Amino acid dipepetide frequency for Bacillus vietnamensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.143AlaAla: 5.143 ± 0.083	0.564AlaCys: 0.564 ± 0.02	3.225AlaAsp: 3.225 ± 0.06	4.373AlaGlu: 4.373 ± 0.066	3.176AlaPhe: 3.176 ± 0.058	5.382AlaGly: 5.382 ± 0.093	1.296AlaHis: 1.296 ± 0.036	5.361AlaIle: 5.361 ± 0.064	4.11AlaLys: 4.11 ± 0.063	6.913AlaLeu: 6.913 ± 0.09	1.884AlaMet: 1.884 ± 0.043	2.266AlaAsn: 2.266 ± 0.045	2.023AlaPro: 2.023 ± 0.049	1.971AlaGln: 1.971 ± 0.045	2.575AlaArg: 2.575 ± 0.049	4.201AlaSer: 4.201 ± 0.072	3.344AlaThr: 3.344 ± 0.101	5.177AlaVal: 5.177 ± 0.082	0.614AlaTrp: 0.614 ± 0.025	2.191AlaTyr: 2.191 ± 0.043	0.001AlaXaa: 0.001 ± 0.001
Cys	0.398CysAla: 0.398 ± 0.016	0.084CysCys: 0.084 ± 0.009	0.384CysAsp: 0.384 ± 0.019	0.46CysGlu: 0.46 ± 0.022	0.304CysPhe: 0.304 ± 0.015	0.638CysGly: 0.638 ± 0.025	0.215CysHis: 0.215 ± 0.013	0.497CysIle: 0.497 ± 0.021	0.315CysLys: 0.315 ± 0.021	0.693CysLeu: 0.693 ± 0.026	0.182CysMet: 0.182 ± 0.013	0.241CysAsn: 0.241 ± 0.018	0.345CysPro: 0.345 ± 0.019	0.231CysGln: 0.231 ± 0.014	0.276CysArg: 0.276 ± 0.017	0.506CysSer: 0.506 ± 0.023	0.38CysThr: 0.38 ± 0.018	0.441CysVal: 0.441 ± 0.021	0.064CysTrp: 0.064 ± 0.007	0.257CysTyr: 0.257 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.229AspAla: 3.229 ± 0.055	0.376AspCys: 0.376 ± 0.022	2.579AspAsp: 2.579 ± 0.053	4.636AspGlu: 4.636 ± 0.071	2.457AspPhe: 2.457 ± 0.049	3.765AspGly: 3.765 ± 0.067	1.376AspHis: 1.376 ± 0.035	4.121AspIle: 4.121 ± 0.059	3.101AspLys: 3.101 ± 0.056	5.322AspLeu: 5.322 ± 0.065	1.421AspMet: 1.421 ± 0.038	1.673AspAsn: 1.673 ± 0.035	2.167AspPro: 2.167 ± 0.049	2.132AspGln: 2.132 ± 0.044	2.47AspArg: 2.47 ± 0.045	2.927AspSer: 2.927 ± 0.055	2.516AspThr: 2.516 ± 0.052	3.891AspVal: 3.891 ± 0.05	0.689AspTrp: 0.689 ± 0.024	2.211AspTyr: 2.211 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.327GluAla: 5.327 ± 0.076	0.398GluCys: 0.398 ± 0.02	4.387GluAsp: 4.387 ± 0.065	7.884GluGlu: 7.884 ± 0.094	2.683GluPhe: 2.683 ± 0.045	4.955GluGly: 4.955 ± 0.065	1.523GluHis: 1.523 ± 0.037	5.215GluIle: 5.215 ± 0.078	6.694GluLys: 6.694 ± 0.087	7.274GluLeu: 7.274 ± 0.087	2.532GluMet: 2.532 ± 0.051	3.48GluAsn: 3.48 ± 0.062	1.919GluPro: 1.919 ± 0.044	2.862GluGln: 2.862 ± 0.047	3.664GluArg: 3.664 ± 0.066	3.921GluSer: 3.921 ± 0.057	3.944GluThr: 3.944 ± 0.058	5.502GluVal: 5.502 ± 0.081	0.984GluTrp: 0.984 ± 0.031	2.384GluTyr: 2.384 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.834PheAla: 2.834 ± 0.055	0.312PheCys: 0.312 ± 0.016	2.35PheAsp: 2.35 ± 0.04	2.755PheGlu: 2.755 ± 0.054	2.368PhePhe: 2.368 ± 0.053	3.342PheGly: 3.342 ± 0.065	1.192PheHis: 1.192 ± 0.028	3.792PheIle: 3.792 ± 0.064	2.438PheLys: 2.438 ± 0.04	4.809PheLeu: 4.809 ± 0.084	1.269PheMet: 1.269 ± 0.041	1.838PheAsn: 1.838 ± 0.038	1.631PhePro: 1.631 ± 0.036	1.686PheGln: 1.686 ± 0.038	1.619PheArg: 1.619 ± 0.038	3.355PheSer: 3.355 ± 0.055	2.716PheThr: 2.716 ± 0.056	3.13PheVal: 3.13 ± 0.056	0.515PheTrp: 0.515 ± 0.022	1.745PheTyr: 1.745 ± 0.046	0.001PheXaa: 0.001 ± 0.001
Gly	4.947GlyAla: 4.947 ± 0.079	0.625GlyCys: 0.625 ± 0.026	3.664GlyAsp: 3.664 ± 0.055	5.143GlyGlu: 5.143 ± 0.066	3.532GlyPhe: 3.532 ± 0.061	5.255GlyGly: 5.255 ± 0.099	1.398GlyHis: 1.398 ± 0.033	6.014GlyIle: 6.014 ± 0.073	5.246GlyLys: 5.246 ± 0.065	6.843GlyLeu: 6.843 ± 0.092	2.401GlyMet: 2.401 ± 0.046	2.723GlyAsn: 2.723 ± 0.053	1.736GlyPro: 1.736 ± 0.044	2.129GlyGln: 2.129 ± 0.044	2.827GlyArg: 2.827 ± 0.053	4.216GlySer: 4.216 ± 0.064	4.301GlyThr: 4.301 ± 0.133	5.435GlyVal: 5.435 ± 0.069	0.839GlyTrp: 0.839 ± 0.029	2.771GlyTyr: 2.771 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.253HisAla: 1.253 ± 0.036	0.216HisCys: 0.216 ± 0.013	1.143HisAsp: 1.143 ± 0.032	1.547HisGlu: 1.547 ± 0.034	1.194HisPhe: 1.194 ± 0.03	1.457HisGly: 1.457 ± 0.04	0.811HisHis: 0.811 ± 0.03	1.537HisIle: 1.537 ± 0.038	1.151HisLys: 1.151 ± 0.036	2.234HisLeu: 2.234 ± 0.04	0.563HisMet: 0.563 ± 0.022	0.775HisAsn: 0.775 ± 0.029	1.183HisPro: 1.183 ± 0.035	0.88HisGln: 0.88 ± 0.029	0.989HisArg: 0.989 ± 0.03	1.468HisSer: 1.468 ± 0.034	1.154HisThr: 1.154 ± 0.033	1.425HisVal: 1.425 ± 0.03	0.239HisTrp: 0.239 ± 0.014	1.02HisTyr: 1.02 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.299IleAla: 5.299 ± 0.072	0.581IleCys: 0.581 ± 0.022	4.163IleAsp: 4.163 ± 0.057	5.559IleGlu: 5.559 ± 0.079	3.14IlePhe: 3.14 ± 0.056	6.138IleGly: 6.138 ± 0.076	1.788IleHis: 1.788 ± 0.041	5.536IleIle: 5.536 ± 0.081	4.223IleLys: 4.223 ± 0.063	7.237IleLeu: 7.237 ± 0.091	1.852IleMet: 1.852 ± 0.044	2.842IleAsn: 2.842 ± 0.064	3.365IlePro: 3.365 ± 0.05	2.872IleGln: 2.872 ± 0.059	3.156IleArg: 3.156 ± 0.046	5.048IleSer: 5.048 ± 0.078	4.093IleThr: 4.093 ± 0.073	5.448IleVal: 5.448 ± 0.075	0.592IleTrp: 0.592 ± 0.026	2.24IleTyr: 2.24 ± 0.04	0.001IleXaa: 0.001 ± 0.001
Lys	4.416LysAla: 4.416 ± 0.071	0.31LysCys: 0.31 ± 0.018	4.11LysAsp: 4.11 ± 0.071	7.329LysGlu: 7.329 ± 0.093	1.765LysPhe: 1.765 ± 0.035	4.975LysGly: 4.975 ± 0.069	1.331LysHis: 1.331 ± 0.04	4.119LysIle: 4.119 ± 0.067	5.828LysLys: 5.828 ± 0.085	5.518LysLeu: 5.518 ± 0.067	2.139LysMet: 2.139 ± 0.048	2.89LysAsn: 2.89 ± 0.056	2.284LysPro: 2.284 ± 0.05	2.666LysGln: 2.666 ± 0.06	3.37LysArg: 3.37 ± 0.052	3.627LysSer: 3.627 ± 0.057	3.42LysThr: 3.42 ± 0.056	4.896LysVal: 4.896 ± 0.072	0.881LysTrp: 0.881 ± 0.029	1.964LysTyr: 1.964 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	6.825LeuAla: 6.825 ± 0.083	0.66LeuCys: 0.66 ± 0.024	4.938LeuAsp: 4.938 ± 0.073	6.637LeuGlu: 6.637 ± 0.084	5.1LeuPhe: 5.1 ± 0.091	6.546LeuGly: 6.546 ± 0.095	2.162LeuHis: 2.162 ± 0.043	7.132LeuIle: 7.132 ± 0.089	6.692LeuLys: 6.692 ± 0.08	10.23LeuLeu: 10.23 ± 0.115	2.658LeuMet: 2.658 ± 0.055	4.116LeuAsn: 4.116 ± 0.082	4.007LeuPro: 4.007 ± 0.064	3.515LeuGln: 3.515 ± 0.062	3.556LeuArg: 3.556 ± 0.062	7.327LeuSer: 7.327 ± 0.082	5.63LeuThr: 5.63 ± 0.069	6.526LeuVal: 6.526 ± 0.076	0.88LeuTrp: 0.88 ± 0.031	3.234LeuTyr: 3.234 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.976MetAla: 1.976 ± 0.041	0.15MetCys: 0.15 ± 0.011	1.606MetAsp: 1.606 ± 0.039	2.205MetGlu: 2.205 ± 0.044	1.092MetPhe: 1.092 ± 0.029	1.893MetGly: 1.893 ± 0.04	0.412MetHis: 0.412 ± 0.018	2.265MetIle: 2.265 ± 0.047	2.815MetLys: 2.815 ± 0.052	2.44MetLeu: 2.44 ± 0.044	0.999MetMet: 0.999 ± 0.029	1.702MetAsn: 1.702 ± 0.036	0.928MetPro: 0.928 ± 0.03	0.759MetGln: 0.759 ± 0.025	1.112MetArg: 1.112 ± 0.03	1.792MetSer: 1.792 ± 0.035	1.778MetThr: 1.778 ± 0.036	1.969MetVal: 1.969 ± 0.044	0.213MetTrp: 0.213 ± 0.014	0.731MetTyr: 0.731 ± 0.025	0.001MetXaa: 0.001 ± 0.001
Asn	2.451AsnAla: 2.451 ± 0.055	0.252AsnCys: 0.252 ± 0.016	2.055AsnAsp: 2.055 ± 0.045	3.378AsnGlu: 3.378 ± 0.056	1.355AsnPhe: 1.355 ± 0.032	3.25AsnGly: 3.25 ± 0.06	1.013AsnHis: 1.013 ± 0.032	2.968AsnIle: 2.968 ± 0.049	2.571AsnLys: 2.571 ± 0.058	3.626AsnLeu: 3.626 ± 0.063	1.117AsnMet: 1.117 ± 0.029	1.502AsnAsn: 1.502 ± 0.045	2.075AsnPro: 2.075 ± 0.042	1.8AsnGln: 1.8 ± 0.033	1.916AsnArg: 1.916 ± 0.044	2.159AsnSer: 2.159 ± 0.048	1.997AsnThr: 1.997 ± 0.044	2.963AsnVal: 2.963 ± 0.055	0.472AsnTrp: 0.472 ± 0.022	1.317AsnTyr: 1.317 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.179ProAla: 2.179 ± 0.047	0.229ProCys: 0.229 ± 0.014	2.182ProAsp: 2.182 ± 0.049	2.984ProGlu: 2.984 ± 0.049	2.073ProPhe: 2.073 ± 0.044	2.475ProGly: 2.475 ± 0.054	0.924ProHis: 0.924 ± 0.031	2.614ProIle: 2.614 ± 0.045	2.035ProLys: 2.035 ± 0.042	3.649ProLeu: 3.649 ± 0.057	0.83ProMet: 0.83 ± 0.028	1.441ProAsn: 1.441 ± 0.034	1.03ProPro: 1.03 ± 0.03	1.138ProGln: 1.138 ± 0.029	1.126ProArg: 1.126 ± 0.033	2.515ProSer: 2.515 ± 0.052	1.83ProThr: 1.83 ± 0.043	2.937ProVal: 2.937 ± 0.051	0.369ProTrp: 0.369 ± 0.018	1.413ProTyr: 1.413 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.509GlnAla: 2.509 ± 0.05	0.205GlnCys: 0.205 ± 0.015	1.743GlnAsp: 1.743 ± 0.041	2.876GlnGlu: 2.876 ± 0.055	1.52GlnPhe: 1.52 ± 0.039	2.237GlnGly: 2.237 ± 0.042	0.827GlnHis: 0.827 ± 0.029	2.176GlnIle: 2.176 ± 0.043	2.525GlnLys: 2.525 ± 0.049	3.617GlnLeu: 3.617 ± 0.048	1.036GlnMet: 1.036 ± 0.031	1.425GlnAsn: 1.425 ± 0.037	1.126GlnPro: 1.126 ± 0.028	1.52GlnGln: 1.52 ± 0.039	1.508GlnArg: 1.508 ± 0.041	2.288GlnSer: 2.288 ± 0.043	1.946GlnThr: 1.946 ± 0.04	2.169GlnVal: 2.169 ± 0.044	0.426GlnTrp: 0.426 ± 0.02	1.368GlnTyr: 1.368 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.295ArgAla: 2.295 ± 0.045	0.256ArgCys: 0.256 ± 0.015	2.224ArgAsp: 2.224 ± 0.041	3.599ArgGlu: 3.599 ± 0.062	2.093ArgPhe: 2.093 ± 0.045	2.517ArgGly: 2.517 ± 0.047	0.877ArgHis: 0.877 ± 0.029	3.098ArgIle: 3.098 ± 0.056	3.285ArgLys: 3.285 ± 0.053	3.98ArgLeu: 3.98 ± 0.061	1.33ArgMet: 1.33 ± 0.032	1.885ArgAsn: 1.885 ± 0.043	1.267ArgPro: 1.267 ± 0.03	1.422ArgGln: 1.422 ± 0.034	1.918ArgArg: 1.918 ± 0.051	2.36ArgSer: 2.36 ± 0.044	2.094ArgThr: 2.094 ± 0.04	2.804ArgVal: 2.804 ± 0.044	0.457ArgTrp: 0.457 ± 0.021	1.583ArgTyr: 1.583 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.814SerAla: 3.814 ± 0.063	0.41SerCys: 0.41 ± 0.02	3.1SerAsp: 3.1 ± 0.049	4.115SerGlu: 4.115 ± 0.06	3.59SerPhe: 3.59 ± 0.054	4.758SerGly: 4.758 ± 0.069	1.404SerHis: 1.404 ± 0.031	5.358SerIle: 5.358 ± 0.063	3.931SerLys: 3.931 ± 0.063	6.665SerLeu: 6.665 ± 0.08	1.891SerMet: 1.891 ± 0.038	2.398SerAsn: 2.398 ± 0.046	2.302SerPro: 2.302 ± 0.048	2.038SerGln: 2.038 ± 0.04	2.518SerArg: 2.518 ± 0.042	4.32SerSer: 4.32 ± 0.072	3.305SerThr: 3.305 ± 0.056	4.493SerVal: 4.493 ± 0.081	0.66SerTrp: 0.66 ± 0.022	2.229SerTyr: 2.229 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.595ThrAla: 3.595 ± 0.063	0.362ThrCys: 0.362 ± 0.02	2.833ThrAsp: 2.833 ± 0.05	3.451ThrGlu: 3.451 ± 0.054	2.663ThrPhe: 2.663 ± 0.053	4.378ThrGly: 4.378 ± 0.068	1.097ThrHis: 1.097 ± 0.029	4.661ThrIle: 4.661 ± 0.147	3.198ThrLys: 3.198 ± 0.053	5.611ThrLeu: 5.611 ± 0.092	1.406ThrMet: 1.406 ± 0.037	2.218ThrAsn: 2.218 ± 0.043	2.256ThrPro: 2.256 ± 0.045	1.353ThrGln: 1.353 ± 0.033	1.976ThrArg: 1.976 ± 0.04	3.346ThrSer: 3.346 ± 0.048	2.76ThrThr: 2.76 ± 0.054	4.183ThrVal: 4.183 ± 0.081	0.499ThrTrp: 0.499 ± 0.022	1.91ThrTyr: 1.91 ± 0.043	0.001ThrXaa: 0.001 ± 0.001
Val	4.783ValAla: 4.783 ± 0.065	0.535ValCys: 0.535 ± 0.023	3.84ValAsp: 3.84 ± 0.066	5.359ValGlu: 5.359 ± 0.075	3.221ValPhe: 3.221 ± 0.057	4.854ValGly: 4.854 ± 0.071	1.539ValHis: 1.539 ± 0.034	5.452ValIle: 5.452 ± 0.073	4.844ValLys: 4.844 ± 0.065	7.037ValLeu: 7.037 ± 0.085	2.042ValMet: 2.042 ± 0.042	2.983ValAsn: 2.983 ± 0.054	2.671ValPro: 2.671 ± 0.043	2.342ValGln: 2.342 ± 0.046	2.742ValArg: 2.742 ± 0.053	4.896ValSer: 4.896 ± 0.068	4.227ValThr: 4.227 ± 0.074	5.161ValVal: 5.161 ± 0.073	0.659ValTrp: 0.659 ± 0.026	2.311ValTyr: 2.311 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.605TrpAla: 0.605 ± 0.022	0.085TrpCys: 0.085 ± 0.008	0.578TrpAsp: 0.578 ± 0.024	0.694TrpGlu: 0.694 ± 0.024	0.542TrpPhe: 0.542 ± 0.022	0.754TrpGly: 0.754 ± 0.026	0.213TrpHis: 0.213 ± 0.015	0.895TrpIle: 0.895 ± 0.031	0.782TrpLys: 0.782 ± 0.027	1.134TrpLeu: 1.134 ± 0.039	0.388TrpMet: 0.388 ± 0.018	0.514TrpAsn: 0.514 ± 0.021	0.271TrpPro: 0.271 ± 0.017	0.322TrpGln: 0.322 ± 0.016	0.401TrpArg: 0.401 ± 0.019	0.675TrpSer: 0.675 ± 0.025	0.538TrpThr: 0.538 ± 0.023	0.69TrpVal: 0.69 ± 0.025	0.17TrpTrp: 0.17 ± 0.014	0.375TrpTyr: 0.375 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.911TyrAla: 1.911 ± 0.04	0.299TyrCys: 0.299 ± 0.016	1.955TyrAsp: 1.955 ± 0.045	2.551TyrGlu: 2.551 ± 0.054	1.829TyrPhe: 1.829 ± 0.04	2.477TyrGly: 2.477 ± 0.047	0.837TyrHis: 0.837 ± 0.027	2.362TyrIle: 2.362 ± 0.043	2.052TyrLys: 2.052 ± 0.046	3.538TyrLeu: 3.538 ± 0.049	0.896TyrMet: 0.896 ± 0.027	1.328TyrAsn: 1.328 ± 0.039	1.388TyrPro: 1.388 ± 0.035	1.406TyrGln: 1.406 ± 0.032	1.625TyrArg: 1.625 ± 0.035	2.354TyrSer: 2.354 ± 0.043	1.787TyrThr: 1.787 ± 0.037	2.258TyrVal: 2.258 ± 0.046	0.4TyrTrp: 0.4 ± 0.021	1.473TyrTyr: 1.473 ± 0.035	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4104 proteins (1185518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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