Amino acid dipepetide frequency for Nonlabens sp. MB-3u-79

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.588AlaAla: 5.588 ± 0.106	0.615AlaCys: 0.615 ± 0.058	3.669AlaAsp: 3.669 ± 0.075	3.369AlaGlu: 3.369 ± 0.068	3.571AlaPhe: 3.571 ± 0.067	4.945AlaGly: 4.945 ± 0.104	1.235AlaHis: 1.235 ± 0.043	5.546AlaIle: 5.546 ± 0.08	4.039AlaLys: 4.039 ± 0.093	6.503AlaLeu: 6.503 ± 0.103	1.791AlaMet: 1.791 ± 0.052	3.286AlaAsn: 3.286 ± 0.085	2.361AlaPro: 2.361 ± 0.123	3.082AlaGln: 3.082 ± 0.057	2.422AlaArg: 2.422 ± 0.053	4.557AlaSer: 4.557 ± 0.087	4.525AlaThr: 4.525 ± 0.127	4.884AlaVal: 4.884 ± 0.084	0.613AlaTrp: 0.613 ± 0.023	2.564AlaTyr: 2.564 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.546CysAla: 0.546 ± 0.061	0.096CysCys: 0.096 ± 0.01	0.574CysAsp: 0.574 ± 0.06	0.46CysGlu: 0.46 ± 0.031	0.397CysPhe: 0.397 ± 0.023	0.69CysGly: 0.69 ± 0.061	0.187CysHis: 0.187 ± 0.018	0.592CysIle: 0.592 ± 0.025	0.439CysLys: 0.439 ± 0.025	0.617CysLeu: 0.617 ± 0.031	0.141CysMet: 0.141 ± 0.011	0.366CysAsn: 0.366 ± 0.022	0.322CysPro: 0.322 ± 0.027	0.194CysGln: 0.194 ± 0.014	0.209CysArg: 0.209 ± 0.016	0.631CysSer: 0.631 ± 0.064	0.423CysThr: 0.423 ± 0.024	0.422CysVal: 0.422 ± 0.022	0.091CysTrp: 0.091 ± 0.012	0.31CysTyr: 0.31 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.337AspAla: 4.337 ± 0.145	0.521AspCys: 0.521 ± 0.06	3.135AspAsp: 3.135 ± 0.083	3.253AspGlu: 3.253 ± 0.066	3.565AspPhe: 3.565 ± 0.07	4.025AspGly: 4.025 ± 0.096	1.308AspHis: 1.308 ± 0.04	4.407AspIle: 4.407 ± 0.131	3.634AspLys: 3.634 ± 0.084	6.005AspLeu: 6.005 ± 0.106	1.309AspMet: 1.309 ± 0.037	2.967AspAsn: 2.967 ± 0.088	2.15AspPro: 2.15 ± 0.084	2.491AspGln: 2.491 ± 0.053	2.406AspArg: 2.406 ± 0.046	3.426AspSer: 3.426 ± 0.071	2.943AspThr: 2.943 ± 0.068	3.731AspVal: 3.731 ± 0.077	0.726AspTrp: 0.726 ± 0.026	2.913AspTyr: 2.913 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.068GluAla: 4.068 ± 0.079	0.339GluCys: 0.339 ± 0.02	3.659GluAsp: 3.659 ± 0.067	5.146GluGlu: 5.146 ± 0.109	2.867GluPhe: 2.867 ± 0.059	3.39GluGly: 3.39 ± 0.073	1.174GluHis: 1.174 ± 0.04	5.002GluIle: 5.002 ± 0.094	5.272GluLys: 5.272 ± 0.11	6.467GluLeu: 6.467 ± 0.109	1.762GluMet: 1.762 ± 0.046	4.155GluAsn: 4.155 ± 0.077	1.543GluPro: 1.543 ± 0.041	2.544GluGln: 2.544 ± 0.06	2.609GluArg: 2.609 ± 0.065	3.495GluSer: 3.495 ± 0.062	3.263GluThr: 3.263 ± 0.068	4.684GluVal: 4.684 ± 0.083	0.675GluTrp: 0.675 ± 0.026	2.184GluTyr: 2.184 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.221PheAla: 3.221 ± 0.067	0.412PheCys: 0.412 ± 0.023	3.382PheAsp: 3.382 ± 0.077	3.18PheGlu: 3.18 ± 0.059	2.573PhePhe: 2.573 ± 0.07	3.064PheGly: 3.064 ± 0.071	0.932PheHis: 0.932 ± 0.032	3.83PheIle: 3.83 ± 0.08	3.49PheLys: 3.49 ± 0.081	4.6PheLeu: 4.6 ± 0.09	1.135PheMet: 1.135 ± 0.038	3.009PheAsn: 3.009 ± 0.076	1.672PhePro: 1.672 ± 0.044	1.664PheGln: 1.664 ± 0.051	1.578PheArg: 1.578 ± 0.044	3.543PheSer: 3.543 ± 0.077	3.224PheThr: 3.224 ± 0.072	2.728PheVal: 2.728 ± 0.063	0.509PheTrp: 0.509 ± 0.027	2.173PheTyr: 2.173 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	4.629GlyAla: 4.629 ± 0.112	0.599GlyCys: 0.599 ± 0.032	3.693GlyAsp: 3.693 ± 0.069	3.413GlyGlu: 3.413 ± 0.06	3.558GlyPhe: 3.558 ± 0.067	4.535GlyGly: 4.535 ± 0.118	1.202GlyHis: 1.202 ± 0.033	5.425GlyIle: 5.425 ± 0.075	4.548GlyLys: 4.548 ± 0.08	5.653GlyLeu: 5.653 ± 0.082	1.782GlyMet: 1.782 ± 0.048	3.568GlyAsn: 3.568 ± 0.093	1.44GlyPro: 1.44 ± 0.05	2.097GlyGln: 2.097 ± 0.052	2.31GlyArg: 2.31 ± 0.058	4.276GlySer: 4.276 ± 0.084	4.391GlyThr: 4.391 ± 0.153	4.528GlyVal: 4.528 ± 0.078	0.78GlyTrp: 0.78 ± 0.029	2.82GlyTyr: 2.82 ± 0.077	0.0GlyXaa: 0.0 ± 0.0
His	1.089HisAla: 1.089 ± 0.034	0.169HisCys: 0.169 ± 0.012	0.903HisAsp: 0.903 ± 0.034	1.016HisGlu: 1.016 ± 0.034	1.081HisPhe: 1.081 ± 0.032	1.146HisGly: 1.146 ± 0.038	0.541HisHis: 0.541 ± 0.028	1.488HisIle: 1.488 ± 0.046	1.264HisLys: 1.264 ± 0.039	2.007HisLeu: 2.007 ± 0.054	0.366HisMet: 0.366 ± 0.02	0.881HisAsn: 0.881 ± 0.031	0.905HisPro: 0.905 ± 0.035	0.845HisGln: 0.845 ± 0.032	0.775HisArg: 0.775 ± 0.031	1.126HisSer: 1.126 ± 0.039	0.952HisThr: 0.952 ± 0.031	1.038HisVal: 1.038 ± 0.032	0.22HisTrp: 0.22 ± 0.016	0.801HisTyr: 0.801 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.062IleAla: 6.062 ± 0.104	0.686IleCys: 0.686 ± 0.061	5.021IleAsp: 5.021 ± 0.073	5.092IleGlu: 5.092 ± 0.082	3.204IlePhe: 3.204 ± 0.061	5.105IleGly: 5.105 ± 0.093	1.397IleHis: 1.397 ± 0.04	5.738IleIle: 5.738 ± 0.111	5.297IleLys: 5.297 ± 0.089	6.598IleLeu: 6.598 ± 0.11	1.433IleMet: 1.433 ± 0.04	4.413IleAsn: 4.413 ± 0.074	3.185IlePro: 3.185 ± 0.067	2.399IleGln: 2.399 ± 0.066	2.34IleArg: 2.34 ± 0.05	5.299IleSer: 5.299 ± 0.08	4.874IleThr: 4.874 ± 0.089	4.481IleVal: 4.481 ± 0.08	0.658IleTrp: 0.658 ± 0.032	2.739IleTyr: 2.739 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.903LysAla: 4.903 ± 0.101	0.295LysCys: 0.295 ± 0.019	4.121LysAsp: 4.121 ± 0.088	6.135LysGlu: 6.135 ± 0.113	2.498LysPhe: 2.498 ± 0.065	4.229LysGly: 4.229 ± 0.097	1.236LysHis: 1.236 ± 0.046	5.076LysIle: 5.076 ± 0.097	5.98LysLys: 5.98 ± 0.122	5.722LysLeu: 5.722 ± 0.102	2.007LysMet: 2.007 ± 0.054	4.518LysAsn: 4.518 ± 0.096	1.917LysPro: 1.917 ± 0.049	2.263LysGln: 2.263 ± 0.066	2.743LysArg: 2.743 ± 0.062	4.084LysSer: 4.084 ± 0.085	4.044LysThr: 4.044 ± 0.083	4.139LysVal: 4.139 ± 0.084	0.764LysTrp: 0.764 ± 0.03	2.568LysTyr: 2.568 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.853LeuAla: 5.853 ± 0.086	0.703LeuCys: 0.703 ± 0.031	5.487LeuAsp: 5.487 ± 0.087	6.301LeuGlu: 6.301 ± 0.112	4.755LeuPhe: 4.755 ± 0.097	5.933LeuGly: 5.933 ± 0.081	1.687LeuHis: 1.687 ± 0.05	7.113LeuIle: 7.113 ± 0.121	7.048LeuLys: 7.048 ± 0.108	9.045LeuLeu: 9.045 ± 0.159	2.229LeuMet: 2.229 ± 0.053	4.976LeuAsn: 4.976 ± 0.081	3.612LeuPro: 3.612 ± 0.105	3.5LeuGln: 3.5 ± 0.07	3.576LeuArg: 3.576 ± 0.072	6.639LeuSer: 6.639 ± 0.097	5.19LeuThr: 5.19 ± 0.107	5.511LeuVal: 5.511 ± 0.088	0.946LeuTrp: 0.946 ± 0.033	3.139LeuTyr: 3.139 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.685MetAla: 1.685 ± 0.052	0.154MetCys: 0.154 ± 0.014	1.44MetAsp: 1.44 ± 0.041	1.595MetGlu: 1.595 ± 0.046	0.798MetPhe: 0.798 ± 0.033	1.529MetGly: 1.529 ± 0.042	0.438MetHis: 0.438 ± 0.024	1.815MetIle: 1.815 ± 0.046	2.202MetLys: 2.202 ± 0.049	2.023MetLeu: 2.023 ± 0.053	0.737MetMet: 0.737 ± 0.03	1.369MetAsn: 1.369 ± 0.039	0.877MetPro: 0.877 ± 0.032	0.866MetGln: 0.866 ± 0.031	1.026MetArg: 1.026 ± 0.035	1.673MetSer: 1.673 ± 0.044	1.291MetThr: 1.291 ± 0.04	1.386MetVal: 1.386 ± 0.039	0.178MetTrp: 0.178 ± 0.017	0.691MetTyr: 0.691 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.798AsnAla: 3.798 ± 0.088	0.48AsnCys: 0.48 ± 0.057	3.426AsnAsp: 3.426 ± 0.082	3.401AsnGlu: 3.401 ± 0.067	2.64AsnPhe: 2.64 ± 0.066	4.02AsnGly: 4.02 ± 0.11	0.999AsnHis: 0.999 ± 0.032	3.978AsnIle: 3.978 ± 0.082	3.675AsnLys: 3.675 ± 0.09	4.726AsnLeu: 4.726 ± 0.08	1.279AsnMet: 1.279 ± 0.036	3.374AsnAsn: 3.374 ± 0.084	2.524AsnPro: 2.524 ± 0.061	2.072AsnGln: 2.072 ± 0.055	2.227AsnArg: 2.227 ± 0.054	3.606AsnSer: 3.606 ± 0.085	3.416AsnThr: 3.416 ± 0.088	3.089AsnVal: 3.089 ± 0.074	0.725AsnTrp: 0.725 ± 0.026	2.718AsnTyr: 2.718 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	2.26ProAla: 2.26 ± 0.053	0.202ProCys: 0.202 ± 0.017	2.24ProAsp: 2.24 ± 0.07	2.706ProGlu: 2.706 ± 0.057	1.843ProPhe: 1.843 ± 0.047	1.973ProGly: 1.973 ± 0.057	0.65ProHis: 0.65 ± 0.033	2.538ProIle: 2.538 ± 0.066	2.084ProLys: 2.084 ± 0.049	3.08ProLeu: 3.08 ± 0.06	0.701ProMet: 0.701 ± 0.028	1.974ProAsn: 1.974 ± 0.061	0.749ProPro: 0.749 ± 0.036	1.348ProGln: 1.348 ± 0.044	1.009ProArg: 1.009 ± 0.036	2.37ProSer: 2.37 ± 0.117	2.063ProThr: 2.063 ± 0.063	2.62ProVal: 2.62 ± 0.093	0.35ProTrp: 0.35 ± 0.022	1.483ProTyr: 1.483 ± 0.062	0.0ProXaa: 0.0 ± 0.0
Gln	2.355GlnAla: 2.355 ± 0.058	0.166GlnCys: 0.166 ± 0.013	1.908GlnAsp: 1.908 ± 0.055	2.764GlnGlu: 2.764 ± 0.06	1.694GlnPhe: 1.694 ± 0.044	2.041GlnGly: 2.041 ± 0.05	0.672GlnHis: 0.672 ± 0.029	2.882GlnIle: 2.882 ± 0.06	2.614GlnLys: 2.614 ± 0.067	4.155GlnLeu: 4.155 ± 0.09	0.945GlnMet: 0.945 ± 0.034	2.053GlnAsn: 2.053 ± 0.053	1.322GlnPro: 1.322 ± 0.044	1.8GlnGln: 1.8 ± 0.071	1.422GlnArg: 1.422 ± 0.044	2.071GlnSer: 2.071 ± 0.054	2.013GlnThr: 2.013 ± 0.067	2.475GlnVal: 2.475 ± 0.053	0.441GlnTrp: 0.441 ± 0.024	1.293GlnTyr: 1.293 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.406ArgAla: 2.406 ± 0.059	0.208ArgCys: 0.208 ± 0.015	2.148ArgAsp: 2.148 ± 0.049	2.498ArgGlu: 2.498 ± 0.057	2.057ArgPhe: 2.057 ± 0.046	2.155ArgGly: 2.155 ± 0.051	0.645ArgHis: 0.645 ± 0.025	3.022ArgIle: 3.022 ± 0.062	2.864ArgLys: 2.864 ± 0.072	3.383ArgLeu: 3.383 ± 0.073	1.043ArgMet: 1.043 ± 0.037	2.136ArgAsn: 2.136 ± 0.054	1.155ArgPro: 1.155 ± 0.037	1.186ArgGln: 1.186 ± 0.035	1.469ArgArg: 1.469 ± 0.048	2.316ArgSer: 2.316 ± 0.064	1.978ArgThr: 1.978 ± 0.047	2.284ArgVal: 2.284 ± 0.055	0.454ArgTrp: 0.454 ± 0.055	1.575ArgTyr: 1.575 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.876SerAla: 3.876 ± 0.079	0.696SerCys: 0.696 ± 0.026	3.656SerAsp: 3.656 ± 0.118	3.511SerGlu: 3.511 ± 0.07	3.858SerPhe: 3.858 ± 0.071	4.871SerGly: 4.871 ± 0.103	1.094SerHis: 1.094 ± 0.038	5.213SerIle: 5.213 ± 0.085	4.342SerLys: 4.342 ± 0.094	6.305SerLeu: 6.305 ± 0.095	1.423SerMet: 1.423 ± 0.045	3.543SerAsn: 3.543 ± 0.086	2.115SerPro: 2.115 ± 0.058	2.422SerGln: 2.422 ± 0.058	2.507SerArg: 2.507 ± 0.059	4.773SerSer: 4.773 ± 0.091	3.921SerThr: 3.921 ± 0.113	3.967SerVal: 3.967 ± 0.092	0.791SerTrp: 0.791 ± 0.033	2.894SerTyr: 2.894 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.8ThrAla: 4.8 ± 0.133	0.409ThrCys: 0.409 ± 0.027	3.813ThrAsp: 3.813 ± 0.088	3.429ThrGlu: 3.429 ± 0.07	2.814ThrPhe: 2.814 ± 0.096	4.529ThrGly: 4.529 ± 0.099	1.016ThrHis: 1.016 ± 0.035	4.215ThrIle: 4.215 ± 0.075	3.14ThrLys: 3.14 ± 0.071	5.515ThrLeu: 5.515 ± 0.183	1.079ThrMet: 1.079 ± 0.034	3.089ThrAsn: 3.089 ± 0.078	2.487ThrPro: 2.487 ± 0.071	2.056ThrGln: 2.056 ± 0.047	1.814ThrArg: 1.814 ± 0.046	4.191ThrSer: 4.191 ± 0.093	3.943ThrThr: 3.943 ± 0.111	3.946ThrVal: 3.946 ± 0.104	0.558ThrTrp: 0.558 ± 0.03	2.554ThrTyr: 2.554 ± 0.072	0.0ThrXaa: 0.0 ± 0.0
Val	4.602ValAla: 4.602 ± 0.076	0.525ValCys: 0.525 ± 0.032	3.802ValAsp: 3.802 ± 0.118	3.925ValGlu: 3.925 ± 0.08	3.372ValPhe: 3.372 ± 0.058	3.748ValGly: 3.748 ± 0.075	1.101ValHis: 1.101 ± 0.038	4.928ValIle: 4.928 ± 0.08	3.878ValLys: 3.878 ± 0.083	6.126ValLeu: 6.126 ± 0.1	1.474ValMet: 1.474 ± 0.039	3.426ValAsn: 3.426 ± 0.067	2.283ValPro: 2.283 ± 0.075	2.102ValGln: 2.102 ± 0.057	2.261ValArg: 2.261 ± 0.063	4.409ValSer: 4.409 ± 0.112	3.918ValThr: 3.918 ± 0.094	4.459ValVal: 4.459 ± 0.084	0.57ValTrp: 0.57 ± 0.028	2.346ValTyr: 2.346 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.551TrpAla: 0.551 ± 0.026	0.102TrpCys: 0.102 ± 0.012	0.648TrpAsp: 0.648 ± 0.026	0.696TrpGlu: 0.696 ± 0.031	0.522TrpPhe: 0.522 ± 0.026	0.549TrpGly: 0.549 ± 0.025	0.233TrpHis: 0.233 ± 0.018	0.754TrpIle: 0.754 ± 0.031	0.776TrpLys: 0.776 ± 0.026	1.015TrpLeu: 1.015 ± 0.034	0.359TrpMet: 0.359 ± 0.019	0.779TrpAsn: 0.779 ± 0.031	0.261TrpPro: 0.261 ± 0.019	0.394TrpGln: 0.394 ± 0.021	0.42TrpArg: 0.42 ± 0.023	0.741TrpSer: 0.741 ± 0.033	0.671TrpThr: 0.671 ± 0.061	0.631TrpVal: 0.631 ± 0.026	0.161TrpTrp: 0.161 ± 0.013	0.439TrpTyr: 0.439 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.535TyrAla: 2.535 ± 0.08	0.329TyrCys: 0.329 ± 0.022	2.527TyrAsp: 2.527 ± 0.053	2.41TyrGlu: 2.41 ± 0.057	2.25TyrPhe: 2.25 ± 0.054	2.77TyrGly: 2.77 ± 0.061	0.869TyrHis: 0.869 ± 0.032	2.458TyrIle: 2.458 ± 0.063	2.658TyrLys: 2.658 ± 0.064	3.695TyrLeu: 3.695 ± 0.076	0.776TyrMet: 0.776 ± 0.029	2.289TyrAsn: 2.289 ± 0.052	1.364TyrPro: 1.364 ± 0.037	1.764TyrGln: 1.764 ± 0.052	1.858TyrArg: 1.858 ± 0.065	2.551TyrSer: 2.551 ± 0.054	2.354TyrThr: 2.354 ± 0.076	2.251TyrVal: 2.251 ± 0.053	0.494TyrTrp: 0.494 ± 0.025	1.706TyrTyr: 1.706 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2710 proteins (909226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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