Amino acid dipepetide frequency for Turnip yellow mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.632AlaAla: 2.632 ± 0.811
0.752AlaCys: 0.752 ± 0.373
1.504AlaAsp: 1.504 ± 0.747
2.256AlaGlu: 2.256 ± 0.606
3.008AlaPhe: 3.008 ± 1.493
1.88AlaGly: 1.88 ± 0.771
2.632AlaHis: 2.632 ± 1.307
3.008AlaIle: 3.008 ± 0.545
2.256AlaLys: 2.256 ± 1.12
8.647AlaLeu: 8.647 ± 2.013
1.504AlaMet: 1.504 ± 0.747
2.632AlaAsn: 2.632 ± 1.841
8.271AlaPro: 8.271 ± 4.335
2.632AlaGln: 2.632 ± 1.598
0.752AlaArg: 0.752 ± 0.278
6.767AlaSer: 6.767 ± 1.819
4.135AlaThr: 4.135 ± 0.33
3.008AlaVal: 3.008 ± 0.988
0.752AlaTrp: 0.752 ± 0.373
0.752AlaTyr: 0.752 ± 0.278
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.376CysAsp: 0.376 ± 0.187
0.0CysGlu: 0.0 ± 0.0
0.376CysPhe: 0.376 ± 0.187
1.128CysGly: 1.128 ± 0.56
0.0CysHis: 0.0 ± 0.0
1.88CysIle: 1.88 ± 1.737
0.376CysLys: 0.376 ± 0.187
0.376CysLeu: 0.376 ± 0.187
0.376CysMet: 0.376 ± 0.187
0.0CysAsn: 0.0 ± 0.0
1.88CysPro: 1.88 ± 0.712
1.128CysGln: 1.128 ± 0.56
0.752CysArg: 0.752 ± 0.373
0.0CysSer: 0.0 ± 0.0
1.128CysThr: 1.128 ± 0.233
0.0CysVal: 0.0 ± 0.0
0.752CysTrp: 0.752 ± 0.916
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.383AspAla: 3.383 ± 0.395
0.0AspCys: 0.0 ± 0.0
3.759AspAsp: 3.759 ± 0.747
0.376AspGlu: 0.376 ± 0.187
1.88AspPhe: 1.88 ± 0.478
0.752AspGly: 0.752 ± 0.373
1.504AspHis: 1.504 ± 0.317
0.752AspIle: 0.752 ± 0.278
0.376AspLys: 0.376 ± 1.03
3.759AspLeu: 3.759 ± 0.747
1.128AspMet: 1.128 ± 0.295
1.88AspAsn: 1.88 ± 0.466
7.143AspPro: 7.143 ± 1.465
2.256AspGln: 2.256 ± 1.12
3.383AspArg: 3.383 ± 1.115
6.767AspSer: 6.767 ± 2.598
2.632AspThr: 2.632 ± 0.695
2.256AspVal: 2.256 ± 0.635
1.504AspTrp: 1.504 ± 0.747
1.504AspTyr: 1.504 ± 0.317
0.0AspXaa: 0.0 ± 0.0
Glu
3.008GluAla: 3.008 ± 0.533
0.376GluCys: 0.376 ± 0.187
0.752GluAsp: 0.752 ± 0.826
1.504GluGlu: 1.504 ± 0.317
0.752GluPhe: 0.752 ± 0.373
1.128GluGly: 1.128 ± 0.679
1.128GluHis: 1.128 ± 0.56
1.504GluIle: 1.504 ± 0.778
0.376GluLys: 0.376 ± 0.187
5.263GluLeu: 5.263 ± 1.326
0.376GluMet: 0.376 ± 1.03
0.376GluAsn: 0.376 ± 0.187
3.008GluPro: 3.008 ± 0.635
0.376GluGln: 0.376 ± 0.187
2.632GluArg: 2.632 ± 0.747
4.511GluSer: 4.511 ± 0.996
2.632GluThr: 2.632 ± 0.525
1.504GluVal: 1.504 ± 0.847
0.376GluTrp: 0.376 ± 0.187
0.752GluTyr: 0.752 ± 0.373
0.0GluXaa: 0.0 ± 0.0
Phe
3.008PheAla: 3.008 ± 0.988
1.88PheCys: 1.88 ± 0.771
3.008PheAsp: 3.008 ± 0.992
0.376PheGlu: 0.376 ± 0.187
1.504PhePhe: 1.504 ± 0.747
1.504PheGly: 1.504 ± 0.317
2.256PheHis: 2.256 ± 0.835
0.0PheIle: 0.0 ± 0.0
1.128PheLys: 1.128 ± 0.56
3.383PheLeu: 3.383 ± 1.68
1.504PheMet: 1.504 ± 0.317
2.632PheAsn: 2.632 ± 0.811
4.135PhePro: 4.135 ± 0.413
1.88PheGln: 1.88 ± 0.771
3.759PheArg: 3.759 ± 0.747
2.256PheSer: 2.256 ± 0.635
1.504PheThr: 1.504 ± 0.747
1.128PheVal: 1.128 ± 0.56
0.0PheTrp: 0.0 ± 0.0
0.752PheTyr: 0.752 ± 0.916
0.0PheXaa: 0.0 ± 0.0
Gly
2.256GlyAla: 2.256 ± 1.341
0.752GlyCys: 0.752 ± 0.373
0.752GlyAsp: 0.752 ± 0.373
2.256GlyGlu: 2.256 ± 0.635
1.504GlyPhe: 1.504 ± 0.557
1.128GlyGly: 1.128 ± 1.94
2.256GlyHis: 2.256 ± 0.835
1.504GlyIle: 1.504 ± 1.089
2.256GlyLys: 2.256 ± 0.466
2.632GlyLeu: 2.632 ± 0.525
0.0GlyMet: 0.0 ± 0.0
1.128GlyAsn: 1.128 ± 0.233
7.519GlyPro: 7.519 ± 1.195
1.128GlyGln: 1.128 ± 0.998
0.752GlyArg: 0.752 ± 0.826
4.511GlySer: 4.511 ± 1.269
2.632GlyThr: 2.632 ± 1.624
1.504GlyVal: 1.504 ± 0.778
0.0GlyTrp: 0.0 ± 0.0
1.128GlyTyr: 1.128 ± 0.56
0.0GlyXaa: 0.0 ± 0.0
His
3.383HisAla: 3.383 ± 0.395
0.376HisCys: 0.376 ± 0.187
4.511HisAsp: 4.511 ± 0.932
1.128HisGlu: 1.128 ± 0.233
1.88HisPhe: 1.88 ± 0.466
1.128HisGly: 1.128 ± 0.233
2.632HisHis: 2.632 ± 0.747
1.128HisIle: 1.128 ± 0.679
1.504HisLys: 1.504 ± 0.747
7.519HisLeu: 7.519 ± 1.863
0.0HisMet: 0.0 ± 0.0
0.376HisAsn: 0.376 ± 0.187
5.639HisPro: 5.639 ± 0.922
1.504HisGln: 1.504 ± 0.747
2.632HisArg: 2.632 ± 0.525
7.143HisSer: 7.143 ± 2.463
2.256HisThr: 2.256 ± 0.466
1.88HisVal: 1.88 ± 0.478
0.752HisTrp: 0.752 ± 0.373
1.128HisTyr: 1.128 ± 0.56
0.0HisXaa: 0.0 ± 0.0
Ile
2.632IleAla: 2.632 ± 0.695
0.0IleCys: 0.0 ± 0.0
2.632IleAsp: 2.632 ± 1.598
1.88IleGlu: 1.88 ± 0.466
1.88IlePhe: 1.88 ± 0.771
1.504IleGly: 1.504 ± 0.847
1.88IleHis: 1.88 ± 1.528
2.256IleIle: 2.256 ± 0.606
0.752IleLys: 0.752 ± 0.916
5.639IleLeu: 5.639 ± 1.397
1.128IleMet: 1.128 ± 0.56
1.504IleAsn: 1.504 ± 0.778
3.759IlePro: 3.759 ± 1.358
2.256IleGln: 2.256 ± 0.807
2.256IleArg: 2.256 ± 0.635
3.759IleSer: 3.759 ± 0.313
5.263IleThr: 5.263 ± 3.424
1.504IleVal: 1.504 ± 0.847
0.376IleTrp: 0.376 ± 0.413
1.128IleTyr: 1.128 ± 0.56
0.0IleXaa: 0.0 ± 0.0
Lys
1.504LysAla: 1.504 ± 0.747
0.376LysCys: 0.376 ± 1.03
2.256LysAsp: 2.256 ± 1.742
1.88LysGlu: 1.88 ± 0.712
0.376LysPhe: 0.376 ± 0.187
0.752LysGly: 0.752 ± 0.278
0.376LysHis: 0.376 ± 0.187
1.128LysIle: 1.128 ± 0.233
0.752LysLys: 0.752 ± 0.373
4.887LysLeu: 4.887 ± 0.584
1.128LysMet: 1.128 ± 0.56
1.504LysAsn: 1.504 ± 0.747
1.88LysPro: 1.88 ± 0.478
0.376LysGln: 0.376 ± 1.03
2.632LysArg: 2.632 ± 0.811
1.504LysSer: 1.504 ± 0.747
3.759LysThr: 3.759 ± 0.711
1.504LysVal: 1.504 ± 0.317
0.376LysTrp: 0.376 ± 0.187
0.376LysTyr: 0.376 ± 0.187
0.0LysXaa: 0.0 ± 0.0
Leu
6.767LeuAla: 6.767 ± 0.403
0.752LeuCys: 0.752 ± 0.373
4.887LeuAsp: 4.887 ± 0.584
4.511LeuGlu: 4.511 ± 1.306
5.263LeuPhe: 5.263 ± 1.903
4.887LeuGly: 4.887 ± 0.975
6.015LeuHis: 6.015 ± 1.562
4.135LeuIle: 4.135 ± 2.372
3.383LeuLys: 3.383 ± 1.174
12.782LeuLeu: 12.782 ± 1.965
1.88LeuMet: 1.88 ± 0.933
2.256LeuAsn: 2.256 ± 1.12
19.925LeuPro: 19.925 ± 4.584
6.391LeuGln: 6.391 ± 0.242
8.647LeuArg: 8.647 ± 2.13
10.15LeuSer: 10.15 ± 0.755
7.895LeuThr: 7.895 ± 2.214
3.008LeuVal: 3.008 ± 0.992
1.128LeuTrp: 1.128 ± 0.829
2.256LeuTyr: 2.256 ± 0.635
0.0LeuXaa: 0.0 ± 0.0
Met
0.376MetAla: 0.376 ± 0.187
0.0MetCys: 0.0 ± 0.0
1.128MetAsp: 1.128 ± 0.233
0.752MetGlu: 0.752 ± 0.916
0.752MetPhe: 0.752 ± 0.373
0.752MetGly: 0.752 ± 0.373
1.504MetHis: 1.504 ± 0.778
0.376MetIle: 0.376 ± 0.187
1.504MetLys: 1.504 ± 0.747
0.752MetLeu: 0.752 ± 0.373
0.376MetMet: 0.376 ± 1.03
0.376MetAsn: 0.376 ± 1.03
0.376MetPro: 0.376 ± 0.187
0.0MetGln: 0.0 ± 0.0
0.376MetArg: 0.376 ± 0.187
0.376MetSer: 0.376 ± 0.413
0.752MetThr: 0.752 ± 0.373
0.752MetVal: 0.752 ± 0.278
0.0MetTrp: 0.0 ± 0.0
1.128MetTyr: 1.128 ± 0.56
0.0MetXaa: 0.0 ± 0.0
Asn
2.632AsnAla: 2.632 ± 1.307
0.376AsnCys: 0.376 ± 0.187
1.504AsnAsp: 1.504 ± 0.747
0.752AsnGlu: 0.752 ± 0.373
1.504AsnPhe: 1.504 ± 0.317
1.88AsnGly: 1.88 ± 0.466
1.88AsnHis: 1.88 ± 0.933
1.504AsnIle: 1.504 ± 0.847
0.752AsnLys: 0.752 ± 0.373
2.256AsnLeu: 2.256 ± 0.466
0.376AsnMet: 0.376 ± 0.187
0.376AsnAsn: 0.376 ± 0.187
3.008AsnPro: 3.008 ± 0.969
1.504AsnGln: 1.504 ± 0.317
0.752AsnArg: 0.752 ± 0.826
4.135AsnSer: 4.135 ± 0.845
2.256AsnThr: 2.256 ± 0.606
1.128AsnVal: 1.128 ± 0.56
0.0AsnTrp: 0.0 ± 0.0
1.504AsnTyr: 1.504 ± 0.747
0.0AsnXaa: 0.0 ± 0.0
Pro
9.774ProAla: 9.774 ± 2.474
0.376ProCys: 0.376 ± 0.413
5.263ProAsp: 5.263 ± 1.049
4.511ProGlu: 4.511 ± 0.932
3.008ProPhe: 3.008 ± 0.988
4.511ProGly: 4.511 ± 1.334
4.511ProHis: 4.511 ± 0.932
4.887ProIle: 4.887 ± 1.089
4.135ProLys: 4.135 ± 1.514
13.91ProLeu: 13.91 ± 2.945
0.376ProMet: 0.376 ± 0.413
5.639ProAsn: 5.639 ± 1.435
18.797ProPro: 18.797 ± 4.864
4.135ProGln: 4.135 ± 0.947
9.398ProArg: 9.398 ± 4.94
14.286ProSer: 14.286 ± 2.734
12.782ProThr: 12.782 ± 2.548
5.263ProVal: 5.263 ± 0.406
1.88ProTrp: 1.88 ± 0.478
0.752ProTyr: 0.752 ± 0.278
0.0ProXaa: 0.0 ± 0.0
Gln
3.008GlnAla: 3.008 ± 0.988
0.376GlnCys: 0.376 ± 0.187
1.128GlnAsp: 1.128 ± 0.998
0.752GlnGlu: 0.752 ± 0.373
1.504GlnPhe: 1.504 ± 0.317
1.504GlnGly: 1.504 ± 0.747
2.256GlnHis: 2.256 ± 0.635
2.256GlnIle: 2.256 ± 1.658
1.128GlnLys: 1.128 ± 0.56
5.263GlnLeu: 5.263 ± 1.049
0.0GlnMet: 0.0 ± 0.189
0.376GlnAsn: 0.376 ± 0.187
4.887GlnPro: 4.887 ± 1.559
1.504GlnGln: 1.504 ± 0.557
3.008GlnArg: 3.008 ± 0.699
5.263GlnSer: 5.263 ± 0.172
3.383GlnThr: 3.383 ± 0.699
0.752GlnVal: 0.752 ± 0.278
0.376GlnTrp: 0.376 ± 0.187
1.128GlnTyr: 1.128 ± 0.829
0.0GlnXaa: 0.0 ± 0.0
Arg
1.504ArgAla: 1.504 ± 0.747
0.376ArgCys: 0.376 ± 0.187
2.632ArgAsp: 2.632 ± 0.747
1.128ArgGlu: 1.128 ± 0.56
3.008ArgPhe: 3.008 ± 0.635
3.008ArgGly: 3.008 ± 1.114
4.135ArgHis: 4.135 ± 1.514
3.759ArgIle: 3.759 ± 0.931
1.128ArgLys: 1.128 ± 0.233
9.774ArgLeu: 9.774 ± 1.984
0.376ArgMet: 0.376 ± 0.187
0.752ArgAsn: 0.752 ± 0.373
8.271ArgPro: 8.271 ± 5.163
2.256ArgGln: 2.256 ± 1.358
5.639ArgArg: 5.639 ± 2.857
7.519ArgSer: 7.519 ± 2.318
6.015ArgThr: 6.015 ± 2.376
1.128ArgVal: 1.128 ± 0.829
0.376ArgTrp: 0.376 ± 0.187
1.128ArgTyr: 1.128 ± 0.56
0.0ArgXaa: 0.0 ± 0.0
Ser
5.639SerAla: 5.639 ± 1.149
1.504SerCys: 1.504 ± 0.747
5.263SerAsp: 5.263 ± 1.623
4.511SerGlu: 4.511 ± 0.764
3.383SerPhe: 3.383 ± 0.775
3.383SerGly: 3.383 ± 1.317
3.759SerHis: 3.759 ± 1.358
7.519SerIle: 7.519 ± 0.626
1.504SerLys: 1.504 ± 0.747
13.158SerLeu: 13.158 ± 1.182
0.752SerMet: 0.752 ± 0.916
3.383SerAsn: 3.383 ± 0.775
13.534SerPro: 13.534 ± 5.588
4.887SerGln: 4.887 ± 1.089
5.263SerArg: 5.263 ± 2.989
10.15SerSer: 10.15 ± 2.098
8.647SerThr: 8.647 ± 1.449
4.511SerVal: 4.511 ± 1.334
1.88SerTrp: 1.88 ± 0.933
3.759SerTyr: 3.759 ± 0.931
0.0SerXaa: 0.0 ± 0.0
Thr
6.391ThrAla: 6.391 ± 1.137
1.128ThrCys: 1.128 ± 0.998
2.256ThrAsp: 2.256 ± 1.341
2.632ThrGlu: 2.632 ± 0.525
3.759ThrPhe: 3.759 ± 1.367
3.008ThrGly: 3.008 ± 0.699
4.135ThrHis: 4.135 ± 1.097
3.759ThrIle: 3.759 ± 2.423
3.008ThrLys: 3.008 ± 1.693
6.391ThrLeu: 6.391 ± 2.965
0.376ThrMet: 0.376 ± 0.716
2.256ThrAsn: 2.256 ± 1.12
9.398ThrPro: 9.398 ± 0.853
2.256ThrGln: 2.256 ± 0.466
5.263ThrArg: 5.263 ± 1.155
9.023ThrSer: 9.023 ± 1.745
6.767ThrThr: 6.767 ± 1.211
4.511ThrVal: 4.511 ± 4.639
0.376ThrTrp: 0.376 ± 0.187
2.632ThrTyr: 2.632 ± 0.883
0.0ThrXaa: 0.0 ± 0.0
Val
1.128ValAla: 1.128 ± 0.829
0.376ValCys: 0.376 ± 1.03
1.504ValAsp: 1.504 ± 0.317
0.0ValGlu: 0.0 ± 0.0
1.128ValPhe: 1.128 ± 0.233
2.256ValGly: 2.256 ± 0.866
3.383ValHis: 3.383 ± 2.038
1.88ValIle: 1.88 ± 0.933
1.88ValLys: 1.88 ± 1.737
6.767ValLeu: 6.767 ± 1.097
0.376ValMet: 0.376 ± 0.187
1.128ValAsn: 1.128 ± 0.56
3.759ValPro: 3.759 ± 1.367
1.504ValGln: 1.504 ± 0.317
2.632ValArg: 2.632 ± 0.747
4.887ValSer: 4.887 ± 1.681
2.256ValThr: 2.256 ± 2.748
2.632ValVal: 2.632 ± 0.811
0.0ValTrp: 0.0 ± 0.0
1.504ValTyr: 1.504 ± 0.747
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.376TrpCys: 0.376 ± 0.187
0.376TrpAsp: 0.376 ± 0.187
1.128TrpGlu: 1.128 ± 0.56
0.752TrpPhe: 0.752 ± 0.278
0.376TrpGly: 0.376 ± 0.187
0.376TrpHis: 0.376 ± 0.187
0.376TrpIle: 0.376 ± 0.413
0.752TrpLys: 0.752 ± 0.373
1.128TrpLeu: 1.128 ± 0.56
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.376TrpPro: 0.376 ± 0.187
0.752TrpGln: 0.752 ± 0.373
1.128TrpArg: 1.128 ± 0.56
1.504TrpSer: 1.504 ± 0.317
0.376TrpThr: 0.376 ± 0.187
1.128TrpVal: 1.128 ± 1.94
0.376TrpTrp: 0.376 ± 0.187
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.752TyrAla: 0.752 ± 0.373
0.376TyrCys: 0.376 ± 0.187
1.504TyrAsp: 1.504 ± 0.317
0.0TyrGlu: 0.0 ± 0.0
0.376TyrPhe: 0.376 ± 0.187
1.128TyrGly: 1.128 ± 0.998
1.88TyrHis: 1.88 ± 0.933
0.376TyrIle: 0.376 ± 0.187
0.376TyrLys: 0.376 ± 0.187
2.632TyrLeu: 2.632 ± 0.883
0.0TyrMet: 0.0 ± 0.0
1.504TyrAsn: 1.504 ± 0.747
2.632TyrPro: 2.632 ± 0.811
1.504TyrGln: 1.504 ± 0.317
2.256TyrArg: 2.256 ± 0.606
1.88TyrSer: 1.88 ± 0.933
2.256TyrThr: 2.256 ± 0.635
1.88TyrVal: 1.88 ± 0.933
0.0TyrTrp: 0.0 ± 0.0
0.752TyrTyr: 0.752 ± 0.373
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski