Amino acid dipepetide frequency for Tupanvirus soda lake

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.904AlaAla: 1.904 ± 0.081
0.73AlaCys: 0.73 ± 0.049
2.255AlaAsp: 2.255 ± 0.086
1.922AlaGlu: 1.922 ± 0.075
1.614AlaPhe: 1.614 ± 0.075
1.849AlaGly: 1.849 ± 0.083
0.816AlaHis: 0.816 ± 0.048
3.563AlaIle: 3.563 ± 0.1
3.208AlaLys: 3.208 ± 0.099
3.258AlaLeu: 3.258 ± 0.122
0.839AlaMet: 0.839 ± 0.048
2.88AlaAsn: 2.88 ± 0.093
1.541AlaPro: 1.541 ± 0.09
1.425AlaGln: 1.425 ± 0.095
1.402AlaArg: 1.402 ± 0.059
2.745AlaSer: 2.745 ± 0.093
2.341AlaThr: 2.341 ± 0.087
2.166AlaVal: 2.166 ± 0.082
0.326AlaTrp: 0.326 ± 0.026
1.828AlaTyr: 1.828 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.793CysAla: 0.793 ± 0.045
0.533CysCys: 0.533 ± 0.049
1.325CysAsp: 1.325 ± 0.071
0.951CysGlu: 0.951 ± 0.06
0.787CysPhe: 0.787 ± 0.042
1.254CysGly: 1.254 ± 0.076
0.556CysHis: 0.556 ± 0.059
1.277CysIle: 1.277 ± 0.046
1.48CysLys: 1.48 ± 0.075
1.281CysLeu: 1.281 ± 0.061
0.463CysMet: 0.463 ± 0.033
1.325CysAsn: 1.325 ± 0.074
0.812CysPro: 0.812 ± 0.063
0.62CysGln: 0.62 ± 0.049
0.597CysArg: 0.597 ± 0.043
1.06CysSer: 1.06 ± 0.061
0.948CysThr: 0.948 ± 0.049
1.078CysVal: 1.078 ± 0.054
0.13CysTrp: 0.13 ± 0.017
0.926CysTyr: 0.926 ± 0.057
0.0CysXaa: 0.0 ± 0.0
Asp
2.314AspAla: 2.314 ± 0.079
1.049AspCys: 1.049 ± 0.057
4.617AspAsp: 4.617 ± 0.153
4.127AspGlu: 4.127 ± 0.123
3.128AspPhe: 3.128 ± 0.08
2.517AspGly: 2.517 ± 0.086
1.108AspHis: 1.108 ± 0.067
6.548AspIle: 6.548 ± 0.118
5.469AspLys: 5.469 ± 0.147
4.843AspLeu: 4.843 ± 0.108
1.587AspMet: 1.587 ± 0.069
5.114AspAsn: 5.114 ± 0.123
2.43AspPro: 2.43 ± 0.095
1.833AspGln: 1.833 ± 0.08
1.885AspArg: 1.885 ± 0.09
3.465AspSer: 3.465 ± 0.095
3.418AspThr: 3.418 ± 0.097
3.525AspVal: 3.525 ± 0.082
0.545AspTrp: 0.545 ± 0.044
3.121AspTyr: 3.121 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
2.006GluAla: 2.006 ± 0.079
0.985GluCys: 0.985 ± 0.06
2.966GluAsp: 2.966 ± 0.11
3.869GluGlu: 3.869 ± 0.128
2.709GluPhe: 2.709 ± 0.083
1.685GluGly: 1.685 ± 0.063
1.233GluHis: 1.233 ± 0.059
5.855GluIle: 5.855 ± 0.137
5.675GluLys: 5.675 ± 0.149
5.216GluLeu: 5.216 ± 0.128
1.414GluMet: 1.414 ± 0.053
5.474GluAsn: 5.474 ± 0.115
1.856GluPro: 1.856 ± 0.078
2.041GluGln: 2.041 ± 0.101
1.888GluArg: 1.888 ± 0.087
3.484GluSer: 3.484 ± 0.091
3.212GluThr: 3.212 ± 0.093
2.323GluVal: 2.323 ± 0.084
0.511GluTrp: 0.511 ± 0.038
3.153GluTyr: 3.153 ± 0.096
0.0GluXaa: 0.0 ± 0.0
Phe
1.671PheAla: 1.671 ± 0.058
0.901PheCys: 0.901 ± 0.047
3.851PheAsp: 3.851 ± 0.112
2.697PheGlu: 2.697 ± 0.071
2.264PhePhe: 2.264 ± 0.082
2.483PheGly: 2.483 ± 0.084
0.855PheHis: 0.855 ± 0.044
3.937PheIle: 3.937 ± 0.096
3.454PheLys: 3.454 ± 0.107
3.639PheLeu: 3.639 ± 0.118
1.366PheMet: 1.366 ± 0.061
3.632PheAsn: 3.632 ± 0.114
1.457PhePro: 1.457 ± 0.061
1.174PheGln: 1.174 ± 0.058
1.53PheArg: 1.53 ± 0.062
3.028PheSer: 3.028 ± 0.089
2.346PheThr: 2.346 ± 0.073
3.119PheVal: 3.119 ± 0.088
0.415PheTrp: 0.415 ± 0.031
2.649PheTyr: 2.649 ± 0.096
0.0PheXaa: 0.0 ± 0.0
Gly
2.038GlyAla: 2.038 ± 0.113
1.008GlyCys: 1.008 ± 0.08
2.72GlyAsp: 2.72 ± 0.197
2.291GlyGlu: 2.291 ± 0.236
2.186GlyPhe: 2.186 ± 0.086
2.658GlyGly: 2.658 ± 0.173
1.033GlyHis: 1.033 ± 0.074
4.599GlyIle: 4.599 ± 0.296
3.573GlyLys: 3.573 ± 0.107
3.411GlyLeu: 3.411 ± 0.111
1.012GlyMet: 1.012 ± 0.055
3.094GlyAsn: 3.094 ± 0.096
1.607GlyPro: 1.607 ± 0.153
1.363GlyGln: 1.363 ± 0.085
1.566GlyArg: 1.566 ± 0.068
3.659GlySer: 3.659 ± 0.242
2.763GlyThr: 2.763 ± 0.092
2.51GlyVal: 2.51 ± 0.106
0.506GlyTrp: 0.506 ± 0.038
2.389GlyTyr: 2.389 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.844HisAla: 0.844 ± 0.065
0.461HisCys: 0.461 ± 0.036
1.227HisAsp: 1.227 ± 0.052
1.11HisGlu: 1.11 ± 0.055
0.987HisPhe: 0.987 ± 0.047
1.06HisGly: 1.06 ± 0.059
0.616HisHis: 0.616 ± 0.044
2.107HisIle: 2.107 ± 0.073
1.728HisLys: 1.728 ± 0.1
1.906HisLeu: 1.906 ± 0.095
0.497HisMet: 0.497 ± 0.035
1.639HisAsn: 1.639 ± 0.06
0.891HisPro: 0.891 ± 0.048
0.654HisGln: 0.654 ± 0.042
0.643HisArg: 0.643 ± 0.041
1.265HisSer: 1.265 ± 0.072
1.078HisThr: 1.078 ± 0.051
1.017HisVal: 1.017 ± 0.047
0.182HisTrp: 0.182 ± 0.021
1.062HisTyr: 1.062 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
3.37IleAla: 3.37 ± 0.096
1.578IleCys: 1.578 ± 0.064
6.514IleAsp: 6.514 ± 0.134
5.112IleGlu: 5.112 ± 0.123
4.393IlePhe: 4.393 ± 0.119
3.869IleGly: 3.869 ± 0.13
2.013IleHis: 2.013 ± 0.084
9.051IleIle: 9.051 ± 0.195
8.205IleLys: 8.205 ± 0.161
7.448IleLeu: 7.448 ± 0.149
2.262IleMet: 2.262 ± 0.078
8.299IleAsn: 8.299 ± 0.187
3.627IlePro: 3.627 ± 0.117
2.82IleGln: 2.82 ± 0.235
2.82IleArg: 2.82 ± 0.11
6.049IleSer: 6.049 ± 0.127
5.458IleThr: 5.458 ± 0.145
5.257IleVal: 5.257 ± 0.126
0.746IleTrp: 0.746 ± 0.048
4.669IleTyr: 4.669 ± 0.118
0.0IleXaa: 0.0 ± 0.0
Lys
2.351LysAla: 2.351 ± 0.086
1.575LysCys: 1.575 ± 0.066
3.908LysAsp: 3.908 ± 0.102
5.324LysGlu: 5.324 ± 0.155
3.819LysPhe: 3.819 ± 0.109
3.037LysGly: 3.037 ± 0.212
1.883LysHis: 1.883 ± 0.091
9.286LysIle: 9.286 ± 0.206
9.25LysLys: 9.25 ± 0.265
7.344LysLeu: 7.344 ± 0.151
2.243LysMet: 2.243 ± 0.065
8.253LysAsn: 8.253 ± 0.166
2.932LysPro: 2.932 ± 0.105
2.964LysGln: 2.964 ± 0.092
2.569LysArg: 2.569 ± 0.081
5.187LysSer: 5.187 ± 0.131
4.9LysThr: 4.9 ± 0.134
3.502LysVal: 3.502 ± 0.194
0.834LysTrp: 0.834 ± 0.05
6.108LysTyr: 6.108 ± 0.15
0.0LysXaa: 0.0 ± 0.0
Leu
3.627LeuAla: 3.627 ± 0.094
1.448LeuCys: 1.448 ± 0.074
5.397LeuAsp: 5.397 ± 0.111
5.102LeuGlu: 5.102 ± 0.112
3.88LeuPhe: 3.88 ± 0.111
3.408LeuGly: 3.408 ± 0.118
1.646LeuHis: 1.646 ± 0.073
6.525LeuIle: 6.525 ± 0.152
6.334LeuLys: 6.334 ± 0.134
6.935LeuLeu: 6.935 ± 0.164
1.981LeuMet: 1.981 ± 0.074
5.766LeuAsn: 5.766 ± 0.139
2.914LeuPro: 2.914 ± 0.086
2.478LeuGln: 2.478 ± 0.075
2.905LeuArg: 2.905 ± 0.094
5.786LeuSer: 5.786 ± 0.152
4.222LeuThr: 4.222 ± 0.101
5.21LeuVal: 5.21 ± 0.143
0.647LeuTrp: 0.647 ± 0.045
3.951LeuTyr: 3.951 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
1.199MetAla: 1.199 ± 0.049
0.449MetCys: 0.449 ± 0.036
1.642MetAsp: 1.642 ± 0.06
1.822MetGlu: 1.822 ± 0.064
1.131MetPhe: 1.131 ± 0.052
1.06MetGly: 1.06 ± 0.057
0.559MetHis: 0.559 ± 0.037
2.031MetIle: 2.031 ± 0.077
1.605MetLys: 1.605 ± 0.057
1.911MetLeu: 1.911 ± 0.062
0.613MetMet: 0.613 ± 0.049
1.831MetAsn: 1.831 ± 0.066
0.958MetPro: 0.958 ± 0.061
0.875MetGln: 0.875 ± 0.049
0.803MetArg: 0.803 ± 0.05
2.088MetSer: 2.088 ± 0.068
1.512MetThr: 1.512 ± 0.063
1.395MetVal: 1.395 ± 0.058
0.178MetTrp: 0.178 ± 0.021
1.108MetTyr: 1.108 ± 0.053
0.0MetXaa: 0.0 ± 0.0
Asn
3.039AsnAla: 3.039 ± 0.087
1.261AsnCys: 1.261 ± 0.072
5.123AsnAsp: 5.123 ± 0.138
4.722AsnGlu: 4.722 ± 0.11
3.764AsnPhe: 3.764 ± 0.104
4.04AsnGly: 4.04 ± 0.121
1.667AsnHis: 1.667 ± 0.068
9.026AsnIle: 9.026 ± 0.2
8.155AsnLys: 8.155 ± 0.152
6.11AsnLeu: 6.11 ± 0.138
2.253AsnMet: 2.253 ± 0.078
8.6AsnAsn: 8.6 ± 0.223
3.06AsnPro: 3.06 ± 0.086
2.631AsnGln: 2.631 ± 0.108
2.49AsnArg: 2.49 ± 0.096
4.918AsnSer: 4.918 ± 0.119
5.004AsnThr: 5.004 ± 0.139
4.14AsnVal: 4.14 ± 0.1
0.524AsnTrp: 0.524 ± 0.036
4.12AsnTyr: 4.12 ± 0.091
0.0AsnXaa: 0.0 ± 0.0
Pro
1.466ProAla: 1.466 ± 0.079
0.773ProCys: 0.773 ± 0.115
1.986ProAsp: 1.986 ± 0.069
2.132ProGlu: 2.132 ± 0.073
1.696ProPhe: 1.696 ± 0.065
1.71ProGly: 1.71 ± 0.1
0.711ProHis: 0.711 ± 0.041
3.313ProIle: 3.313 ± 0.095
3.135ProLys: 3.135 ± 0.095
2.736ProLeu: 2.736 ± 0.085
0.873ProMet: 0.873 ± 0.059
3.121ProAsn: 3.121 ± 0.1
1.696ProPro: 1.696 ± 0.145
1.571ProGln: 1.571 ± 0.116
1.135ProArg: 1.135 ± 0.062
2.604ProSer: 2.604 ± 0.09
2.419ProThr: 2.419 ± 0.096
2.141ProVal: 2.141 ± 0.092
0.278ProTrp: 0.278 ± 0.031
1.826ProTyr: 1.826 ± 0.082
0.0ProXaa: 0.0 ± 0.0
Gln
1.092GlnAla: 1.092 ± 0.051
0.57GlnCys: 0.57 ± 0.04
1.382GlnAsp: 1.382 ± 0.061
1.594GlnGlu: 1.594 ± 0.062
1.477GlnPhe: 1.477 ± 0.058
2.038GlnGly: 2.038 ± 0.585
0.632GlnHis: 0.632 ± 0.036
2.996GlnIle: 2.996 ± 0.101
2.925GlnLys: 2.925 ± 0.107
2.777GlnLeu: 2.777 ± 0.089
1.019GlnMet: 1.019 ± 0.065
3.021GlnAsn: 3.021 ± 0.103
1.318GlnPro: 1.318 ± 0.092
1.594GlnGln: 1.594 ± 0.111
1.088GlnArg: 1.088 ± 0.067
1.965GlnSer: 1.965 ± 0.065
1.949GlnThr: 1.949 ± 0.08
1.338GlnVal: 1.338 ± 0.055
0.299GlnTrp: 0.299 ± 0.029
1.797GlnTyr: 1.797 ± 0.083
0.0GlnXaa: 0.0 ± 0.0
Arg
1.249ArgAla: 1.249 ± 0.061
0.581ArgCys: 0.581 ± 0.038
1.86ArgAsp: 1.86 ± 0.072
1.819ArgGlu: 1.819 ± 0.074
1.491ArgPhe: 1.491 ± 0.064
1.516ArgGly: 1.516 ± 0.081
0.661ArgHis: 0.661 ± 0.038
3.064ArgIle: 3.064 ± 0.098
2.857ArgLys: 2.857 ± 0.08
2.592ArgLeu: 2.592 ± 0.078
0.809ArgMet: 0.809 ± 0.043
2.934ArgAsn: 2.934 ± 0.116
1.14ArgPro: 1.14 ± 0.071
1.001ArgGln: 1.001 ± 0.047
1.525ArgArg: 1.525 ± 0.074
2.205ArgSer: 2.205 ± 0.133
1.735ArgThr: 1.735 ± 0.074
1.439ArgVal: 1.439 ± 0.058
0.312ArgTrp: 0.312 ± 0.034
1.781ArgTyr: 1.781 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
2.72SerAla: 2.72 ± 0.098
1.17SerCys: 1.17 ± 0.05
4.569SerAsp: 4.569 ± 0.131
3.855SerGlu: 3.855 ± 0.106
2.941SerPhe: 2.941 ± 0.089
3.411SerGly: 3.411 ± 0.134
1.281SerHis: 1.281 ± 0.061
5.28SerIle: 5.28 ± 0.12
5.967SerLys: 5.967 ± 0.129
4.774SerLeu: 4.774 ± 0.134
1.507SerMet: 1.507 ± 0.065
5.333SerAsn: 5.333 ± 0.134
2.05SerPro: 2.05 ± 0.092
2.337SerGln: 2.337 ± 0.154
2.15SerArg: 2.15 ± 0.125
4.717SerSer: 4.717 ± 0.192
3.782SerThr: 3.782 ± 0.09
3.374SerVal: 3.374 ± 0.094
0.529SerTrp: 0.529 ± 0.034
3.215SerTyr: 3.215 ± 0.092
0.0SerXaa: 0.0 ± 0.0
Thr
2.298ThrAla: 2.298 ± 0.097
0.818ThrCys: 0.818 ± 0.049
3.52ThrAsp: 3.52 ± 0.116
3.071ThrGlu: 3.071 ± 0.087
2.385ThrPhe: 2.385 ± 0.074
2.843ThrGly: 2.843 ± 0.13
1.067ThrHis: 1.067 ± 0.049
5.26ThrIle: 5.26 ± 0.127
5.123ThrLys: 5.123 ± 0.12
4.031ThrLeu: 4.031 ± 0.114
1.217ThrMet: 1.217 ± 0.049
5.424ThrAsn: 5.424 ± 0.129
2.414ThrPro: 2.414 ± 0.085
1.751ThrGln: 1.751 ± 0.077
1.769ThrArg: 1.769 ± 0.064
3.712ThrSer: 3.712 ± 0.114
3.874ThrThr: 3.874 ± 0.161
3.048ThrVal: 3.048 ± 0.11
0.44ThrTrp: 0.44 ± 0.035
2.613ThrTyr: 2.613 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
2.278ValAla: 2.278 ± 0.076
0.985ValCys: 0.985 ± 0.051
3.602ValAsp: 3.602 ± 0.096
3.044ValGlu: 3.044 ± 0.088
2.439ValPhe: 2.439 ± 0.075
2.512ValGly: 2.512 ± 0.094
1.113ValHis: 1.113 ± 0.068
4.708ValIle: 4.708 ± 0.11
4.396ValLys: 4.396 ± 0.141
4.259ValLeu: 4.259 ± 0.108
1.336ValMet: 1.336 ± 0.058
4.136ValAsn: 4.136 ± 0.1
2.223ValPro: 2.223 ± 0.08
1.541ValGln: 1.541 ± 0.07
1.767ValArg: 1.767 ± 0.068
3.509ValSer: 3.509 ± 0.105
2.889ValThr: 2.889 ± 0.101
3.684ValVal: 3.684 ± 0.137
0.461ValTrp: 0.461 ± 0.031
2.763ValTyr: 2.763 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.376TrpAla: 0.376 ± 0.029
0.189TrpCys: 0.189 ± 0.025
0.543TrpAsp: 0.543 ± 0.04
0.365TrpGlu: 0.365 ± 0.029
0.47TrpPhe: 0.47 ± 0.052
0.365TrpGly: 0.365 ± 0.031
0.18TrpHis: 0.18 ± 0.019
0.834TrpIle: 0.834 ± 0.046
0.677TrpLys: 0.677 ± 0.043
0.761TrpLeu: 0.761 ± 0.045
0.237TrpMet: 0.237 ± 0.023
0.673TrpAsn: 0.673 ± 0.04
0.258TrpPro: 0.258 ± 0.026
0.271TrpGln: 0.271 ± 0.024
0.312TrpArg: 0.312 ± 0.035
0.622TrpSer: 0.622 ± 0.045
0.401TrpThr: 0.401 ± 0.031
0.388TrpVal: 0.388 ± 0.029
0.087TrpTrp: 0.087 ± 0.014
0.42TrpTyr: 0.42 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.977TyrAla: 1.977 ± 0.079
1.133TyrCys: 1.133 ± 0.056
3.639TyrAsp: 3.639 ± 0.091
2.626TyrGlu: 2.626 ± 0.081
2.905TyrPhe: 2.905 ± 0.082
2.672TyrGly: 2.672 ± 0.084
1.345TyrHis: 1.345 ± 0.062
4.3TyrIle: 4.3 ± 0.111
4.054TyrLys: 4.054 ± 0.107
4.931TyrLeu: 4.931 ± 0.13
1.238TyrMet: 1.238 ± 0.056
4.102TyrAsn: 4.102 ± 0.104
2.139TyrPro: 2.139 ± 0.08
1.924TyrGln: 1.924 ± 0.069
1.728TyrArg: 1.728 ± 0.068
2.893TyrSer: 2.893 ± 0.088
2.426TyrThr: 2.426 ± 0.074
2.989TyrVal: 2.989 ± 0.077
0.479TyrTrp: 0.479 ± 0.034
3.183TyrTyr: 3.183 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1331 proteins (438616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski