly: 0.621 ± 0.044
0.224TrpHis: 0.224 ± 0.021
0.933TrpIle: 0.933 ± 0.055
0.568TrpLys: 0.568 ± 0.034
1.053TrpLeu: 1.053 ± 0.063
0.284TrpMet: 0.284 ± 0.03
0.581TrpAsn: 0.581 ± 0.044
0.282TrpPro: 0.282 ± 0.028
0.289TrpGln: 0.289 ± 0.027
0.299TrpArg: 0.299 ± 0.026
0.478TrpSer: 0.478 ± 0.033
0.427TrpThr: 0.427 ± 0.036
0.563TrpVal: 0.563 ± 0.041
0.131TrpTrp: 0.131 ± 0.019
0.342TrpTyr: 0.342 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.132TyrAla: 2.132 ± 0.076
0.204TyrCys: 0.204 ± 0.028
2.497TyrAsp: 2.497 ± 0.098
1.695TyrGlu: 1.695 ± 0.061
1.971TyrPhe: 1.971 ± 0.079
2.429TyrGly: 2.429 ± 0.075
1.043TyrHis: 1.043 ± 0.051
2.122TyrIle: 2.122 ± 0.079
1.984TyrLys: 1.984 ± 0.078
3.721TyrLeu: 3.721 ± 0.111
0.81TyrMet: 0.81 ± 0.051
1.725TyrAsn: 1.725 ± 0.066
1.468TyrPro: 1.468 ± 0.056
1.896TyrGln: 1.896 ± 0.075
1.591TyrArg: 1.591 ± 0.064
2.238TyrSer: 2.238 ± 0.076
1.657TyrThr: 1.657 ± 0.078
2.562TyrVal: 2.562 ± 0.077
0.367TyrTrp: 0.367 ± 0.033
1.398TyrTyr: 1.398 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1281 proteins (397748 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski