Amino acid dipepetide frequency for Roseovarius indicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.418AlaAla: 15.418 ± 0.137	1.201AlaCys: 1.201 ± 0.028	6.79AlaAsp: 6.79 ± 0.071	8.525AlaGlu: 8.525 ± 0.069	4.328AlaPhe: 4.328 ± 0.047	10.517AlaGly: 10.517 ± 0.094	2.351AlaHis: 2.351 ± 0.036	5.673AlaIle: 5.673 ± 0.061	3.682AlaLys: 3.682 ± 0.055	12.879AlaLeu: 12.879 ± 0.099	3.803AlaMet: 3.803 ± 0.049	2.629AlaAsn: 2.629 ± 0.037	5.408AlaPro: 5.408 ± 0.06	3.901AlaGln: 3.901 ± 0.053	8.403AlaArg: 8.403 ± 0.088	5.528AlaSer: 5.528 ± 0.057	5.807AlaThr: 5.807 ± 0.064	8.319AlaVal: 8.319 ± 0.075	1.503AlaTrp: 1.503 ± 0.032	2.575AlaTyr: 2.575 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.123CysAla: 1.123 ± 0.028	0.127CysCys: 0.127 ± 0.009	0.685CysAsp: 0.685 ± 0.021	0.539CysGlu: 0.539 ± 0.018	0.375CysPhe: 0.375 ± 0.017	1.041CysGly: 1.041 ± 0.028	0.293CysHis: 0.293 ± 0.012	0.44CysIle: 0.44 ± 0.015	0.21CysLys: 0.21 ± 0.01	0.907CysLeu: 0.907 ± 0.024	0.19CysMet: 0.19 ± 0.011	0.266CysAsn: 0.266 ± 0.015	0.537CysPro: 0.537 ± 0.02	0.244CysGln: 0.244 ± 0.011	0.622CysArg: 0.622 ± 0.02	0.442CysSer: 0.442 ± 0.016	0.499CysThr: 0.499 ± 0.017	0.656CysVal: 0.656 ± 0.021	0.137CysTrp: 0.137 ± 0.01	0.227CysTyr: 0.227 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.01AspAla: 7.01 ± 0.07	0.56AspCys: 0.56 ± 0.019	3.566AspAsp: 3.566 ± 0.056	3.896AspGlu: 3.896 ± 0.045	2.23AspPhe: 2.23 ± 0.036	5.589AspGly: 5.589 ± 0.063	1.349AspHis: 1.349 ± 0.031	3.213AspIle: 3.213 ± 0.047	1.785AspLys: 1.785 ± 0.034	6.139AspLeu: 6.139 ± 0.063	1.813AspMet: 1.813 ± 0.036	1.273AspAsn: 1.273 ± 0.028	3.605AspPro: 3.605 ± 0.047	1.712AspGln: 1.712 ± 0.033	4.415AspArg: 4.415 ± 0.057	2.258AspSer: 2.258 ± 0.039	3.294AspThr: 3.294 ± 0.054	4.196AspVal: 4.196 ± 0.058	1.188AspTrp: 1.188 ± 0.026	1.582AspTyr: 1.582 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.585GluAla: 8.585 ± 0.079	0.421GluCys: 0.421 ± 0.018	3.883GluAsp: 3.883 ± 0.053	4.407GluGlu: 4.407 ± 0.059	1.994GluPhe: 1.994 ± 0.039	5.395GluGly: 5.395 ± 0.061	1.263GluHis: 1.263 ± 0.024	3.768GluIle: 3.768 ± 0.054	2.543GluLys: 2.543 ± 0.048	5.476GluLeu: 5.476 ± 0.07	2.084GluMet: 2.084 ± 0.038	1.86GluAsn: 1.86 ± 0.039	2.859GluPro: 2.859 ± 0.05	1.999GluGln: 1.999 ± 0.035	4.597GluArg: 4.597 ± 0.064	2.427GluSer: 2.427 ± 0.035	4.301GluThr: 4.301 ± 0.051	4.681GluVal: 4.681 ± 0.055	0.779GluTrp: 0.779 ± 0.022	1.189GluTyr: 1.189 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.317PheAla: 4.317 ± 0.06	0.444PheCys: 0.444 ± 0.018	2.801PheAsp: 2.801 ± 0.036	2.388PheGlu: 2.388 ± 0.037	1.461PhePhe: 1.461 ± 0.031	3.715PheGly: 3.715 ± 0.053	0.807PheHis: 0.807 ± 0.021	1.629PheIle: 1.629 ± 0.035	0.91PheLys: 0.91 ± 0.025	3.432PheLeu: 3.432 ± 0.054	0.852PheMet: 0.852 ± 0.026	1.045PheAsn: 1.045 ± 0.027	1.624PhePro: 1.624 ± 0.032	1.0PheGln: 1.0 ± 0.023	2.307PheArg: 2.307 ± 0.036	2.159PheSer: 2.159 ± 0.034	2.07PheThr: 2.07 ± 0.035	2.675PheVal: 2.675 ± 0.041	0.575PheTrp: 0.575 ± 0.017	0.936PheTyr: 0.936 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.691GlyAla: 9.691 ± 0.094	0.932GlyCys: 0.932 ± 0.023	4.774GlyAsp: 4.774 ± 0.057	5.362GlyGlu: 5.362 ± 0.063	3.696GlyPhe: 3.696 ± 0.052	7.457GlyGly: 7.457 ± 0.083	2.044GlyHis: 2.044 ± 0.04	4.429GlyIle: 4.429 ± 0.054	3.2GlyLys: 3.2 ± 0.05	9.347GlyLeu: 9.347 ± 0.09	2.788GlyMet: 2.788 ± 0.047	2.191GlyAsn: 2.191 ± 0.043	3.944GlyPro: 3.944 ± 0.052	3.159GlyGln: 3.159 ± 0.041	5.919GlyArg: 5.919 ± 0.065	4.223GlySer: 4.223 ± 0.054	4.824GlyThr: 4.824 ± 0.06	6.517GlyVal: 6.517 ± 0.069	1.56GlyTrp: 1.56 ± 0.037	2.398GlyTyr: 2.398 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.374HisAla: 2.374 ± 0.043	0.253HisCys: 0.253 ± 0.013	1.401HisAsp: 1.401 ± 0.031	1.191HisGlu: 1.191 ± 0.028	0.859HisPhe: 0.859 ± 0.023	2.008HisGly: 2.008 ± 0.039	0.617HisHis: 0.617 ± 0.024	0.957HisIle: 0.957 ± 0.024	0.523HisLys: 0.523 ± 0.02	2.124HisLeu: 2.124 ± 0.038	0.554HisMet: 0.554 ± 0.02	0.454HisAsn: 0.454 ± 0.018	1.383HisPro: 1.383 ± 0.031	0.569HisGln: 0.569 ± 0.018	1.311HisArg: 1.311 ± 0.032	0.938HisSer: 0.938 ± 0.025	0.89HisThr: 0.89 ± 0.022	1.655HisVal: 1.655 ± 0.03	0.363HisTrp: 0.363 ± 0.012	0.547HisTyr: 0.547 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.473IleAla: 6.473 ± 0.059	0.621IleCys: 0.621 ± 0.023	3.468IleAsp: 3.468 ± 0.048	3.649IleGlu: 3.649 ± 0.051	1.736IlePhe: 1.736 ± 0.036	4.832IleGly: 4.832 ± 0.061	0.907IleHis: 0.907 ± 0.022	2.139IleIle: 2.139 ± 0.045	1.28IleLys: 1.28 ± 0.031	4.711IleLeu: 4.711 ± 0.056	1.102IleMet: 1.102 ± 0.031	1.339IleAsn: 1.339 ± 0.031	2.312IlePro: 2.312 ± 0.037	1.11IleGln: 1.11 ± 0.029	3.252IleArg: 3.252 ± 0.048	2.888IleSer: 2.888 ± 0.042	2.834IleThr: 2.834 ± 0.043	3.856IleVal: 3.856 ± 0.046	0.703IleTrp: 0.703 ± 0.017	1.196IleTyr: 1.196 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.989LysAla: 3.989 ± 0.059	0.197LysCys: 0.197 ± 0.011	1.693LysAsp: 1.693 ± 0.034	1.752LysGlu: 1.752 ± 0.043	0.864LysPhe: 0.864 ± 0.025	2.755LysGly: 2.755 ± 0.049	0.657LysHis: 0.657 ± 0.022	1.567LysIle: 1.567 ± 0.036	1.166LysLys: 1.166 ± 0.03	3.105LysLeu: 3.105 ± 0.045	0.849LysMet: 0.849 ± 0.021	0.746LysAsn: 0.746 ± 0.024	1.973LysPro: 1.973 ± 0.041	0.915LysGln: 0.915 ± 0.022	2.271LysArg: 2.271 ± 0.039	1.748LysSer: 1.748 ± 0.037	1.937LysThr: 1.937 ± 0.037	2.34LysVal: 2.34 ± 0.041	0.401LysTrp: 0.401 ± 0.016	0.641LysTyr: 0.641 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.411LeuAla: 12.411 ± 0.123	1.015LeuCys: 1.015 ± 0.027	6.024LeuAsp: 6.024 ± 0.067	5.8LeuGlu: 5.8 ± 0.067	3.486LeuPhe: 3.486 ± 0.054	8.456LeuGly: 8.456 ± 0.086	1.871LeuHis: 1.871 ± 0.039	4.96LeuIle: 4.96 ± 0.061	3.285LeuLys: 3.285 ± 0.05	8.766LeuLeu: 8.766 ± 0.099	2.584LeuMet: 2.584 ± 0.042	2.584LeuAsn: 2.584 ± 0.039	5.368LeuPro: 5.368 ± 0.055	2.677LeuGln: 2.677 ± 0.042	6.683LeuArg: 6.683 ± 0.067	6.577LeuSer: 6.577 ± 0.06	5.939LeuThr: 5.939 ± 0.057	6.917LeuVal: 6.917 ± 0.072	1.302LeuTrp: 1.302 ± 0.031	2.09LeuTyr: 2.09 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.512MetAla: 3.512 ± 0.048	0.216MetCys: 0.216 ± 0.011	1.351MetAsp: 1.351 ± 0.029	1.512MetGlu: 1.512 ± 0.029	0.803MetPhe: 0.803 ± 0.02	2.358MetGly: 2.358 ± 0.044	0.515MetHis: 0.515 ± 0.019	1.568MetIle: 1.568 ± 0.031	1.109MetLys: 1.109 ± 0.026	2.642MetLeu: 2.642 ± 0.044	0.836MetMet: 0.836 ± 0.03	0.833MetAsn: 0.833 ± 0.02	1.601MetPro: 1.601 ± 0.03	0.971MetGln: 0.971 ± 0.025	1.999MetArg: 1.999 ± 0.04	1.826MetSer: 1.826 ± 0.034	2.16MetThr: 2.16 ± 0.04	1.903MetVal: 1.903 ± 0.037	0.275MetTrp: 0.275 ± 0.014	0.389MetTyr: 0.389 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.045AsnAla: 3.045 ± 0.045	0.271AsnCys: 0.271 ± 0.014	1.428AsnAsp: 1.428 ± 0.03	1.309AsnGlu: 1.309 ± 0.029	0.936AsnPhe: 0.936 ± 0.023	2.369AsnGly: 2.369 ± 0.044	0.503AsnHis: 0.503 ± 0.015	1.357AsnIle: 1.357 ± 0.032	0.65AsnLys: 0.65 ± 0.019	2.447AsnLeu: 2.447 ± 0.038	0.68AsnMet: 0.68 ± 0.021	0.678AsnAsn: 0.678 ± 0.022	1.77AsnPro: 1.77 ± 0.034	0.694AsnGln: 0.694 ± 0.019	1.741AsnArg: 1.741 ± 0.03	1.147AsnSer: 1.147 ± 0.027	1.338AsnThr: 1.338 ± 0.031	1.846AsnVal: 1.846 ± 0.033	0.445AsnTrp: 0.445 ± 0.019	0.648AsnTyr: 0.648 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.432ProAla: 5.432 ± 0.064	0.374ProCys: 0.374 ± 0.017	4.066ProAsp: 4.066 ± 0.055	4.579ProGlu: 4.579 ± 0.053	1.985ProPhe: 1.985 ± 0.028	4.833ProGly: 4.833 ± 0.058	1.078ProHis: 1.078 ± 0.023	2.167ProIle: 2.167 ± 0.038	1.667ProLys: 1.667 ± 0.036	4.623ProLeu: 4.623 ± 0.053	1.329ProMet: 1.329 ± 0.028	1.253ProAsn: 1.253 ± 0.029	2.323ProPro: 2.323 ± 0.045	1.496ProGln: 1.496 ± 0.03	2.755ProArg: 2.755 ± 0.039	2.46ProSer: 2.46 ± 0.036	2.341ProThr: 2.341 ± 0.034	4.307ProVal: 4.307 ± 0.051	0.636ProTrp: 0.636 ± 0.02	1.187ProTyr: 1.187 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.833GlnAla: 3.833 ± 0.051	0.214GlnCys: 0.214 ± 0.011	1.602GlnAsp: 1.602 ± 0.035	1.729GlnGlu: 1.729 ± 0.033	1.029GlnPhe: 1.029 ± 0.024	2.476GlnGly: 2.476 ± 0.041	0.587GlnHis: 0.587 ± 0.019	1.748GlnIle: 1.748 ± 0.033	1.052GlnLys: 1.052 ± 0.026	2.664GlnLeu: 2.664 ± 0.044	1.037GlnMet: 1.037 ± 0.024	0.855GlnAsn: 0.855 ± 0.022	1.553GlnPro: 1.553 ± 0.033	1.053GlnGln: 1.053 ± 0.028	2.034GlnArg: 2.034 ± 0.038	1.761GlnSer: 1.761 ± 0.035	1.744GlnThr: 1.744 ± 0.03	2.275GlnVal: 2.275 ± 0.039	0.405GlnTrp: 0.405 ± 0.017	0.584GlnTyr: 0.584 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.771ArgAla: 7.771 ± 0.081	0.525ArgCys: 0.525 ± 0.018	4.244ArgAsp: 4.244 ± 0.056	4.34ArgGlu: 4.34 ± 0.058	2.721ArgPhe: 2.721 ± 0.043	4.669ArgGly: 4.669 ± 0.054	1.616ArgHis: 1.616 ± 0.036	3.735ArgIle: 3.735 ± 0.045	2.374ArgLys: 2.374 ± 0.041	7.237ArgLeu: 7.237 ± 0.072	1.989ArgMet: 1.989 ± 0.034	1.808ArgAsn: 1.808 ± 0.028	3.273ArgPro: 3.273 ± 0.041	2.303ArgGln: 2.303 ± 0.05	5.064ArgArg: 5.064 ± 0.076	3.17ArgSer: 3.17 ± 0.045	3.077ArgThr: 3.077 ± 0.055	4.757ArgVal: 4.757 ± 0.06	0.923ArgTrp: 0.923 ± 0.023	1.611ArgTyr: 1.611 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.564SerAla: 5.564 ± 0.062	0.452SerCys: 0.452 ± 0.018	3.347SerAsp: 3.347 ± 0.045	3.233SerGlu: 3.233 ± 0.049	2.187SerPhe: 2.187 ± 0.037	5.455SerGly: 5.455 ± 0.068	1.087SerHis: 1.087 ± 0.023	2.466SerIle: 2.466 ± 0.037	1.48SerLys: 1.48 ± 0.029	4.908SerLeu: 4.908 ± 0.055	1.407SerMet: 1.407 ± 0.03	1.297SerAsn: 1.297 ± 0.032	2.524SerPro: 2.524 ± 0.037	1.516SerGln: 1.516 ± 0.035	3.221SerArg: 3.221 ± 0.052	2.533SerSer: 2.533 ± 0.047	2.479SerThr: 2.479 ± 0.042	3.887SerVal: 3.887 ± 0.054	0.69SerTrp: 0.69 ± 0.021	1.297SerTyr: 1.297 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.168ThrAla: 6.168 ± 0.063	0.568ThrCys: 0.568 ± 0.019	3.184ThrAsp: 3.184 ± 0.05	3.356ThrGlu: 3.356 ± 0.045	1.989ThrPhe: 1.989 ± 0.034	5.796ThrGly: 5.796 ± 0.059	1.126ThrHis: 1.126 ± 0.024	2.711ThrIle: 2.711 ± 0.037	1.423ThrLys: 1.423 ± 0.034	5.9ThrLeu: 5.9 ± 0.066	1.325ThrMet: 1.325 ± 0.028	1.236ThrAsn: 1.236 ± 0.028	3.336ThrPro: 3.336 ± 0.04	1.578ThrGln: 1.578 ± 0.031	3.574ThrArg: 3.574 ± 0.051	2.699ThrSer: 2.699 ± 0.039	2.82ThrThr: 2.82 ± 0.044	4.31ThrVal: 4.31 ± 0.054	0.75ThrTrp: 0.75 ± 0.02	1.32ThrTyr: 1.32 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	8.574ValAla: 8.574 ± 0.076	0.74ValCys: 0.74 ± 0.025	4.004ValAsp: 4.004 ± 0.057	4.782ValGlu: 4.782 ± 0.056	2.929ValPhe: 2.929 ± 0.04	5.471ValGly: 5.471 ± 0.067	1.357ValHis: 1.357 ± 0.029	4.207ValIle: 4.207 ± 0.057	2.156ValLys: 2.156 ± 0.043	7.502ValLeu: 7.502 ± 0.082	2.185ValMet: 2.185 ± 0.038	1.923ValAsn: 1.923 ± 0.04	3.61ValPro: 3.61 ± 0.052	2.074ValGln: 2.074 ± 0.033	4.349ValArg: 4.349 ± 0.056	4.301ValSer: 4.301 ± 0.057	4.879ValThr: 4.879 ± 0.063	5.643ValVal: 5.643 ± 0.069	1.005ValTrp: 1.005 ± 0.027	1.58ValTyr: 1.58 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.401TrpAla: 1.401 ± 0.031	0.162TrpCys: 0.162 ± 0.011	0.729TrpAsp: 0.729 ± 0.02	0.752TrpGlu: 0.752 ± 0.023	0.591TrpPhe: 0.591 ± 0.019	1.064TrpGly: 1.064 ± 0.026	0.38TrpHis: 0.38 ± 0.015	0.687TrpIle: 0.687 ± 0.019	0.47TrpLys: 0.47 ± 0.017	1.655TrpLeu: 1.655 ± 0.036	0.431TrpMet: 0.431 ± 0.017	0.439TrpAsn: 0.439 ± 0.016	0.754TrpPro: 0.754 ± 0.021	0.614TrpGln: 0.614 ± 0.02	1.083TrpArg: 1.083 ± 0.026	0.797TrpSer: 0.797 ± 0.022	0.767TrpThr: 0.767 ± 0.02	0.949TrpVal: 0.949 ± 0.022	0.235TrpTrp: 0.235 ± 0.012	0.309TrpTyr: 0.309 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.041	0.265TyrCys: 0.265 ± 0.013	1.633TyrAsp: 1.633 ± 0.03	1.41TyrGlu: 1.41 ± 0.036	0.949TyrPhe: 0.949 ± 0.026	2.201TyrGly: 2.201 ± 0.04	0.562TyrHis: 0.562 ± 0.018	0.986TyrIle: 0.986 ± 0.024	0.598TyrLys: 0.598 ± 0.018	2.333TyrLeu: 2.333 ± 0.041	0.542TyrMet: 0.542 ± 0.017	0.595TyrAsn: 0.595 ± 0.021	1.136TyrPro: 1.136 ± 0.026	0.648TyrGln: 0.648 ± 0.022	1.607TyrArg: 1.607 ± 0.031	1.147TyrSer: 1.147 ± 0.025	1.169TyrThr: 1.169 ± 0.026	1.582TyrVal: 1.582 ± 0.028	0.393TyrTrp: 0.393 ± 0.017	0.615TyrTyr: 0.615 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5534 proteins (1712709 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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