Amino acid dipepetide frequency for Collinsella sp. An2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.481AlaAla: 15.481 ± 0.278	2.088AlaCys: 2.088 ± 0.055	7.167AlaAsp: 7.167 ± 0.113	7.14AlaGlu: 7.14 ± 0.142	3.99AlaPhe: 3.99 ± 0.088	9.855AlaGly: 9.855 ± 0.131	2.423AlaHis: 2.423 ± 0.066	5.471AlaIle: 5.471 ± 0.111	3.521AlaLys: 3.521 ± 0.097	11.313AlaLeu: 11.313 ± 0.19	3.028AlaMet: 3.028 ± 0.069	2.731AlaAsn: 2.731 ± 0.061	4.647AlaPro: 4.647 ± 0.109	3.913AlaGln: 3.913 ± 0.089	7.675AlaArg: 7.675 ± 0.129	7.07AlaSer: 7.07 ± 0.126	6.076AlaThr: 6.076 ± 0.103	8.874AlaVal: 8.874 ± 0.14	1.285AlaTrp: 1.285 ± 0.045	2.879AlaTyr: 2.879 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	1.8CysAla: 1.8 ± 0.052	0.288CysCys: 0.288 ± 0.023	1.077CysAsp: 1.077 ± 0.047	0.939CysGlu: 0.939 ± 0.037	0.47CysPhe: 0.47 ± 0.025	1.65CysGly: 1.65 ± 0.051	0.337CysHis: 0.337 ± 0.024	0.821CysIle: 0.821 ± 0.035	0.351CysLys: 0.351 ± 0.024	1.18CysLeu: 1.18 ± 0.043	0.382CysMet: 0.382 ± 0.022	0.398CysAsn: 0.398 ± 0.022	0.805CysPro: 0.805 ± 0.04	0.338CysGln: 0.338 ± 0.022	0.953CysArg: 0.953 ± 0.036	0.9CysSer: 0.9 ± 0.034	0.852CysThr: 0.852 ± 0.034	1.254CysVal: 1.254 ± 0.045	0.163CysTrp: 0.163 ± 0.017	0.419CysTyr: 0.419 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	8.638AspAla: 8.638 ± 0.153	0.798AspCys: 0.798 ± 0.031	4.386AspAsp: 4.386 ± 0.09	5.407AspGlu: 5.407 ± 0.094	2.182AspPhe: 2.182 ± 0.059	5.742AspGly: 5.742 ± 0.118	1.243AspHis: 1.243 ± 0.046	3.346AspIle: 3.346 ± 0.075	1.703AspLys: 1.703 ± 0.058	5.562AspLeu: 5.562 ± 0.098	1.55AspMet: 1.55 ± 0.045	1.486AspAsn: 1.486 ± 0.056	3.16AspPro: 3.16 ± 0.075	1.514AspGln: 1.514 ± 0.047	3.829AspArg: 3.829 ± 0.077	2.723AspSer: 2.723 ± 0.073	3.147AspThr: 3.147 ± 0.073	5.4AspVal: 5.4 ± 0.081	0.697AspTrp: 0.697 ± 0.031	2.007AspTyr: 2.007 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	7.36GluAla: 7.36 ± 0.121	0.704GluCys: 0.704 ± 0.031	3.886GluAsp: 3.886 ± 0.069	4.204GluGlu: 4.204 ± 0.108	1.919GluPhe: 1.919 ± 0.056	5.076GluGly: 5.076 ± 0.075	1.818GluHis: 1.818 ± 0.065	2.789GluIle: 2.789 ± 0.07	2.089GluLys: 2.089 ± 0.068	6.844GluLeu: 6.844 ± 0.125	1.615GluMet: 1.615 ± 0.044	1.859GluAsn: 1.859 ± 0.057	2.866GluPro: 2.866 ± 0.076	2.63GluGln: 2.63 ± 0.069	5.472GluArg: 5.472 ± 0.108	2.917GluSer: 2.917 ± 0.073	3.15GluThr: 3.15 ± 0.078	4.849GluVal: 4.849 ± 0.089	0.564GluTrp: 0.564 ± 0.028	1.43GluTyr: 1.43 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.872PheAla: 3.872 ± 0.085	0.636PheCys: 0.636 ± 0.029	2.686PheAsp: 2.686 ± 0.068	2.284PheGlu: 2.284 ± 0.066	1.363PhePhe: 1.363 ± 0.055	3.19PheGly: 3.19 ± 0.069	0.638PheHis: 0.638 ± 0.031	1.76PheIle: 1.76 ± 0.055	1.071PheLys: 1.071 ± 0.04	2.711PheLeu: 2.711 ± 0.08	0.98PheMet: 0.98 ± 0.04	1.041PheAsn: 1.041 ± 0.041	1.332PhePro: 1.332 ± 0.041	0.912PheGln: 0.912 ± 0.039	1.709PheArg: 1.709 ± 0.054	2.41PheSer: 2.41 ± 0.067	2.183PheThr: 2.183 ± 0.077	2.96PheVal: 2.96 ± 0.07	0.378PheTrp: 0.378 ± 0.025	1.045PheTyr: 1.045 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	8.694GlyAla: 8.694 ± 0.142	1.578GlyCys: 1.578 ± 0.045	4.788GlyAsp: 4.788 ± 0.079	4.991GlyGlu: 4.991 ± 0.081	3.164GlyPhe: 3.164 ± 0.07	6.648GlyGly: 6.648 ± 0.142	1.726GlyHis: 1.726 ± 0.057	5.068GlyIle: 5.068 ± 0.088	3.248GlyLys: 3.248 ± 0.083	7.238GlyLeu: 7.238 ± 0.125	2.608GlyMet: 2.608 ± 0.064	2.254GlyAsn: 2.254 ± 0.077	2.434GlyPro: 2.434 ± 0.067	2.19GlyGln: 2.19 ± 0.063	5.076GlyArg: 5.076 ± 0.093	5.325GlySer: 5.325 ± 0.13	5.208GlyThr: 5.208 ± 0.124	7.097GlyVal: 7.097 ± 0.116	1.028GlyTrp: 1.028 ± 0.053	2.682GlyTyr: 2.682 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	2.353HisAla: 2.353 ± 0.071	0.29HisCys: 0.29 ± 0.021	1.497HisAsp: 1.497 ± 0.044	1.474HisGlu: 1.474 ± 0.052	0.66HisPhe: 0.66 ± 0.033	1.905HisGly: 1.905 ± 0.062	0.489HisHis: 0.489 ± 0.027	1.149HisIle: 1.149 ± 0.045	0.499HisLys: 0.499 ± 0.028	1.747HisLeu: 1.747 ± 0.061	0.56HisMet: 0.56 ± 0.03	0.571HisAsn: 0.571 ± 0.033	1.219HisPro: 1.219 ± 0.048	0.516HisGln: 0.516 ± 0.029	1.229HisArg: 1.229 ± 0.045	0.855HisSer: 0.855 ± 0.036	1.045HisThr: 1.045 ± 0.04	1.815HisVal: 1.815 ± 0.054	0.158HisTrp: 0.158 ± 0.015	0.558HisTyr: 0.558 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.313IleAla: 6.313 ± 0.092	0.873IleCys: 0.873 ± 0.035	4.223IleAsp: 4.223 ± 0.09	3.6IleGlu: 3.6 ± 0.081	1.616IlePhe: 1.616 ± 0.054	3.794IleGly: 3.794 ± 0.087	0.848IleHis: 0.848 ± 0.034	2.596IleIle: 2.596 ± 0.067	1.581IleLys: 1.581 ± 0.053	3.845IleLeu: 3.845 ± 0.095	1.369IleMet: 1.369 ± 0.05	1.42IleAsn: 1.42 ± 0.05	2.488IlePro: 2.488 ± 0.068	1.263IleGln: 1.263 ± 0.044	2.505IleArg: 2.505 ± 0.06	3.157IleSer: 3.157 ± 0.075	2.809IleThr: 2.809 ± 0.071	4.687IleVal: 4.687 ± 0.099	0.44IleTrp: 0.44 ± 0.024	1.243IleTyr: 1.243 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.359LysAla: 3.359 ± 0.079	0.32LysCys: 0.32 ± 0.022	1.704LysAsp: 1.704 ± 0.053	1.802LysGlu: 1.802 ± 0.062	0.815LysPhe: 0.815 ± 0.039	2.53LysGly: 2.53 ± 0.065	0.649LysHis: 0.649 ± 0.03	1.692LysIle: 1.692 ± 0.061	1.696LysLys: 1.696 ± 0.066	2.97LysLeu: 2.97 ± 0.077	0.812LysMet: 0.812 ± 0.035	1.094LysAsn: 1.094 ± 0.044	1.609LysPro: 1.609 ± 0.057	1.089LysGln: 1.089 ± 0.044	2.518LysArg: 2.518 ± 0.063	1.604LysSer: 1.604 ± 0.056	2.076LysThr: 2.076 ± 0.068	2.517LysVal: 2.517 ± 0.069	0.232LysTrp: 0.232 ± 0.018	0.801LysTyr: 0.801 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	11.517LeuAla: 11.517 ± 0.18	1.305LeuCys: 1.305 ± 0.041	6.445LeuAsp: 6.445 ± 0.108	5.532LeuGlu: 5.532 ± 0.092	3.193LeuPhe: 3.193 ± 0.086	7.627LeuGly: 7.627 ± 0.119	1.66LeuHis: 1.66 ± 0.044	4.132LeuIle: 4.132 ± 0.088	2.811LeuLys: 2.811 ± 0.06	8.128LeuLeu: 8.128 ± 0.162	2.451LeuMet: 2.451 ± 0.058	2.307LeuAsn: 2.307 ± 0.059	4.36LeuPro: 4.36 ± 0.087	2.21LeuGln: 2.21 ± 0.066	5.265LeuArg: 5.265 ± 0.107	6.063LeuSer: 6.063 ± 0.099	5.213LeuThr: 5.213 ± 0.089	7.79LeuVal: 7.79 ± 0.141	0.814LeuTrp: 0.814 ± 0.038	2.274LeuTyr: 2.274 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	3.103MetAla: 3.103 ± 0.062	0.342MetCys: 0.342 ± 0.022	1.574MetAsp: 1.574 ± 0.052	1.406MetGlu: 1.406 ± 0.045	0.768MetPhe: 0.768 ± 0.038	2.329MetGly: 2.329 ± 0.059	0.513MetHis: 0.513 ± 0.028	1.165MetIle: 1.165 ± 0.046	0.937MetLys: 0.937 ± 0.041	2.535MetLeu: 2.535 ± 0.064	0.625MetMet: 0.625 ± 0.03	0.906MetAsn: 0.906 ± 0.037	1.523MetPro: 1.523 ± 0.05	0.818MetGln: 0.818 ± 0.037	1.844MetArg: 1.844 ± 0.062	1.69MetSer: 1.69 ± 0.049	1.506MetThr: 1.506 ± 0.046	1.983MetVal: 1.983 ± 0.053	0.19MetTrp: 0.19 ± 0.018	0.588MetTyr: 0.588 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.012AsnAla: 3.012 ± 0.069	0.328AsnCys: 0.328 ± 0.023	1.609AsnAsp: 1.609 ± 0.057	1.629AsnGlu: 1.629 ± 0.05	0.876AsnPhe: 0.876 ± 0.038	2.471AsnGly: 2.471 ± 0.075	0.564AsnHis: 0.564 ± 0.029	1.542AsnIle: 1.542 ± 0.053	0.871AsnLys: 0.871 ± 0.04	2.545AsnLeu: 2.545 ± 0.062	0.777AsnMet: 0.777 ± 0.034	0.814AsnAsn: 0.814 ± 0.04	1.625AsnPro: 1.625 ± 0.047	0.798AsnGln: 0.798 ± 0.035	1.498AsnArg: 1.498 ± 0.053	1.331AsnSer: 1.331 ± 0.045	1.527AsnThr: 1.527 ± 0.056	2.344AsnVal: 2.344 ± 0.053	0.263AsnTrp: 0.263 ± 0.02	0.842AsnTyr: 0.842 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	5.38ProAla: 5.38 ± 0.112	0.591ProCys: 0.591 ± 0.034	3.14ProAsp: 3.14 ± 0.077	3.768ProGlu: 3.768 ± 0.087	1.727ProPhe: 1.727 ± 0.051	3.514ProGly: 3.514 ± 0.076	0.97ProHis: 0.97 ± 0.039	2.02ProIle: 2.02 ± 0.056	1.436ProLys: 1.436 ± 0.043	3.785ProLeu: 3.785 ± 0.079	0.888ProMet: 0.888 ± 0.034	1.175ProAsn: 1.175 ± 0.044	1.141ProPro: 1.141 ± 0.04	1.449ProGln: 1.449 ± 0.046	2.413ProArg: 2.413 ± 0.057	2.751ProSer: 2.751 ± 0.073	2.569ProThr: 2.569 ± 0.068	3.867ProVal: 3.867 ± 0.074	0.541ProTrp: 0.541 ± 0.029	1.317ProTyr: 1.317 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.512GlnAla: 3.512 ± 0.074	0.26GlnCys: 0.26 ± 0.019	1.633GlnAsp: 1.633 ± 0.052	1.872GlnGlu: 1.872 ± 0.058	0.926GlnPhe: 0.926 ± 0.038	2.324GlnGly: 2.324 ± 0.061	0.636GlnHis: 0.636 ± 0.03	1.584GlnIle: 1.584 ± 0.05	1.024GlnLys: 1.024 ± 0.043	2.87GlnLeu: 2.87 ± 0.069	0.878GlnMet: 0.878 ± 0.039	0.876GlnAsn: 0.876 ± 0.039	1.248GlnPro: 1.248 ± 0.044	1.194GlnGln: 1.194 ± 0.05	2.014GlnArg: 2.014 ± 0.066	1.435GlnSer: 1.435 ± 0.043	1.611GlnThr: 1.611 ± 0.048	2.495GlnVal: 2.495 ± 0.059	0.287GlnTrp: 0.287 ± 0.022	0.719GlnTyr: 0.719 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.17ArgAla: 7.17 ± 0.118	0.91ArgCys: 0.91 ± 0.036	3.841ArgAsp: 3.841 ± 0.09	4.477ArgGlu: 4.477 ± 0.097	2.278ArgPhe: 2.278 ± 0.054	4.673ArgGly: 4.673 ± 0.094	1.405ArgHis: 1.405 ± 0.044	3.348ArgIle: 3.348 ± 0.075	2.02ArgLys: 2.02 ± 0.059	5.893ArgLeu: 5.893 ± 0.114	1.969ArgMet: 1.969 ± 0.048	1.569ArgAsn: 1.569 ± 0.046	2.728ArgPro: 2.728 ± 0.074	1.825ArgGln: 1.825 ± 0.049	5.302ArgArg: 5.302 ± 0.125	3.576ArgSer: 3.576 ± 0.089	3.252ArgThr: 3.252 ± 0.069	4.813ArgVal: 4.813 ± 0.08	0.656ArgTrp: 0.656 ± 0.035	1.949ArgTyr: 1.949 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.14SerAla: 6.14 ± 0.124	1.024SerCys: 1.024 ± 0.039	3.537SerAsp: 3.537 ± 0.095	3.174SerGlu: 3.174 ± 0.07	2.491SerPhe: 2.491 ± 0.068	5.356SerGly: 5.356 ± 0.112	1.217SerHis: 1.217 ± 0.041	3.157SerIle: 3.157 ± 0.073	1.771SerLys: 1.771 ± 0.049	5.305SerLeu: 5.305 ± 0.1	1.588SerMet: 1.588 ± 0.054	1.694SerAsn: 1.694 ± 0.06	2.447SerPro: 2.447 ± 0.07	1.738SerGln: 1.738 ± 0.05	3.48SerArg: 3.48 ± 0.086	3.93SerSer: 3.93 ± 0.09	3.38SerThr: 3.38 ± 0.072	4.536SerVal: 4.536 ± 0.085	0.804SerTrp: 0.804 ± 0.037	1.961SerTyr: 1.961 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.563ThrAla: 5.563 ± 0.113	0.93ThrCys: 0.93 ± 0.039	3.275ThrAsp: 3.275 ± 0.063	2.781ThrGlu: 2.781 ± 0.061	2.282ThrPhe: 2.282 ± 0.069	5.107ThrGly: 5.107 ± 0.113	1.135ThrHis: 1.135 ± 0.042	3.047ThrIle: 3.047 ± 0.085	1.677ThrLys: 1.677 ± 0.053	5.312ThrLeu: 5.312 ± 0.096	1.337ThrMet: 1.337 ± 0.049	1.554ThrAsn: 1.554 ± 0.065	3.226ThrPro: 3.226 ± 0.073	1.586ThrGln: 1.586 ± 0.059	3.092ThrArg: 3.092 ± 0.064	3.512ThrSer: 3.512 ± 0.079	3.152ThrThr: 3.152 ± 0.083	5.12ThrVal: 5.12 ± 0.113	0.608ThrTrp: 0.608 ± 0.03	1.804ThrTyr: 1.804 ± 0.079	0.0ThrXaa: 0.0 ± 0.0
Val	9.519ValAla: 9.519 ± 0.137	1.559ValCys: 1.559 ± 0.052	5.293ValAsp: 5.293 ± 0.09	5.176ValGlu: 5.176 ± 0.086	2.99ValPhe: 2.99 ± 0.068	6.151ValGly: 6.151 ± 0.09	1.476ValHis: 1.476 ± 0.05	4.225ValIle: 4.225 ± 0.087	2.471ValLys: 2.471 ± 0.063	7.57ValLeu: 7.57 ± 0.136	2.059ValMet: 2.059 ± 0.059	2.287ValAsn: 2.287 ± 0.061	3.939ValPro: 3.939 ± 0.08	2.064ValGln: 2.064 ± 0.047	5.051ValArg: 5.051 ± 0.098	5.465ValSer: 5.465 ± 0.105	5.129ValThr: 5.129 ± 0.12	7.486ValVal: 7.486 ± 0.132	0.82ValTrp: 0.82 ± 0.034	2.054ValTyr: 2.054 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.018TrpAla: 1.018 ± 0.041	0.175TrpCys: 0.175 ± 0.015	0.621TrpAsp: 0.621 ± 0.035	0.629TrpGlu: 0.629 ± 0.031	0.415TrpPhe: 0.415 ± 0.024	0.827TrpGly: 0.827 ± 0.04	0.237TrpHis: 0.237 ± 0.02	0.477TrpIle: 0.477 ± 0.028	0.325TrpLys: 0.325 ± 0.022	1.0TrpLeu: 1.0 ± 0.046	0.288TrpMet: 0.288 ± 0.02	0.402TrpAsn: 0.402 ± 0.025	0.376TrpPro: 0.376 ± 0.022	0.413TrpGln: 0.413 ± 0.028	0.744TrpArg: 0.744 ± 0.031	0.639TrpSer: 0.639 ± 0.033	0.54TrpThr: 0.54 ± 0.027	0.736TrpVal: 0.736 ± 0.031	0.17TrpTrp: 0.17 ± 0.017	0.374TrpTyr: 0.374 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.822TyrAla: 2.822 ± 0.061	0.376TyrCys: 0.376 ± 0.024	2.139TyrAsp: 2.139 ± 0.064	1.758TyrGlu: 1.758 ± 0.053	1.034TyrPhe: 1.034 ± 0.041	2.275TyrGly: 2.275 ± 0.07	0.605TyrHis: 0.605 ± 0.028	1.284TyrIle: 1.284 ± 0.046	0.788TyrLys: 0.788 ± 0.037	2.744TyrLeu: 2.744 ± 0.074	0.581TyrMet: 0.581 ± 0.026	0.829TyrAsn: 0.829 ± 0.036	1.267TyrPro: 1.267 ± 0.053	0.937TyrGln: 0.937 ± 0.037	1.984TyrArg: 1.984 ± 0.059	1.378TyrSer: 1.378 ± 0.057	1.675TyrThr: 1.675 ± 0.061	2.159TyrVal: 2.159 ± 0.059	0.308TyrTrp: 0.308 ± 0.02	0.902TyrTyr: 0.902 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2074 proteins (704075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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