Amino acid dipepetide frequency for Aeromonas phage 2_L372X

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.644AlaAla: 3.644 ± 0.543
0.694AlaCys: 0.694 ± 0.159
2.516AlaAsp: 2.516 ± 0.273
2.863AlaGlu: 2.863 ± 0.36
2.111AlaPhe: 2.111 ± 0.28
3.991AlaGly: 3.991 ± 0.457
0.925AlaHis: 0.925 ± 0.142
3.76AlaIle: 3.76 ± 0.325
4.338AlaLys: 4.338 ± 0.41
4.541AlaLeu: 4.541 ± 0.39
1.157AlaMet: 1.157 ± 0.214
1.822AlaAsn: 1.822 ± 0.221
1.504AlaPro: 1.504 ± 0.258
2.053AlaGln: 2.053 ± 0.284
2.516AlaArg: 2.516 ± 0.293
3.586AlaSer: 3.586 ± 0.375
3.095AlaThr: 3.095 ± 0.356
2.632AlaVal: 2.632 ± 0.281
0.665AlaTrp: 0.665 ± 0.148
2.314AlaTyr: 2.314 ± 0.305
0.0AlaXaa: 0.0 ± 0.0
Cys
0.954CysAla: 0.954 ± 0.174
0.231CysCys: 0.231 ± 0.081
0.897CysAsp: 0.897 ± 0.15
1.475CysGlu: 1.475 ± 0.237
0.954CysPhe: 0.954 ± 0.17
1.62CysGly: 1.62 ± 0.231
0.174CysHis: 0.174 ± 0.062
1.273CysIle: 1.273 ± 0.222
2.024CysLys: 2.024 ± 0.266
1.07CysLeu: 1.07 ± 0.159
0.463CysMet: 0.463 ± 0.097
0.521CysAsn: 0.521 ± 0.144
0.752CysPro: 0.752 ± 0.177
0.607CysGln: 0.607 ± 0.16
0.636CysArg: 0.636 ± 0.148
1.562CysSer: 1.562 ± 0.243
0.694CysThr: 0.694 ± 0.161
0.925CysVal: 0.925 ± 0.2
0.434CysTrp: 0.434 ± 0.117
0.607CysTyr: 0.607 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
2.603AspAla: 2.603 ± 0.279
1.07AspCys: 1.07 ± 0.199
3.326AspAsp: 3.326 ± 0.397
4.02AspGlu: 4.02 ± 0.388
4.078AspPhe: 4.078 ± 0.326
4.801AspGly: 4.801 ± 0.315
1.012AspHis: 1.012 ± 0.171
4.396AspIle: 4.396 ± 0.373
6.044AspLys: 6.044 ± 0.524
5.466AspLeu: 5.466 ± 0.404
1.822AspMet: 1.822 ± 0.212
4.396AspAsn: 4.396 ± 0.345
2.4AspPro: 2.4 ± 0.247
0.983AspGln: 0.983 ± 0.179
2.024AspArg: 2.024 ± 0.254
3.731AspSer: 3.731 ± 0.308
3.239AspThr: 3.239 ± 0.298
3.818AspVal: 3.818 ± 0.377
1.33AspTrp: 1.33 ± 0.153
4.136AspTyr: 4.136 ± 0.352
0.0AspXaa: 0.0 ± 0.0
Glu
3.557GluAla: 3.557 ± 0.317
1.273GluCys: 1.273 ± 0.262
5.755GluAsp: 5.755 ± 0.381
6.044GluGlu: 6.044 ± 0.51
3.326GluPhe: 3.326 ± 0.308
3.557GluGly: 3.557 ± 0.297
1.099GluHis: 1.099 ± 0.201
5.061GluIle: 5.061 ± 0.436
5.09GluLys: 5.09 ± 0.394
6.392GluLeu: 6.392 ± 0.383
2.921GluMet: 2.921 ± 0.315
3.933GluAsn: 3.933 ± 0.378
1.706GluPro: 1.706 ± 0.204
3.846GluGln: 3.846 ± 0.368
3.037GluArg: 3.037 ± 0.309
4.367GluSer: 4.367 ± 0.383
3.008GluThr: 3.008 ± 0.284
5.669GluVal: 5.669 ± 0.387
1.128GluTrp: 1.128 ± 0.162
3.933GluTyr: 3.933 ± 0.293
0.0GluXaa: 0.0 ± 0.0
Phe
2.169PheAla: 2.169 ± 0.204
0.81PheCys: 0.81 ± 0.149
3.702PheAsp: 3.702 ± 0.362
3.586PheGlu: 3.586 ± 0.31
1.07PhePhe: 1.07 ± 0.175
2.979PheGly: 2.979 ± 0.304
0.405PheHis: 0.405 ± 0.108
4.367PheIle: 4.367 ± 0.379
3.875PheLys: 3.875 ± 0.303
2.256PheLeu: 2.256 ± 0.249
1.417PheMet: 1.417 ± 0.205
2.805PheAsn: 2.805 ± 0.285
1.157PhePro: 1.157 ± 0.188
1.388PheGln: 1.388 ± 0.191
1.62PheArg: 1.62 ± 0.224
3.239PheSer: 3.239 ± 0.301
2.719PheThr: 2.719 ± 0.28
4.483PheVal: 4.483 ± 0.333
0.463PheTrp: 0.463 ± 0.12
2.14PheTyr: 2.14 ± 0.286
0.0PheXaa: 0.0 ± 0.0
Gly
3.239GlyAla: 3.239 ± 0.446
1.388GlyCys: 1.388 ± 0.251
3.123GlyAsp: 3.123 ± 0.279
3.095GlyGlu: 3.095 ± 0.291
3.384GlyPhe: 3.384 ± 0.29
4.078GlyGly: 4.078 ± 0.623
0.925GlyHis: 0.925 ± 0.175
3.76GlyIle: 3.76 ± 0.31
4.974GlyLys: 4.974 ± 0.407
4.541GlyLeu: 4.541 ± 0.385
1.215GlyMet: 1.215 ± 0.201
3.499GlyAsn: 3.499 ± 0.424
0.839GlyPro: 0.839 ± 0.189
2.632GlyGln: 2.632 ± 0.239
2.661GlyArg: 2.661 ± 0.294
4.396GlySer: 4.396 ± 0.463
3.326GlyThr: 3.326 ± 0.446
4.57GlyVal: 4.57 ± 0.394
1.157GlyTrp: 1.157 ± 0.191
3.789GlyTyr: 3.789 ± 0.357
0.0GlyXaa: 0.0 ± 0.0
His
0.521HisAla: 0.521 ± 0.116
0.434HisCys: 0.434 ± 0.116
0.983HisAsp: 0.983 ± 0.164
1.099HisGlu: 1.099 ± 0.181
0.983HisPhe: 0.983 ± 0.205
1.504HisGly: 1.504 ± 0.224
0.318HisHis: 0.318 ± 0.095
1.157HisIle: 1.157 ± 0.184
1.909HisLys: 1.909 ± 0.235
1.33HisLeu: 1.33 ± 0.184
0.405HisMet: 0.405 ± 0.116
1.273HisAsn: 1.273 ± 0.178
0.549HisPro: 0.549 ± 0.121
0.665HisGln: 0.665 ± 0.133
0.636HisArg: 0.636 ± 0.131
1.244HisSer: 1.244 ± 0.187
0.925HisThr: 0.925 ± 0.182
0.81HisVal: 0.81 ± 0.119
0.26HisTrp: 0.26 ± 0.086
1.186HisTyr: 1.186 ± 0.208
0.0HisXaa: 0.0 ± 0.0
Ile
3.586IleAla: 3.586 ± 0.328
1.359IleCys: 1.359 ± 0.209
5.177IleAsp: 5.177 ± 0.435
4.743IleGlu: 4.743 ± 0.372
2.719IlePhe: 2.719 ± 0.275
3.442IleGly: 3.442 ± 0.342
1.273IleHis: 1.273 ± 0.215
4.454IleIle: 4.454 ± 0.437
6.478IleLys: 6.478 ± 0.521
4.83IleLeu: 4.83 ± 0.43
1.706IleMet: 1.706 ± 0.202
4.656IleAsn: 4.656 ± 0.343
1.996IlePro: 1.996 ± 0.225
2.111IleGln: 2.111 ± 0.239
2.256IleArg: 2.256 ± 0.257
3.615IleSer: 3.615 ± 0.364
3.066IleThr: 3.066 ± 0.262
5.09IleVal: 5.09 ± 0.472
0.694IleTrp: 0.694 ± 0.153
3.008IleTyr: 3.008 ± 0.328
0.0IleXaa: 0.0 ± 0.0
Lys
4.656LysAla: 4.656 ± 0.446
1.417LysCys: 1.417 ± 0.237
6.449LysAsp: 6.449 ± 0.555
7.577LysGlu: 7.577 ± 0.629
3.875LysPhe: 3.875 ± 0.348
4.078LysGly: 4.078 ± 0.371
1.764LysHis: 1.764 ± 0.196
5.64LysIle: 5.64 ± 0.432
5.553LysLys: 5.553 ± 0.567
8.127LysLeu: 8.127 ± 0.535
3.268LysMet: 3.268 ± 0.385
4.454LysAsn: 4.454 ± 0.365
2.429LysPro: 2.429 ± 0.289
4.743LysGln: 4.743 ± 0.458
2.516LysArg: 2.516 ± 0.336
5.293LysSer: 5.293 ± 0.483
4.512LysThr: 4.512 ± 0.359
5.842LysVal: 5.842 ± 0.471
1.041LysTrp: 1.041 ± 0.176
3.818LysTyr: 3.818 ± 0.344
0.0LysXaa: 0.0 ± 0.0
Leu
3.846LeuAla: 3.846 ± 0.384
0.839LeuCys: 0.839 ± 0.162
5.669LeuAsp: 5.669 ± 0.415
6.363LeuGlu: 6.363 ± 0.379
3.933LeuPhe: 3.933 ± 0.341
4.28LeuGly: 4.28 ± 0.344
1.938LeuHis: 1.938 ± 0.221
4.483LeuIle: 4.483 ± 0.314
7.288LeuLys: 7.288 ± 0.412
5.582LeuLeu: 5.582 ± 0.491
1.764LeuMet: 1.764 ± 0.234
5.148LeuAsn: 5.148 ± 0.421
2.95LeuPro: 2.95 ± 0.29
3.066LeuGln: 3.066 ± 0.29
3.181LeuArg: 3.181 ± 0.346
5.235LeuSer: 5.235 ± 0.447
4.338LeuThr: 4.338 ± 0.405
4.57LeuVal: 4.57 ± 0.43
0.925LeuTrp: 0.925 ± 0.192
3.499LeuTyr: 3.499 ± 0.324
0.0LeuXaa: 0.0 ± 0.0
Met
1.359MetAla: 1.359 ± 0.204
0.376MetCys: 0.376 ± 0.127
1.041MetAsp: 1.041 ± 0.197
1.909MetGlu: 1.909 ± 0.226
1.388MetPhe: 1.388 ± 0.212
1.128MetGly: 1.128 ± 0.185
0.521MetHis: 0.521 ± 0.16
1.677MetIle: 1.677 ± 0.199
3.095MetLys: 3.095 ± 0.407
2.227MetLeu: 2.227 ± 0.232
0.521MetMet: 0.521 ± 0.135
1.533MetAsn: 1.533 ± 0.2
0.752MetPro: 0.752 ± 0.158
0.868MetGln: 0.868 ± 0.156
0.781MetArg: 0.781 ± 0.171
2.4MetSer: 2.4 ± 0.311
1.62MetThr: 1.62 ± 0.236
1.33MetVal: 1.33 ± 0.187
0.202MetTrp: 0.202 ± 0.077
1.215MetTyr: 1.215 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
3.037AsnAla: 3.037 ± 0.346
1.128AsnCys: 1.128 ± 0.185
3.066AsnAsp: 3.066 ± 0.314
3.297AsnGlu: 3.297 ± 0.32
2.69AsnPhe: 2.69 ± 0.323
4.222AsnGly: 4.222 ± 0.373
1.244AsnHis: 1.244 ± 0.208
3.528AsnIle: 3.528 ± 0.333
6.825AsnLys: 6.825 ± 0.478
4.859AsnLeu: 4.859 ± 0.414
0.983AsnMet: 0.983 ± 0.179
3.846AsnAsn: 3.846 ± 0.389
1.996AsnPro: 1.996 ± 0.255
1.909AsnGln: 1.909 ± 0.261
2.256AsnArg: 2.256 ± 0.223
3.471AsnSer: 3.471 ± 0.401
2.69AsnThr: 2.69 ± 0.296
3.442AsnVal: 3.442 ± 0.256
0.492AsnTrp: 0.492 ± 0.124
2.574AsnTyr: 2.574 ± 0.262
0.0AsnXaa: 0.0 ± 0.0
Pro
1.359ProAla: 1.359 ± 0.215
0.723ProCys: 0.723 ± 0.14
2.545ProAsp: 2.545 ± 0.322
3.239ProGlu: 3.239 ± 0.344
1.128ProPhe: 1.128 ± 0.187
0.607ProGly: 0.607 ± 0.172
0.405ProHis: 0.405 ± 0.099
2.053ProIle: 2.053 ± 0.206
2.198ProLys: 2.198 ± 0.24
2.082ProLeu: 2.082 ± 0.267
0.636ProMet: 0.636 ± 0.129
1.388ProAsn: 1.388 ± 0.202
0.607ProPro: 0.607 ± 0.131
1.128ProGln: 1.128 ± 0.186
0.897ProArg: 0.897 ± 0.176
2.632ProSer: 2.632 ± 0.344
1.938ProThr: 1.938 ± 0.249
2.343ProVal: 2.343 ± 0.287
0.26ProTrp: 0.26 ± 0.087
1.244ProTyr: 1.244 ± 0.169
0.0ProXaa: 0.0 ± 0.0
Gln
1.909GlnAla: 1.909 ± 0.27
0.694GlnCys: 0.694 ± 0.152
2.314GlnAsp: 2.314 ± 0.243
3.355GlnGlu: 3.355 ± 0.3
1.967GlnPhe: 1.967 ± 0.228
2.227GlnGly: 2.227 ± 0.218
0.521GlnHis: 0.521 ± 0.138
2.574GlnIle: 2.574 ± 0.312
2.921GlnLys: 2.921 ± 0.338
3.673GlnLeu: 3.673 ± 0.403
0.925GlnMet: 0.925 ± 0.17
2.314GlnAsn: 2.314 ± 0.252
1.186GlnPro: 1.186 ± 0.176
2.053GlnGln: 2.053 ± 0.316
1.677GlnArg: 1.677 ± 0.246
1.967GlnSer: 1.967 ± 0.22
1.591GlnThr: 1.591 ± 0.212
1.938GlnVal: 1.938 ± 0.286
0.492GlnTrp: 0.492 ± 0.121
2.198GlnTyr: 2.198 ± 0.245
0.0GlnXaa: 0.0 ± 0.0
Arg
1.822ArgAla: 1.822 ± 0.227
0.897ArgCys: 0.897 ± 0.19
2.14ArgAsp: 2.14 ± 0.227
3.008ArgGlu: 3.008 ± 0.33
1.996ArgPhe: 1.996 ± 0.228
2.082ArgGly: 2.082 ± 0.261
0.636ArgHis: 0.636 ± 0.129
2.545ArgIle: 2.545 ± 0.308
3.037ArgLys: 3.037 ± 0.266
3.384ArgLeu: 3.384 ± 0.279
0.781ArgMet: 0.781 ± 0.166
2.169ArgAsn: 2.169 ± 0.231
0.925ArgPro: 0.925 ± 0.163
1.591ArgGln: 1.591 ± 0.214
1.417ArgArg: 1.417 ± 0.212
2.372ArgSer: 2.372 ± 0.285
1.938ArgThr: 1.938 ± 0.261
1.735ArgVal: 1.735 ± 0.233
0.578ArgTrp: 0.578 ± 0.13
1.446ArgTyr: 1.446 ± 0.235
0.0ArgXaa: 0.0 ± 0.0
Ser
3.615SerAla: 3.615 ± 0.368
1.041SerCys: 1.041 ± 0.149
4.136SerAsp: 4.136 ± 0.315
4.801SerGlu: 4.801 ± 0.382
3.123SerPhe: 3.123 ± 0.274
4.888SerGly: 4.888 ± 0.437
1.273SerHis: 1.273 ± 0.225
4.251SerIle: 4.251 ± 0.338
5.64SerLys: 5.64 ± 0.433
5.09SerLeu: 5.09 ± 0.385
1.764SerMet: 1.764 ± 0.248
3.442SerAsn: 3.442 ± 0.3
2.024SerPro: 2.024 ± 0.306
1.996SerGln: 1.996 ± 0.26
2.545SerArg: 2.545 ± 0.271
3.789SerSer: 3.789 ± 0.381
3.471SerThr: 3.471 ± 0.317
4.627SerVal: 4.627 ± 0.366
1.417SerTrp: 1.417 ± 0.222
2.661SerTyr: 2.661 ± 0.288
0.0SerXaa: 0.0 ± 0.0
Thr
2.632ThrAla: 2.632 ± 0.319
0.752ThrCys: 0.752 ± 0.142
2.95ThrAsp: 2.95 ± 0.31
4.483ThrGlu: 4.483 ± 0.414
2.314ThrPhe: 2.314 ± 0.298
3.673ThrGly: 3.673 ± 0.348
1.359ThrHis: 1.359 ± 0.24
3.586ThrIle: 3.586 ± 0.333
5.09ThrLys: 5.09 ± 0.439
3.933ThrLeu: 3.933 ± 0.374
0.954ThrMet: 0.954 ± 0.169
2.892ThrAsn: 2.892 ± 0.295
1.793ThrPro: 1.793 ± 0.221
1.88ThrGln: 1.88 ± 0.219
1.706ThrArg: 1.706 ± 0.192
3.066ThrSer: 3.066 ± 0.282
3.326ThrThr: 3.326 ± 0.318
3.384ThrVal: 3.384 ± 0.384
0.578ThrTrp: 0.578 ± 0.146
2.256ThrTyr: 2.256 ± 0.261
0.0ThrXaa: 0.0 ± 0.0
Val
3.442ValAla: 3.442 ± 0.375
1.244ValCys: 1.244 ± 0.182
5.061ValAsp: 5.061 ± 0.362
5.032ValGlu: 5.032 ± 0.423
2.69ValPhe: 2.69 ± 0.244
4.627ValGly: 4.627 ± 0.391
1.186ValHis: 1.186 ± 0.19
3.557ValIle: 3.557 ± 0.333
5.235ValLys: 5.235 ± 0.433
4.743ValLeu: 4.743 ± 0.387
1.591ValMet: 1.591 ± 0.226
3.152ValAsn: 3.152 ± 0.293
1.88ValPro: 1.88 ± 0.22
2.4ValGln: 2.4 ± 0.295
2.024ValArg: 2.024 ± 0.256
4.888ValSer: 4.888 ± 0.381
4.222ValThr: 4.222 ± 0.392
5.64ValVal: 5.64 ± 0.516
0.925ValTrp: 0.925 ± 0.149
3.123ValTyr: 3.123 ± 0.283
0.0ValXaa: 0.0 ± 0.0
Trp
0.752TrpAla: 0.752 ± 0.176
0.405TrpCys: 0.405 ± 0.116
0.868TrpAsp: 0.868 ± 0.168
0.868TrpGlu: 0.868 ± 0.136
0.694TrpPhe: 0.694 ± 0.137
0.636TrpGly: 0.636 ± 0.135
0.174TrpHis: 0.174 ± 0.07
1.012TrpIle: 1.012 ± 0.165
1.273TrpLys: 1.273 ± 0.249
1.273TrpLeu: 1.273 ± 0.229
0.347TrpMet: 0.347 ± 0.083
0.752TrpAsn: 0.752 ± 0.141
0.174TrpPro: 0.174 ± 0.075
0.839TrpGln: 0.839 ± 0.194
0.26TrpArg: 0.26 ± 0.105
1.157TrpSer: 1.157 ± 0.17
0.694TrpThr: 0.694 ± 0.133
0.723TrpVal: 0.723 ± 0.159
0.202TrpTrp: 0.202 ± 0.095
0.607TrpTyr: 0.607 ± 0.14
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.024TyrAla: 2.024 ± 0.227
1.099TyrCys: 1.099 ± 0.194
3.008TyrAsp: 3.008 ± 0.326
3.846TyrGlu: 3.846 ± 0.37
2.227TyrPhe: 2.227 ± 0.261
2.169TyrGly: 2.169 ± 0.23
1.041TyrHis: 1.041 ± 0.155
3.123TyrIle: 3.123 ± 0.306
4.165TyrLys: 4.165 ± 0.351
3.499TyrLeu: 3.499 ± 0.28
1.273TyrMet: 1.273 ± 0.249
3.557TyrAsn: 3.557 ± 0.35
1.793TyrPro: 1.793 ± 0.201
1.735TyrGln: 1.735 ± 0.238
1.851TyrArg: 1.851 ± 0.243
3.586TyrSer: 3.586 ± 0.395
2.198TyrThr: 2.198 ± 0.281
3.095TyrVal: 3.095 ± 0.303
0.463TyrTrp: 0.463 ± 0.139
2.14TyrTyr: 2.14 ± 0.25
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 211 proteins (34578 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski