Amino acid dipepetide frequency for Circovirus-like genome DCCV-11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.058AlaAla: 3.058 ± 1.75
0.765AlaCys: 0.765 ± 0.547
2.294AlaAsp: 2.294 ± 1.641
0.765AlaGlu: 0.765 ± 0.662
3.058AlaPhe: 3.058 ± 1.174
3.823AlaGly: 3.823 ± 1.912
0.0AlaHis: 0.0 ± 0.0
3.058AlaIle: 3.058 ± 0.928
5.352AlaLys: 5.352 ± 0.725
6.116AlaLeu: 6.116 ± 3.224
0.765AlaMet: 0.765 ± 0.687
3.823AlaAsn: 3.823 ± 1.453
1.529AlaPro: 1.529 ± 0.753
0.765AlaGln: 0.765 ± 1.094
3.058AlaArg: 3.058 ± 1.141
1.529AlaSer: 1.529 ± 1.11
3.058AlaThr: 3.058 ± 0.759
2.294AlaVal: 2.294 ± 1.344
0.765AlaTrp: 0.765 ± 1.094
3.058AlaTyr: 3.058 ± 0.765
0.0AlaXaa: 0.0 ± 0.0
Cys
1.529CysAla: 1.529 ± 1.375
0.765CysCys: 0.765 ± 0.662
0.765CysAsp: 0.765 ± 0.547
0.765CysGlu: 0.765 ± 0.662
0.0CysPhe: 0.0 ± 0.0
0.765CysGly: 0.765 ± 0.547
0.765CysHis: 0.765 ± 0.662
0.765CysIle: 0.765 ± 0.687
4.587CysLys: 4.587 ± 1.821
0.765CysLeu: 0.765 ± 0.687
0.765CysMet: 0.765 ± 0.547
0.0CysAsn: 0.0 ± 0.0
1.529CysPro: 1.529 ± 0.587
0.0CysGln: 0.0 ± 0.0
0.765CysArg: 0.765 ± 0.547
1.529CysSer: 1.529 ± 1.375
1.529CysThr: 1.529 ± 0.758
0.765CysVal: 0.765 ± 0.662
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.294AspAla: 2.294 ± 0.922
0.765AspCys: 0.765 ± 0.687
6.116AspAsp: 6.116 ± 1.856
2.294AspGlu: 2.294 ± 1.042
3.823AspPhe: 3.823 ± 2.027
2.294AspGly: 2.294 ± 1.125
1.529AspHis: 1.529 ± 1.216
1.529AspIle: 1.529 ± 0.758
2.294AspLys: 2.294 ± 0.526
6.116AspLeu: 6.116 ± 1.518
0.765AspMet: 0.765 ± 0.547
0.765AspAsn: 0.765 ± 0.662
5.352AspPro: 5.352 ± 2.976
2.294AspGln: 2.294 ± 1.344
3.823AspArg: 3.823 ± 1.668
4.587AspSer: 4.587 ± 1.873
6.881AspThr: 6.881 ± 2.15
3.058AspVal: 3.058 ± 1.47
0.765AspTrp: 0.765 ± 0.687
0.765AspTyr: 0.765 ± 0.662
0.0AspXaa: 0.0 ± 0.0
Glu
0.765GluAla: 0.765 ± 0.547
1.529GluCys: 1.529 ± 1.323
6.116GluAsp: 6.116 ± 2.237
3.058GluGlu: 3.058 ± 1.682
2.294GluPhe: 2.294 ± 0.526
0.765GluGly: 0.765 ± 0.547
2.294GluHis: 2.294 ± 1.784
2.294GluIle: 2.294 ± 1.122
2.294GluLys: 2.294 ± 1.125
5.352GluLeu: 5.352 ± 2.41
0.765GluMet: 0.765 ± 0.687
1.529GluAsn: 1.529 ± 1.094
1.529GluPro: 1.529 ± 1.094
1.529GluGln: 1.529 ± 0.753
3.823GluArg: 3.823 ± 1.904
5.352GluSer: 5.352 ± 3.322
4.587GluThr: 4.587 ± 2.301
3.058GluVal: 3.058 ± 1.712
0.765GluTrp: 0.765 ± 0.687
1.529GluTyr: 1.529 ± 1.094
0.0GluXaa: 0.0 ± 0.0
Phe
0.765PheAla: 0.765 ± 0.662
0.0PheCys: 0.0 ± 0.0
1.529PheAsp: 1.529 ± 0.587
1.529PheGlu: 1.529 ± 1.323
0.0PhePhe: 0.0 ± 0.0
3.823PheGly: 3.823 ± 1.814
0.0PheHis: 0.0 ± 0.0
1.529PheIle: 1.529 ± 1.094
3.058PheLys: 3.058 ± 1.398
0.765PheLeu: 0.765 ± 1.061
0.0PheMet: 0.0 ± 0.0
1.529PheAsn: 1.529 ± 0.587
2.294PhePro: 2.294 ± 1.635
1.529PheGln: 1.529 ± 1.243
2.294PheArg: 2.294 ± 1.045
3.823PheSer: 3.823 ± 2.193
0.765PheThr: 0.765 ± 0.547
1.529PheVal: 1.529 ± 1.094
0.765PheTrp: 0.765 ± 0.547
0.765PheTyr: 0.765 ± 0.662
0.0PheXaa: 0.0 ± 0.0
Gly
3.823GlyAla: 3.823 ± 1.294
0.0GlyCys: 0.0 ± 0.0
5.352GlyAsp: 5.352 ± 2.304
3.823GlyGlu: 3.823 ± 1.337
1.529GlyPhe: 1.529 ± 1.097
5.352GlyGly: 5.352 ± 1.415
0.0GlyHis: 0.0 ± 0.0
3.823GlyIle: 3.823 ± 1.274
5.352GlyLys: 5.352 ± 2.97
3.823GlyLeu: 3.823 ± 1.814
1.529GlyMet: 1.529 ± 1.375
2.294GlyAsn: 2.294 ± 0.526
2.294GlyPro: 2.294 ± 1.122
3.058GlyGln: 3.058 ± 1.074
3.823GlyArg: 3.823 ± 3.405
5.352GlySer: 5.352 ± 0.917
6.881GlyThr: 6.881 ± 1.218
3.058GlyVal: 3.058 ± 2.02
0.765GlyTrp: 0.765 ± 0.662
5.352GlyTyr: 5.352 ± 1.543
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.765HisCys: 0.765 ± 0.662
0.765HisAsp: 0.765 ± 0.547
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.529HisGly: 1.529 ± 2.122
0.0HisHis: 0.0 ± 0.0
0.765HisIle: 0.765 ± 0.547
0.0HisLys: 0.0 ± 0.0
2.294HisLeu: 2.294 ± 1.624
0.765HisMet: 0.765 ± 1.061
0.765HisAsn: 0.765 ± 1.094
0.765HisPro: 0.765 ± 0.662
1.529HisGln: 1.529 ± 1.323
0.0HisArg: 0.0 ± 0.0
3.823HisSer: 3.823 ± 2.191
0.765HisThr: 0.765 ± 0.662
0.765HisVal: 0.765 ± 0.547
1.529HisTrp: 1.529 ± 1.097
0.765HisTyr: 0.765 ± 1.094
0.0HisXaa: 0.0 ± 0.0
Ile
3.058IleAla: 3.058 ± 2.188
1.529IleCys: 1.529 ± 0.587
3.823IleAsp: 3.823 ± 0.877
2.294IleGlu: 2.294 ± 0.922
0.765IlePhe: 0.765 ± 0.547
0.0IleGly: 0.0 ± 0.0
0.0IleHis: 0.0 ± 0.0
1.529IleIle: 1.529 ± 0.942
2.294IleLys: 2.294 ± 1.042
4.587IleLeu: 4.587 ± 1.821
0.0IleMet: 0.0 ± 0.0
6.116IleAsn: 6.116 ± 2.786
3.058IlePro: 3.058 ± 1.506
0.0IleGln: 0.0 ± 0.0
0.0IleArg: 0.0 ± 0.0
3.058IleSer: 3.058 ± 1.122
6.116IleThr: 6.116 ± 2.786
0.765IleVal: 0.765 ± 0.662
0.0IleTrp: 0.0 ± 0.0
2.294IleTyr: 2.294 ± 0.922
0.0IleXaa: 0.0 ± 0.0
Lys
4.587LysAla: 4.587 ± 3.175
2.294LysCys: 2.294 ± 0.526
3.058LysAsp: 3.058 ± 1.074
3.058LysGlu: 3.058 ± 1.174
1.529LysPhe: 1.529 ± 1.097
7.645LysGly: 7.645 ± 1.517
1.529LysHis: 1.529 ± 2.122
5.352LysIle: 5.352 ± 2.976
3.823LysLys: 3.823 ± 1.633
3.058LysLeu: 3.058 ± 1.027
2.294LysMet: 2.294 ± 0.976
0.765LysAsn: 0.765 ± 0.547
1.529LysPro: 1.529 ± 0.587
4.587LysGln: 4.587 ± 3.163
5.352LysArg: 5.352 ± 1.454
4.587LysSer: 4.587 ± 1.094
2.294LysThr: 2.294 ± 0.526
2.294LysVal: 2.294 ± 1.125
0.0LysTrp: 0.0 ± 0.0
5.352LysTyr: 5.352 ± 2.351
0.0LysXaa: 0.0 ± 0.0
Leu
2.294LeuAla: 2.294 ± 1.045
1.529LeuCys: 1.529 ± 1.323
3.058LeuAsp: 3.058 ± 2.351
7.645LeuGlu: 7.645 ± 1.932
2.294LeuPhe: 2.294 ± 2.217
6.116LeuGly: 6.116 ± 2.283
1.529LeuHis: 1.529 ± 1.216
2.294LeuIle: 2.294 ± 1.042
4.587LeuLys: 4.587 ± 1.887
9.174LeuLeu: 9.174 ± 2.42
1.529LeuMet: 1.529 ± 0.96
3.823LeuAsn: 3.823 ± 1.725
5.352LeuPro: 5.352 ± 2.444
4.587LeuGln: 4.587 ± 2.393
7.645LeuArg: 7.645 ± 2.553
5.352LeuSer: 5.352 ± 1.938
5.352LeuThr: 5.352 ± 1.831
4.587LeuVal: 4.587 ± 1.67
1.529LeuTrp: 1.529 ± 1.323
0.765LeuTyr: 0.765 ± 1.061
0.0LeuXaa: 0.0 ± 0.0
Met
0.765MetAla: 0.765 ± 0.662
0.765MetCys: 0.765 ± 1.061
3.823MetAsp: 3.823 ± 1.831
1.529MetGlu: 1.529 ± 1.375
1.529MetPhe: 1.529 ± 0.587
0.765MetGly: 0.765 ± 0.547
0.0MetHis: 0.0 ± 0.0
0.765MetIle: 0.765 ± 0.687
0.765MetLys: 0.765 ± 0.547
1.529MetLeu: 1.529 ± 1.243
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.294MetPro: 2.294 ± 1.016
0.0MetGln: 0.0 ± 0.0
1.529MetArg: 1.529 ± 0.753
2.294MetSer: 2.294 ± 0.526
0.765MetThr: 0.765 ± 0.547
0.765MetVal: 0.765 ± 0.547
0.0MetTrp: 0.0 ± 0.0
0.765MetTyr: 0.765 ± 0.547
0.0MetXaa: 0.0 ± 0.0
Asn
4.587AsnAla: 4.587 ± 2.685
0.0AsnCys: 0.0 ± 0.0
3.058AsnAsp: 3.058 ± 1.398
3.058AsnGlu: 3.058 ± 0.759
1.529AsnPhe: 1.529 ± 0.942
3.058AsnGly: 3.058 ± 1.174
0.765AsnHis: 0.765 ± 0.547
3.823AsnIle: 3.823 ± 1.274
3.058AsnLys: 3.058 ± 2.188
4.587AsnLeu: 4.587 ± 0.793
0.765AsnMet: 0.765 ± 0.547
3.823AsnAsn: 3.823 ± 1.941
2.294AsnPro: 2.294 ± 1.641
0.765AsnGln: 0.765 ± 1.094
2.294AsnArg: 2.294 ± 1.045
4.587AsnSer: 4.587 ± 1.161
0.765AsnThr: 0.765 ± 0.687
1.529AsnVal: 1.529 ± 1.375
0.765AsnTrp: 0.765 ± 0.662
1.529AsnTyr: 1.529 ± 1.094
0.0AsnXaa: 0.0 ± 0.0
Pro
3.058ProAla: 3.058 ± 1.196
0.765ProCys: 0.765 ± 0.687
1.529ProAsp: 1.529 ± 0.758
3.058ProGlu: 3.058 ± 1.516
1.529ProPhe: 1.529 ± 1.216
3.823ProGly: 3.823 ± 1.558
0.765ProHis: 0.765 ± 0.547
2.294ProIle: 2.294 ± 1.641
3.823ProLys: 3.823 ± 1.558
3.823ProLeu: 3.823 ± 1.878
0.0ProMet: 0.0 ± 0.0
2.294ProAsn: 2.294 ± 1.641
3.823ProPro: 3.823 ± 2.056
1.529ProGln: 1.529 ± 1.216
2.294ProArg: 2.294 ± 1.334
6.116ProSer: 6.116 ± 2.989
4.587ProThr: 4.587 ± 1.051
2.294ProVal: 2.294 ± 1.042
0.765ProTrp: 0.765 ± 0.662
0.765ProTyr: 0.765 ± 0.547
0.0ProXaa: 0.0 ± 0.0
Gln
2.294GlnAla: 2.294 ± 2.217
0.765GlnCys: 0.765 ± 0.687
0.765GlnAsp: 0.765 ± 0.547
1.529GlnGlu: 1.529 ± 1.243
0.765GlnPhe: 0.765 ± 0.547
3.058GlnGly: 3.058 ± 2.161
0.0GlnHis: 0.0 ± 0.0
1.529GlnIle: 1.529 ± 1.094
3.823GlnLys: 3.823 ± 1.419
3.823GlnLeu: 3.823 ± 3.094
0.0GlnMet: 0.0 ± 0.0
0.765GlnAsn: 0.765 ± 1.061
0.765GlnPro: 0.765 ± 0.687
2.294GlnGln: 2.294 ± 1.641
5.352GlnArg: 5.352 ± 2.179
4.587GlnSer: 4.587 ± 2.32
2.294GlnThr: 2.294 ± 1.641
2.294GlnVal: 2.294 ± 1.306
0.765GlnTrp: 0.765 ± 0.687
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.058ArgAla: 3.058 ± 1.414
0.0ArgCys: 0.0 ± 0.0
3.823ArgAsp: 3.823 ± 1.923
2.294ArgGlu: 2.294 ± 1.246
2.294ArgPhe: 2.294 ± 1.641
3.823ArgGly: 3.823 ± 1.184
3.823ArgHis: 3.823 ± 1.012
1.529ArgIle: 1.529 ± 0.587
3.823ArgLys: 3.823 ± 1.999
8.41ArgLeu: 8.41 ± 2.542
3.058ArgMet: 3.058 ± 0.759
3.823ArgAsn: 3.823 ± 1.814
2.294ArgPro: 2.294 ± 1.085
5.352ArgGln: 5.352 ± 2.176
18.349ArgArg: 18.349 ± 4.59
7.645ArgSer: 7.645 ± 1.37
6.116ArgThr: 6.116 ± 2.049
5.352ArgVal: 5.352 ± 1.706
0.765ArgTrp: 0.765 ± 0.662
6.116ArgTyr: 6.116 ± 1.908
0.0ArgXaa: 0.0 ± 0.0
Ser
3.823SerAla: 3.823 ± 1.831
3.058SerCys: 3.058 ± 1.984
3.058SerAsp: 3.058 ± 2.97
0.765SerGlu: 0.765 ± 0.687
1.529SerPhe: 1.529 ± 0.753
6.116SerGly: 6.116 ± 3.047
0.765SerHis: 0.765 ± 1.094
3.058SerIle: 3.058 ± 0.759
7.645SerLys: 7.645 ± 2.476
4.587SerLeu: 4.587 ± 1.255
2.294SerMet: 2.294 ± 1.072
6.116SerAsn: 6.116 ± 2.021
2.294SerPro: 2.294 ± 1.287
2.294SerGln: 2.294 ± 1.931
12.997SerArg: 12.997 ± 3.579
12.997SerSer: 12.997 ± 5.162
12.997SerThr: 12.997 ± 5.88
3.823SerVal: 3.823 ± 2.39
0.765SerTrp: 0.765 ± 0.687
3.823SerTyr: 3.823 ± 1.998
0.0SerXaa: 0.0 ± 0.0
Thr
4.587ThrAla: 4.587 ± 1.724
0.765ThrCys: 0.765 ± 0.687
1.529ThrAsp: 1.529 ± 1.375
4.587ThrGlu: 4.587 ± 1.036
1.529ThrPhe: 1.529 ± 1.094
4.587ThrGly: 4.587 ± 2.028
0.765ThrHis: 0.765 ± 1.061
1.529ThrIle: 1.529 ± 1.094
3.058ThrLys: 3.058 ± 1.141
7.645ThrLeu: 7.645 ± 2.028
3.058ThrMet: 3.058 ± 1.398
1.529ThrAsn: 1.529 ± 1.094
5.352ThrPro: 5.352 ± 2.33
2.294ThrGln: 2.294 ± 0.526
9.174ThrArg: 9.174 ± 2.154
9.174ThrSer: 9.174 ± 4.792
8.41ThrThr: 8.41 ± 2.172
3.058ThrVal: 3.058 ± 1.846
1.529ThrTrp: 1.529 ± 1.323
3.058ThrTyr: 3.058 ± 1.174
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
6.116ValAsp: 6.116 ± 2.035
4.587ValGlu: 4.587 ± 2.19
1.529ValPhe: 1.529 ± 1.31
5.352ValGly: 5.352 ± 1.879
2.294ValHis: 2.294 ± 1.246
1.529ValIle: 1.529 ± 0.758
2.294ValLys: 2.294 ± 1.641
3.823ValLeu: 3.823 ± 1.668
0.765ValMet: 0.765 ± 0.566
4.587ValAsn: 4.587 ± 1.882
2.294ValPro: 2.294 ± 1.287
2.294ValGln: 2.294 ± 1.487
3.823ValArg: 3.823 ± 1.008
2.294ValSer: 2.294 ± 1.931
0.0ValThr: 0.0 ± 0.0
1.529ValVal: 1.529 ± 1.375
0.0ValTrp: 0.0 ± 0.0
3.058ValTyr: 3.058 ± 1.75
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.765TrpCys: 0.765 ± 0.547
0.765TrpAsp: 0.765 ± 0.662
0.765TrpGlu: 0.765 ± 0.687
0.0TrpPhe: 0.0 ± 0.0
0.765TrpGly: 0.765 ± 0.662
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
2.294TrpLys: 2.294 ± 1.125
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.765TrpAsn: 0.765 ± 0.547
0.765TrpPro: 0.765 ± 1.094
0.0TrpGln: 0.0 ± 0.0
1.529TrpArg: 1.529 ± 1.11
0.0TrpSer: 0.0 ± 0.0
1.529TrpThr: 1.529 ± 0.758
3.058TrpVal: 3.058 ± 0.928
0.765TrpTrp: 0.765 ± 0.662
0.765TrpTyr: 0.765 ± 0.662
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.587TyrAla: 4.587 ± 1.71
1.529TyrCys: 1.529 ± 0.587
0.765TyrAsp: 0.765 ± 0.662
3.823TyrGlu: 3.823 ± 0.853
0.765TyrPhe: 0.765 ± 0.547
3.823TyrGly: 3.823 ± 1.008
0.765TyrHis: 0.765 ± 0.547
2.294TyrIle: 2.294 ± 1.125
0.765TyrLys: 0.765 ± 0.547
1.529TyrLeu: 1.529 ± 0.942
0.765TyrMet: 0.765 ± 0.547
1.529TyrAsn: 1.529 ± 1.094
1.529TyrPro: 1.529 ± 1.216
0.765TyrGln: 0.765 ± 0.547
3.823TyrArg: 3.823 ± 1.215
6.116TyrSer: 6.116 ± 2.009
1.529TyrThr: 1.529 ± 1.323
2.294TyrVal: 2.294 ± 2.217
1.529TyrTrp: 1.529 ± 1.094
2.294TyrTyr: 2.294 ± 1.641
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski