Amino acid dipepetide frequency for Thiothrix caldifontis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.03AlaAla: 11.03 ± 0.128
1.156AlaCys: 1.156 ± 0.035
5.718AlaAsp: 5.718 ± 0.085
6.388AlaGlu: 6.388 ± 0.086
3.527AlaPhe: 3.527 ± 0.057
7.691AlaGly: 7.691 ± 0.095
2.112AlaHis: 2.112 ± 0.048
5.353AlaIle: 5.353 ± 0.066
4.039AlaLys: 4.039 ± 0.067
10.959AlaLeu: 10.959 ± 0.131
2.742AlaMet: 2.742 ± 0.051
3.776AlaAsn: 3.776 ± 0.057
3.738AlaPro: 3.738 ± 0.083
4.529AlaGln: 4.529 ± 0.072
4.657AlaArg: 4.657 ± 0.066
5.332AlaSer: 5.332 ± 0.082
5.39AlaThr: 5.39 ± 0.076
6.956AlaVal: 6.956 ± 0.092
1.464AlaTrp: 1.464 ± 0.039
2.687AlaTyr: 2.687 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.028
0.141CysCys: 0.141 ± 0.011
0.516CysAsp: 0.516 ± 0.022
0.585CysGlu: 0.585 ± 0.022
0.336CysPhe: 0.336 ± 0.017
0.896CysGly: 0.896 ± 0.03
0.354CysHis: 0.354 ± 0.017
0.514CysIle: 0.514 ± 0.021
0.375CysLys: 0.375 ± 0.02
0.986CysLeu: 0.986 ± 0.032
0.21CysMet: 0.21 ± 0.014
0.347CysAsn: 0.347 ± 0.018
0.544CysPro: 0.544 ± 0.026
0.433CysGln: 0.433 ± 0.018
0.584CysArg: 0.584 ± 0.023
0.626CysSer: 0.626 ± 0.026
0.504CysThr: 0.504 ± 0.018
0.631CysVal: 0.631 ± 0.022
0.138CysTrp: 0.138 ± 0.013
0.309CysTyr: 0.309 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.636AspAla: 5.636 ± 0.109
0.524AspCys: 0.524 ± 0.024
3.003AspAsp: 3.003 ± 0.071
3.221AspGlu: 3.221 ± 0.06
2.335AspPhe: 2.335 ± 0.049
4.198AspGly: 4.198 ± 0.11
1.02AspHis: 1.02 ± 0.03
3.257AspIle: 3.257 ± 0.056
2.82AspLys: 2.82 ± 0.061
5.01AspLeu: 5.01 ± 0.079
1.514AspMet: 1.514 ± 0.035
2.24AspAsn: 2.24 ± 0.062
2.452AspPro: 2.452 ± 0.056
1.749AspGln: 1.749 ± 0.038
2.312AspArg: 2.312 ± 0.054
2.876AspSer: 2.876 ± 0.06
3.484AspThr: 3.484 ± 0.072
3.771AspVal: 3.771 ± 0.055
0.935AspTrp: 0.935 ± 0.029
2.017AspTyr: 2.017 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.79GluAla: 5.79 ± 0.083
0.528GluCys: 0.528 ± 0.024
2.509GluAsp: 2.509 ± 0.051
3.078GluGlu: 3.078 ± 0.068
1.978GluPhe: 1.978 ± 0.045
3.426GluGly: 3.426 ± 0.06
1.54GluHis: 1.54 ± 0.035
3.359GluIle: 3.359 ± 0.056
3.041GluLys: 3.041 ± 0.056
6.022GluLeu: 6.022 ± 0.085
1.621GluMet: 1.621 ± 0.038
2.131GluAsn: 2.131 ± 0.048
2.248GluPro: 2.248 ± 0.054
3.456GluGln: 3.456 ± 0.063
4.007GluArg: 4.007 ± 0.078
2.843GluSer: 2.843 ± 0.049
3.439GluThr: 3.439 ± 0.055
3.868GluVal: 3.868 ± 0.055
0.885GluTrp: 0.885 ± 0.029
1.748GluTyr: 1.748 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.778PheAla: 3.778 ± 0.065
0.433PheCys: 0.433 ± 0.018
2.266PheAsp: 2.266 ± 0.04
1.938PheGlu: 1.938 ± 0.048
1.636PhePhe: 1.636 ± 0.044
2.969PheGly: 2.969 ± 0.049
0.878PheHis: 0.878 ± 0.025
2.125PheIle: 2.125 ± 0.049
1.466PheLys: 1.466 ± 0.04
3.659PheLeu: 3.659 ± 0.074
1.047PheMet: 1.047 ± 0.032
1.51PheAsn: 1.51 ± 0.034
1.649PhePro: 1.649 ± 0.042
1.397PheGln: 1.397 ± 0.033
1.934PheArg: 1.934 ± 0.041
2.574PheSer: 2.574 ± 0.044
2.22PheThr: 2.22 ± 0.05
2.42PheVal: 2.42 ± 0.046
0.61PheTrp: 0.61 ± 0.024
1.206PheTyr: 1.206 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.781GlyAla: 5.781 ± 0.093
0.962GlyCys: 0.962 ± 0.031
3.873GlyAsp: 3.873 ± 0.074
4.36GlyGlu: 4.36 ± 0.062
3.119GlyPhe: 3.119 ± 0.058
5.368GlyGly: 5.368 ± 0.093
1.552GlyHis: 1.552 ± 0.036
4.763GlyIle: 4.763 ± 0.077
4.57GlyLys: 4.57 ± 0.069
7.383GlyLeu: 7.383 ± 0.103
2.384GlyMet: 2.384 ± 0.085
3.088GlyAsn: 3.088 ± 0.066
1.235GlyPro: 1.235 ± 0.036
3.006GlyGln: 3.006 ± 0.053
3.521GlyArg: 3.521 ± 0.064
4.235GlySer: 4.235 ± 0.076
3.973GlyThr: 3.973 ± 0.088
5.564GlyVal: 5.564 ± 0.074
1.228GlyTrp: 1.228 ± 0.035
2.475GlyTyr: 2.475 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.151HisAla: 2.151 ± 0.048
0.3HisCys: 0.3 ± 0.015
1.357HisAsp: 1.357 ± 0.036
1.315HisGlu: 1.315 ± 0.034
1.083HisPhe: 1.083 ± 0.029
1.77HisGly: 1.77 ± 0.04
0.776HisHis: 0.776 ± 0.028
1.347HisIle: 1.347 ± 0.037
0.885HisLys: 0.885 ± 0.032
2.725HisLeu: 2.725 ± 0.049
0.515HisMet: 0.515 ± 0.019
0.867HisAsn: 0.867 ± 0.028
1.407HisPro: 1.407 ± 0.04
1.053HisGln: 1.053 ± 0.03
1.156HisArg: 1.156 ± 0.033
1.334HisSer: 1.334 ± 0.032
1.496HisThr: 1.496 ± 0.036
1.454HisVal: 1.454 ± 0.037
0.469HisTrp: 0.469 ± 0.021
0.984HisTyr: 0.984 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.755IleAla: 5.755 ± 0.07
0.473IleCys: 0.473 ± 0.02
3.164IleAsp: 3.164 ± 0.052
3.167IleGlu: 3.167 ± 0.056
1.759IlePhe: 1.759 ± 0.041
4.144IleGly: 4.144 ± 0.072
1.35IleHis: 1.35 ± 0.032
2.914IleIle: 2.914 ± 0.052
2.325IleLys: 2.325 ± 0.055
5.108IleLeu: 5.108 ± 0.08
1.121IleMet: 1.121 ± 0.031
2.179IleAsn: 2.179 ± 0.046
3.18IlePro: 3.18 ± 0.059
2.169IleGln: 2.169 ± 0.043
3.344IleArg: 3.344 ± 0.058
3.341IleSer: 3.341 ± 0.06
3.327IleThr: 3.327 ± 0.059
3.508IleVal: 3.508 ± 0.049
0.527IleTrp: 0.527 ± 0.023
1.392IleTyr: 1.392 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.534LysAla: 4.534 ± 0.077
0.27LysCys: 0.27 ± 0.015
2.164LysAsp: 2.164 ± 0.053
2.229LysGlu: 2.229 ± 0.053
1.161LysPhe: 1.161 ± 0.033
2.962LysGly: 2.962 ± 0.067
1.132LysHis: 1.132 ± 0.031
2.32LysIle: 2.32 ± 0.053
2.028LysLys: 2.028 ± 0.053
4.713LysLeu: 4.713 ± 0.059
1.082LysMet: 1.082 ± 0.031
1.514LysAsn: 1.514 ± 0.041
2.612LysPro: 2.612 ± 0.059
2.358LysGln: 2.358 ± 0.044
2.524LysArg: 2.524 ± 0.051
2.272LysSer: 2.272 ± 0.055
2.729LysThr: 2.729 ± 0.05
3.147LysVal: 3.147 ± 0.058
0.422LysTrp: 0.422 ± 0.019
1.11LysTyr: 1.11 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.041LeuAla: 11.041 ± 0.116
0.966LeuCys: 0.966 ± 0.032
6.009LeuAsp: 6.009 ± 0.087
6.394LeuGlu: 6.394 ± 0.085
4.08LeuPhe: 4.08 ± 0.072
7.532LeuGly: 7.532 ± 0.096
2.782LeuHis: 2.782 ± 0.055
5.242LeuIle: 5.242 ± 0.085
4.521LeuLys: 4.521 ± 0.07
12.806LeuLeu: 12.806 ± 0.18
2.616LeuMet: 2.616 ± 0.049
3.889LeuAsn: 3.889 ± 0.062
6.014LeuPro: 6.014 ± 0.083
5.444LeuGln: 5.444 ± 0.087
5.957LeuArg: 5.957 ± 0.084
6.602LeuSer: 6.602 ± 0.09
6.065LeuThr: 6.065 ± 0.075
6.86LeuVal: 6.86 ± 0.099
1.401LeuTrp: 1.401 ± 0.048
2.771LeuTyr: 2.771 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.504MetAla: 2.504 ± 0.046
0.186MetCys: 0.186 ± 0.013
1.242MetAsp: 1.242 ± 0.034
1.395MetGlu: 1.395 ± 0.034
0.776MetPhe: 0.776 ± 0.028
1.848MetGly: 1.848 ± 0.04
0.53MetHis: 0.53 ± 0.021
1.243MetIle: 1.243 ± 0.033
1.301MetLys: 1.301 ± 0.03
2.832MetLeu: 2.832 ± 0.054
0.705MetMet: 0.705 ± 0.026
1.001MetAsn: 1.001 ± 0.033
1.425MetPro: 1.425 ± 0.035
1.469MetGln: 1.469 ± 0.039
1.482MetArg: 1.482 ± 0.032
1.589MetSer: 1.589 ± 0.047
1.576MetThr: 1.576 ± 0.036
1.67MetVal: 1.67 ± 0.043
0.205MetTrp: 0.205 ± 0.011
0.473MetTyr: 0.473 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.639AsnAla: 3.639 ± 0.065
0.347AsnCys: 0.347 ± 0.021
1.938AsnAsp: 1.938 ± 0.066
1.692AsnGlu: 1.692 ± 0.041
1.243AsnPhe: 1.243 ± 0.033
2.958AsnGly: 2.958 ± 0.066
0.916AsnHis: 0.916 ± 0.025
2.161AsnIle: 2.161 ± 0.049
1.535AsnLys: 1.535 ± 0.042
3.875AsnLeu: 3.875 ± 0.063
0.797AsnMet: 0.797 ± 0.027
1.695AsnAsn: 1.695 ± 0.055
2.469AsnPro: 2.469 ± 0.056
1.574AsnGln: 1.574 ± 0.039
2.003AsnArg: 2.003 ± 0.042
1.942AsnSer: 1.942 ± 0.044
2.588AsnThr: 2.588 ± 0.056
2.52AsnVal: 2.52 ± 0.05
0.522AsnTrp: 0.522 ± 0.023
1.069AsnTyr: 1.069 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
5.034ProAla: 5.034 ± 0.073
0.361ProCys: 0.361 ± 0.019
3.192ProAsp: 3.192 ± 0.061
3.395ProGlu: 3.395 ± 0.06
1.795ProPhe: 1.795 ± 0.037
2.829ProGly: 2.829 ± 0.057
1.095ProHis: 1.095 ± 0.035
2.22ProIle: 2.22 ± 0.044
1.659ProLys: 1.659 ± 0.043
4.952ProLeu: 4.952 ± 0.077
1.069ProMet: 1.069 ± 0.033
1.751ProAsn: 1.751 ± 0.046
2.282ProPro: 2.282 ± 0.062
2.061ProGln: 2.061 ± 0.045
1.913ProArg: 1.913 ± 0.043
2.407ProSer: 2.407 ± 0.05
2.74ProThr: 2.74 ± 0.055
3.806ProVal: 3.806 ± 0.068
0.638ProTrp: 0.638 ± 0.027
1.317ProTyr: 1.317 ± 0.032
0.001ProXaa: 0.001 ± 0.001
Gln
5.627GlnAla: 5.627 ± 0.088
0.404GlnCys: 0.404 ± 0.018
2.025GlnAsp: 2.025 ± 0.041
2.449GlnGlu: 2.449 ± 0.053
1.538GlnPhe: 1.538 ± 0.036
3.243GlnGly: 3.243 ± 0.053
1.639GlnHis: 1.639 ± 0.042
2.197GlnIle: 2.197 ± 0.046
1.628GlnLys: 1.628 ± 0.043
4.722GlnLeu: 4.722 ± 0.076
1.112GlnMet: 1.112 ± 0.032
1.375GlnAsn: 1.375 ± 0.034
2.283GlnPro: 2.283 ± 0.048
3.762GlnGln: 3.762 ± 0.087
3.313GlnArg: 3.313 ± 0.065
2.108GlnSer: 2.108 ± 0.047
2.769GlnThr: 2.769 ± 0.055
3.286GlnVal: 3.286 ± 0.062
0.705GlnTrp: 0.705 ± 0.025
1.358GlnTyr: 1.358 ± 0.036
0.001GlnXaa: 0.001 ± 0.001
Arg
4.228ArgAla: 4.228 ± 0.067
0.517ArgCys: 0.517 ± 0.022
3.15ArgAsp: 3.15 ± 0.073
3.815ArgGlu: 3.815 ± 0.058
2.513ArgPhe: 2.513 ± 0.053
3.077ArgGly: 3.077 ± 0.061
1.533ArgHis: 1.533 ± 0.044
3.286ArgIle: 3.286 ± 0.056
2.447ArgLys: 2.447 ± 0.045
6.383ArgLeu: 6.383 ± 0.097
1.497ArgMet: 1.497 ± 0.034
2.001ArgAsn: 2.001 ± 0.041
2.022ArgPro: 2.022 ± 0.043
2.909ArgGln: 2.909 ± 0.06
2.902ArgArg: 2.902 ± 0.059
2.707ArgSer: 2.707 ± 0.043
2.563ArgThr: 2.563 ± 0.045
3.603ArgVal: 3.603 ± 0.053
0.865ArgTrp: 0.865 ± 0.028
1.998ArgTyr: 1.998 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.211SerAla: 5.211 ± 0.068
0.59SerCys: 0.59 ± 0.023
2.826SerAsp: 2.826 ± 0.064
2.739SerGlu: 2.739 ± 0.054
2.112SerPhe: 2.112 ± 0.044
5.02SerGly: 5.02 ± 0.086
1.384SerHis: 1.384 ± 0.035
3.153SerIle: 3.153 ± 0.062
2.281SerLys: 2.281 ± 0.044
6.203SerLeu: 6.203 ± 0.074
1.392SerMet: 1.392 ± 0.035
2.216SerAsn: 2.216 ± 0.051
2.626SerPro: 2.626 ± 0.051
2.254SerGln: 2.254 ± 0.049
2.994SerArg: 2.994 ± 0.05
3.523SerSer: 3.523 ± 0.073
3.256SerThr: 3.256 ± 0.066
3.907SerVal: 3.907 ± 0.053
0.754SerTrp: 0.754 ± 0.027
1.546SerTyr: 1.546 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
5.803ThrAla: 5.803 ± 0.086
0.507ThrCys: 0.507 ± 0.021
3.267ThrAsp: 3.267 ± 0.096
2.904ThrGlu: 2.904 ± 0.049
2.141ThrPhe: 2.141 ± 0.045
4.668ThrGly: 4.668 ± 0.078
1.422ThrHis: 1.422 ± 0.039
2.842ThrIle: 2.842 ± 0.048
1.743ThrLys: 1.743 ± 0.043
7.559ThrLeu: 7.559 ± 0.095
1.061ThrMet: 1.061 ± 0.028
1.878ThrAsn: 1.878 ± 0.053
3.539ThrPro: 3.539 ± 0.066
2.541ThrGln: 2.541 ± 0.053
2.921ThrArg: 2.921 ± 0.057
3.109ThrSer: 3.109 ± 0.063
3.603ThrThr: 3.603 ± 0.081
4.347ThrVal: 4.347 ± 0.067
0.717ThrTrp: 0.717 ± 0.027
1.509ThrTyr: 1.509 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
6.96ValAla: 6.96 ± 0.091
0.723ValCys: 0.723 ± 0.027
3.995ValAsp: 3.995 ± 0.062
4.168ValGlu: 4.168 ± 0.068
2.786ValPhe: 2.786 ± 0.047
4.669ValGly: 4.669 ± 0.071
1.303ValHis: 1.303 ± 0.034
3.981ValIle: 3.981 ± 0.06
3.021ValLys: 3.021 ± 0.058
7.629ValLeu: 7.629 ± 0.094
1.995ValMet: 1.995 ± 0.048
2.525ValAsn: 2.525 ± 0.048
2.858ValPro: 2.858 ± 0.054
2.74ValGln: 2.74 ± 0.051
3.655ValArg: 3.655 ± 0.059
4.242ValSer: 4.242 ± 0.063
4.129ValThr: 4.129 ± 0.079
5.072ValVal: 5.072 ± 0.084
1.0ValTrp: 1.0 ± 0.035
1.839ValTyr: 1.839 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.065TrpAla: 1.065 ± 0.032
0.134TrpCys: 0.134 ± 0.011
0.649TrpAsp: 0.649 ± 0.027
0.842TrpGlu: 0.842 ± 0.027
0.594TrpPhe: 0.594 ± 0.025
0.964TrpGly: 0.964 ± 0.028
0.382TrpHis: 0.382 ± 0.015
0.661TrpIle: 0.661 ± 0.025
0.594TrpLys: 0.594 ± 0.023
2.154TrpLeu: 2.154 ± 0.059
0.411TrpMet: 0.411 ± 0.02
0.516TrpAsn: 0.516 ± 0.025
0.402TrpPro: 0.402 ± 0.017
1.037TrpGln: 1.037 ± 0.035
0.868TrpArg: 0.868 ± 0.028
0.696TrpSer: 0.696 ± 0.026
0.551TrpThr: 0.551 ± 0.022
1.08TrpVal: 1.08 ± 0.033
0.273TrpTrp: 0.273 ± 0.017
0.409TrpTyr: 0.409 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.832TyrAla: 2.832 ± 0.057
0.351TyrCys: 0.351 ± 0.019
1.51TyrAsp: 1.51 ± 0.046
1.443TyrGlu: 1.443 ± 0.037
1.203TyrPhe: 1.203 ± 0.036
2.208TyrGly: 2.208 ± 0.043
0.746TyrHis: 0.746 ± 0.026
1.312TyrIle: 1.312 ± 0.036
1.006TyrLys: 1.006 ± 0.032
3.312TyrLeu: 3.312 ± 0.061
0.563TyrMet: 0.563 ± 0.021
0.982TyrAsn: 0.982 ± 0.035
1.531TyrPro: 1.531 ± 0.036
1.604TyrGln: 1.604 ± 0.043
1.969TyrArg: 1.969 ± 0.042
1.628TyrSer: 1.628 ± 0.035
1.679TyrThr: 1.679 ± 0.041
1.819TyrVal: 1.819 ± 0.042
0.521TyrTrp: 0.521 ± 0.02
0.985TyrTyr: 0.985 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.004
Statistics based on 3757 proteins (1212283 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski