Amino acid dipepetide frequency for Klebsiella phage vB_KpnP_SU503

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.014AlaAla: 15.014 ± 1.314
0.736AlaCys: 0.736 ± 0.242
6.182AlaAsp: 6.182 ± 0.761
5.446AlaGlu: 5.446 ± 0.686
3.238AlaPhe: 3.238 ± 0.458
8.317AlaGly: 8.317 ± 0.959
1.619AlaHis: 1.619 ± 0.477
4.048AlaIle: 4.048 ± 0.61
5.594AlaLys: 5.594 ± 1.052
9.789AlaLeu: 9.789 ± 0.952
2.87AlaMet: 2.87 ± 0.392
3.238AlaAsn: 3.238 ± 0.38
4.269AlaPro: 4.269 ± 1.017
5.446AlaGln: 5.446 ± 0.874
5.814AlaArg: 5.814 ± 0.65
5.667AlaSer: 5.667 ± 0.618
4.858AlaThr: 4.858 ± 0.778
6.33AlaVal: 6.33 ± 0.734
1.03AlaTrp: 1.03 ± 0.284
4.048AlaTyr: 4.048 ± 0.471
0.0AlaXaa: 0.0 ± 0.0
Cys
0.883CysAla: 0.883 ± 0.287
0.147CysCys: 0.147 ± 0.106
0.368CysAsp: 0.368 ± 0.151
0.589CysGlu: 0.589 ± 0.228
0.442CysPhe: 0.442 ± 0.165
0.957CysGly: 0.957 ± 0.3
0.442CysHis: 0.442 ± 0.182
0.589CysIle: 0.589 ± 0.212
0.589CysLys: 0.589 ± 0.196
0.957CysLeu: 0.957 ± 0.31
0.589CysMet: 0.589 ± 0.177
0.662CysAsn: 0.662 ± 0.207
0.736CysPro: 0.736 ± 0.348
0.368CysGln: 0.368 ± 0.198
0.81CysArg: 0.81 ± 0.228
0.883CysSer: 0.883 ± 0.252
1.104CysThr: 1.104 ± 0.326
0.883CysVal: 0.883 ± 0.267
0.368CysTrp: 0.368 ± 0.179
0.662CysTyr: 0.662 ± 0.193
0.0CysXaa: 0.0 ± 0.0
Asp
7.507AspAla: 7.507 ± 0.945
1.546AspCys: 1.546 ± 0.341
2.944AspAsp: 2.944 ± 0.432
3.754AspGlu: 3.754 ± 0.585
2.355AspPhe: 2.355 ± 0.353
4.563AspGly: 4.563 ± 0.477
0.515AspHis: 0.515 ± 0.22
3.165AspIle: 3.165 ± 0.466
2.576AspLys: 2.576 ± 0.431
4.931AspLeu: 4.931 ± 0.576
2.502AspMet: 2.502 ± 0.39
3.459AspAsn: 3.459 ± 0.662
2.208AspPro: 2.208 ± 0.377
1.472AspGln: 1.472 ± 0.322
2.65AspArg: 2.65 ± 0.568
4.858AspSer: 4.858 ± 0.556
3.901AspThr: 3.901 ± 0.549
4.122AspVal: 4.122 ± 0.475
1.104AspTrp: 1.104 ± 0.185
2.282AspTyr: 2.282 ± 0.421
0.0AspXaa: 0.0 ± 0.0
Glu
5.52GluAla: 5.52 ± 0.728
0.515GluCys: 0.515 ± 0.25
2.944GluAsp: 2.944 ± 0.526
3.754GluGlu: 3.754 ± 0.699
2.429GluPhe: 2.429 ± 0.42
3.901GluGly: 3.901 ± 0.479
2.134GluHis: 2.134 ± 0.413
2.65GluIle: 2.65 ± 0.412
1.914GluLys: 1.914 ± 0.365
5.52GluLeu: 5.52 ± 0.532
2.061GluMet: 2.061 ± 0.324
1.914GluAsn: 1.914 ± 0.401
2.061GluPro: 2.061 ± 0.394
3.606GluGln: 3.606 ± 0.607
4.269GluArg: 4.269 ± 0.559
2.502GluSer: 2.502 ± 0.493
3.018GluThr: 3.018 ± 0.561
4.858GluVal: 4.858 ± 0.675
0.662GluTrp: 0.662 ± 0.194
2.723GluTyr: 2.723 ± 0.49
0.0GluXaa: 0.0 ± 0.0
Phe
2.797PheAla: 2.797 ± 0.475
0.515PheCys: 0.515 ± 0.254
1.987PheAsp: 1.987 ± 0.437
2.208PheGlu: 2.208 ± 0.399
1.325PhePhe: 1.325 ± 0.257
2.208PheGly: 2.208 ± 0.326
0.442PheHis: 0.442 ± 0.219
1.472PheIle: 1.472 ± 0.298
1.84PheLys: 1.84 ± 0.421
2.061PheLeu: 2.061 ± 0.411
0.589PheMet: 0.589 ± 0.22
1.619PheAsn: 1.619 ± 0.414
1.178PhePro: 1.178 ± 0.296
1.398PheGln: 1.398 ± 0.283
1.987PheArg: 1.987 ± 0.449
1.619PheSer: 1.619 ± 0.342
2.134PheThr: 2.134 ± 0.403
1.693PheVal: 1.693 ± 0.325
0.368PheTrp: 0.368 ± 0.14
1.251PheTyr: 1.251 ± 0.225
0.0PheXaa: 0.0 ± 0.0
Gly
5.52GlyAla: 5.52 ± 0.547
1.619GlyCys: 1.619 ± 0.442
4.637GlyAsp: 4.637 ± 0.592
4.195GlyGlu: 4.195 ± 0.417
2.576GlyPhe: 2.576 ± 0.463
4.269GlyGly: 4.269 ± 0.588
1.472GlyHis: 1.472 ± 0.357
4.342GlyIle: 4.342 ± 0.618
4.122GlyLys: 4.122 ± 0.661
6.403GlyLeu: 6.403 ± 0.704
2.355GlyMet: 2.355 ± 0.526
3.606GlyAsn: 3.606 ± 0.541
1.251GlyPro: 1.251 ± 0.319
2.944GlyGln: 2.944 ± 0.453
4.637GlyArg: 4.637 ± 0.484
5.667GlySer: 5.667 ± 0.737
4.931GlyThr: 4.931 ± 0.808
5.741GlyVal: 5.741 ± 0.692
0.589GlyTrp: 0.589 ± 0.21
3.386GlyTyr: 3.386 ± 0.549
0.0GlyXaa: 0.0 ± 0.0
His
1.546HisAla: 1.546 ± 0.438
0.221HisCys: 0.221 ± 0.107
1.251HisAsp: 1.251 ± 0.268
1.251HisGlu: 1.251 ± 0.345
0.368HisPhe: 0.368 ± 0.138
1.693HisGly: 1.693 ± 0.472
0.147HisHis: 0.147 ± 0.087
1.325HisIle: 1.325 ± 0.349
1.03HisLys: 1.03 ± 0.3
2.429HisLeu: 2.429 ± 0.437
0.368HisMet: 0.368 ± 0.126
0.957HisAsn: 0.957 ± 0.286
0.883HisPro: 0.883 ± 0.307
0.589HisGln: 0.589 ± 0.256
1.546HisArg: 1.546 ± 0.362
0.81HisSer: 0.81 ± 0.296
0.515HisThr: 0.515 ± 0.171
0.515HisVal: 0.515 ± 0.212
0.294HisTrp: 0.294 ± 0.151
0.589HisTyr: 0.589 ± 0.251
0.0HisXaa: 0.0 ± 0.0
Ile
3.606IleAla: 3.606 ± 0.531
0.294IleCys: 0.294 ± 0.151
3.606IleAsp: 3.606 ± 0.414
2.429IleGlu: 2.429 ± 0.443
0.515IlePhe: 0.515 ± 0.169
2.797IleGly: 2.797 ± 0.391
0.662IleHis: 0.662 ± 0.229
2.061IleIle: 2.061 ± 0.383
3.238IleLys: 3.238 ± 0.532
4.416IleLeu: 4.416 ± 0.585
1.251IleMet: 1.251 ± 0.252
1.766IleAsn: 1.766 ± 0.378
2.576IlePro: 2.576 ± 0.417
2.944IleGln: 2.944 ± 0.451
2.944IleArg: 2.944 ± 0.383
3.459IleSer: 3.459 ± 0.513
2.87IleThr: 2.87 ± 0.494
3.018IleVal: 3.018 ± 0.511
0.147IleTrp: 0.147 ± 0.099
1.178IleTyr: 1.178 ± 0.328
0.0IleXaa: 0.0 ± 0.0
Lys
6.33LysAla: 6.33 ± 0.76
0.515LysCys: 0.515 ± 0.199
2.65LysAsp: 2.65 ± 0.382
3.165LysGlu: 3.165 ± 0.484
1.251LysPhe: 1.251 ± 0.269
2.87LysGly: 2.87 ± 0.643
0.883LysHis: 0.883 ± 0.255
1.398LysIle: 1.398 ± 0.261
2.134LysLys: 2.134 ± 0.375
5.078LysLeu: 5.078 ± 0.724
1.178LysMet: 1.178 ± 0.28
1.104LysAsn: 1.104 ± 0.264
1.472LysPro: 1.472 ± 0.365
3.312LysGln: 3.312 ± 0.583
3.238LysArg: 3.238 ± 0.526
3.165LysSer: 3.165 ± 0.413
2.502LysThr: 2.502 ± 0.366
3.901LysVal: 3.901 ± 0.628
1.03LysTrp: 1.03 ± 0.262
1.766LysTyr: 1.766 ± 0.38
0.0LysXaa: 0.0 ± 0.0
Leu
8.39LeuAla: 8.39 ± 0.887
1.398LeuCys: 1.398 ± 0.379
6.698LeuAsp: 6.698 ± 0.674
5.888LeuGlu: 5.888 ± 0.598
2.87LeuPhe: 2.87 ± 0.446
7.213LeuGly: 7.213 ± 0.714
1.398LeuHis: 1.398 ± 0.327
4.71LeuIle: 4.71 ± 0.635
3.386LeuLys: 3.386 ± 0.549
6.771LeuLeu: 6.771 ± 0.617
2.134LeuMet: 2.134 ± 0.377
3.974LeuAsn: 3.974 ± 0.507
3.238LeuPro: 3.238 ± 0.436
3.974LeuGln: 3.974 ± 0.561
6.035LeuArg: 6.035 ± 0.504
5.078LeuSer: 5.078 ± 0.655
4.858LeuThr: 4.858 ± 0.657
6.035LeuVal: 6.035 ± 0.657
1.104LeuTrp: 1.104 ± 0.32
3.312LeuTyr: 3.312 ± 0.517
0.0LeuXaa: 0.0 ± 0.0
Met
3.312MetAla: 3.312 ± 0.574
0.221MetCys: 0.221 ± 0.124
1.84MetAsp: 1.84 ± 0.468
0.957MetGlu: 0.957 ± 0.219
0.883MetPhe: 0.883 ± 0.309
1.472MetGly: 1.472 ± 0.255
0.589MetHis: 0.589 ± 0.244
0.883MetIle: 0.883 ± 0.22
1.03MetLys: 1.03 ± 0.333
4.048MetLeu: 4.048 ± 0.506
0.515MetMet: 0.515 ± 0.221
1.104MetAsn: 1.104 ± 0.288
1.251MetPro: 1.251 ± 0.258
2.061MetGln: 2.061 ± 0.425
2.355MetArg: 2.355 ± 0.492
2.282MetSer: 2.282 ± 0.521
0.957MetThr: 0.957 ± 0.258
1.914MetVal: 1.914 ± 0.335
0.368MetTrp: 0.368 ± 0.144
1.03MetTyr: 1.03 ± 0.315
0.0MetXaa: 0.0 ± 0.0
Asn
3.091AsnAla: 3.091 ± 0.492
0.442AsnCys: 0.442 ± 0.205
2.502AsnAsp: 2.502 ± 0.487
1.693AsnGlu: 1.693 ± 0.367
1.104AsnPhe: 1.104 ± 0.289
3.754AsnGly: 3.754 ± 0.437
0.147AsnHis: 0.147 ± 0.103
2.355AsnIle: 2.355 ± 0.445
2.355AsnLys: 2.355 ± 0.393
2.944AsnLeu: 2.944 ± 0.531
1.325AsnMet: 1.325 ± 0.326
1.619AsnAsn: 1.619 ± 0.401
2.65AsnPro: 2.65 ± 0.393
1.693AsnGln: 1.693 ± 0.347
1.766AsnArg: 1.766 ± 0.434
3.386AsnSer: 3.386 ± 0.509
3.091AsnThr: 3.091 ± 0.539
3.091AsnVal: 3.091 ± 0.375
0.589AsnTrp: 0.589 ± 0.247
1.325AsnTyr: 1.325 ± 0.331
0.0AsnXaa: 0.0 ± 0.0
Pro
4.269ProAla: 4.269 ± 1.005
0.221ProCys: 0.221 ± 0.131
2.723ProAsp: 2.723 ± 0.492
3.901ProGlu: 3.901 ± 0.47
1.03ProPhe: 1.03 ± 0.231
2.502ProGly: 2.502 ± 0.466
0.515ProHis: 0.515 ± 0.218
1.693ProIle: 1.693 ± 0.343
1.619ProLys: 1.619 ± 0.42
3.238ProLeu: 3.238 ± 0.482
1.178ProMet: 1.178 ± 0.271
1.398ProAsn: 1.398 ± 0.329
0.736ProPro: 0.736 ± 0.184
1.325ProGln: 1.325 ± 0.318
1.766ProArg: 1.766 ± 0.336
2.576ProSer: 2.576 ± 0.534
2.355ProThr: 2.355 ± 0.391
3.018ProVal: 3.018 ± 0.47
0.589ProTrp: 0.589 ± 0.225
1.178ProTyr: 1.178 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
4.931GlnAla: 4.931 ± 0.829
0.442GlnCys: 0.442 ± 0.195
3.312GlnAsp: 3.312 ± 0.506
3.459GlnGlu: 3.459 ± 0.563
1.546GlnPhe: 1.546 ± 0.361
3.091GlnGly: 3.091 ± 0.434
1.619GlnHis: 1.619 ± 0.368
1.398GlnIle: 1.398 ± 0.376
2.282GlnLys: 2.282 ± 0.404
4.71GlnLeu: 4.71 ± 0.546
1.251GlnMet: 1.251 ± 0.284
1.914GlnAsn: 1.914 ± 0.391
1.398GlnPro: 1.398 ± 0.368
3.018GlnGln: 3.018 ± 0.659
2.87GlnArg: 2.87 ± 0.426
3.312GlnSer: 3.312 ± 0.454
1.619GlnThr: 1.619 ± 0.393
3.018GlnVal: 3.018 ± 0.411
0.736GlnTrp: 0.736 ± 0.26
2.134GlnTyr: 2.134 ± 0.459
0.0GlnXaa: 0.0 ± 0.0
Arg
6.992ArgAla: 6.992 ± 0.931
1.03ArgCys: 1.03 ± 0.34
3.459ArgAsp: 3.459 ± 0.535
3.974ArgGlu: 3.974 ± 0.551
1.987ArgPhe: 1.987 ± 0.344
4.342ArgGly: 4.342 ± 0.752
1.104ArgHis: 1.104 ± 0.248
3.312ArgIle: 3.312 ± 0.626
3.165ArgLys: 3.165 ± 0.522
5.078ArgLeu: 5.078 ± 0.629
2.061ArgMet: 2.061 ± 0.444
2.355ArgAsn: 2.355 ± 0.339
1.766ArgPro: 1.766 ± 0.358
2.576ArgGln: 2.576 ± 0.379
4.416ArgArg: 4.416 ± 0.666
2.576ArgSer: 2.576 ± 0.609
3.386ArgThr: 3.386 ± 0.426
4.122ArgVal: 4.122 ± 0.648
0.957ArgTrp: 0.957 ± 0.222
1.84ArgTyr: 1.84 ± 0.303
0.0ArgXaa: 0.0 ± 0.0
Ser
7.875SerAla: 7.875 ± 0.673
1.03SerCys: 1.03 ± 0.277
3.754SerAsp: 3.754 ± 0.573
3.018SerGlu: 3.018 ± 0.538
1.693SerPhe: 1.693 ± 0.316
5.299SerGly: 5.299 ± 0.607
0.589SerHis: 0.589 ± 0.241
2.429SerIle: 2.429 ± 0.439
4.048SerLys: 4.048 ± 0.608
4.858SerLeu: 4.858 ± 0.717
2.797SerMet: 2.797 ± 0.41
2.87SerAsn: 2.87 ± 0.553
2.87SerPro: 2.87 ± 0.431
1.914SerGln: 1.914 ± 0.399
2.87SerArg: 2.87 ± 0.386
3.606SerSer: 3.606 ± 0.591
4.122SerThr: 4.122 ± 0.588
3.974SerVal: 3.974 ± 0.547
0.883SerTrp: 0.883 ± 0.238
1.693SerTyr: 1.693 ± 0.367
0.0SerXaa: 0.0 ± 0.0
Thr
5.888ThrAla: 5.888 ± 0.696
0.515ThrCys: 0.515 ± 0.234
3.386ThrAsp: 3.386 ± 0.532
2.208ThrGlu: 2.208 ± 0.474
1.914ThrPhe: 1.914 ± 0.324
5.299ThrGly: 5.299 ± 0.605
1.178ThrHis: 1.178 ± 0.297
2.65ThrIle: 2.65 ± 0.491
2.65ThrLys: 2.65 ± 0.386
4.416ThrLeu: 4.416 ± 0.702
1.472ThrMet: 1.472 ± 0.333
2.208ThrAsn: 2.208 ± 0.59
2.65ThrPro: 2.65 ± 0.315
2.944ThrGln: 2.944 ± 0.401
2.797ThrArg: 2.797 ± 0.492
3.606ThrSer: 3.606 ± 0.534
3.459ThrThr: 3.459 ± 0.523
3.974ThrVal: 3.974 ± 0.632
0.883ThrTrp: 0.883 ± 0.217
2.65ThrTyr: 2.65 ± 0.569
0.0ThrXaa: 0.0 ± 0.0
Val
6.109ValAla: 6.109 ± 0.563
0.515ValCys: 0.515 ± 0.208
5.373ValAsp: 5.373 ± 0.614
3.974ValGlu: 3.974 ± 0.604
1.178ValPhe: 1.178 ± 0.293
5.888ValGly: 5.888 ± 0.608
1.84ValHis: 1.84 ± 0.421
2.797ValIle: 2.797 ± 0.552
2.87ValLys: 2.87 ± 0.506
5.594ValLeu: 5.594 ± 0.825
1.693ValMet: 1.693 ± 0.389
2.944ValAsn: 2.944 ± 0.546
3.018ValPro: 3.018 ± 0.454
3.901ValGln: 3.901 ± 0.731
4.122ValArg: 4.122 ± 0.5
4.342ValSer: 4.342 ± 0.552
3.312ValThr: 3.312 ± 0.587
5.667ValVal: 5.667 ± 0.572
0.736ValTrp: 0.736 ± 0.224
3.165ValTyr: 3.165 ± 0.486
0.0ValXaa: 0.0 ± 0.0
Trp
1.104TrpAla: 1.104 ± 0.286
0.294TrpCys: 0.294 ± 0.141
0.662TrpAsp: 0.662 ± 0.211
0.957TrpGlu: 0.957 ± 0.297
0.736TrpPhe: 0.736 ± 0.314
0.662TrpGly: 0.662 ± 0.226
0.294TrpHis: 0.294 ± 0.133
0.662TrpIle: 0.662 ± 0.224
0.442TrpLys: 0.442 ± 0.212
1.325TrpLeu: 1.325 ± 0.233
0.074TrpMet: 0.074 ± 0.084
0.81TrpAsn: 0.81 ± 0.249
0.442TrpPro: 0.442 ± 0.177
0.368TrpGln: 0.368 ± 0.182
1.178TrpArg: 1.178 ± 0.259
0.515TrpSer: 0.515 ± 0.2
1.03TrpThr: 1.03 ± 0.204
0.736TrpVal: 0.736 ± 0.185
0.294TrpTrp: 0.294 ± 0.156
0.736TrpTyr: 0.736 ± 0.277
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.87TyrAla: 2.87 ± 0.431
0.81TyrCys: 0.81 ± 0.284
2.134TyrAsp: 2.134 ± 0.341
2.134TyrGlu: 2.134 ± 0.521
1.251TyrPhe: 1.251 ± 0.257
3.165TyrGly: 3.165 ± 0.573
0.736TyrHis: 0.736 ± 0.247
1.84TyrIle: 1.84 ± 0.442
2.134TyrLys: 2.134 ± 0.375
3.901TyrLeu: 3.901 ± 0.486
0.736TyrMet: 0.736 ± 0.259
1.398TyrAsn: 1.398 ± 0.277
1.178TyrPro: 1.178 ± 0.269
2.208TyrGln: 2.208 ± 0.424
2.429TyrArg: 2.429 ± 0.463
2.282TyrSer: 2.282 ± 0.354
2.723TyrThr: 2.723 ± 0.498
2.429TyrVal: 2.429 ± 0.561
0.589TyrTrp: 0.589 ± 0.195
0.957TyrTyr: 0.957 ± 0.262
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (13588 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski